scholarly journals EVALUATION OF INTRAOCULAR PRESSURE AND CENTRAL CORNEAL THICKNESS CHANGES AFTER HEMODIALYSIS IN PATIENTS WITH CHRONIC RENAL FAILURE

2019 ◽  
Author(s):  
Seyfettin Erdem ◽  
Muslum Gunes
Keyword(s):  
Renal Failure ◽  
Intraocular Pressure ◽  
Chronic Renal Failure ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Total Body Weight ◽  
Body Volume ◽  
Ophthalmological Examination ◽  
Before And After ◽  
The Mean

Abstract Background: This study evaluated short-term changes in intraocular pressure (IOP) and corneal thickness (CCT) following haemodialysis (HD) in chronic renal failure (CRF) patients. Methods: We studied 34 eyes of 34 patients with CRF undergoing HD. Patients included in the study were classified into two subgroups: group 1 (with DM) and group 2 (non DM). All patients underwent a detailed ophthalmological examination including CCT and IOP before and after the HD session. Total body weight and body volume loss after haemodialysis were also measured. Results: The sex distribution of patients were 22 female (64.7%) and 12 male (35.3%). The DM group was comprised of 19 patients (55.9%), and the non-DM had 15 (44.1%). The mean age was 60.3 ± 17.2 (range 21–88) years, and the dialysis time was 51.4 ± 38.5 (range 5–132) months. The mean IOP change after HD decreased from 15.88±2.37 to 14.11±2.02 mmHg (95% CI, 1.40–2.11; p < 0.001). The mean CCT decreased from 554.88±14.27 to 550.52±13.67 μm. (95% CI, 1.97–4.08; P = p < 0.001). The loss in body volume was positively correlated with a decrease in IOP (r = 0.737, p < 0.001) and CCT (r = 0.784, p < 0.001). Conclusions: In patients with CRF who have glaucoma, visual acuity may be adversely affected by IOP and CCT changes following HD. Therefore, a detailed ophthalmologic examination should be performed to take preventive measures for at-risk patients before and after HD. Keywords: Hemodialysis, Intraocular pressure, Central Corneal thickness.

scholarly journals Effect of Hemodialysis on Intraocular Pressure and Central Corneal Thickness in Patients With Chronic Renal Failure

2019 ◽  
Author(s):  
Seyfettin Erdem ◽  
Muslum Gunes
Keyword(s):  
Diabetes Mellitus ◽  
Renal Failure ◽  
Intraocular Pressure ◽  
Chronic Renal Failure ◽  
Corneal Thickness ◽  
Total Body Weight ◽  
Body Volume ◽  
Ophthalmological Examination ◽  
Before And After ◽  
The Mean

Abstract Background: This study evaluated short-term changes in intraocular pressure (IOP) and corneal thickness (CCT) following haemodialysis (HD) in chronic renal failure (CRF) patients. Methods: We studied 34 eyes of 34 patients with CRF undergoing HD. Patients included in the study were classified into two subgroups: with diabetes mellitus (DM, group 1) and without diabetes mellitus (non-DM, group 2). All patients underwent a detailed ophthalmological examination including CCT and IOP before and after the HD session. Total body weight and body volume loss after haemodialysis were also measured. Results: The sex distribution of patients were as 22 females (64.7%) and 12 males (35.3%). The DM group was comprised of 19 patients (55.9%), and the non-DM had 15 patients (44.1%). The mean age was 60.3 ± 17.2 (range 21–88) years, and the dialysis time was 51.4 ± 38.5 (range 5–132) months. The mean IOP change after HD decreased from 15.88±2.37 to 14.11±2.02 mmHg (95% CI, 1.40–2.11; p < 0.001). The mean CCT decreased from 554.88±14.27 to 550.52±13.67 μm. (95% CI, 1.97–4.08; P = p < 0.001). The loss in body volume was positively correlated with a decrease in IOP (r = 0.737, p < 0.001) and CCT (r = 0.784, p < 0.001). Conclusions: Patients at high risk of being affected by changes in intraocular pressure , may be adversely affected by IOP and CCT changes following HD. Therefore, a detailed ophthalmologic examination should be performed to take preventive measures for at-risk patients before and after HD.

scholarly journals Effect of Mydriasis-Caused Intraocular Pressure Changes on Corneal Biomechanical Metrics

2021 ◽  
Vol 9 ◽  
Author(s):  
Yufeng Ye ◽  
Yi Li ◽  
Zehui Zhu ◽  
Anas Ziad Masoud Abu Said ◽  
Kevin Nguelemo Mayopa ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Disease Progression ◽  
Refractive Surgery ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Medical Procedures ◽  
Corvis St ◽  
Before And After ◽  
The Mean ◽  
Pressure Changes

Purpose: To evaluate the dependence of biomechanical metrics on intraocular pressure (IOP).Methods: 233 refractive surgery patients were included in this study—all were examined 3 times with the Corvis ST before and after dilation, and the differences (∆) in the main device parameters were assessed. The data collected included the biomechanically corrected IOP (bIOP), the central corneal thickness (CCT), and six dynamic corneal response (DCR) parameters, namely DA, DARatio2mm, IIR, SP-A1, CBI, and SSI. Participants were divided into three groups according to the changes in patients’ bIOP after mydriasis.Results: Intra-operator repeatability was generally high in most of the DCR parameters obtained before and after dilation. The mean changes in bIOP and CCT after dilation were −0.12 ± 1.36 mmHg and 1.95 ± 5.23 μm, respectively. Only ∆DARatio2mm, ∆IIR, and ∆CBI exhibited a statistically significant correlation with ∆CCT (p &lt; 0.05). The changes in all DCR parameters, especially ∆DA and ∆SP-A1 were also correlated with ∆bIOP (p &lt; 0.01)—a 1-mmHg change in bIOP was associated, on average, with 5.612 and −0.037 units of change in SP-A1 and DA, respectively. In contrast, the weakest correlation with ∆bIOP was exhibited by ∆SSI.Conclusion: Most corneal DCR parameters, provided by the Corvis ST, were correlated with IOP, and more weakly with CCT. Changes experienced in CCT and IOP should therefore be considered in studies on corneal biomechanics and how it is affected by disease progression and surgical or medical procedures.

scholarly journals Assessment of Central Corneal Thickness in Adults With Indications For Kidney Transplantation and Commenting On Some Related Factors

2021 ◽  
Author(s):  
Nguyen Kien Trung ◽  
Vu Anh Tuan ◽  
Le Viet Thang ◽  
Nguyen Dinh Ngan ◽  
Nguyen Chien Thang ◽  
...  
Keyword(s):  
Renal Failure ◽  
Kidney Transplantation ◽  
Intraocular Pressure ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Smoking Habits ◽  
Related Factors ◽  
Blood Calcium ◽  
Central Cornea ◽  
The Mean

Abstract Objectives Central corneal thickness (CCT) is an important biological indicator of eyeball affecting intraocular pressure, which plays a vital role in glaucoma pathology. This study investigated the central corneal thickness in renal failure subjects with indications for kidney transplantation and commented on some related factors. Methods A cross-sectional descriptive study was conducted from January to June 2021 in Hanoi, Vietnam. Ninety-six adult patients with grade 3 and 4 renal failure indicated kidney transplantation had central corneal thickness measured. We investigated the mean value of central corneal thickness in patients with indications for kidney transplantation. The related factors were evaluated by multivariable linear regression. Results The mean thickness of the central cornea in the right eye was 529.3 ± 32 µm, and the left eye was 528.5 ± 32.1 µm, with no difference between the central corneal thickness in the two eyes. Corneal thickness has a positive correlation with IOP after dialysis and smoking habits, adjusted R2 = 0.2405, has a negative correlation with age, adjusted R2 = 0.2405, and with calcium concentration blood, adjusted R2 = 0.032. Conclusion The thickness of the central cornea in patients with renal failure with indications for kidney transplantation in both eyes is similar. Factors related to corneal thickness are age, smoking habits, intraocular pressure after dialysis, and blood calcium levels.

Self-measurement with Icare HOME tonometer, patients’ feasibility and acceptability

2019 ◽  
Vol 30 (2) ◽  
pp. 258-263 ◽  
Author(s):  
Barbara Cvenkel ◽  
Makedonka Atanasovska Velkovska ◽  
Vesna Dimovska Jordanova
Keyword(s):  
Intraocular Pressure ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Pressure Data ◽  
Limits Of Agreement ◽  
Goldmann Applanation Tonometer ◽  
Applanation Tonometer ◽  
Perception Of Self ◽  
The Mean

Purpose: To evaluate and compare the accuracy of self-measurement of intraocular pressure using Icare Home rebound tonometer with Goldmann applanation tonometer and assess acceptability of self-tonometry in patients with glaucoma and ocular hypertension. Methods: In the study, 117 subjects were trained to use Icare Home for self-measurement. Icare Home tonometer readings were compared with Goldmann applanation tonometer, including one eye per patient. Agreement between the two methods of measurement was evaluated by Bland and Altmann analysis. Questionnaire was used to evaluate patients’ perception of self-tonometry. Results: One hundred and three out of 117 patients (88%) were able to measure their own intraocular pressure and 96 (82%) fulfilled the requirements for certification. The mean (SD) difference Goldmann applanation tonometer minus Icare Home was 1.2 (2.4) mmHg (95% limits of agreement, –3.4 to 5.9 mmHg). The magnitude of bias between the two methods depended on central corneal thickness, with greater bias at central corneal thickness <500 µm. In 65 out of 96 subjects (67.7%), Icare Home results were within 2 mmHg of the Goldmann applanation tonometer. Seventy-three out of 93 (78.5%) felt that self-tonometry was easy to use and 75 patients (80.6%) responded that they would use the device at home. Conclusion: Icare Home tonometry tends to slightly underestimate intraocular pressure compared to Goldmann applanation tonometer. Most patients were able to perform self-tonometry and found it acceptable for home use. Measurements using rebound self-tonometry could improve the quality of intraocular pressure data and optimize treatment regimen.

scholarly journals Effects of SMILE Surgery on Intraocular Pressure, Central Corneal Thickness, Axial Length, Peripapillary Retinal Nerve Fiber Layer, and Macular Ganglion Cell Complex Thickness

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Zhanlin Zhao ◽  
Sylvain Michée ◽  
Jean-François Faure ◽  
Christophe Baudouin ◽  
Antoine Labbé
Keyword(s):  
Intraocular Pressure ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Axial Length ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Ganglion Cell Complex ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
The Mean

Purpose. To evaluate the change in intraocular pressure (IOP), central corneal thickness (CCT), axial length, peripapillary retinal nerve fiber layer (RNFL) thickness, and macular ganglion cell complex (GCC) thickness after small incision lenticule extraction (SMILE) surgery. Methods. This prospective observational study was conducted in Espace Nouvelle Vision, Ophthalmological Clinic, Paris, France. Fifty eyes of 25 patients were enrolled in this study and underwent SMILE surgeries. IOP, central corneal thickness (CCT), axial length (AL), peripapillary RNFL thickness, and macular GCC thickness were measured before and at 3 months after SMILE. Results. The mean preoperative spherical equivalent was −3.15 ± 1.50 diopters (D), and the mean postoperative value was 0.15 ± 0.28 D. After SMILE surgery, IOP decreased from 15.03 ± 2.79 mmHg to 11.02 ± 2.73 mmHg and 10.02 ± 2.21 mmHg at 1 and 3 months, respectively ( P < 0.01 for both comparisons). The mean decrease in measured IOP as a function of ablation depth was 0.065 ± 0.031 mmHg/μm. CCT decreased from 545.98 ± 26.61 μm to 478.40 ± 30.26 μm after SMILE surgery ( P < 0.01 ). AL decreased from 24.80 ± 0.84 mm to 24.70 ± 0.83 mm ( P < 0.01 ). There was no statistically significant change in mean peripapillary RNFL or mean GCC thickness after SMILE surgery. Conclusions. SMILE surgery modified IOP measurement, CCT, and AL but did not change peripapillary RNFL and macular GCC thicknesses. The postoperative drop in measured IOP might be explained by the decreased CCT. An accurate re-evaluation of AL should be performed before cataract surgery among post-SMILE patients.

Comparison of Intraocular Pressure before and after Laser in Situ Keratomileusis Measured with Applanation Tonometry, Non Contact Tonometry and Rebound Tonometry

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Fatma Gebreel Ahmed Gaber ◽  
Tamer Mohamed El- Raggal ◽  
Mohamed Gamil Metwally ◽  
Ahmed Abdelmonsef Ebeid
Keyword(s):  
Intraocular Pressure ◽  
Central Corneal Thickness ◽  
Open Angle Glaucoma ◽  
Corneal Thickness ◽  
Applanation Tonometry ◽  
Goldmann Applanation Tonometry ◽  
Rebound Tonometry ◽  
Different Types ◽  
Before And After

Abstract Background Measurement of intraocular pressure (IOP) plays a central role throughout ophthalmology. It is part of routine ophthalmologic examinations and important in the management and follow-up of patients with glaucoma. While elevated IOP remains the most important risk factor for development and progression of open angle glaucoma, at least half of the population diagnosed with open angle glaucoma is asymptomatic. Objectives The aim of our study is to compare the accuracy of intraocular pressure measurement before and after Laser in situ keratomeulsis (LASIK) surgery using three different types of Tonometers: Goldmann Applanation tonometry (GAT), Non contact tonometry (NCT) and Rebound tonometry (I care), considering the change in the central corneal thickness (CCT). Patients and Methods In this study Eighty eyes of 40 patients with mean age of 27.00±6.00 years were scheduled for LASIK..Central corneal thickness before and after surgery was obtained by Ultrasound (US) pachymetry.IOP values were measured before and after surgery using three different types of Tonometers: Goldmann Applanation tonometry, Non contact tonometry and Rebound tonometry. Results The results revealed that lower post-operative IOP measurements using all techniques. The least affected technique was Non –contact with IOP change 16%, followed by GAT with IOP change 18%, and finally Rebound with IOP change 19 %, respectively. The percentage of change in CCT between pre- and post- LASIK surgery measured with the Ultrasound pachymetry was statistically highly significant. There was a clinical significant correlation between Percentage of tissue ablation (PTA) and IOP change for GAT, NCT and rebound tonometry. Also, there was a significant correlation between Residual stromal bed (RSB) and IOP change for GAT and NCT. There was no clinical significant correlation between Ablation depth (AD) and percentage of change of IOP measurements pre and post LASIK, except for IOP measured with GAT when AD &lt; 40.00 µm. Conclusion Refractive surgery causes significant lowering of IOP as measured using Goldmann applanation tonometry, non contact tonometry and rebound tonometry. The least affected tonometry post LASIK is non contact tonometry. The reduction was correlated to the percentage of tissue ablated. The ideal method to measure IOP in post-LASIK patients would be a device that is free of corneal factors.

Comparison of central corneal thickness and intraocular pressure measured with two different tono/pachymeter devices in non-glaucomatouse children

2021 ◽  
pp. 112067212199149
Author(s):  
Kuddusi Teberik ◽  
Mehmet Tahir Eski ◽  
Handan Ankarali
Keyword(s):  
Intraocular Pressure ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Intraclass Correlation ◽  
Applanation Tonometry ◽  
Healthy Children ◽  
Clinical Trial Registration ◽  
Registration Number ◽  
The Mean ◽  
The Right

Purpose: The goal of this research is to compare the intraocular pressure (IOP) and the mean central corneal thickness (CCT) values obtained from the measurements with Nidek NT-530P and Canon TX-20P devices with the values obtained by ultrasound pachymetry (UP) and Goldmann applanation tonometry (GAT) in children. Methods: This prospective study was conducted with 119 healthy children. The measurements were repeated three times for each eye. The intraclass correlation coefficient (ICC) was used to assess the correlation between the measurements obtained from different devices. The Bland–Altman plot was used to analyze the agreement between two different devices graphically. The measurements were taken in the same order in all subjects: TX-20P, NT-530P, UP, and GAT. Results: The mean age of the children was 10.1 ± 3.2 (6–17) years. The mean CCT values for the eyes were 568.90 and 569.68 (TX-20P), 571.44 and 566.37 (NT-530P), 564.77 and 564.67 μm UP, (right and left, respectively). The highest correspondence observed for CCT was between UP and NT-530P devices (ICC, 0.982, the left eye). The mean IOP measurements for Canon TX-20P, NT-530P, and GAT were 16.5 ± 3.2, 16.3 ± 3.2, and 16.8 ± 3.6 mmHg for the right eyes, respectively, while those for the left eyes were 16.6 ± 3.1, 16.2 ± 3.3, and 16.8 ± 3.7 mmHg. The highest correspondence was noted between measurements obtained using GAT and Nidek NT-530P devices (ICC, 0.945, in the left eye). Conclusion: Tono/pachymetry devices in the healthy children are provides significant agreements with the gold standard methods for IOP and CCT measurements. Clinical Trial Registration number: 2016-94

scholarly journals The influence of oral cimetidine administration on creatinine clearance in chilren with chronic renal failure: A preliminary study

2016 ◽  
Vol 45 (1) ◽  
pp. 14
Author(s):  
Rosalina D Roeslani ◽  
Partini P Trihono ◽  
Sri Rezeki Harun
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Creatinine Clearance ◽  
Reference Value ◽  
Oral Ingestion ◽  
Serum Cystatin ◽  
Before And After ◽  
The Mean ◽  
Preliminary Study ◽  
Oral Cimetidine

Background Serum creatinine and creatinine clearance are usedto assess glomerular filtration rate but have a major disadvantagesince a variable amount of creatinine is secreted in the proximaltubule. This may cause an unpredictable overestimation of GFR.Tubular creatinine secretion can be blocked by cimetidine throughcompetitive inhibition of cation transport in the proximal tubularluminal membrane.Objective Cimetidine administration might improve the reliabilityof creatinine as a marker of glomerular filtration.Methods A preliminary study with a one-group pretest-posttestdesign in 11 children with chronic renal failure. Serum cystatin Clevel as reference value was compared with creatinine clearancemeasured before and after oral ingestion of cimetidine. The doseof cimetidine was adjusted with the GFR using Schwartz formula.Statistical evaluation was done with the Wilcoxon signed rankstest.Result The mean creatinine clearance before cimetidine adminis-tration was 27.4 (SD 14.6) ml/minute/1.73 m 2 BSA, and decreasedafter cimetidine to 21.1 (SD 13,1) ml/minute/1.73 m 2 BSA (p=0.015).Conclusion Oral cimetidine was effective in inhibiting creatininetubular secretion. This study could not prove that cimetidine im-proves the accuracy of creatinine clearance

scholarly journals A comparative study of central corneal thickness (CCT) and intraocular pressure (IOP) in University of KwaZulu-Natal students of Black and Indian ethnicity*

2012 ◽  
Vol 71 (4) ◽  
Author(s):  
Z. Sardiwalla ◽  
D. Moodley ◽  
T. Ndawonde ◽  
A. Madikizela ◽  
N. Ngobese ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Ethnic Groups ◽  
Black Males ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Total Sample ◽  
Black Females ◽  
The Mean ◽  
The Difference ◽  
The Right

Thisstudy compared central corneal thickness (CCT) and intraocular pressure (IOP) of Black and Indian students from the University of Kwa-Zulu-Natal. Two hundred (100 Black and 100 Indi-an) participants of both genders aged 18-25 years (mean and standard deviation; 20.1±1.6 years) participated in this study. CCT and IOP were measured for the right eye of each participant using a Tono-Pachymeter (NT530P) and a Goldmann applanation tonometer (GAT) respectively. Data was analyzed with descriptive, t-test and Pearson’s cor-relation statistics. In the total sample (N = 200), the mean CCT value was 519.5 ± 38.6 μm and CCT was higher in the Indians (526.5 ± 37.2 µm) than in the Blacks (512.4 ± 38.9 µm) (p = 0.01).  Also, it was higher in the females (522.3 µm) than in males (516.7 µm), but the difference was insignificant (p = 0.07). The mean CCT was higher in the Indian males (520.1 µm) than in the Black males (513.2 µm), but the difference was insignificant (p=0.39).  However, it was significantly higher in the Indian females (533 µm) than in the Black females (511.6 µm) (p = 0.003). In the total sample, the mean IOP was 14.6 mmHg and IOP was greater in Indiansthan Blacks (mean = 15.3 ± 2.9 mmHg and 13.8 ± 2.6 mmHg respectively) (p = 0.01). Also, the mean IOP (N = 200) value was slightly higher in the females (14.7 mmHg) than in males (14.5 mmHg) (p = 0.51). The mean IOP was higher in the Indian males (15.0 mmHg) than in the Black males (14.0 mmHg) (p = 0.07) and the mean IOP value was higher in the Indian females (15.7 mmHg) than in the Black females (13.6 mmHg) (p < 0.001). The higher mean IOP value in the Indian than Black participants was attributed to the higher mean CCT values. A positive, but inconsistent association between CCT and IOP was found in this study, the coefficient in the total sample (r = 0.382, p = 0.000), in the Blacks (r = 0.196, p = 0.05) and in Indians (r = 0.498, p = 0.000). A national population study comparing CCT and IOP in the various South African ethnic groups is recommended. Cognizance of these differences should be taken in the diagnoses of glaucoma in these ethnic groups. (S Afr Optom 2012 71(4) 171-177)

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