scholarly journals Importance of lipid ratios for predicting intracranial atherosclerotic stenosis

2020 ◽  
Author(s):  
Wen-Song Yang ◽  
Rui Li ◽  
Yi-Qing Shen ◽  
Xing-Chen Wang ◽  
Qing-Jun Liu ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Lipid Level ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Apo B ◽  
Lipid Ratios ◽  
Intracranial Atherosclerotic Stenosis ◽  
Atherosclerotic Stenosis

Abstract Background: We wished to investigate the association of lipid ratios with intracranial atherosclerotic stenosis (ICAS) in a Chinese population. Methods: We included 658 consecutive patients with ischemic stroke in our cross-sectional study. Intracranial and extracranial arteries were evaluated for atherosclerotic stenosis using digital subtraction angiography or computed tomography angiography. Lipid ratios [total cholesterol (TC)/high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG)/HDL-C, low-density lipoprotein-cholesterol (LDL-C)/HDL-C, non-high-density lipoprotein-cholesterol (non-HDL-C)/HDL-C, remnant cholesterol (RC)/HDL-C, apolipoprotein B (apo B)/apolipoprotein A-I (apo A-I), and apo B/HDL-C] were calculated. Results : Ratios of TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C, apo B/HDL-C and apo B/apo A-I were associated significantly with ICAS but not with extracranial atherosclerotic stenosis after adjustment for confounding factors. Analyses of receiver operating characteristic (ROC) curves revealed the apo B/apo A-I ratio have the highest area under the ROC curve (AUC) value for a lipid level alone and for lipid ratios (AUC = 0.588). Lipid ratios had higher AUC values than those for a lipid level alone for identifying ICAS. Conclusion : The ratios of TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C apo B/HDL-C and apo B/apo A-I were related significantly to ICAS risk. Compared with the other variables tested, the apo B/apo A-I ratio appeared to be better discriminator for identifying ICAS risk.

scholarly journals Importance of lipid ratios for predicting intracranial atherosclerotic stenosis

2020 ◽  
Author(s):  
Wen-Song Yang ◽  
Rui Li ◽  
Yi-Qing Shen ◽  
Xing-Chen Wang ◽  
Qing-Jun Liu ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Lipid Levels ◽  
Apo B ◽  
Lipid Ratios ◽  
Intracranial Atherosclerotic Stenosis ◽  
Atherosclerotic Stenosis

Abstract Background: This study aims to investigate the association of lipid ratios with intracranial atherosclerotic stenosis (ICAS) in a Chinese population.Methods: This cross-sectional study included 658 consecutive patients with ischemic stroke. Intracranial and extracranial arteries were evaluated for atherosclerotic stenosis using digital subtraction angiography or computed tomography angiography. Lipid ratios [total cholesterol (TC)/high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG)/HDL-C, low-density lipoprotein-cholesterol (LDL-C)/HDL-C, non-high-density lipoprotein-cholesterol (non-HDL-C)/HDL-C, remnant cholesterol (RC)/HDL-C, apolipoprotein B (apo B)/apolipoprotein A-I (apo A-I), and apo B/HDL-C] were calculated.Results: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C, apo B/HDL-C and apo B/apo A-I ratios (all P <0.05) were significantly associated with ICAS but not with extracranial atherosclerotic stenosis after adjustment for confounding factors. Receiver operating characteristic (ROC) curves analyses revealed that the apo B/apo A-I ratio had the largest area under the ROC curve (AUC) among lipid levels alone and for lipid ratios (AUC = 0.588). Lipid ratios had higher AUC values than those for lipid levels alone for the identification of ICAS.Conclusion: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C apo B/HDL-C, and apo B/apo A-I ratios were significantly related to ICAS risk. Compared with the other variables tested, the apo B/apo A-I ratio appeared to be a better discriminator for identifying ICAS risk in stroke patients.

scholarly journals Importance of lipid ratios for predicting intracranial atherosclerotic stenosis

2020 ◽  
Author(s):  
Wen-Song Yang ◽  
Rui Li ◽  
Yi-Qing Shen ◽  
Xing-Chen Wang ◽  
Qing-Jun Liu ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Lipid Levels ◽  
Stroke Patients ◽  
Apo B ◽  
Lipid Ratios ◽  
Atherosclerotic Stenosis

Abstract Background: This study aims to investigate the association of lipid ratios with intracranial atherosclerotic stenosis (ICAS) in a Chinese population.Methods: This cross-sectional study included 658 consecutive patients with ischemic stroke. Intracranial and extracranial arteries were evaluated for atherosclerotic stenosis using digital subtraction angiography or computed tomography angiography. Lipid ratios [total cholesterol (TC)/high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG)/HDL-C, low-density lipoprotein-cholesterol (LDL-C)/HDL-C, non-high-density lipoprotein-cholesterol (non-HDL-C)/HDL-C, remnant cholesterol (RC)/HDL-C, apolipoprotein B (apo B)/apolipoprotein A-I (apo A-I), and apo B/HDL-C] were calculated.Results: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C, apo B/HDL-C and apo B/apo A-I ratios (all P <0.05) were significantly associated with ICAS but not with extracranial atherosclerotic stenosis after adjustment for confounding factors. Receiver operating characteristic (ROC) curves analyses revealed that the apo B/apo A-I ratio had the largest area under the ROC curve (AUC) among lipid levels alone and for lipid ratios (AUC = 0.588). Lipid ratios had higher AUC values than those for lipid levels alone for the identification of ICAS.Conclusion: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C apo B/HDL-C, and apo B/apo A-I ratios were significantly related to ICAS risk. Compared with the other variables tested, the apo B/apo A-I ratio appeared to be a better discriminator for identifying ICAS risk in stroke patients. Take home message: Several lipid ratios were significantly related to ICAS risk and have several differences between men and women in stroke patients.

scholarly journals Importance of lipid ratios for predicting intracranial atherosclerotic stenosis

2020 ◽  
Author(s):  
Wen-Song Yang ◽  
Rui Li ◽  
Yi-Qing Shen ◽  
Xing-Chen Wang ◽  
Qing-Jun Liu ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Lipid Levels ◽  
Stroke Patients ◽  
Apo B ◽  
Lipid Ratios ◽  
Atherosclerotic Stenosis

Abstract Background: This study aims to investigate the association of lipid ratios with intracranial atherosclerotic stenosis (ICAS) in a Chinese population.Methods: This cross-sectional study included 658 consecutive patients with ischemic stroke. Intracranial and extracranial arteries were evaluated for atherosclerotic stenosis using digital subtraction angiography or computed tomography angiography. Lipid ratios [total cholesterol (TC)/high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG)/HDL-C, low-density lipoprotein-cholesterol (LDL-C)/HDL-C, non-high-density lipoprotein-cholesterol (non-HDL-C)/HDL-C, remnant cholesterol (RC)/HDL-C, apolipoprotein B (apo B)/apolipoprotein A-I (apo A-I), and apo B/HDL-C] were calculated.Results: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C, apo B/HDL-C and apo B/apo A-I ratios were significantly associated with ICAS but not with extracranial atherosclerotic stenosis after adjustment for confounding factors. Receiver operating characteristic (ROC) curves analyses revealed that the apo B/apo A-I ratio had the largest area under the ROC curve (AUC) among lipid levels alone and for lipid ratios (AUC = 0.588). Lipid ratios had higher AUC values than those for lipid levels alone for identification of ICAS.Conclusion: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C apo B/HDL-C, and apo B/apo A-I ratios were significantly related to ICAS risk. Compared with the other variables tested, the apo B/apo A-I ratio appeared to be a better discriminator for identifying ICAS risk in stroke patients. Take home message: Variables that were significantly related to ICAS risk included the TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C, apo B/HDL-C, and apo B/apo A-I ratios. Among the variables tested, the apo B/apo A-I ratio showed the best performance in identifying ICAS risk in stroke patients. Besides, several gender differences were observed with regard to other lipid ratios.

Homogeneous assay for direct determination of high-density lipoprotein cholesterol evaluated

1996 ◽  
Vol 42 (3) ◽  
pp. 424-429 ◽  
Author(s):  
M Nauck ◽  
W März ◽  
B Haas ◽  
H Wieland
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
Low Density Lipoproteins ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Apo B ◽  
Homogeneous Assay

Abstract We evaluated a new homogeneous assay for quantifying high-density lipoprotein cholesterol (HDL-C). The assay included four reagents: polyethylene glycol for "wrapping" chylomicrons, very-low-density lipoproteins (VLDL), and low-density lipoproteins (LDL); antibodies specific for apolipoprotein (apo) B and apo C-III to produce aggregates of chylomicrons, VLDL, and LDL; enzymes for the enzymatic cholesterol determination of the noncomplexed lipoproteins with 4-aminoantipyrine as the color reagent; and guanidine salt to stop the enzymatic reaction and to solubilize the complexes of apo B-containing lipoproteins, which would otherwise interfere with the reading of absorbance. The total CVs of the new method ranged between 2.4% and 8.4%. The HDL-C values (y) were in good agreement with those by a comparison phosphotungstic acid/MgCl2 method (x): y= 0.987x + 17.2 mg/L (68th percentile of the residuals on the regression line= 21.49, r= 0.970). At triglyceride concentrations of 20 g/L (Intralipid) the homogeneous HDL-C concentrations increased by 2%. Hemoglobin markedly increased the results, whereas bilirubin reduced them. The homogeneous HDL-C assay was easy to handle and allows full automation. This test should considerably facilitate the screening of individuals at an increased risk of cardiovascular disease.

Impact of the Triglyceride/High-Density Lipoprotein Cholesterol Ratio and the Hypertriglyceremic-Waist Phenotype to Predict the Metabolic Syndrome and Insulin Resistance

2017 ◽  
Vol 49 (07) ◽  
pp. 542-549 ◽  
Author(s):  
Helene von Bibra ◽  
Sarama Saha ◽  
Alexander Hapfelmeier ◽  
Gabriele Müller ◽  
Peter Schwarz
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Lipid Ratios ◽  
The Metabolic Syndrome ◽  
European Populations

AbstractInsulin resistance is the underlying mechanism for the metabolic syndrome and associated dyslipidaemia that theoretically implies a practical tool for identifying individuals at risk for cardiovascular disease and type-2-diabetes. Another screening tool is the hypertriglyceremic-waist phenotype (HTW). There is important impact of the ethnic background but a lack of studied European populations for the association of the triglyceride/high-density lipoprotein cholesterol (HDL-C) ratio and insulin resistance. This observational, retrospective study evaluated lipid ratios and the HTW for predicting the metabolic syndrome/insulin resistance in 1932 non-diabetic individuals from Germany in the fasting state and during a glucose tolerance test. The relations of triglyceride/HDL-C, total-cholesterol/HDL-C, and low-density lipoprotein cholesterol/HDL-C with 5 surrogate estimates of insulin resistance/sensitivity and metabolic syndrome were analysed by linear regression analysis and receiver operating characteristics (ROC) in participants with normal (n=1 333) or impaired fasting glucose (n=599), also for the impact of gender. Within the lipid ratios, triglyceride/HDL-C had the strongest associations with insulin resistance/sensitivity markers. In the prediction of metabolic syndrome, diagnostic accuracy was good for triglyceride/HDL-C (area under the ROC curve 0.817) with optimal cut-off points (in mg/dl units) of 2.8 for men (80% sensitivity, 71% specificity) and 1.9 for women (80% sensitivity, 75% specificity) and fair for HTW and HOMA-IR (area under the curve 0.773 and 0.761). These data suggest the triglyceride/HDL-C ratio as a physiologically relevant and practical index for predicting the concomitant presence of metabolic syndrome, insulin resistance and dyslipidaemia for therapeutic and preventive care in apparently healthy European populations.

scholarly journals Dyslipidemia Aterogenic, antara fakta dan harapan yang akan datang

2016 ◽  
pp. 127-9
Author(s):  
Djanggan Sargowo
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Apo B

Disregulasi dari metabolisme lipoprotein merupakan inti dari perkembangan aterosklerosis. Suatu studi epidemi prospektif secara konsisten menunjukkan bahwa kenaikan dari Low Density Lipoprotein Cholesterol (LDL-C) dihubungkan dengan peningkatan risiko dari penyakit kardiovaskular, namun hal tersebut mungkin secara terpisah menyebabkan dislipidemia aterogenik, jika bergabung dengan hipertensi, obesitas sentral dan resistensi insulin, yang secara bersamaan dikenal sebagai sindroma metabolik. Dislipidemia aterogenik ditandai dengan tingginya trigliserid (TG) plasma, rendahnya High Density Lipoprotein Cholesterol (HDL-C) dan tingginya konsentrasi apolipoprotein (apo)-B yang berisi lipoprotein, khususnya peningkatan small dense LDL.Hipertrigliserid (HTG) adalah peningkatan kadar trigliserid (TG) puasa di atas normal (> 150 mg/dl). Pada 2010 di Amerika Serikat ada 74,6 juta penduduk mempunyai peningkatan kadar trigliserid, 36,4 juta diantara mereka memiliki kadar triglsierid yang tinggi (200-499 mg/dl), dengan meningkatnya prevalensi ini secara paralel juga terjadi peningkatan yang tajam terhadap kejadian obesitas.1

scholarly journals The Association Between Lipid Ratio and Depression: A Cross-Sectional Study

2021 ◽  
Author(s):  
A Lum Han
Keyword(s):  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Cross Sectional ◽  
Cholesterol Ratio ◽  
Lipid Ratios

Abstract Background: Depression is associated with the total cholesterol, low-density cholesterol, triglycerides, and high-density cholesterol levels in the blood. However, there are only a few studies on the relationship between depression and lipid ratios. Therefore, the aim of this study was to investigate the correlation between depression and different lipid ratios.Methods: This study was conducted using data from the Korea National Health and Nutrition Examination Survey. A total of 11,648 adult men and women aged 19 years and older, without missing data, were included in this study. Depression was diagnosed using the Patient Health Questionnaire-9. The associations between depression and total cholesterol/high-density lipoprotein cholesterol, low-density cholesterol/high-density lipoprotein cholesterol, and triglyceride/high-density lipoprotein cholesterol ratio were analyzed. A complex sample logistic regression test was used for the analysis of the odds ratios of depression.Results: In males, the total cholesterol/high-density lipoprotein cholesterol and low-density cholesterol/high-density lipoprotein cholesterol ratios were not associated with depression. In addition, an increase in triglyceride/high-density lipoprotein cholesterol ratio by 1 was associated with a 1.041-fold higher probability of depression in males. In females, the three lipid ratios were not associated with depression.Conclusions: Triglyceride/high-density lipoprotein cholesterol ratio is associated with depression in males. Further studies are necessary to cross-validate, explore the biological mechanism, and identify the clinical implication of this correlation.

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