scholarly journals Superficial Flat-type Early-stage Gastric Signet Ring Cell Carcinoma in the Atrophic Background Mucosa: Two Case Reports

2022 ◽  
Author(s):  
Wenhua Wang ◽  
Yicheng Yang ◽  
Qinwei Xu ◽  
Shunli Wang ◽  
Li Zhang ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Early Stage ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
White Light Endoscopy ◽  
Signet Ring ◽  
Ring Cell ◽  
Background Mucosa

Abstract Gastric signet ring cell carcinoma is a rare and highly malignant adenocarcinoma, which is characterized by early metastasis, rapid progression and poor prognosis. Several studies have shown that early-stage gastric signet ring cell carcinoma may have equal or better prognosis than other types of gastric cancer. However, most of the early-stage lesions are difficult to detect by endoscopy. Two female cases of early-stage gastric signet ring cell carcinoma with atrophic background mucosa occurring in the middle and lower part of the stomach were found in our endoscopy center. The diagnosis was confirmed by upper gastrointestinal white light endoscopy combined with narrow-band imaging and endoscopic biopsy, both lesions less than 2.0cm in diameter were surgically removed and identified as intramucosal adenocarcinoma. Through these two cases, we aim to illustrate the difficulty of early detection of gastric signet ring cell carcinoma with mucosal atrophy. We can roughly identify the demarcation of the lesion by combining white light endoscopy and narrow-band imaging, and slightly irregular microsurface and microvascular pattern of the lesion were found via magnifying endoscopic observation, but the demarcation can hardly be accurately identified.

Sa1906 Non-Magnifying Narrow-Band Imaging of Small Intramucosal Signet Ring Cell Carcinoma of the Stomach

2015 ◽  
Vol 148 (4) ◽  
pp. S-351
Author(s):  
Shota Fukui ◽  
Jiro Watari ◽  
Toshihiko Tomita ◽  
Hisatomo Ikehara ◽  
Tomohiro Ogawa ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Carcinoma Of The Stomach ◽  
Signet Ring ◽  
Ring Cell

scholarly journals Signet-Ring Cell Carcinoma of the Colon: A Case Report and Review of the Literature

2015 ◽  
Vol 8 (3) ◽  
pp. 466-471 ◽  
Author(s):  
Peter Y. Park ◽  
Teresa Goldin ◽  
John Chang ◽  
Maurie Markman ◽  
Madappa N. Kundranda
Keyword(s):  
Cell Carcinoma ◽  
Early Stage ◽  
Single Agent ◽  
The United States ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Early Stage Disease ◽  
Lower Quadrant ◽  
Signet Ring ◽  
Ring Cell

Background: Colorectal adenocarcinoma (CRC) is the third leading cause of death in the United States. One of the histologic subtypes of CRC is signet-ring cell carcinoma (SRCC), which has a distinct molecular and tumor biology from that of adenocarcinoma. Primary SRCC diagnosed at an early stage is very rare as most cases are detected at an advanced stage. Therefore, overall prognosis of SRCC is poor. Case Presentation: A 36-year-old female presented to her primary care physician with new-onset progressive right lower quadrant pain without any significant past medical or family history. Computed tomography scan of the abdomen and pelvis with contrast showed a 4.9 × 3.5 × 3.1 cm, lobulated, septated cystic mass arising from the cecum. The mass demonstrated wall enhancement and contained focal areas of coarse calcification. There was nodal involvement either locally or distally. The patient underwent right hemicolectomy, and pathology revealed a high-grade mucinous carcinoma with signet-ring cell variant invading through the muscularis propria and into the subserosal adipose tissue. The margins were negative for tumor, and no lymphovascular or perineural invasion was noted. None of the 14 resected pericolonic lymph nodes was positive for malignancy. Hence, she was staged as pT3, pN0, pMx-stage IIA. The appendix was not involved. Microsatellite instability testing showed the preservation of MLH1, PMS2, MSH2 and MSH6 proteins by IHC and PCR. Carcinoembryonic antigen level was within normal limits. Due to the patient's young age, aggressive histology and microsatellite-stable status, adjuvant fluropyrimidine (5-FU)-based therapy with the single agent capecitabine was initiated. The patient completed 6 months of adjuvant therapy and has been disease free for approximately 18 months. Conclusion: Primary SRCC of the cecum is a rare disease. Given the poor prognosis of these patients, early-stage disease with microsatellite-stable patients should be considered for adjuvant 5-FU-based therapy in an attempt to prevent recurrence.

Early-stage primary signet ring cell carcinoma of the colon with magnifying endoscopic findings

2019 ◽  
Vol 90 (3) ◽  
pp. 529-531
Author(s):  
Tatsunori Minamide ◽  
Kensuke Shinmura ◽  
Hiroaki Ikematsu ◽  
Tomonori Yano
Keyword(s):  
Cell Carcinoma ◽  
Early Stage ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Carcinoma Of The Colon ◽  
Endoscopic Findings ◽  
Signet Ring ◽  
Ring Cell

Incidence, Survival, and Predictors of Lymph Node Involvement in Early-Stage Gastric Signet Ring Cell Carcinoma in the US

2018 ◽  
Vol 22 (4) ◽  
pp. 569-577 ◽  
Author(s):  
Sridevi K. Pokala ◽  
Chao Zhang ◽  
Zhengjia Chen ◽  
Anthony M. Gamboa ◽  
Sarah L. Cristofaro ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cell Carcinoma ◽  
Early Stage ◽  
Lymph Node Involvement ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Signet Ring ◽  
The Us ◽  
Node Involvement ◽  
Ring Cell

scholarly journals Prognosis and Biological Behavior of Gastric Signet-Ring Cell Carcinoma Better or Worse: A Meta-Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Shuai Zhao ◽  
Ling Lv ◽  
Kai Zheng ◽  
Yu Tian ◽  
Jian-Chun Zheng ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Early Stage ◽  
Meta Analysis ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Biological Behavior ◽  
Advanced Stage ◽  
Female Ratio ◽  
Signet Ring ◽  
Ring Cell

BackgroundThe clinical pathology of gastric signet-ring cell carcinoma (SRC) is still unclear. This meta-analysis was performed to evaluate the difference in biological behavior and prognosis between SRC and non-signet ring cell carcinoma (NSRC).MethodsA total of 58 eligible studies were analyzed using RevMan and other auxiliary software. Biological behaviors were compared based on odds ratio (OR) and mean difference (MD). Hazards ratio (HR) was calculated for prognosis based on Kaplan–Meier curves.ResultsTotally, 28,946 SRC patients were compared with 81,917 NSRC patients. Compared with NSRC patients, lower male: female ratio (OR = 0.53, P < 0.01), younger age (MD = −4.89, P < 0.01), more middle location (OR = 1.64, P < 0.01), more depressed type at early stage (OR = 1.31, P < 0.05), higher incidence of Borrmann type IV (OR = 1.96, P < 0.01), less lymph node metastasis at early stage (OR = 0.78, P < 0.05), better prognosis at early stage (HR = 0.59, P < 0.01), and worse prognosis at advanced stage (HR = 1.19, P < 0.01) were associated with SRC patients.ConclusionThe prognosis of SRC at early stage is better than other types of gastric cancer, while that of SRC at advanced stage is relatively poorer.

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