scholarly journals Hidden Blood Loss of Total Knee FVIII Prophylaxis in Hemophilia Arthritis : An Analysis of Influencing Factors

2022 ◽  
Author(s):  
ShaoNing Shen ◽  
DongXiao Wu ◽  
ShuaiJie Lv ◽  
PeiJian Tong
Keyword(s):  
Total Knee Arthroplasty ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Influencing Factors ◽  
Knee Arthroplasty ◽  
Linear Regression Analysis ◽  
Laboratory Data ◽  
Hidden Blood Loss ◽  
Surgical Data ◽  
Total Knee

Abstract BackgroundTotal knee arthroplasty is the leading way to treat hemophilia arthritis. At present, there is a lack of research on the influencing factors of blood loss in total knee arthroplasty for hemophilia arthritis. This study comprehensively explores the definite factors affecting the hidden blood loss in total knee arthroplasty for hemophilia patients.Materials and methodsNinety-two hemophilia A patients who underwent total knee arthroplasty in our center were included. Demographic characteristics, laboratory data, surgical data, and complications were collected. The Gross equation and Sehat equation were used to calculate the estimated value of hidden blood loss. Multivariate stepwise linear regression analysis was used to determine the influencing factors of hidden blood loss.ResultThe hidden blood loss of hemophilia patients undergoing total knee arthroplasty was 1069.51±341.99mL, and the age was positively correlated with the hidden blood loss (P<0.001), while tranexamic acid, FVIII prophylaxis, and incremental invivo recovery were negatively correlated with the hidden blood loss (P<0.001, P=0.008, P=0.017).ConclusionElderly patients have a greater risk of blood loss, and additional preventive measures can be appropriately added. Intraoperative intra-articular injection of tranexamic acid is recommended to reduce hidden blood loss, FVIII prophylaxis is recommended for every patient. We recommend that all HA patients measure the incremental invivo recovery and develop a personalized coagulation factor infusion regimen.

Tranexamic Acid Treatment Decreases Hidden Blood Loss in Total Knee Arthroplasty

2016 ◽  
Vol 23 (6) ◽  
pp. e1397-e1405 ◽  
Author(s):  
Xin Chen ◽  
Xiongbai Zhu ◽  
Shengwu Yang ◽  
Wenjun Lin ◽  
Lu Wang
Keyword(s):  
Total Knee Arthroplasty ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Acid Treatment ◽  
Hidden Blood Loss ◽  
Total Knee

scholarly journals Multimodal Peri-articular Injection with Tranexamic Acid can reduce postoperative blood loss versus Intravenous Tranexamic Acid in Total Knee Arthroplasty: A Randomized Controlled Trial

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Hui-ming Peng ◽  
Wei Wang ◽  
Jin Lin ◽  
Xi-sheng Weng ◽  
Wen-wei Qian ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Total Blood Loss ◽  
Postoperative Blood Loss ◽  
Total Blood ◽  
Randomized Controlled ◽  
Hidden Blood Loss ◽  
Total Knee

Abstract Background Tranexamic acid (TXA) has shown significant reductions in blood loss and transfusion rates in total knee arthroplasty (TKA). However, the optimal administration route continues to be debated. The aim of this trial was to compare the effectiveness of intravenous (IV) versus peri-articular injection (PAI) application of tranexamic acid in patients undergoing total knee arthroplasty. Methods We conducted a randomized controlled, double-blinded study. A total of 93 patients undergoing primary unilateral TKA were randomly distributed between 2 groups: the IV group (47 cases; 1 g TXA IV) and the PAI group (46 cases; 1 g TXA injected peri-articularly). The amount of total and hidden blood loss (HBL), drainage, transfusion rate, hemoglobin and hematocrit drift, and complications were recorded. Results Peri-articular injection of TXA reduced total blood loss (P < 0.001) and HBL more than IV use of TXA (P < 0.001). No patients in either group received a transfusion. No symptomatic deep venous thrombosis or other severe complications occurred. Conclusion Peri-articular injection of TXA significantly reduced total blood loss and hidden blood loss to a greater degree than IV injection in total knee arthroplasty without reduction of drainage volume. Trial registration Chinese Clinical Trial Registry, ChiCTR-INR-16010270. Date of registration: December 27, 2016.

scholarly journals Tranexamic Acid Reduces Hidden Blood Loss in Patients Undergoing Total Knee Arthroplasty: A Comparative Study and Meta-Analysis

2016 ◽  
Vol 22 ◽  
pp. 797-802 ◽  
Author(s):  
Guang-Ping Huang ◽  
Xu-Feng Jia ◽  
Zhou Xiang ◽  
Yong Ji ◽  
Guo-Yong Wu ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Comparative Study ◽  
Knee Arthroplasty ◽  
Meta Analysis ◽  
Hidden Blood Loss ◽  
Total Knee

Six-Dose Intravenous Tranexamic Acid Regimen Further Inhibits Postoperative Fibrinolysis and Reduces Hidden Blood Loss Following Total Knee Arthroplasty

2019 ◽  
Author(s):  
Shaoyun Zhang ◽  
Jinwei Xie ◽  
Guorui Cao ◽  
Yiting Lei ◽  
Qiang Huang ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Transfusion Rate ◽  
Thromboembolic Events ◽  
Total Dosage ◽  
Hidden Blood Loss ◽  
Total Knee ◽  
D Dimer

AbstractThere is no consensus regarding the ideal dosages and times of multiple-dose intravenous tranexamic acid (IV-TXA) administration in total knee arthroplasty (TKA). This study aimed to assess the effect of six-dose IV-TXA with the total dosage more than 6 g on postoperative fibrinolysis and hidden blood loss (HBL) after primary TKA. A total of 175 patients were randomized into three groups to receive placebo (group A), or a single preoperative dose of 20 mg/kg IV-TXA (group B), or six-dose IV-TXA from the beginning of the procedure to subsequent 24 hours with the total dosage more than 6 g (group C). The calculated HBL, maximum hemoglobin (Hb) drop, transfusion rate, and the incidence of thromboembolic events were compared among groups. The levels of fibrinolysis parameters in plasma including fibrin(-ogen) degradation products (FDP) and D-dimer were measured at six time points from preoperatively to 3-month postoperative period. The mean HBL and maximum Hb drop in group C (515.51 ± 245.79 mL, and 2.06 ± 0.73 g/dL, respectively) were significantly lower than those in groups B (756.06 ± 226.79 mL, p < 0.001; and 2.77 ± 0.78 g/dL, p < 0.001, respectively) and A (987.65 ± 275.38 mL, p < 0.001; and 3.49 ± 0.86 g/dL, p < 0.001, respectively). Such differences were also detected between groups A and B (p < 0.001 and p < 0.001, respectively). The levels of FDP and D-dimer in plasma were lower in group C than those in groups B and A on postoperative 24, 48, 72 hours (p < 0.001 for all). No episode of transfusion occurred, and the incidence of thromboembolic events were similar among groups (p > 0.05). The administration of six-dose IV-TXA during the first 24 hours resulted in reduced HBL following TKA without a measured increase in thromboembolic events.

scholarly journals Hidden Blood Loss, Infection and Cost-Effectiveness of Tranexamic Acid Protocol in Primary Total Knee Arthroplasty

2018 ◽  
Vol 8 (2) ◽  
pp. 423-431
Author(s):  
Hakkı Çağdaş Basat ◽  
Berk Güçlü ◽  
Ömer Bozduman ◽  
Yasin Köker ◽  
Cihan Kırçıl ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Cost Effectiveness ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Primary Total Knee Arthroplasty ◽  
Hidden Blood Loss ◽  
Total Knee ◽  
Primary Total Knee
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