scholarly journals Robot-Assisted Partial Nephrectomy for Renal Pelvic Urothelial Carcinoma Complicated with Renal Insufficiency: A Case Report

Author(s):  
Shikai Chen ◽  
Ping Li ◽  
Shizhang Song ◽  
Sichuan Hou

Abstract Background Primary malignant tumors of the renal pelvis are relatively few in urinary tumors, with a high degree of malignancy and a relatively poor prognosis. Most of the pathological results are urothelial carcinoma. The standard surgical operation is full-length resection of the kidney and ureter and sleeve resection of the bladder. However, for patients with renal insufficiency or solitary kidney, clinicians find it terribly difficult to make the decision on the surgical resection and protection of the renal function. A patient with renal pelvis malignant tumor complicated with renal insufficiency was treated in our hospital.Case presentation: A 77-year-old Chinese female with a more than 5-year history of renal dysfunction,was hospitalized due to "painless gross hematuria found for 4 months". The patient had no other significant discomfort. CT discovered that the volume of both kidneys is small, and the soft tissue density shadow was exactly at the right ureteropelvic junction. Therefore we consider the diagnosis was tumor of right renal pelvis. Patient did not accept radical surgical resection and was required to preserve the kidney. So the patient underwent robot-assisted partial nephrectomy for right renal pelvic , and the operation was successful. After surgery chemotherapy drugs were instilled into the renal pelvis through a single J-tube infusion. During nearly three years of follow-up, the patient regularly reviewed ureteroscopy and MRI/CT, no significant abnormalities were seen. Postoperative creatinine control was better and no hemodialysis was performed. The curative effect is acceptable.Conclusions Partial nephrectomy for renal pelvic is also an option for patients with malignant tumor of renal pelvis who need to preserve their kidneys.

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Dong Fang ◽  
Qifu Zhang ◽  
Xuesong Li ◽  
Cheng Qian ◽  
Gengyan Xiong ◽  
...  

Objectives.To report the decline of renal function after radical nephroureterectomy (RNU) in upper tract urothelial carcinoma (UTUC) patients and to develop a nomogram to predict ineligibility for cisplatin-based adjuvant chemotherapy (AC).Methods.We retrospectively analyzed 606 consecutive Chinese UTUC patients treated by RNU from 2000 to 2010. We chose an eGFR of 60 and 45 ml/min/1.73 m2as cut-offs for full-dose and reduced-dose AC eligibility.Results.Median eGFR for all patients before and after surgery was 64 and 49 ml/min/1.73 m2(P<0.001). The proportion of patients ineligible to receive full-dose and reduced-dose AC changed from 42% to 74% and from 20% to 38.1%. Older age (OR = 1.007), preoperative eGFR (OR = 0.993), absence of hydronephrosis (OR = 0.801), smaller tumor size (OR = 0.962), and tumor without multifocality (OR = 0.876) were predictive for ineligibility for full-dose AC. Preoperative eGFR (OR = 0.991), absence of hydronephrosis (OR = 0.881), tumor located in renal pelvis (OR = 1.164), and smaller tumor size (OR = 0.969) could predict ineligibility for reduced-dose AC. The c-index of the two models was 0.757 and 0.836. Postoperative renal function was not associated with worse survival.Conclusions.Older age, lower preoperative eGFR, smaller tumor size, tumor located in renal pelvis, and absence of hydronephrosis or multifocality were predictors of postoperative renal insufficiency.


Author(s):  
H. J. Finol ◽  
M. E. Correa ◽  
L.A. Sosa ◽  
A. Márquez ◽  
N.L. Díaz

In classical oncological literature two mechanisms for tissue aggression in patients with cancer have been described. The first is the progressive invasion, infiltration and destruction of tissues surrounding primary malignant tumor or their metastases; the other includes alterations produced in remote sites that are not directly affected by any focus of disease, the so called paraneoplastic phenomenon. The non-invaded tissue which surrounds a primary malignant tumor or its metastases has been usually considered a normal tissue . In this work we describe the ultrastructural changes observed in hepatocytes located next to metastases from diverse malignant tumors.Hepatic biopsies were obtained surgically in patients with different malignant tumors which metatastized in liver. Biopsies included tumor mass, the zone of macroscopic contact between the tumor and the surrounding tissue, and the tissue adjacent to the tumor but outside the macroscopic area of infiltration. The patients (n = 5), 36–75 years old, presented different tumors including rhabdomyosarcoma, leiomyosarcoma, pancreas carcinoma, biliar duct carcinoma and colon carcinoma. Tissue samples were processed with routine techniques for transmission electron microscopy and observed in a Hitachi H-500 electron microscope.


2017 ◽  
Vol 63 (5) ◽  
pp. 759-765
Author(s):  
Svetlana Kutukova ◽  
Natalya Belyak ◽  
Grigoriy Raskin ◽  
Marina Mukhina ◽  
Georgiy Manikhas ◽  
...  

The most frequent of malignant tumor cites of the oral mucosa are tongue - 55 %, mucosa of the cheek - 12 %, the fundus of the oral cavity - 10 %, the alveolar process of the upper jaw and the hard palate - 9 %, the alveolar process of the lower jaw - 6 %, the soft palate - 2 %. Malignant tumor cells carry PD-L1 ligands on their surface and its expression level is often correlated with an unfavorable prognosis in particular for such tumors as melanoma, kidney cancer and non-small cell lung cancer. It is relevant to evaluate the correlation between overexpression of PD-L1 and overall survival in patients with malignant tumors of the oral mucosa.


2020 ◽  
Vol 19 ◽  
pp. e225-e226
Author(s):  
A. Brassetti ◽  
U. Anceschi ◽  
R. Bertolo ◽  
S. Guaglianone ◽  
M. Ferriero ◽  
...  

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