Effect of Hemodialysis on Intraocular Pressure and Central Corneal Thickness in Patients With Chronic Renal Failure

Abstract Background: This study evaluated short-term changes in intraocular pressure (IOP) and corneal thickness (CCT) following haemodialysis (HD) in chronic renal failure (CRF) patients. Methods: We studied 34 eyes of 34 patients with CRF undergoing HD. Patients included in the study were classified into two subgroups: with diabetes mellitus (DM, group 1) and without diabetes mellitus (non-DM, group 2). All patients underwent a detailed ophthalmological examination including CCT and IOP before and after the HD session. Total body weight and body volume loss after haemodialysis were also measured. Results: The sex distribution of patients were as 22 females (64.7%) and 12 males (35.3%). The DM group was comprised of 19 patients (55.9%), and the non-DM had 15 patients (44.1%). The mean age was 60.3 ± 17.2 (range 21–88) years, and the dialysis time was 51.4 ± 38.5 (range 5–132) months. The mean IOP change after HD decreased from 15.88±2.37 to 14.11±2.02 mmHg (95% CI, 1.40–2.11; p < 0.001). The mean CCT decreased from 554.88±14.27 to 550.52±13.67 μm. (95% CI, 1.97–4.08; P = p < 0.001). The loss in body volume was positively correlated with a decrease in IOP (r = 0.737, p < 0.001) and CCT (r = 0.784, p < 0.001). Conclusions: Patients at high risk of being affected by changes in intraocular pressure , may be adversely affected by IOP and CCT changes following HD. Therefore, a detailed ophthalmologic examination should be performed to take preventive measures for at-risk patients before and after HD.

EVALUATION OF INTRAOCULAR PRESSURE AND CENTRAL CORNEAL THICKNESS CHANGES AFTER HEMODIALYSIS IN PATIENTS WITH CHRONIC RENAL FAILURE

10.21203/rs.2.332/v1 ◽

2019 ◽

Author(s):

Seyfettin Erdem ◽

Muslum Gunes

Keyword(s):

Renal Failure ◽

Intraocular Pressure ◽

Chronic Renal Failure ◽

Corneal Thickness ◽

Total Body Weight ◽

Body Volume ◽

Ophthalmological Examination ◽

Before And After ◽

Abstract Background: This study evaluated short-term changes in intraocular pressure (IOP) and corneal thickness (CCT) following haemodialysis (HD) in chronic renal failure (CRF) patients. Methods: We studied 34 eyes of 34 patients with CRF undergoing HD. Patients included in the study were classified into two subgroups: group 1 (with DM) and group 2 (non DM). All patients underwent a detailed ophthalmological examination including CCT and IOP before and after the HD session. Total body weight and body volume loss after haemodialysis were also measured. Results: The sex distribution of patients were 22 female (64.7%) and 12 male (35.3%). The DM group was comprised of 19 patients (55.9%), and the non-DM had 15 (44.1%). The mean age was 60.3 ± 17.2 (range 21–88) years, and the dialysis time was 51.4 ± 38.5 (range 5–132) months. The mean IOP change after HD decreased from 15.88±2.37 to 14.11±2.02 mmHg (95% CI, 1.40–2.11; p < 0.001). The mean CCT decreased from 554.88±14.27 to 550.52±13.67 μm. (95% CI, 1.97–4.08; P = p < 0.001). The loss in body volume was positively correlated with a decrease in IOP (r = 0.737, p < 0.001) and CCT (r = 0.784, p < 0.001). Conclusions: In patients with CRF who have glaucoma, visual acuity may be adversely affected by IOP and CCT changes following HD. Therefore, a detailed ophthalmologic examination should be performed to take preventive measures for at-risk patients before and after HD. Keywords: Hemodialysis, Intraocular pressure, Central Corneal thickness.

Evaluation Of Intraocular Pressure and Central Corneal Thickness Changes After Hemodıalysis in Patıents With Chronic Renal Failure

Eastern Journal Of Medicine ◽

10.5505/ejm.2019.15986 ◽

2019 ◽

Vol 24 (4) ◽

pp. 510-514

Author(s):

Seyfettin Erdem ◽

Müslüm Güneş

Keyword(s):

Renal Failure ◽

Intraocular Pressure ◽

Chronic Renal Failure ◽

Corneal Thickness

The influence of oral cimetidine administration on creatinine clearance in chilren with chronic renal failure: A preliminary study

Paediatrica Indonesiana ◽

10.14238/pi45.1.2005.14-7 ◽

2016 ◽

Vol 45 (1) ◽

pp. 14

Author(s):

Rosalina D Roeslani ◽

Partini P Trihono ◽

Sri Rezeki Harun

Keyword(s):

Renal Failure ◽

Chronic Renal Failure ◽

Creatinine Clearance ◽

Reference Value ◽

Oral Ingestion ◽

Serum Cystatin ◽

Before And After ◽

The Mean ◽

Preliminary Study ◽

Oral Cimetidine

Background Serum creatinine and creatinine clearance are usedto assess glomerular filtration rate but have a major disadvantagesince a variable amount of creatinine is secreted in the proximaltubule. This may cause an unpredictable overestimation of GFR.Tubular creatinine secretion can be blocked by cimetidine throughcompetitive inhibition of cation transport in the proximal tubularluminal membrane.Objective Cimetidine administration might improve the reliabilityof creatinine as a marker of glomerular filtration.Methods A preliminary study with a one-group pretest-posttestdesign in 11 children with chronic renal failure. Serum cystatin Clevel as reference value was compared with creatinine clearancemeasured before and after oral ingestion of cimetidine. The doseof cimetidine was adjusted with the GFR using Schwartz formula.Statistical evaluation was done with the Wilcoxon signed rankstest.Result The mean creatinine clearance before cimetidine adminis-tration was 27.4 (SD 14.6) ml/minute/1.73 m 2 BSA, and decreasedafter cimetidine to 21.1 (SD 13,1) ml/minute/1.73 m 2 BSA (p=0.015).Conclusion Oral cimetidine was effective in inhibiting creatininetubular secretion. This study could not prove that cimetidine im-proves the accuracy of creatinine clearance

Evaluation of Thyroid Hormones Levels in Libyan Patients with Chronic Renal Failure Before and AFTER Maintenance Hemodialysis

Biomedical Research and Clinical Reviews ◽

10.31579/2692-9406/036 ◽

2021 ◽

Vol 3 (2) ◽

pp. 01-03

Author(s):

Aisha Muhammed

Keyword(s):

Diabetes Mellitus ◽

Renal Failure ◽

Chronic Renal Failure ◽

Thyroid Hormone ◽

Serum Levels ◽

Normal Range ◽

Hormone Levels ◽

Kidney Dialysis ◽

Before And After ◽

Thyroid Hormone Levels

Data from recent studies revealed that kidney diseases might affect the thyroid function in various ways. A variety of alterations in thyroid hormone levels and metabolism have also been reported in patients with chronic renal failure (CRF) in some studied population. In addition, it was reported that serum levels of both T3 and T4 might altered immediately after a hemodialysis (HD) treatment than before. Therefore, this study was aimed to investigate the level of triiodothyronine (T3) and thyroxine (T4) in CRF Libyan patients before and after HD. This study was carried out on 46 CRF patients (30 male and 16 female) with a mean age of 47.46 ±15.75 years. These patients were treated at the hemodialysis unit of Educational Central Zelitin Hospital, Zelitin, Libya. None of these patients apparently have any thyroid problems and no history of drug intake that may affect thyroid function. Blood samples were taken from each patient to measure serum levels of T3 and T4, before and after HD. In addition, the effect of several variables include age, gender, body mass index (BMI), presence of both hypertension and, diabetes mellitus and duration of kidney dialysis on serum levels of T3and T4 before and after HD were also studied. After HD, there was a statistically significant increase in the serum levels of T3, T4. The age, gender, BMI, duration of kidney dialysis and the presence of hypertension and diabetes mellitus did not have any significant effect on the serum level of T3 and T4 before and after HD. However, the serum levels of T3 and T4 were still in the normal range in these examined patients either before or after HD. From these findings, it can be concluded that these CRF patients may be in a euthyroid state, because the serum levels of T3 and T4 were in the normal range. In addition, HD was seem to improve the T3 and T4 thyroid hormone concentrations, suggesting that HD might activate the secretion of thyroid glandand catabolism. The other variables did not play any role in thyroid hormone levels in these patients either before or after HD. It is highly recommended that large scale evaluation of thyroid hormone levels in Libyan CRF patients is performed more patients, especially elderly patients.

Effect of Mydriasis-Caused Intraocular Pressure Changes on Corneal Biomechanical Metrics

Frontiers in Bioengineering and Biotechnology ◽

10.3389/fbioe.2021.751628 ◽

2021 ◽

Vol 9 ◽

Author(s):

Yufeng Ye ◽

Yi Li ◽

Zehui Zhu ◽

Anas Ziad Masoud Abu Said ◽

Kevin Nguelemo Mayopa ◽

...

Keyword(s):

Intraocular Pressure ◽

Disease Progression ◽

Refractive Surgery ◽

Corneal Thickness ◽

Medical Procedures ◽

Corvis St ◽

Before And After ◽

The Mean ◽

Pressure Changes

Purpose: To evaluate the dependence of biomechanical metrics on intraocular pressure (IOP).Methods: 233 refractive surgery patients were included in this study—all were examined 3 times with the Corvis ST before and after dilation, and the differences (∆) in the main device parameters were assessed. The data collected included the biomechanically corrected IOP (bIOP), the central corneal thickness (CCT), and six dynamic corneal response (DCR) parameters, namely DA, DARatio2mm, IIR, SP-A1, CBI, and SSI. Participants were divided into three groups according to the changes in patients’ bIOP after mydriasis.Results: Intra-operator repeatability was generally high in most of the DCR parameters obtained before and after dilation. The mean changes in bIOP and CCT after dilation were −0.12 ± 1.36 mmHg and 1.95 ± 5.23 μm, respectively. Only ∆DARatio2mm, ∆IIR, and ∆CBI exhibited a statistically significant correlation with ∆CCT (p < 0.05). The changes in all DCR parameters, especially ∆DA and ∆SP-A1 were also correlated with ∆bIOP (p < 0.01)—a 1-mmHg change in bIOP was associated, on average, with 5.612 and −0.037 units of change in SP-A1 and DA, respectively. In contrast, the weakest correlation with ∆bIOP was exhibited by ∆SSI.Conclusion: Most corneal DCR parameters, provided by the Corvis ST, were correlated with IOP, and more weakly with CCT. Changes experienced in CCT and IOP should therefore be considered in studies on corneal biomechanics and how it is affected by disease progression and surgical or medical procedures.

Assessment of Central Corneal Thickness in Adults With Indications For Kidney Transplantation and Commenting On Some Related Factors

10.21203/rs.3.rs-809686/v1 ◽

2021 ◽

Author(s):

Nguyen Kien Trung ◽

Vu Anh Tuan ◽

Le Viet Thang ◽

Nguyen Dinh Ngan ◽

Nguyen Chien Thang ◽

...

Keyword(s):

Renal Failure ◽

Kidney Transplantation ◽

Intraocular Pressure ◽

Corneal Thickness ◽

Smoking Habits ◽

Related Factors ◽

Blood Calcium ◽

Central Cornea ◽

Abstract Objectives Central corneal thickness (CCT) is an important biological indicator of eyeball affecting intraocular pressure, which plays a vital role in glaucoma pathology. This study investigated the central corneal thickness in renal failure subjects with indications for kidney transplantation and commented on some related factors. Methods A cross-sectional descriptive study was conducted from January to June 2021 in Hanoi, Vietnam. Ninety-six adult patients with grade 3 and 4 renal failure indicated kidney transplantation had central corneal thickness measured. We investigated the mean value of central corneal thickness in patients with indications for kidney transplantation. The related factors were evaluated by multivariable linear regression. Results The mean thickness of the central cornea in the right eye was 529.3 ± 32 µm, and the left eye was 528.5 ± 32.1 µm, with no difference between the central corneal thickness in the two eyes. Corneal thickness has a positive correlation with IOP after dialysis and smoking habits, adjusted R2 = 0.2405, has a negative correlation with age, adjusted R2 = 0.2405, and with calcium concentration blood, adjusted R2 = 0.032. Conclusion The thickness of the central cornea in patients with renal failure with indications for kidney transplantation in both eyes is similar. Factors related to corneal thickness are age, smoking habits, intraocular pressure after dialysis, and blood calcium levels.

RELATIONSHIP BETWEEN CARDIOVASCULAR DISEASES AND ANATOMOSIS OF ARTERIOVENOUS FISTULAR IN PATIENTS WITH REGULARLY HEMODIALYSIS

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2017.3.13 ◽

2017 ◽

pp. 88-92

Author(s):

Van Hien Pham ◽

Huu Vu Quang Nguyen ◽

Tam Vo

Keyword(s):

Heart Failure ◽

Blood Pressure ◽

Renal Failure ◽

Chronic Renal Failure ◽

Cardiovascular Diseases ◽

Systolic Blood Pressure ◽

Diastolic Blood Pressure ◽

Negative Correlation ◽

Mean Value ◽

Background: Cardiovascular diseases are the leading cause of death in patients with chronic renal failure. When a patient undergoes dialysis, making AVF or AVG causes cardiovascular events. Understanding the relationship between complications: hypertension, heart failure, AVF or AVG (formation time, position, diameter) helps us monitor, detect, prevent and treatment of complications to limit the risk of death in patients with dialysis. Objective: Relationship between cardiovascular diseases and anatomosis of arteriovenous fistular in patients with regularly hemodialysis at Cho Ray Hospital. Methods: A cross-sectional study was conducted at Cho Ray Hospital from 2015 to 2016. The survey some cardiovascular diseases are done by clinical examination, tests for diagnostic imaging such as X-ray, electrocardiogram and echocardiogram: heart and diameter of anastomosis AVF, AVG. Results: The study population included 303 patients with chronic renal failure who were dialysis. Of which, patients aged 25-45 accounted for the highest proportion (43.9%). The proportion of male and female patients was similar (48.5% and 51.5% respectively). The mean value of systolic blood pressure on patients made AVF, AVG less than 12 months is higher than patients made AVF, AVG over 12 months, and there is negative correlation (r = -0.43) between AVF, AVG and systolic blood pressure (p <0.05). The mean value of diastolic blood pressure on patients made AVF, AVG less than 12 months is lower than patients made AVF, AVG over 12 months, and and there is positive correlation (r = -0.43) between AVF, AVG and diastolic blood pressure (p <0.05) (p <0.05). The prevalence of patients with heart failure made AVF, AVG over 12 months is higher than that of the under 12 months group, there is a negative correlation (r = - 0.43) between AVF, AVG diameter and EF index (p <0.05). Conclusion: It is important to note the diameter of anastomosis AVF, AVG in patients with chronic renal failure dialysis to limit cardiovascular complications, especially heart failure. Key words: Chronic kidney disease, hemodialysis.

Oral and Maxillofacial Manifestations of Mineral and Bone Disorders Associated with Chronic Renal Failure

Revista de Chimie ◽

10.37358/rc.17.6.5667 ◽

2017 ◽

Vol 68 (6) ◽

pp. 1325-1328

Author(s):

Andrada Raluca Doscas ◽

Mihail Balan ◽

Mihai Liviu Ciofu ◽

Doriana Agop Forna ◽

Marius Cristian Martu ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Renal Failure ◽

Renal Function ◽

Chronic Renal Failure ◽

Health Concern ◽

Oral Manifestations ◽

End Stage Renal Failure ◽

Brown Tumors ◽

The Mean ◽

End Stage

Chronic kidney disease (CKD) is a multifactorial syndrome and a global health concern. As renal function declines, there is a progressive deterioration of mineral homeostasis. Starting from stage 3 of CKD oral manifestations of mineral disorders can occasionally appear and become more frequent and evident in stage 5. We retrospectively analysed 43 patients diagnosed with end stage renal failure undergoing dialysis, hospitalized in our clinic for different oral and maxillofacial pathologies. The mean dialysis period was 5.43 years. Radiographic alterations afecting the jaws were found in all patients. The most common feature was partial or total loss of lamina dura, followed by alterations of the bony trabeculae. 9 patients presented brown tumors which are considered the final stage of secondary hyperparathyroidism associated with renal failure.