Can18F-FDG PET/CT overcome endoscopy in the staging of gastrointestinal involvement in Mantle Cell Lymphoma? A retrospective multi-center cohort analysis.

Abstract Background. Mantle-cell lymphoma (MCL) represents the 5-7% of all lymphoid malignancies. In 15-30% of cases by different data, MCL may affect the gastrointestinal tract (GI), but the real frequency by endoscopy and imaging could be significantly higher. Actually, by guidelines there are no recommendations for GI endoscopy in every patient with MCL. Therefore, we conducted the present multi-center study with the aim to evaluate the performance of the 18F-FDG PET/CT in the detection of GI involvement in patients with MCL and establish whether it is possible to omit endoscopy.Methods. We retrospectively evaluated 79 patients with newly diagnosed MCL, who had performed a pretreatment 18F-FDG PET/CT scan and GI endoscopy with biopsy. Results. By PET/CT, overall GI tract involvement was found in 24% of patients. The performance of PET/CT have been evaluated by sensitivity, specificity, positive predictive value, negative predictive value and accuracy in the upper and lower GI tract. Using Cohen's k test, PET/CT and EGD with biopsy showed a fair agreement (0.20, 66.6%). However, PET/CT and colorectal biopsy showed a moderate agreement (0.49, 76%). Conclusion. Analyzed data suggest that the performance of 18F-FDG PET/CT is not excellent in the detection of gastric lesions by MCL, and thus EGD with biopsy has yet to be considered a "golden standard" in this subset, while colonoscopy could be omitted due to a higher accuracy and specificity. Taking into account the limit of the retrospective nature of the study, data should be confirmed on larger and prospective cohort.

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18F-FDG PET/CT in a bilateral lacrimal gland infiltration of mantle cell lymphoma

Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) ◽

10.1016/j.remnie.2015.09.001 ◽

2015 ◽

Vol 34 (6) ◽

pp. 396-397

Author(s):

A. Martínez-Esteve ◽

F.J. García-Gómez ◽

J.J. Borrero-Martin ◽

E. Fajardo-Pico ◽

I. Borrego-Dorado

Keyword(s):

Mantle Cell Lymphoma ◽

Lacrimal Gland ◽

Fdg Pet ◽

Cell Lymphoma ◽

Pet Ct ◽

Mantle Cell ◽

18F Fdg ◽

Fdg Pet Ct

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Diagnosis of Mantle-Cell Lymphoma Relapse by 18F-FDG PET/CT After Water Gastric Distention

Clinical Nuclear Medicine ◽

10.1097/rlu.0000000000000509 ◽

2014 ◽

Vol 39 (10) ◽

pp. 931-933

Author(s):

Ignacio Banzo ◽

Isabel Martínez-Rodríguez ◽

Remedios Quirce ◽

Julio Jiménez-Bonilla ◽

José Manuel Carril

Keyword(s):

Mantle Cell Lymphoma ◽

Fdg Pet ◽

Cell Lymphoma ◽

Gastric Distention ◽

Pet Ct ◽

Mantle Cell ◽

18F Fdg ◽

Fdg Pet Ct

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Diagnostic and Clinical Impact of Staging 18F-FDG PET/CT in Mantle-Cell Lymphoma: A Two-Center Experience

Clinical Lymphoma Myeloma & Leukemia ◽

10.1016/j.clml.2019.04.016 ◽

2019 ◽

Vol 19 (8) ◽

pp. e457-e464 ◽

Cited By ~ 3

Author(s):

Domenico Albano ◽

Paola Ferro ◽

Giovanni Bosio ◽

Federico Fallanca ◽

Alessandro Re ◽

...

Keyword(s):

Mantle Cell Lymphoma ◽

Fdg Pet ◽

Cell Lymphoma ◽

Clinical Impact ◽

Pet Ct ◽

Mantle Cell ◽

18F Fdg ◽

Fdg Pet Ct

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The Role of 18F-FDG PET/CT in Staging and Prognostication of Mantle Cell Lymphoma: An Italian Multicentric Study

Cancers ◽

10.3390/cancers11121831 ◽

2019 ◽

Vol 11 (12) ◽

pp. 1831 ◽

Cited By ~ 4

Author(s):

Domenico Albano ◽

Riccardo Laudicella ◽

Paola Ferro ◽

Michela Allocca ◽

Elisabetta Abenavoli ◽

...

Keyword(s):

Predictive Value ◽

Fdg Pet ◽

Cell Lymphoma ◽

Multicentric Study ◽

Pet Ct ◽

Mantle Cell ◽

18F Fdg ◽

Sensitivity Specificity ◽

Fdg Pet Ct

Mantle cell lymphoma (MCL) is an aggressive lymphoma subtype with poor prognosis in which 18F-FDG-PET/CT role in treatment response evaluation and prediction of outcome is still unclear. The aim of this multicentric study was to investigate the role of 18F-FDG-PET/CT in staging MCL and the prognostic role of Deauville criteria (DC) in terms of progression-free survival (PFS) and overall survival (OS). We retrospectively enrolled 229 patients who underwent baseline and end-of-treatment (eot) 18F-FDG-PET/CT after first-line therapy. EotPET/CT scans were visually interpreted according to DC. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of PET/CT for evaluation of bone marrow (BM) were 27%, 100%, 100%, 48% and 57%, respectively. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of PET/CT for evaluation of the gastrointestinal (GI) tract were 60%, 99%, 93%, 90% and 91%, respectively. At a median follow-up of 40 months, relapse occurred in 104 cases and death in 49. EotPET/CT results using DC significantly correlated with PFS, not with OS. Instead, considering OS, only MIPI score was significantly correlated. In conclusion, we demonstrated that MCL is an FDG-avid lymphoma and 18F-FDG-PET/CT is a useful tool for staging purpose, showing good specificity for BM and GI evaluation, but suboptimal sensitivity. EotPET/CT result was the only independent significant prognostic factor that correlated with PFS.

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18F-FDG PET/CT in Intramuscular Mantle Cell Lymphoma With Elongated Lymphomatous Neurovascular Extension

Clinical Nuclear Medicine ◽

10.1097/rlu.0000000000002466 ◽

2019 ◽

Vol 44 (4) ◽

pp. e298-e300 ◽

Cited By ~ 2

Author(s):

Nir Hod ◽

Daniel Levin ◽

Reut Anconina ◽

Dina Ezroh Kazap ◽

Sophie Lantsberg

Keyword(s):

Mantle Cell Lymphoma ◽

Fdg Pet ◽

Cell Lymphoma ◽

Pet Ct ◽

Mantle Cell ◽

18F Fdg ◽

Fdg Pet Ct

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18F-FDG PET/CT Cannot Substitute Endoscopy in the Staging of Gastrointestinal Involvement in Mantle Cell Lymphoma. A Retrospective Multi-Center Cohort Analysis

Journal of Personalized Medicine ◽

10.3390/jpm11020123 ◽

2021 ◽

Vol 11 (2) ◽

pp. 123

Author(s):

Tetiana Skrypets ◽

Cristina Ferrari ◽

Luca Nassi ◽

Gloria Margiotta Casaluci ◽

Benedetta Puccini ◽

...

Keyword(s):

Mantle Cell Lymphoma ◽

Fdg Pet ◽

Cell Lymphoma ◽

Cohort Analysis ◽

Endoscopic Biopsy ◽

Asymptomatic Patients ◽

Pet Ct ◽

Mantle Cell ◽

18F Fdg ◽

Fdg Pet Ct

The detection of gastrointestinal (GI) involvement in Mantle Cell Lymphoma is often underestimated and may have an impact on outcome and clinical management. We aimed to evaluate whether baseline 18F-FDG PET/CT presents comparable results to endoscopic biopsy in the diagnosis of GI localizations. In our retrospective cohort of 79 patients, sensitivity and specificity of 18F-FDG PET/CT were low for the stomach, with a fair concordance (k = 0.32), while higher concordance with pathologic results (k = 0.65) was detected in the colorectal tract. Thus, gastric biopsy remains helpful in the staging of MCL despite 18F-FDG PET/CT, while colonoscopy could be omitted in asymptomatic patients. The validation of our data in prospective cohorts is desirable

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Prognostic role of baseline 18F-FDG PET/CT metabolic parameters in mantle cell lymphoma

Annals of Nuclear Medicine ◽

10.1007/s12149-019-01354-9 ◽

2019 ◽

Vol 33 (7) ◽

pp. 449-458 ◽

Cited By ~ 18

Author(s):

Domenico Albano ◽

Giovanni Bosio ◽

Nicola Bianchetti ◽

Chiara Pagani ◽

Alessandro Re ◽

...

Keyword(s):

Mantle Cell Lymphoma ◽

Fdg Pet ◽

Cell Lymphoma ◽

Metabolic Parameters ◽

Prognostic Role ◽

Pet Ct ◽

Mantle Cell ◽

18F Fdg ◽

Fdg Pet Ct

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18F-FDG PET/CT imaging for a gastrointestinal mantle cell lymphoma with multiple lymphomatous polyposis

World Journal of Gastroenterology ◽

10.3748/wjg.v20.i17.5141 ◽

2014 ◽

Vol 20 (17) ◽

pp. 5141 ◽

Cited By ~ 5

Author(s):

Makoto Saito

Keyword(s):

Mantle Cell Lymphoma ◽

Fdg Pet ◽

Cell Lymphoma ◽

Ct Imaging ◽

Pet Ct ◽

Mantle Cell ◽

18F Fdg ◽

Multiple Lymphomatous Polyposis ◽

Fdg Pet Ct

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[18F]FDG-PET/CT Radiomics for Prediction of Bone Marrow Involvement in Mantle Cell Lymphoma: A Retrospective Study in 97 Patients

Cancers ◽

10.3390/cancers12051138 ◽

2020 ◽

Vol 12 (5) ◽

pp. 1138 ◽

Cited By ~ 2

Author(s):

Marius E. Mayerhoefer ◽

Christopher C. Riedl ◽

Anita Kumar ◽

Ahmet Dogan ◽

Peter Gibbs ◽

...

Keyword(s):

Bone Marrow ◽

Fdg Pet ◽

Cell Lymphoma ◽

Bone Marrow Involvement ◽

Laboratory Data ◽

Texture Features ◽

Pet Ct ◽

Mantle Cell ◽

18F Fdg ◽

Fdg Pet Ct

Biopsy is the standard for assessment of bone marrow involvement in mantle cell lymphoma (MCL). We investigated whether [18F]FDG-PET radiomic texture features can improve prediction of bone marrow involvement in MCL, compared to standardized uptake values (SUV), and whether combination with laboratory data improves results. Ninety-seven MCL patients were retrospectively included. SUVmax, SUVmean, SUVpeak and 16 co-occurrence matrix texture features were extracted from pelvic bones on [18F]FDG-PET/CT. A multi-layer perceptron neural network was used to compare three combinations for prediction of bone marrow involvement—the SUVs, a radiomic signature based on SUVs and texture features, and the radiomic signature combined with laboratory parameters. This step was repeated using two cut-off values for relative bone marrow involvement: REL > 5% (>5% of red/cellular bone marrow); and REL > 10%. Biopsy demonstrated bone marrow involvement in 67/97 patients (69.1%). SUVs, the radiomic signature, and the radiomic signature with laboratory data showed AUCs of up to 0.66, 0.73, and 0.81 for involved vs. uninvolved bone marrow; 0.68, 0.84, and 0.84 for REL ≤ 5% vs. REL > 5%; and 0.69, 0.85, and 0.87 for REL ≤ 10% vs. REL > 10%. In conclusion, [18F]FDG-PET texture features improve SUV-based prediction of bone marrow involvement in MCL. The results may be further improved by combination with laboratory parameters.

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