scholarly journals Prognosis and Biological Behavior of Gastric Signet-Ring Cell Carcinoma Better or Worse: A Meta-Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Shuai Zhao ◽  
Ling Lv ◽  
Kai Zheng ◽  
Yu Tian ◽  
Jian-Chun Zheng ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Early Stage ◽  
Meta Analysis ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Biological Behavior ◽  
Advanced Stage ◽  
Female Ratio ◽  
Signet Ring ◽  
Ring Cell

BackgroundThe clinical pathology of gastric signet-ring cell carcinoma (SRC) is still unclear. This meta-analysis was performed to evaluate the difference in biological behavior and prognosis between SRC and non-signet ring cell carcinoma (NSRC).MethodsA total of 58 eligible studies were analyzed using RevMan and other auxiliary software. Biological behaviors were compared based on odds ratio (OR) and mean difference (MD). Hazards ratio (HR) was calculated for prognosis based on Kaplan–Meier curves.ResultsTotally, 28,946 SRC patients were compared with 81,917 NSRC patients. Compared with NSRC patients, lower male: female ratio (OR = 0.53, P < 0.01), younger age (MD = −4.89, P < 0.01), more middle location (OR = 1.64, P < 0.01), more depressed type at early stage (OR = 1.31, P < 0.05), higher incidence of Borrmann type IV (OR = 1.96, P < 0.01), less lymph node metastasis at early stage (OR = 0.78, P < 0.05), better prognosis at early stage (HR = 0.59, P < 0.01), and worse prognosis at advanced stage (HR = 1.19, P < 0.01) were associated with SRC patients.ConclusionThe prognosis of SRC at early stage is better than other types of gastric cancer, while that of SRC at advanced stage is relatively poorer.

scholarly journals Signet-Ring Cell Carcinoma of the Colon: A Case Report and Review of the Literature

2015 ◽  
Vol 8 (3) ◽  
pp. 466-471 ◽  
Author(s):  
Peter Y. Park ◽  
Teresa Goldin ◽  
John Chang ◽  
Maurie Markman ◽  
Madappa N. Kundranda
Keyword(s):  
Cell Carcinoma ◽  
Early Stage ◽  
Single Agent ◽  
The United States ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Early Stage Disease ◽  
Lower Quadrant ◽  
Signet Ring ◽  
Ring Cell

Background: Colorectal adenocarcinoma (CRC) is the third leading cause of death in the United States. One of the histologic subtypes of CRC is signet-ring cell carcinoma (SRCC), which has a distinct molecular and tumor biology from that of adenocarcinoma. Primary SRCC diagnosed at an early stage is very rare as most cases are detected at an advanced stage. Therefore, overall prognosis of SRCC is poor. Case Presentation: A 36-year-old female presented to her primary care physician with new-onset progressive right lower quadrant pain without any significant past medical or family history. Computed tomography scan of the abdomen and pelvis with contrast showed a 4.9 × 3.5 × 3.1 cm, lobulated, septated cystic mass arising from the cecum. The mass demonstrated wall enhancement and contained focal areas of coarse calcification. There was nodal involvement either locally or distally. The patient underwent right hemicolectomy, and pathology revealed a high-grade mucinous carcinoma with signet-ring cell variant invading through the muscularis propria and into the subserosal adipose tissue. The margins were negative for tumor, and no lymphovascular or perineural invasion was noted. None of the 14 resected pericolonic lymph nodes was positive for malignancy. Hence, she was staged as pT3, pN0, pMx-stage IIA. The appendix was not involved. Microsatellite instability testing showed the preservation of MLH1, PMS2, MSH2 and MSH6 proteins by IHC and PCR. Carcinoembryonic antigen level was within normal limits. Due to the patient's young age, aggressive histology and microsatellite-stable status, adjuvant fluropyrimidine (5-FU)-based therapy with the single agent capecitabine was initiated. The patient completed 6 months of adjuvant therapy and has been disease free for approximately 18 months. Conclusion: Primary SRCC of the cecum is a rare disease. Given the poor prognosis of these patients, early-stage disease with microsatellite-stable patients should be considered for adjuvant 5-FU-based therapy in an attempt to prevent recurrence.

Early-stage primary signet ring cell carcinoma of the colon with magnifying endoscopic findings

2019 ◽  
Vol 90 (3) ◽  
pp. 529-531
Author(s):  
Tatsunori Minamide ◽  
Kensuke Shinmura ◽  
Hiroaki Ikematsu ◽  
Tomonori Yano
Keyword(s):  
Cell Carcinoma ◽  
Early Stage ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Carcinoma Of The Colon ◽  
Endoscopic Findings ◽  
Signet Ring ◽  
Ring Cell

Incidence, Survival, and Predictors of Lymph Node Involvement in Early-Stage Gastric Signet Ring Cell Carcinoma in the US

2018 ◽  
Vol 22 (4) ◽  
pp. 569-577 ◽  
Author(s):  
Sridevi K. Pokala ◽  
Chao Zhang ◽  
Zhengjia Chen ◽  
Anthony M. Gamboa ◽  
Sarah L. Cristofaro ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cell Carcinoma ◽  
Early Stage ◽  
Lymph Node Involvement ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Signet Ring ◽  
The Us ◽  
Node Involvement ◽  
Ring Cell

scholarly journals Signet ring cell carcinoma of rectum metastasizing to synchronous renal cell carcinoma: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Blagica Krsteska ◽  
Rubens Jovanovic ◽  
Aleksandar Eftimov ◽  
Boro Ilievski ◽  
Dragan Hadzi-Mancev ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cancer Metastasis ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Biological Behavior ◽  
Synchronous Tumors ◽  
Signet Ring ◽  
Ring Cell

Abstract Background Rectal signet ring cell carcinoma is a rare type of colorectal adenocarcinoma characterized by an aggressive biological behavior and poor prognosis. The co-occurrence of colorectal carcinoma and renal cell carcinoma (RCC) has found in many hundreds of patients, many of whom also have additional malignancies. Cancer to cancer metastasis is rare and an uncommon phenomenon in malignancy, especially at the time of initial diagnosis, suggesting a genetic susceptibility. Case presentation We present the case of a 66-year-old Macedonian man with synchronous rectal signet ring cell carcinoma and RCC with tumor to tumor metastasis feature. He underwent a left nephrectomy and anterior rectal resection after complaining of constipation for 3–4 months and the appearance of synchronous tumors on the imaging studies. Morphology and immunohistochemical analysis of specimens from the RCC revealed signet ring cells identical to the rectal signet ring cell carcinoma. The next-generation sequencing study revealed mutations in TP53 and ERBB2, and microsatellite stable signet ring cell carcinoma was determined by deoxyribonucleic acid (DNA) sequencing. Conclusions Cancer to cancer metastasis, although rare, needs to be considered in synchronous tumors. RCC, when diagnosed in multiple synchronous tumors, should be examined carefully. The paucity of reported cases indicates the need for advanced research in imaging methods for metastasis and new therapeutic approaches.

scholarly journals Quantifying the Cell Morphology and Predicting Biological Behavior of Signet Ring Cell Carcinoma using Deep Learning

2021 ◽  
Author(s):  
Qian Da ◽  
Shijie Deng ◽  
Jiahui Li ◽  
Hongmei Yi ◽  
Xiaodi Huang ◽  
...  
Keyword(s):  
Deep Learning ◽  
Cell Carcinoma ◽  
Histopathological Examination ◽  
Morphological Characteristics ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Biological Behavior ◽  
Signet Ring ◽  
Poorly Differentiated ◽  
Ring Cell

Abstract Signet ring cell carcinoma(SRCC) is a malignant tumor of the digestive system. This tumor has long been considered to be poorly differentiated and highly invasive because it has a higher rate of metastasis than well-differentiated adenocarcinoma. But some studies in recent years have shown that the prognosis of some SRCC is more favorable than other poorly differentiated adenocarcinomas, which suggests that SRCC has different degrees of biological behavior. Therefore, we need to find a histological stratification that can predict the biological behavior of SRCC. Some studies indicate that the morphological status of cells can be linked to the invasiveness potential of cells, however, the traditional histopathological examination can not objectively define and evaluate them. Recent improvements in biomedical image analysis using deep learning(DL) based neural networks could be exploited to identify and analyze SRCC. In this study, we used DL to identify each cancer cell of SRCC in whole slide images(WSIs) and quantify their morphological characteristics and atypia. Our results show that the biological behavior of SRCC can be predicted by quantifying the morphology of cancer cells by DL. This technique could be used to predict the biological behavior and may change the stratified treatment of SRCC.

scholarly journals Endoscopic features of early-stage signet-ring-cell carcinoma of the stomach

2015 ◽  
Vol 7 (7) ◽  
pp. 741 ◽  
Author(s):  
Chainarong Phalanusitthepha ◽  
Kevin L Grimes ◽  
Haruo Ikeda ◽  
Hiroki Sato ◽  
Chiaki Sato ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Early Stage ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Carcinoma Of The Stomach ◽  
Signet Ring ◽  
Ring Cell

scholarly journals Quantifying the cell morphology and predicting biological behavior of signet ring cell carcinoma using deep learning

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Qian Da ◽  
Shijie Deng ◽  
Jiahui Li ◽  
Hongmei Yi ◽  
Xiaodi Huang ◽  
...  
Keyword(s):  
Deep Learning ◽  
Cell Carcinoma ◽  
Histopathological Examination ◽  
Morphological Characteristics ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Biological Behavior ◽  
Signet Ring ◽  
Poorly Differentiated ◽  
Ring Cell

AbstractSignet ring cell carcinoma (SRCC) is a malignant tumor of the digestive system. This tumor has long been considered to be poorly differentiated and highly invasive because it has a higher rate of metastasis than well-differentiated adenocarcinoma. But some studies in recent years have shown that the prognosis of some SRCC is more favorable than other poorly differentiated adenocarcinomas, which suggests that SRCC has different degrees of biological behavior. Therefore, we need to find a histological stratification that can predict the biological behavior of SRCC. Some studies indicate that the morphological status of cells can be linked to the invasiveness potential of cells, however, the traditional histopathological examination can not objectively define and evaluate them. Recent improvements in biomedical image analysis using deep learning (DL) based neural networks could be exploited to identify and analyze SRCC. In this study, we used DL to identify each cancer cell of SRCC in whole slide images (WSIs) and quantify their morphological characteristics and atypia. Our results show that the biological behavior of SRCC can be predicted by quantifying the morphology of cancer cells by DL. This technique could be used to predict the biological behavior and may change the stratified treatment of SRCC.

scholarly journals Signet Ring Carcinoma of the Appendix Presenting as Crohn’s Disease in a Young Male

2018 ◽  
Vol 12 (2) ◽  
pp. 277-285 ◽  
Author(s):  
Jonatan Vukovic ◽  
Pavle Vrebalov Cindro ◽  
Snjezana Tomic ◽  
Ante Tonkic
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Cell Carcinoma ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Biological Behavior ◽  
Special Importance ◽  
Ileocecal Region ◽  
Signet Ring ◽  
Ring Cell

Primary signet ring cell carcinoma is a rare event in surgery. It looks like acute appendicitis and it is difficult to diagnose it on clinical grounds alone. The diagnosis is always confirmed by histopathology of a surgically removed appendix. A young man, 22 years old, presented with vomiting, diarrhea, and cramps in his abdomen without abdominal tenderness (mild abdominal discomfort in the right lower abdominal quadrant without signs of peritoneal irritation) during the previous month. The first endoscopic results showed only changes of mucosa that could be attributed to endoscopic and clinical representation of Crohn’s disease. A few days after the initiation of the therapy with aminosalicylates and corticosteroids, the patient went into ileus and was transferred to the Department of Surgery, where he underwent an emergency right-sided hemicolectomy with resection of the transversal colon and forming of an ileostoma. The first pathohistological diagnosis was pseudomembranous colitis. Because the patient’s condition was deteriorating, a revision of the pathohistological diagnosis was done. After careful revision and extensive sampling, a signet ring cell carcinoma arising in the appendix with infiltration of the ileocecal region was found. Immunohistochemically, tumor cells were positive for CDX-2 CK7, CK20, CK19, and carcinoembryonic antigen and negative for chromogranin A. Sixteen isolated lymph nodes were negative. Although the patient had a disease that was localized to the appendix and ileocecal region with no apparent distal metastasis, his clinical condition was worsening rapidly and he died after 2 months. This case shows the aggressive biological behavior of the appendix signet ring cell carcinoma. Scrupulous histopathological examination of the appendix is an obligatory procedure. Elimination of the signet ring cell carcinoma from other carcinoma subtypes is of special importance as it has an exceptionally poor prognosis and is generally diagnosed in its advanced stages.

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