scholarly journals The influence of oral cimetidine administration on creatinine clearance in chilren with chronic renal failure: A preliminary study

2016 ◽  
Vol 45 (1) ◽  
pp. 14
Author(s):  
Rosalina D Roeslani ◽  
Partini P Trihono ◽  
Sri Rezeki Harun
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Creatinine Clearance ◽  
Reference Value ◽  
Oral Ingestion ◽  
Serum Cystatin ◽  
Before And After ◽  
The Mean ◽  
Preliminary Study ◽  
Oral Cimetidine

Background Serum creatinine and creatinine clearance are usedto assess glomerular filtration rate but have a major disadvantagesince a variable amount of creatinine is secreted in the proximaltubule. This may cause an unpredictable overestimation of GFR.Tubular creatinine secretion can be blocked by cimetidine throughcompetitive inhibition of cation transport in the proximal tubularluminal membrane.Objective Cimetidine administration might improve the reliabilityof creatinine as a marker of glomerular filtration.Methods A preliminary study with a one-group pretest-posttestdesign in 11 children with chronic renal failure. Serum cystatin Clevel as reference value was compared with creatinine clearancemeasured before and after oral ingestion of cimetidine. The doseof cimetidine was adjusted with the GFR using Schwartz formula.Statistical evaluation was done with the Wilcoxon signed rankstest.Result The mean creatinine clearance before cimetidine adminis-tration was 27.4 (SD 14.6) ml/minute/1.73 m 2 BSA, and decreasedafter cimetidine to 21.1 (SD 13,1) ml/minute/1.73 m 2 BSA (p=0.015).Conclusion Oral cimetidine was effective in inhibiting creatininetubular secretion. This study could not prove that cimetidine im-proves the accuracy of creatinine clearance

scholarly journals Effect of Hemodialysis on Intraocular Pressure and Central Corneal Thickness in Patients With Chronic Renal Failure

2019 ◽  
Author(s):  
Seyfettin Erdem ◽  
Muslum Gunes
Keyword(s):  
Diabetes Mellitus ◽  
Renal Failure ◽  
Intraocular Pressure ◽  
Chronic Renal Failure ◽  
Corneal Thickness ◽  
Total Body Weight ◽  
Body Volume ◽  
Ophthalmological Examination ◽  
Before And After ◽  
The Mean

Abstract Background: This study evaluated short-term changes in intraocular pressure (IOP) and corneal thickness (CCT) following haemodialysis (HD) in chronic renal failure (CRF) patients. Methods: We studied 34 eyes of 34 patients with CRF undergoing HD. Patients included in the study were classified into two subgroups: with diabetes mellitus (DM, group 1) and without diabetes mellitus (non-DM, group 2). All patients underwent a detailed ophthalmological examination including CCT and IOP before and after the HD session. Total body weight and body volume loss after haemodialysis were also measured. Results: The sex distribution of patients were as 22 females (64.7%) and 12 males (35.3%). The DM group was comprised of 19 patients (55.9%), and the non-DM had 15 patients (44.1%). The mean age was 60.3 ± 17.2 (range 21–88) years, and the dialysis time was 51.4 ± 38.5 (range 5–132) months. The mean IOP change after HD decreased from 15.88±2.37 to 14.11±2.02 mmHg (95% CI, 1.40–2.11; p < 0.001). The mean CCT decreased from 554.88±14.27 to 550.52±13.67 μm. (95% CI, 1.97–4.08; P = p < 0.001). The loss in body volume was positively correlated with a decrease in IOP (r = 0.737, p < 0.001) and CCT (r = 0.784, p < 0.001). Conclusions: Patients at high risk of being affected by changes in intraocular pressure , may be adversely affected by IOP and CCT changes following HD. Therefore, a detailed ophthalmologic examination should be performed to take preventive measures for at-risk patients before and after HD.

scholarly journals Creatinine clearance after cimetidine administration in a new short procedure: comparison with plasma and renal clearances of iohexol

2019 ◽  
Vol 13 (4) ◽  
pp. 587-596 ◽  
Author(s):  
Thomas Stehlé ◽  
Khalil El Karoui ◽  
Mehdi Sakka ◽  
Ahmad Ismail ◽  
Marie Matignon ◽  
...  
Keyword(s):  
Creatinine Clearance ◽  
Good Precision ◽  
Limits Of Agreement ◽  
Reference Limits ◽  
Before And After ◽  
Renal Clearances ◽  
The Mean ◽  
High Level ◽  
Level Of Agreement ◽  
Oral Cimetidine

Abstract Background Creatinine clearance after cimetidine administration (Cim-CreatClr) was once proposed as a method of glomerular filtration rate (GFR) measurement, but has been largely abandoned. We investigated whether a new short procedure for Cim-CreatClr determination could be considered an appropriate method for GFR measurement. Methods A 150-min protocol involving oral cimetidine administration was developed to determine Cim-CreatClr. In total, 168 patients underwent simultaneous assessments of creatinine clearance before and after cimetidine administration [basal creatinine clearance (Basal-CreatClr) and Cim-CreatClr, respectively], renal iohexol clearance and plasma iohexol clearance (R-iohexClr and P-iohexClr, respectively). We compared the agreement between the various methods of GFR measurement, using Bland–Altman plots to determine biases, precisions (standard deviation of the biases) and accuracy (proportions of GFR values falling within 10, 15 and 30% of the mean: P10, P15 and P30, respectively). Results After cimetidine administration, Basal-CreatClr decreased by 19.8% [95% reference limits of agreement (95% LoA): −2.2 to 41.7%]. The bias between Cim-CreatClr and P-iohexClr was −0.6% (95% LoA −26.8 to 28%); the precision was 14.0%; P10, P15 and P30 were 57.1% [95% confidence interval (95% CI) 49.3 to 64.7%], 73.2% (95% CI 65.8 to 79.7%) and 97.0% (95% CI 93.2 to 99.0%), respectively. Due to the positive bias (16.7%; 95% LoA −3.6 to 36.9%) of Cim-CreatClr relative to R-iohexClr, accuracy of Cim-CreatClr relative to R-iohexClr was poor despite a good precision (10.3%). Conclusions Our study shows a high level of agreement between Cim-CreatClr and P-iohexClr. These results suggest that this short Cim-CreatClr procedure is a valid method for GFR measurement, which might be useful, in particular, in situations in which P-iohexClr is not suitable or not available.

scholarly journals Efficacy and safety of rhubarb aconite decoction combined with acupoint application in the treatment of chronic renal failure (CRF)

1970 ◽  
Vol 1 (1) ◽  
Author(s):  
LI Yang
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Serum Creatinine ◽  
Creatinine Clearance ◽  
Blood Urea Nitrogen ◽  
Adverse Reactions ◽  
Efficacy And Safety ◽  
Urea Nitrogen ◽  
Endogenous Creatinine Clearance ◽  
Before And After

Objective To study the efficacy and safety of rhubarb aconite decoction combined with acupoint application in the treatment of chronic renal failure (CRF). Methods 106 cases of CRF patients were randomly divided into two groups, the control group of 53 cases of conventional Western medicine treatment, the treatment group of 53 cases of rhubarb aconite combined with acupoint application, 2 groups were treated continuously for 20 d. (UA), blood urea nitrogen (BUN) and endogenous creatinine clearance (Ccr) were measured before and after treatment. The levels of serum creatinine (Cr), serum creatinine (UA), blood urea nitrogen (BUN) and endogenous creatinine clearance (Ccr) were measured and compared. Level, and observe the occurrence of adverse reactions during the two groups of treatment.

scholarly journals PERBANDINGAN CYSTATIN C DENGAN PARAMETER UJI FUNGSI GINJAL LAINNYA

2018 ◽  
Vol 14 (1) ◽  
pp. 16
Author(s):  
Pusparini .
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Serum Creatinine ◽  
Creatinine Clearance ◽  
Cystatin C ◽  
Normal Serum ◽  
Control Group ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Failure Group

The Gold standard for the evaluation of the glomerular filtration rate (GFR) is inulin clearance, but in widespread use is prevented by several technical difficulties. The most commonly used marker for GFR is serum creatinine alone or in conjunction with 24 hoururine collection for determination of creatinine clearance, but these marker have several limitation include following: influence of age,sex, muscle mass on endogenous creatinine production, dietary intake and the difficulties of 24 hour urine collection. Fifty six patientwith chronic renal failure and 53 control had analyze for serum creatinin, creatinine clearance and serum cystatin C. The chronic renalfailure patient aged range from (64 + 14.54) year and the control group aged range from (62.5+ 17.5) year. The proposed of this studywas to compare cystatin C with another parameter for renal function test. The result showed that in control group serum creatinineand creatinine clearance had influence with age, sex and body mass index, but serum cystatin C was not. The normal value of cystatinC was (0.85 + 0.13) mg/dL In chronic renal failure group there were significant correlation between level of cystatin C with creatininclearance (p = 0.000, r = 0.69). The level of cystatin C increase higher than serum creatinine in patient with low clearance creatinine.In control group we were determined low creatinine clearance in patient with normal serum creatinine and cystatin C.

scholarly journals EVALUATION OF INTRAOCULAR PRESSURE AND CENTRAL CORNEAL THICKNESS CHANGES AFTER HEMODIALYSIS IN PATIENTS WITH CHRONIC RENAL FAILURE

2019 ◽  
Author(s):  
Seyfettin Erdem ◽  
Muslum Gunes
Keyword(s):  
Renal Failure ◽  
Intraocular Pressure ◽  
Chronic Renal Failure ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Total Body Weight ◽  
Body Volume ◽  
Ophthalmological Examination ◽  
Before And After ◽  
The Mean

Abstract Background: This study evaluated short-term changes in intraocular pressure (IOP) and corneal thickness (CCT) following haemodialysis (HD) in chronic renal failure (CRF) patients. Methods: We studied 34 eyes of 34 patients with CRF undergoing HD. Patients included in the study were classified into two subgroups: group 1 (with DM) and group 2 (non DM). All patients underwent a detailed ophthalmological examination including CCT and IOP before and after the HD session. Total body weight and body volume loss after haemodialysis were also measured. Results: The sex distribution of patients were 22 female (64.7%) and 12 male (35.3%). The DM group was comprised of 19 patients (55.9%), and the non-DM had 15 (44.1%). The mean age was 60.3 ± 17.2 (range 21–88) years, and the dialysis time was 51.4 ± 38.5 (range 5–132) months. The mean IOP change after HD decreased from 15.88±2.37 to 14.11±2.02 mmHg (95% CI, 1.40–2.11; p < 0.001). The mean CCT decreased from 554.88±14.27 to 550.52±13.67 μm. (95% CI, 1.97–4.08; P = p < 0.001). The loss in body volume was positively correlated with a decrease in IOP (r = 0.737, p < 0.001) and CCT (r = 0.784, p < 0.001). Conclusions: In patients with CRF who have glaucoma, visual acuity may be adversely affected by IOP and CCT changes following HD. Therefore, a detailed ophthalmologic examination should be performed to take preventive measures for at-risk patients before and after HD. Keywords: Hemodialysis, Intraocular pressure, Central Corneal thickness.

RELATIONSHIP BETWEEN CARDIOVASCULAR DISEASES AND ANATOMOSIS OF ARTERIOVENOUS FISTULAR IN PATIENTS WITH REGULARLY HEMODIALYSIS

2017 ◽  
pp. 88-92
Author(s):  
Van Hien Pham ◽  
Huu Vu Quang Nguyen ◽  
Tam Vo
Keyword(s):  
Heart Failure ◽  
Blood Pressure ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Cardiovascular Diseases ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Negative Correlation ◽  
Mean Value ◽  
The Mean

Background: Cardiovascular diseases are the leading cause of death in patients with chronic renal failure. When a patient undergoes dialysis, making AVF or AVG causes cardiovascular events. Understanding the relationship between complications: hypertension, heart failure, AVF or AVG (formation time, position, diameter) helps us monitor, detect, prevent and treatment of complications to limit the risk of death in patients with dialysis. Objective: Relationship between cardiovascular diseases and anatomosis of arteriovenous fistular in patients with regularly hemodialysis at Cho Ray Hospital. Methods: A cross-sectional study was conducted at Cho Ray Hospital from 2015 to 2016. The survey some cardiovascular diseases are done by clinical examination, tests for diagnostic imaging such as X-ray, electrocardiogram and echocardiogram: heart and diameter of anastomosis AVF, AVG. Results: The study population included 303 patients with chronic renal failure who were dialysis. Of which, patients aged 25-45 accounted for the highest proportion (43.9%). The proportion of male and female patients was similar (48.5% and 51.5% respectively). The mean value of systolic blood pressure on patients made AVF, AVG less than 12 months is higher than patients made AVF, AVG over 12 months, and there is negative correlation (r = -0.43) between AVF, AVG and systolic blood pressure (p <0.05). The mean value of diastolic blood pressure on patients made AVF, AVG less than 12 months is lower than patients made AVF, AVG over 12 months, and and there is positive correlation (r = -0.43) between AVF, AVG and diastolic blood pressure (p <0.05) (p <0.05). The prevalence of patients with heart failure made AVF, AVG over 12 months is higher than that of the under 12 months group, there is a negative correlation (r = - 0.43) between AVF, AVG diameter and EF index (p <0.05). Conclusion: It is important to note the diameter of anastomosis AVF, AVG in patients with chronic renal failure dialysis to limit cardiovascular complications, especially heart failure. Key words: Chronic kidney disease, hemodialysis.

Oral and Maxillofacial Manifestations of Mineral and Bone Disorders Associated with Chronic Renal Failure

2017 ◽  
Vol 68 (6) ◽  
pp. 1325-1328
Author(s):  
Andrada Raluca Doscas ◽  
Mihail Balan ◽  
Mihai Liviu Ciofu ◽  
Doriana Agop Forna ◽  
Marius Cristian Martu ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Renal Function ◽  
Chronic Renal Failure ◽  
Health Concern ◽  
Oral Manifestations ◽  
End Stage Renal Failure ◽  
Brown Tumors ◽  
The Mean ◽  
End Stage

Chronic kidney disease (CKD) is a multifactorial syndrome and a global health concern. As renal function declines, there is a progressive deterioration of mineral homeostasis. Starting from stage 3 of CKD oral manifestations of mineral disorders can occasionally appear and become more frequent and evident in stage 5. We retrospectively analysed 43 patients diagnosed with end stage renal failure undergoing dialysis, hospitalized in our clinic for different oral and maxillofacial pathologies. The mean dialysis period was 5.43 years. Radiographic alterations afecting the jaws were found in all patients. The most common feature was partial or total loss of lamina dura, followed by alterations of the bony trabeculae. 9 patients presented brown tumors which are considered the final stage of secondary hyperparathyroidism associated with renal failure.

Renal Osteodystrophy in Children with Chronic Renal Failure: An Unexpectedly Common and Incapacitating Complication

PEDIATRICS ◽  
1982 ◽  
Vol 70 (5) ◽  
pp. 742-750 ◽  
Author(s):  
Anthony C. Hsu ◽  
Sang Whay Kooh ◽  
Donald Fraser ◽  
William A. Cumming ◽  
Victor L. Fornasier
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Renal Osteodystrophy ◽  
Age At Onset ◽  
Growth Zone ◽  
Growth Patterns ◽  
Bone Lesions ◽  
Older Children ◽  
Before And After ◽  
End Stage

The incidence, age at onset, and progression of the biochemical, radiographic, and histologic characteristics of renal osteodystrophy were studied in 50 children in whom chronic renal failure had been recently diagnosed. During a ten-year observation period, 19 patients progressed to end-stage renal failure and radiographic signs of renal osteodystrophy developed in 15 of these (79%). Renal osteodystrophy developed in all nine patients whose chronic renal failure was diagnosed before 3 years of age and in six of the ten children with later onset of failure. The mean interval from diagnosis of renal failure to development of osteodystrophy was 1.4 years. Radiographically, growth zone lesions predominated in the younger children, whereas cortical erosions were more prevalent in the older children. Histologic examination, performed in 38 patients, showed both defective mineralization and excessive resorption and was a more sensitive diagnostic index than radiography. Noticeable deformities developed in one third of the patients with osteodystrophy, despite medical treatment including vitamin D2 therapy. Deformities were particularly frequent and Severe in patients whose renal failure developed in infancy. In all 13 patients whose growth patterns were studied before and after osteodystrophy developed, the onset of bone lesions was associated with a deterioration of growth, indicating that osteodystrophy plays a major role in causing the growth retardation commonly observed in children with chronic renal failure.

Chronic renal failure in a mouse model of human adenine phosphoribosyltransferase deficiency

1998 ◽  
Vol 275 (1) ◽  
pp. F154-F163 ◽  
Author(s):  
Michael G. Stockelman ◽  
John N. Lorenz ◽  
Frost N. Smith ◽  
Gregory P. Boivin ◽  
Amrik Sahota ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Kidney Disease ◽  
Creatinine Clearance ◽  
Renal Damage ◽  
Male Mice ◽  
Adenine Phosphoribosyltransferase ◽  
Disease Treatment ◽  
Significant Impairment ◽  
Normal Males

In humans, adenine phosphoribosyltransferase (APRT, EC 2.4.2.7 ) deficiency can manifest as nephrolithiasis, interstitial nephritis, and chronic renal failure. APRT catalyzes synthesis of AMP from adenine and 5-phosphoribosyl-1-pyrophosphate. In the absence of APRT, 2,8-dihydroxyadenine (DHA) is produced from adenine by xanthine dehydrogenase (XDH) and can precipitate in the renal interstitium, resulting in kidney disease. Treatment with allopurinol controls formation of DHA stones by inhibiting XDH activity. Kidney disease in APRT-deficient mice resembles that seen in humans. By age 12 wk, APRT-deficient male mice are, on average, mildly anemic and smaller than normal males. They have extensive renal interstitial damage (assessed by image analysis) and elevated blood urea nitrogen (BUN), and their creatinine clearance rates, which measure excretion of infused creatinine as an estimate of glomerular filtration rate (GFR), are about half that of wild-type males. APRT-deficient males treated with allopurinol in the drinking water had normal BUN and less extensive visible renal damage, but creatinine clearance remained low. Throughout their lifespans, homozygous null female mice manifested significantly less renal damage than homozygous null males of the same age. APRT-deficient females showed no significant impairment of GFR at age 12 wk. Consequences of APRT deficiency in male mice are more pronounced than in females, possibly due to differences in rates of adenine or DHA synthesis or to sex-determined responses of the kidneys.

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