scholarly journals Importance of lipid ratios for predicting intracranial atherosclerotic stenosis

2020 ◽  
Author(s):  
Wen-Song Yang ◽  
Rui Li ◽  
Yi-Qing Shen ◽  
Xing-Chen Wang ◽  
Qing-Jun Liu ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Lipid Levels ◽  
Stroke Patients ◽  
Apo B ◽  
Lipid Ratios ◽  
Atherosclerotic Stenosis

Abstract Background: This study aims to investigate the association of lipid ratios with intracranial atherosclerotic stenosis (ICAS) in a Chinese population.Methods: This cross-sectional study included 658 consecutive patients with ischemic stroke. Intracranial and extracranial arteries were evaluated for atherosclerotic stenosis using digital subtraction angiography or computed tomography angiography. Lipid ratios [total cholesterol (TC)/high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG)/HDL-C, low-density lipoprotein-cholesterol (LDL-C)/HDL-C, non-high-density lipoprotein-cholesterol (non-HDL-C)/HDL-C, remnant cholesterol (RC)/HDL-C, apolipoprotein B (apo B)/apolipoprotein A-I (apo A-I), and apo B/HDL-C] were calculated.Results: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C, apo B/HDL-C and apo B/apo A-I ratios were significantly associated with ICAS but not with extracranial atherosclerotic stenosis after adjustment for confounding factors. Receiver operating characteristic (ROC) curves analyses revealed that the apo B/apo A-I ratio had the largest area under the ROC curve (AUC) among lipid levels alone and for lipid ratios (AUC = 0.588). Lipid ratios had higher AUC values than those for lipid levels alone for identification of ICAS.Conclusion: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C apo B/HDL-C, and apo B/apo A-I ratios were significantly related to ICAS risk. Compared with the other variables tested, the apo B/apo A-I ratio appeared to be a better discriminator for identifying ICAS risk in stroke patients. Take home message: Variables that were significantly related to ICAS risk included the TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C, apo B/HDL-C, and apo B/apo A-I ratios. Among the variables tested, the apo B/apo A-I ratio showed the best performance in identifying ICAS risk in stroke patients. Besides, several gender differences were observed with regard to other lipid ratios.

scholarly journals Importance of lipid ratios for predicting intracranial atherosclerotic stenosis

2020 ◽  
Author(s):  
Wen-Song Yang ◽  
Rui Li ◽  
Yi-Qing Shen ◽  
Xing-Chen Wang ◽  
Qing-Jun Liu ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Lipid Levels ◽  
Stroke Patients ◽  
Apo B ◽  
Lipid Ratios ◽  
Atherosclerotic Stenosis

Abstract Background: This study aims to investigate the association of lipid ratios with intracranial atherosclerotic stenosis (ICAS) in a Chinese population.Methods: This cross-sectional study included 658 consecutive patients with ischemic stroke. Intracranial and extracranial arteries were evaluated for atherosclerotic stenosis using digital subtraction angiography or computed tomography angiography. Lipid ratios [total cholesterol (TC)/high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG)/HDL-C, low-density lipoprotein-cholesterol (LDL-C)/HDL-C, non-high-density lipoprotein-cholesterol (non-HDL-C)/HDL-C, remnant cholesterol (RC)/HDL-C, apolipoprotein B (apo B)/apolipoprotein A-I (apo A-I), and apo B/HDL-C] were calculated.Results: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C, apo B/HDL-C and apo B/apo A-I ratios (all P <0.05) were significantly associated with ICAS but not with extracranial atherosclerotic stenosis after adjustment for confounding factors. Receiver operating characteristic (ROC) curves analyses revealed that the apo B/apo A-I ratio had the largest area under the ROC curve (AUC) among lipid levels alone and for lipid ratios (AUC = 0.588). Lipid ratios had higher AUC values than those for lipid levels alone for the identification of ICAS.Conclusion: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C apo B/HDL-C, and apo B/apo A-I ratios were significantly related to ICAS risk. Compared with the other variables tested, the apo B/apo A-I ratio appeared to be a better discriminator for identifying ICAS risk in stroke patients. Take home message: Several lipid ratios were significantly related to ICAS risk and have several differences between men and women in stroke patients.

scholarly journals Importance of lipid ratios for predicting intracranial atherosclerotic stenosis

2020 ◽  
Author(s):  
Wen-Song Yang ◽  
Rui Li ◽  
Yi-Qing Shen ◽  
Xing-Chen Wang ◽  
Qing-Jun Liu ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Lipid Levels ◽  
Apo B ◽  
Lipid Ratios ◽  
Intracranial Atherosclerotic Stenosis ◽  
Atherosclerotic Stenosis

Abstract Background: This study aims to investigate the association of lipid ratios with intracranial atherosclerotic stenosis (ICAS) in a Chinese population.Methods: This cross-sectional study included 658 consecutive patients with ischemic stroke. Intracranial and extracranial arteries were evaluated for atherosclerotic stenosis using digital subtraction angiography or computed tomography angiography. Lipid ratios [total cholesterol (TC)/high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG)/HDL-C, low-density lipoprotein-cholesterol (LDL-C)/HDL-C, non-high-density lipoprotein-cholesterol (non-HDL-C)/HDL-C, remnant cholesterol (RC)/HDL-C, apolipoprotein B (apo B)/apolipoprotein A-I (apo A-I), and apo B/HDL-C] were calculated.Results: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C, apo B/HDL-C and apo B/apo A-I ratios (all P <0.05) were significantly associated with ICAS but not with extracranial atherosclerotic stenosis after adjustment for confounding factors. Receiver operating characteristic (ROC) curves analyses revealed that the apo B/apo A-I ratio had the largest area under the ROC curve (AUC) among lipid levels alone and for lipid ratios (AUC = 0.588). Lipid ratios had higher AUC values than those for lipid levels alone for the identification of ICAS.Conclusion: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C apo B/HDL-C, and apo B/apo A-I ratios were significantly related to ICAS risk. Compared with the other variables tested, the apo B/apo A-I ratio appeared to be a better discriminator for identifying ICAS risk in stroke patients.

scholarly journals Importance of lipid ratios for predicting intracranial atherosclerotic stenosis

2020 ◽  
Author(s):  
Wen-Song Yang ◽  
Rui Li ◽  
Yi-Qing Shen ◽  
Xing-Chen Wang ◽  
Qing-Jun Liu ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Lipid Level ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Apo B ◽  
Lipid Ratios ◽  
Intracranial Atherosclerotic Stenosis ◽  
Atherosclerotic Stenosis

Abstract Background: We wished to investigate the association of lipid ratios with intracranial atherosclerotic stenosis (ICAS) in a Chinese population. Methods: We included 658 consecutive patients with ischemic stroke in our cross-sectional study. Intracranial and extracranial arteries were evaluated for atherosclerotic stenosis using digital subtraction angiography or computed tomography angiography. Lipid ratios [total cholesterol (TC)/high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG)/HDL-C, low-density lipoprotein-cholesterol (LDL-C)/HDL-C, non-high-density lipoprotein-cholesterol (non-HDL-C)/HDL-C, remnant cholesterol (RC)/HDL-C, apolipoprotein B (apo B)/apolipoprotein A-I (apo A-I), and apo B/HDL-C] were calculated. Results : Ratios of TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C, apo B/HDL-C and apo B/apo A-I were associated significantly with ICAS but not with extracranial atherosclerotic stenosis after adjustment for confounding factors. Analyses of receiver operating characteristic (ROC) curves revealed the apo B/apo A-I ratio have the highest area under the ROC curve (AUC) value for a lipid level alone and for lipid ratios (AUC = 0.588). Lipid ratios had higher AUC values than those for a lipid level alone for identifying ICAS. Conclusion : The ratios of TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C apo B/HDL-C and apo B/apo A-I were related significantly to ICAS risk. Compared with the other variables tested, the apo B/apo A-I ratio appeared to be better discriminator for identifying ICAS risk.

scholarly journals Lipid Profiles in Patients With Ulcerative Colitis Receiving Tofacitinib—Implications for Cardiovascular Risk and Patient Management

2020 ◽  
Author(s):  
Bruce E Sands ◽  
Jean-Frédéric Colombel ◽  
Christina Ha ◽  
Michel Farnier ◽  
Alessandro Armuzzi ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Cardiovascular Events ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Major Adverse Cardiovascular Events ◽  
Lipid Levels

Abstract Background Patients with ulcerative colitis (UC) are at elevated risk of cardiovascular disease vs the general population, despite a lower prevalence of traditional risk factors, including hyperlipidemia. Mechanistic studies in patients with rheumatoid arthritis and psoriasis suggest that tofacitinib restores serum lipids to preinflammation levels by reversing inflammation-induced cholesterol metabolism changes. We reviewed data on lipid levels and cardiovascular events, alongside recommendations for managing lipid levels during tofacitinib treatment in patients with UC, based on up-to-date expert guidelines. Methods Data were identified from a phase 3/open-label, long-term extension (OLE) tofacitinib UC clinical program (cutoff May 27, 2019). Literature was identified from PubMed (search terms “lipid,” “cholesterol,” “lipoprotein,” “cardiovascular,” “inflammation,” “atherosclerosis,” “tofacitinib,” “rheumatoid arthritis,” “psoriasis,” “inflammatory bowel disease,” “ulcerative colitis,” “hyperlipidemia,” and “guidelines”) and author knowledge. Data were available from 4 phase 3 clinical trials of 1124 patients with moderately to severely active UC who received ≥1 dose of tofacitinib 5 or 10 mg twice daily in induction (two identical trials), maintenance, and OLE studies (treatment duration ≤6.8 years; 2576.4 patient-years of drug exposure). Results In the OLE study, tofacitinib treatment was not associated with major changes from baseline in total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, total cholesterol/high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol/high-density lipoprotein cholesterol, with lipid levels and ratios generally remaining stable over time. The major adverse cardiovascular events incidence rate was 0.26/100 patient-years (95% confidence interval, 0.11-0.54). Conclusions Lipid levels and ratios remained generally unchanged from baseline in the OLE study after tofacitinib treatment, and major adverse cardiovascular events were infrequent. Long-term studies are ongoing. ClinicalTrials.gov identifiers NCT01465763, NCT01458951, NCT01458574, NCT01470612

scholarly journals Evaluation of High Density Lipoprotein Cholesterol Concentrations among Elderly Ischaemic Stroke Patients

2018 ◽  
Vol 13 (1) ◽  
pp. 8-12
Author(s):  
Kazi Jannat Ara ◽  
Abu Shams Md Hasan Ali Masum ◽  
Md Shafiqus Saleheen ◽  
Sheikh Abdul Kader ◽  
Sk Mahbub Alam ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Ischaemic Stroke ◽  
High Density Lipoprotein Cholesterol ◽  
Heart Diseases ◽  
Smoking Habit ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Stroke Patients ◽  
Female Ratio

Stroke is an alarming health hazard all over the world as well as in Bangladesh and one of the leading causes of mortality and morbidity. There is a well-established inverse relation between serum concentrations of high density lipoprotein cholesterol (HDL-c) and the risk of coronary heart diseases but it is not a welldocumented risk factor for stroke. This study was done to evaluate of the HLD-c concentration among elderly ischaemic stroke patients. This cross sectional study was conducted in Out Patient department (OPD) stroke clinic and Indoor of the department of neurology, BSMMU, Dhaka from July 2015 to June 2016. A total 200 patients suffering from ischaemic stroke within the range of 61-95 years of age of both sexes with TIA, and hemorrhagic stroke were included. Patient with Stoke after one month of onset, cases with anti-lipid drugs were excluded. Male and female ratio was 1.95:1. Mean age was 68.4±8.24 years. 75 (52.8%) patients had hypertension, 20 (14.1%) had diabetes mellitus,10 (7.0%)patients had atrial fibrillation,8(5.6%)had ischemic heart disease. 44 (31.0%) patients had smoking habit ,mean total cholesterol was 190.7±56.0 mg/dl, mean HDL was36.9±8.4mg/dl, mean LDL was123.9±38.8mg/dl and mean Triglyceride was 175.9±70.5 mg/dl. HDL level gradually decreased according to the increment of age. HDL-c is low in elderly ischaemic stroke patient.University Heart Journal Vol. 13, No. 1, January 2017; 8-12

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