scholarly journals Viscoelasticity measured by shear wave elastography in a rat model of NAFLD: comparison with dynamic mechanical analysis

2020 ◽  
Author(s):  
Zhaoke Pi ◽  
Mengke Wang ◽  
Haoming Lin ◽  
Yanrong Guo ◽  
Siping Chen ◽  
...  
Keyword(s):  
Dynamic Mechanical Analysis ◽  
Shear Wave ◽  
Rat Model ◽  
Liver Steatosis ◽  
Shear Wave Elastography ◽  
Mechanical Analysis ◽  
Ultrasound Elastography ◽  
Nonalcoholic Fatty Liver ◽  
Dynamic Mechanical

Abstract Background: Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming one of the most common liver diseases. Ultrasound elastography has been used for the diagnosis of NAFLD. However, clinical research on steatosis by elastography technology has mainly focused on steatosis with fibrosis or non-alcoholic steatohepatitis (NASH), while steatosis without fibrosis has been poorly studied. Moreover, the relationship between liver viscoelasticity and steatosis grade is not clear. In this study, we evaluated the degree of liver steatosis in a simple steatosis rat model using shear wave elastography (SWE). Results: The viscoelasticity values of 69 rats with hepatic steatosis were measured quantitatively by SWE in vivo and validated by a dynamic mechanical analysis (DMA) test. Pathological sections were used to determine the steatosis grading for each rat. The results showed that the elasticity values obtained by the two methods followed the same trend, and the elasticity is significantly correlated with liver steatosis. The Pearson’s correlation coefficients indicate that elasticity obtained by SWE is positively linear correlated with DMA (r = 0.628, p = 7.85×10 -9 ) Conclusion: SWE might have the feasibility to be introduced as an auxiliary technique for NAFLD patients in clinical settings. However, the viscosity results measured by the two methods are significantly different because the two methods work in different frequency bands.

scholarly journals Viscoelasticity Measured by Shear Wave Elastography in a Rat Model of Nonalcoholic Fatty Liver Disease: Comparison With Dynamic Mechanical Analysis

2020 ◽  
Author(s):  
Zhaoke Pi ◽  
Mengke Wang ◽  
Haoming Lin ◽  
Yanrong Guo ◽  
Siping Chen ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Dynamic Mechanical Analysis ◽  
Shear Wave ◽  
Rat Model ◽  
Fatty Liver Disease ◽  
Liver Steatosis ◽  
Shear Wave Elastography ◽  
Mechanical Analysis ◽  
Dynamic Mechanical

Abstract BackgroundNonalcoholic fatty liver disease (NAFLD) is rapidly becoming one of the most common liver diseases. Ultrasound elastography has been used for the diagnosis of NAFLD. However, clinical research on steatosis by elastography technology has mainly focused on steatosis with fibrosis or non-alcoholic steatohepatitis (NASH), while steatosis without fibrosis has been poorly studied. Moreover, the relationship between liver viscoelasticity and steatosis grade is not clear. In this study, we evaluated the degree of liver steatosis in a simple steatosis rat model using shear wave elastography (SWE). ResultsThe viscoelasticity values of 69 rats with hepatic steatosis were measured quantitatively by SWE in vivo and validated by a dynamic mechanical analysis (DMA) test. Pathological sections were used to determine the steatosis grading for each rat. The results showed that the elasticity values obtained by the two methods followed the same trend, and the elasticity is significantly correlated with liver steatosis. The Pearson’s correlation coefficients indicate that elasticity obtained by SWE is positively linear correlated with DMA (r = 0.628, p = 7.85×10-9). The combined Voigt elasticity measurements have high validity in the prediction of steatosis (S0 vs S1-S4), with an AUROC of 0.755 (95% CI = 0.6175-0.8925, p < 0.01) and the optimal cutoff value was 2.08 kPa with a sensitivity of 78% and specificity of 63%.ConclusionSWE might have the feasibility to be introduced as an auxiliary technique for NAFLD patients in clinical settings. However, the viscosity results measured by the two methods are significantly different because the two methods work in different frequency bands.

scholarly journals Viscoelasticity measured by shear wave elastography in a rat model of nonalcoholic fatty liver disease: comparison with dynamic mechanical analysis

2021 ◽  
Author(s):  
Zhaoke Pi ◽  
Mengke Wang ◽  
Haoming Lin ◽  
Yanrong Guo ◽  
Siping Chen ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Dynamic Mechanical Analysis ◽  
Rat Model ◽  
Fatty Liver Disease ◽  
Liver Steatosis ◽  
Shear Wave Elastography ◽  
Mechanical Analysis ◽  
Nonalcoholic Fatty Liver

Abstract Background: Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming one of the most common liver diseases. Ultrasound elastography has been used for the diagnosis of NAFLD. However, clinical research on steatosis by elastography technology has mainly focused on steatosis with fibrosis or non-alcoholic steatohepatitis (NASH), while steatosis without fibrosis has been poorly studied. Moreover, the relationship between liver viscoelasticity and steatosis grade is not clear. In this study, we evaluated the degree of liver steatosis in a simple steatosis rat model using shear wave elastography (SWE). Results: The viscoelasticity values of 69 rats with hepatic steatosis were measured quantitatively by SWE in vivo and validated by a dynamic mechanical analysis (DMA) test. Pathological sections were used to determine the steatosis grading for each rat. The results showed that the elasticity values obtained by the two methods followed the same trend, and is significantly correlated with liver steatosis. The Pearson’s correlation coefficients indicate that obtained by SWE is positively linear correlated with DMA (r = 0.628, p = 7.85×10-9). However, the obtained by SWE were relatively independent of those obtained by DMA with a correlation coefficient of −0.01. The combined Voigt elasticity measurements have high validity in the prediction of steatosis (S0 vs S1-S4), with an AUROC of 0.755 (95% CI = 0.6175-0.8925, p < 0.01) and the optimal cutoff value was 2.08 kPa with a sensitivity of 78% and specificity of 63%.Conclusion: SWE might have the feasibility to be introduced as an auxiliary technique for NAFLD patients in clinical settings. However, the viscosity results measured by the two methods are significantly different because the two methods work in different frequency bands.

scholarly journals Viscoelasticity measured by shear wave elastography in a rat model of nonalcoholic fatty liver disease: comparison with dynamic mechanical analysis

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Zhaoke Pi ◽  
Mengke Wang ◽  
Haoming Lin ◽  
Yanrong Guo ◽  
Siping Chen ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Dynamic Mechanical Analysis ◽  
Rat Model ◽  
Fatty Liver Disease ◽  
Liver Steatosis ◽  
Shear Wave Elastography ◽  
Mechanical Analysis ◽  
Nonalcoholic Fatty Liver

Abstract Background Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming one of the most common liver diseases. Ultrasound elastography has been used for the diagnosis of NAFLD. However, clinical research on steatosis by elastography technology has mainly focused on steatosis with fibrosis or non-alcoholic steatohepatitis (NASH), while steatosis without fibrosis has been poorly studied. Moreover, the relationship between liver viscoelasticity and steatosis grade is not clear. In this study, we evaluated the degree of liver steatosis in a simple steatosis rat model using shear wave elastography (SWE). Results The viscoelasticity values of 69 rats with hepatic steatosis were measured quantitatively by SWE in vivo and validated by a dynamic mechanical analysis (DMA) test. Pathological sections were used to determine the steatosis grade for each rat. The results showed that the elasticity values µ obtained by the two methods followed the same trend, and µ is significantly correlated with liver steatosis. The Pearson’s correlation coefficients indicate that $$\mu$$ μ obtained by SWE is positively linear correlated with DMA (r = 0.628, p = 7.85 × 10–9). However, the viscosity values $$\eta$$ η obtained by SWE were relatively independent of those obtained by DMA with a correlation coefficient of − 0.01. The combined Voigt elasticity measurements have high validity in the prediction of steatosis (S0 vs. S1–S4), with an AUROC of 0.755 (95% CI 0.6175–0.8925, p < 0.01) and the optimal cutoff value was 2.08 kPa with a sensitivity of 78% and specificity of 63%. Conclusion SWE might have the feasibility to be introduced as an auxiliary technique for NAFLD patients in clinical settings. However, the viscosity results measured by SWE and DMA are significantly different, because the two methods work in different frequency bands.

Aging Assessment by Dynamic Mechanical Analysis of in Vivo Encrusted Polymeric Urinary Stents

2006 ◽  
Vol 20 (1) ◽  
pp. 64-68 ◽  
Author(s):  
D.E. Mouzakis ◽  
N. Bouropoulos ◽  
G. Bithelis ◽  
E. Liatsikos
Keyword(s):  
Dynamic Mechanical Analysis ◽  
Mechanical Analysis ◽  
Dynamic Mechanical

scholarly journals EVALUATION OF IRIDOCILIARY AND LENTICULAR ELASTICITY USING SHEAR-WAVE ELASTOGRAPHY IN RABBIT EYES

2014 ◽  
Vol 57 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Efstathios T. Detorakis ◽  
Eleni E. Drakonaki ◽  
Harilaos Ginis ◽  
Nikolaos Karyotakis ◽  
Ioannis G. Pallikaris
Keyword(s):  
Shear Wave ◽  
Ciliary Body ◽  
Ex Vivo ◽  
Anterior Segment ◽  
Anterior Chamber Depth ◽  
Shear Wave Elastography ◽  
Ultrasound Elastography ◽  
Eye Model ◽  
Rabbit Eye

Introduction: A previous study has employed shear-wave ultrasound elastographic imaging to assess corneal rigidity in an ex-vivo porcine eye model. This study employs the same modality in vivo in a rabbit eye model in order to assess lens, ciliary body and total ocular rigidity changes following the instillation of atropine and pilocarpine. Methods: Ten non-pigmented female rabbits were examined. Measurements of the lens, ciliary body and total ocular rigidity as well as lens thickness and anterior chamber depth were taken with the Aixplorer system (SuperSonic Imagine, Aix-en-Provence, France) with the SuperLinear™ SL 15-4 transducer in both eyes at baseline as well as after pilocarpine and atropine instillation. The IOP was also measured with the TonoPen tonometer. Results: Changes in rigidity in the examined areas following atropine instillation were statistically not significant. Ciliary body rigidity was significantly increased whereas lens and total ocular rigidity were significantly reduced following pilocarpine instillation. The decrease in lens rigidity following pilocarpine was significantly associated with the respective increase in ciliary body rigidity. Conclusions: Shear-wave ultrasound elastography can detect in vivo rigidity changes in the anterior segment of the rabbit eye model and may potentially be applied in human eyes, providing useful clinical information on conditions in which rigidity changes play an important role, such as glaucoma, pseudoexfoliation syndrome or presbyopia.

In vivo liver tissue mechanical properties by transient elastography: Comparison with dynamic mechanical analysis

Biorheology ◽  
2011 ◽  
Vol 48 (2) ◽  
pp. 75-88 ◽  
Author(s):  
Simon Chatelin ◽  
Jennifer Oudry ◽  
Nicolas Périchon ◽  
Laurent Sandrin ◽  
Pierre Allemann ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Dynamic Mechanical Analysis ◽  
Liver Tissue ◽  
Transient Elastography ◽  
Mechanical Analysis ◽  
Dynamic Mechanical
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