scholarly journals Evaluation of enhanced external counterpulsation therapy for nonarteritic anterior ischemic optic neuropathy

2020 ◽  
Author(s):  
Lixia Lin ◽  
Wenhui Zhu ◽  
Nan Ma ◽  
Xiaofeng Lin ◽  
Hui Yang
Keyword(s):  
Optic Neuropathy ◽  
Visual Function ◽  
Anterior Ischemic Optic Neuropathy ◽  
Controlled Study ◽  
Control Group ◽  
Ischemic Optic Neuropathy ◽  
External Counterpulsation ◽  
Significant Difference ◽  
And Control ◽  
Enhanced External Counterpulsation

Abstract Background To explore the effects of enhanced external counterpulsation (EECP) and its underlying influencing factors in nonarteritic anterior ischemic optic neuropathy (NAION) patients. Methods Patients at Zhongshan Ophthalmic Center with recent-onset (<8 weeks) NAION were retrospectively recruited. The patients had decided whether or not they would undergo EECP treatment, and the patients who declined were included in the control group. The effectiveness of EECP was evaluated by comparing the visual function and fellow eye involvement in patients with and without EECP treatment. Results In total, 61 patients (76 eyes) were included. Twenty-nine patients (37 eyes) underwent EECP treatment, while 32 patients (39 eyes) were included in the control group. Mean time from NAION onset to EECP initiation was 27.59±16.70 days. In the EECP group, the mean EECP duration was 31.57±18.45 days. EECP was well tolerated by all patients. However, there was no significant difference in visual function between the EECP and control groups, regardless of time to treatment initiation. Furthermore, there was no evidence of the effectiveness of EECP in the subgroup analysis of patients with different systemic health conditions. Among the 42 patients with monocular NAION, the sequential attack rate was comparable between the EECP (27.78%) and control (25.00%) groups. Conclusion This study is the first nonrandomized controlled study to evaluate the effectiveness of EECP in NAION patients. Unfortunately, we failed to demonstrate the effectiveness of EECP in NAION at the 6-month follow-up. Any further application of EECP in NAION patients should be cautious.

scholarly journals Evaluation of enhanced external counterpulsation therapy for nonarteritic anterior ischemic optic neuropathy

2020 ◽  
Author(s):  
Lixia Lin ◽  
Wenhui Zhu ◽  
Nan Ma ◽  
Xiaofeng Lin ◽  
Hui Yang
Keyword(s):  
Optic Neuropathy ◽  
Visual Function ◽  
Anterior Ischemic Optic Neuropathy ◽  
Controlled Study ◽  
Control Group ◽  
Ischemic Optic Neuropathy ◽  
External Counterpulsation ◽  
Significant Difference ◽  
And Control ◽  
Enhanced External Counterpulsation

Abstract Background To explore the effects of enhanced external counterpulsation (EECP) and its underlying influencing factors in nonarteritic anterior ischemic optic neuropathy (NAION) patients. Methods Patients at Zhongshan Ophthalmic Center with recent-onset (<8 weeks) NAION were retrospectively recruited. The patients had decided whether or not they would undergo EECP treatment, and the patients who declined were included in the control group. The effectiveness of EECP was evaluated by comparing the visual function and fellow eye involvement in patients with and without EECP treatment. Results In total, 61 patients (76 eyes) were included. Twenty-nine patients (37 eyes) underwent EECP treatment, while 32 patients (39 eyes) were included in the control group. Mean time from NAION onset to EECP initiation was 27.59±16.70 days. In the EECP group, the mean EECP duration was 31.57±18.45 days. EECP was well tolerated by all patients. However, there was no significant difference in visual function between the EECP and control groups, regardless of time to treatment initiation. Furthermore, there was no evidence of the effectiveness of EECP in the subgroup analysis of patients with different systemic health conditions. Among the 42 patients with monocular NAION, the sequential attack rate was comparable between the EECP (27.78%) and control (25.00%) groups. Conclusion This study is the first nonrandomized controlled study to evaluate the effectiveness of EECP in NAION patients. Unfortunately, we failed to demonstrate the effectiveness of EECP in NAION at the 6-month follow-up. Any further application of EECP in NAION patients should be cautious.

Optical Coherence Tomography Angiography Acute of Non-Arteritic Anterior Ischemic Optic Neuropathy

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Karim Ahmed Hussein Ibrahim ◽  
Ahmed Abd Al Aleem Mohamed
Keyword(s):  
Optic Neuropathy ◽  
Optical Coherence Tomography Angiography ◽  
Acute Stage ◽  
Anterior Ischemic Optic Neuropathy ◽  
Control Group ◽  
Ischemic Optic Neuropathy ◽  
Outer Circle ◽  
Significant Difference ◽  
Perfusion Density ◽  
Peripapillary Area

Abstract Background Anterior ischemic optic neuropathy (AION) is divided into arteritic anterior ischemic optic neuropathy (AAION) which accounts for 15% and Nonarteritic anterior ischemic optic neuropathy (NAION) which accounts for 85% of cases. Non-arteritic anterior ischemic optic neuropathy (NAION) is an ischemic change involves the 1 mm thickness of the optic nerve head (optic disc). It affects around 10 cases per 100,000 per year in the age group over 50. Objective To assess the optical coherence tomography angiography peripapillary area pattern in diagnosed non-arteritic acute ischemic optic neuropathy patients within a period from one week to 3 weeks during (acute stage while the disc is still edematous) of acute painless diminution of vision. Patients and Methods We enrolled 20 patients in cases group and 10 patients in control group were enrolled to assess the OCTA peripapillary area pattern in diagnosed NAAION patients within a period from one week to 3 weeks during (acute stage while the disc is still edematous) of acute painless diminution of vision compared to the pattern seen in the normal control group OCTA, FFA and VF (centralized 30-2 SITA strategy) were done to the cases group. But FFA and VF were excluded in the control group. Results The results of our study show statistically significant difference found between the two studied groups regarding central circle perfusion density, middle circle perfusion density (superior, inferior and nasal) and outer circle perfusion density (superior and temporal) while no statistically significant difference found between them regarding middle circle (temporal) and outer circle (inferior and nasal). Conclusion So according to this study in cases of NAION (acute stage), we can depend on perfusion density within the middle and outer circle of Early Treatment Diabetic Retinopathy Study (ETDRS) grid put on the disc and peripapillary area. As, these are the areas affected by decreased perfusion density. While, there is increased perfusion density within the central and middle circles, which could be due to, diffuse disc edema.

scholarly journals Contrast Sensitivity of Thyroid Associated Ophthalmopathy Patients without Obvious Optic Neuropathy

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Ümit Beden ◽  
Sümeyra Kaya ◽  
Volkan Yeter ◽  
Dilek Erkan
Keyword(s):  
Contrast Sensitivity ◽  
Optic Neuropathy ◽  
Controlled Study ◽  
Control Group ◽  
Clinical Activity ◽  
Sensitivity Functions ◽  
Significant Difference ◽  
Thyroid Associated Ophthalmopathy ◽  
The Difference ◽  
And Control

Purpose. To compare the contrast sensitivity levels of thyroid associated ophthalmopathy (TAO) patients without obvious optic neuropathy with those of healthy people.Methods. Forty eyes of 20 TAO patients without dysthyroid optic neuropathy and 40 eyes of 20 healthy subjects were evaluated in this prospective case-controlled study. The contrast sensitivity functions (CSFs) of all subjects were measured by the functional acuity contrast test (FACT) in five frequencies which were 1,5 cpd (A), 3 cpd (B), 6 cpd (C), 12 cpd (D), and 18 cpd (E). Results were compared for both groups, and a correlation of CSF with Hertel and clinical activity scores was assessed.Results. There was no statistically significant difference between TAO patients and control groups for age and sex. TAO patients had lower levels than the control group in all the frequencies of CSFs (P<0.05) and the difference in contrast sensitivity functions between the groups seems to be more significant in higher frequencies (B, C, D, and E) (P<0.001).Conclusions. TAO patients without DON can have contrast sensitivity loss and this would probably imply subtle optic nerve dysfunction in early disease phase.

scholarly journals Choroidal Thickness in Acute Non-arteritic Anterior Ischemic Optic Neuropathy

2020 ◽  
Author(s):  
Homayoun Nikkhah ◽  
Mohadeseh Feizi ◽  
Naser Abedi ◽  
Saeed Karimi ◽  
Mehdi Yaseri ◽  
...  
Keyword(s):  
Optic Neuropathy ◽  
Choroidal Thickness ◽  
Anterior Ischemic Optic Neuropathy ◽  
Enhanced Depth Imaging ◽  
Ischemic Optic Neuropathy ◽  
Significant Difference ◽  
The Mean ◽  
Contralateral Eye ◽  
And Control ◽  
Fellow Eyes

Purpose: To compare the choroidal thickness in eyes with acute non-arteritic anterior ischemic optic neuropathy (NAION) with healthy contralateral eye and normal controls. Methods: Thirty-eight eyes with NAION, thirty-eight unaffected fellow eyes, and seventy four eyes from 37 healthy, age- and sex-matched subjects were included in this prospective comparative case-control study. Choroidal thickness was measured by enhanced depth imaging (EDI) of spectral domain optical coherence tomography (SDOCT). Peripapillary choroidal thickness (PCT) was measured at 1000 and 1500 μm from Bruch's membrane opening (BMO). Subfoveal choroidal thickness (SFCT) was measured in central subfoveal area, and 500 microns apart in temporal and nasal sides. Choroidal thickness among NAION eyes, uninvolved fellow eyes, and control eyes were compared. Results: The mean of PCT at 1000 μm was significantly thicker in NAION and fellow eyes compared to control eyes (169.7 ± 47, 154.4 ± 42.1, and 127.7 ± 49.9 μm, respectively, P < 0.001 and P = 0.42). The mean PCT at 1500 μm was also significantly thicker in NAION and fellow eyes compared to control eyes (178.6 ± 52.8, 162.6 ± 46.1, and 135.1 ± 59 μm, respectively, P = 0.007 and P = 0.048). The mean PCT at 1000 and 1500 μm was significantly greater in NAION compared to fellow eyes (P = 0.027 and P = 0.035, respectively). The mean of SFCT was significantly thicker in NAION compared to control eyes (P = 0.032); however, there was no significant difference between uninvolved fellow and control eyes (P = 0.248). Conclusion: Thicker choroidal thickness in acute NAION and uninvolved fellow eyes compared to normal eyes suggests a primary choroidal role in NAION pathophysiology.

scholarly journals Central Corneal Thickness Measurements in Nonarteritic Anterior Ischemic Optic Neuropathy Patients: A Controlled Study

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Haneen Jabaly-Habib ◽  
Modi Naftali ◽  
George Habib
Keyword(s):  
Optic Neuropathy ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Anterior Ischemic Optic Neuropathy ◽  
Controlled Study ◽  
Control Group ◽  
Ischemic Optic Neuropathy ◽  
History Of ◽  
Group 2 ◽  
Group 1

Purpose. To measure central corneal thickness (CCT) in patients with history of nonarteritic anterior ischemic optic neuropathy (NAION).Patients and Methods. Patients older than 40 years with a history of NAION (group 1) were prospectively evaluated including full eye examination and central corneal thickness (CCT) pachymetry. Patients with a history of intraocular surgery, corneal disease, glaucoma, and contact lens wear were excluded. Measurements were also performed in a gender and age matched control group (group 2).Results. Thirty-one eyes of 31 NAION patients in group 1 were included and 30 eyes of 30 participants in group 2. There were 15 men in group 1 and 9 in group 2P=0.141, and mean age of the patients was59±10years in group 1 versus61±11years in group 2P=0.708. Mean CCT was539±30microns in group 1 and550±33microns in group 2P=0.155.Conclusion. Patients with NAION have no special characteristic of CCT in contrast to the crowded optic disc known to be a significant anatomic risk factor for NAION. More studies should be carried out to investigate CCT and other structure related elements in NAION patients.

scholarly journals Internal carotid artery velocities in patients with unilateral non-arteritic anterior ischemic optic neuropathy

2017 ◽  
Vol 15 (3) ◽  
Author(s):  
Karen Bulan Reyes
Keyword(s):  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Optic Neuropathy ◽  
Internal Carotid ◽  
Peak Systolic Velocity ◽  
Contralateral Side ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Significant Difference ◽  
Control Study

Objective: This study aims to evaluate and compare the proximal, medial, and distal segments of internal carotid artery (ICA) peak systolic velocities (PSV) in patients with nonarteritic anterior ischemic optic neuropathy (NA-AION) in one eye against the contralateral side with normal eye findings using doppler ultrasound. Methods:  This is a single-center,  prospective, case control study of five patients with unilateral NA-AION.  The peak systolic velocity (PSV) of the proximal, medial, and distal segments of the ICAs on both sides, one side with NA-AION while the contralateral side had normal eye findings, were compared and analyzed. Results: Four females and one male with a mean age of 59 years (SD = 17 years) were included. PSV of the ICA was measured in three segments: Proximal (PICA), Medial (MICA), and Distal (DICA). Mean PSV of eyes with NA-AION was 143cm/sec (SD= 177cm/sec), 159 cm/sec (SD=189 cm/sec), 98 cm/sec (SD=34cm/sec) for PICA, MICA and DICA respectively. Mean PSV of contralateral side without NA-AION was 95cm/sec (SD= 72cm/sec), 101 cm/sec (SD=53cm/sec), 140cm/sec (SD=60 cm/sec) for PICA, MICA and DICA respectively. There was no statistically significant difference between the two groups along the three segments (T-test PICAp=0.369, MICAp=0.402, DICAp=0.112). Conclusion: Mean PSV was higher in eyes with NA-AION at the proximal and medial segments of the ICA, while it was lower at the distal segments compared to the contralateral non-NA-AION side. 

scholarly journals The Effect of Wrist Kinesiotaping on Hand Motor Exercise in Fine Motor Skill for Children with Cerebral Palsy

1970 ◽  
Vol 10 (1) ◽  
pp. 1-10
Author(s):  
Erna Setiawati
Keyword(s):  
Cerebral Palsy ◽  
Motor Skill ◽  
Current Method ◽  
Controlled Study ◽  
Fine Motor ◽  
Control Group ◽  
Fine Motor Skill ◽  
Post Intervention ◽  
Significant Difference ◽  
And Control

ABSTRACTIntroduction: Kinesiotaping (KT) is one of current method that being used for hands problems in cerebral palsy. The purpose of this study was to evaluate the effect of kinesiotaping at wrist combined with hand motor exercise in fine motor skill for children with cerebral palsy.Methods: The design was simple randomized controlled study pre and post intervention. There were 18 children who divided into kinesiotaping and control group. Subjects in the KT group received hand motor exercise and wrist kinesiotaping. Subjects in control group received only hand motor exercise.Both groups received the exercise for 4 weeks. There were difference in the MACS score which is used to measure fine motor skills in this study. Pre and posttest scores were collected before applying kinesiotaping and after 4 weeks of intervention.Results: Both groups showed an increase in MACS score after 4 weeks intervention. For MACS score, there was statistically significant difference in KT group (p = 0.025), but not statistically significant in control group (p = 0.083).Conclusion: Wrist kinesiotaping can be used for adjunct therapy combined with conventional hand motor exercise for improving manual ability in the hand and fin e motor skill in cerebral palsy.Keywords: Cerebral palsy, fine motor skill, wrist kinesiotaping.

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