scholarly journals Real-time surveillance of surgical margins via ICG-based near-infrared fluorescence imaging in patients with OSCC

2020 ◽  
Author(s):  
Jiongru Pan ◽  
Han Deng ◽  
Shiqi Hu ◽  
Chengwan Xia ◽  
Yongfeng Chen ◽  
...  
Keyword(s):  
Near Infrared ◽  
Tumor Resection ◽  
Animal Experiments ◽  
Surgical Margins ◽  
Pathological Examination ◽  
Primary Tumors ◽  
Near Infrared Fluorescence ◽  
Normal Tissues ◽  
Imaging And Spectroscopy ◽  
Complementary Value

Abstract Background Local recurrence is the main cause of death among patients with oral squamous cell carcinoma (OSCC). This study assessed near-infrared fluorescence (NIF) imaging and spectroscopy to monitor surgical margins intraoperative for OSCC. Methods Cytological and animal experiments were first performed to confirm the feasibility of monitoring surgical margins with NIF imaging and spectroscopy. Then, 20 patients with OSCC were included in the clinical trials. At 6–8 hours after 0.75 mg/kg indocyanine green (ICG) injection, all patients underwent surgery with NIF imaging. During the surgery, both NIF images and quantified fluorescence intensity were acquired to monitor the surgical margins. Results In cytological and animal experiments, the results showed it is feasible to monitor surgical margins with NIF imaging and spectroscopy. Fluorescence was detected in primary tumors in all patients. The fluorescence intensities of the tumor, peritumoral, and normal tissues were 398.863±151.47, 278.52±84.89, and 274.5±100.93 arbitrary units (AUs), respectively (P<0.05). The SBR of tumor to peritumoral tissue and normal tissues was computed to be 1.45±0.36 and 1.56±0.41 respectively. After primary tumor excision, the wounds showed abnormal fluorescence in four patients (4/20), and residual cancer cells were confirmed by pathological examination in two patients (2/20). Conclusion These findings confirmed the complementary value of NIF imaging during radical tumor resection of OSCC.

scholarly journals Real-time surveillance of surgical margins via ICG-based near-infrared fluorescence imaging in patients with OSCC

2020 ◽  
Author(s):  
Jiongru Pan ◽  
Han Deng ◽  
Shiqi Hu ◽  
Chengwan Xia ◽  
Yongfeng Chen ◽  
...  
Keyword(s):  
Near Infrared ◽  
Tumor Resection ◽  
Animal Experiments ◽  
Surgical Margin ◽  
Surgical Margins ◽  
Pathological Examination ◽  
Near Infrared Fluorescence ◽  
Normal Tissues ◽  
Imaging And Spectroscopy ◽  
Complementary Value

Abstract Background Local recurrence is the main cause of death among patients with oral squamous cell carcinoma (OSCC). This study assessed near-infrared fluorescence (NIF) imaging and spectroscopy to monitor surgical margins intraoperatively for OSCC. Methods Cytological and animal experiments were first performed to confirm the feasibility of monitoring surgical margins with NIF imaging and spectroscopy. Then, 20 patients with OSCC were included in the clinical trials. At 6–8 hours after 0.75 mg/kg indocyanine green (ICG) injection, all patients underwent surgery with NIF imaging. During the surgery, both NIF images and quantified fluorescence intensity were acquired to monitor the surgical margins. Results In cytological and animal experiments, the results showed it was feasible to monitor surgical margins with NIF imaging and spectroscopy. Fluorescence was detected in primary tumors in all patients. The fluorescence intensities of the tumor, peritumoral, and normal tissues were 398.863±151.47, 278.52±84.89, and 274.5±100.93 arbitrary units (AUs), respectively (P<0.05). The SBR of tumor to peritumoral tissue and normal tissues was computed to be 1.45±0.36 and 1.56±0.41 respectively. After primary tumor excision, the wounds showed abnormal fluorescence in four patients (4/20), and residual cancer cells were confirmed by pathological examination in two patients (2/20). Conclusion These findings confirmed the complementary value of NIF imaging during radical tumor resection of OSCC. Before tumor resection, we could utilize the fluorescence margin produced by ICG NIF imaging to determine the surgical margin. Moreover, after tumor blocks were removed, the status of surgical margin could also be evaluated rapidly by ICG NIF imaging of tumor bed and in vitro specimens.

scholarly journals Pathological Validity of Using Near-infrared Fluorescence Imaging for Securing Surgical Margins During Liver Resection

2020 ◽  
Vol 40 (7) ◽  
pp. 3873-3882
Author(s):  
YOSHIHIKO TASHIRO ◽  
TAKESHI AOKI ◽  
TAKAHITO HIRAI ◽  
TOMOTAKE KOIZUMI ◽  
DOAA A. MANSOU ◽  
...  
Keyword(s):  
Liver Resection ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Surgical Margins ◽  
Near Infrared Fluorescence ◽  
Near Infrared Fluorescence Imaging

scholarly journals Iliosacral Bone Tumor Resection Using Cannulated Screw-Guided Gigli Saw - A Novel Technique

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Tao Ji ◽  
Brian Z. J. Chin ◽  
Xiaodong Tang ◽  
Rongli Yang ◽  
Wei Guo
Keyword(s):  
Local Recurrence ◽  
Tumor Resection ◽  
Surgical Margins ◽  
Osteotomy Site ◽  
R0 Resection ◽  
Primary Tumors ◽  
Current Series ◽  
Common Diagnosis ◽  
Sacral Foramina

Abstract Background Adequate margins are technically difficult to achieve for malignant tumors involving the sacroiliac joint due to limited accessibility and viewing window. In order to address the technical difficulties faced in iliosacral tumor resection, we proposed a technique for precise osteotomy, which involved the use of canulated screws and Gigli saw (CSGS) that facilitated directional control, anteroposterior linkage of resection points and adequate surgical margins. The purpose of the current study was to evaluate whether CSGS technique facilitated sagittal osteotomy at sacral side, and were adequate surgical margins achieved? Also functional and oncological outcomes was determined along with the noteworthy complications. Methods From April 2018 to November 2019, we retrospectively reviewed 15 patients who underwent resections for primary tumors of pelvis or sacrum necessitating iliosacral joint removal using the proposed CSGS technique. Chondrosarcoma was the most common diagnosis. The osteotomy site within sacrum was at ipsilateral ventral sacral foramina in 8 cases, midline of sacrum in 5 cases, and contralateral ventral sacral foramina and sacral ala with 1 case each. The average intraoperative blood loss was 3640 mL (range, 1200 and 6000 mL) with a mean operation duration of 7.4 hours (range, 5 to 12 hours). The mean follow-up was 23.0 months (range, 18 and 39 months) for alive patients. Results Surgical margins were wide in 12 patients (80%), wide-contaminated in 1 patient (6.7%), and marginal in 2 patients (13.3%). R0 resection was achieved in 12 (80%) patients and R1 resection in 3 patients. There were three local recurrences (20%) occurred at a mean time of 11 months postoperatively. No local recurrence was observed at sacral osteotomy. The overall one-year and three-year survival rate was 86.7% and 72.7% respectively.Complications occurred in three patients. Conclusions The current study demonstrated that CSGS technique for tumor resection within the sacrum and pelvis was feasible and can achieve ideal resection accuracies. The use of CSGS was associated with high likelihood of negative margin resections in the current series. Intraoperative use of CSGS appeared to be technically straightforward and allowed achievement of planned surgical margins. It is worthwhile to consider the use of CSGS technique in resection of pelvic tumors with sacral invasion and iliosacral tumors, however further follow-up at mid to long-term is warranted to observe local recurrence rate.

scholarly journals Utility of intraoperative real-time near-infrared fluorescence surgery for spinal schwannoma

2022 ◽  
Vol 6 (1) ◽  
pp. V12
Keyword(s):  
Real Time ◽  
Near Infrared ◽  
Tumor Resection ◽  
Tumor Location ◽  
Tumor Removal ◽  
Near Infrared Fluorescence ◽  
Tumor Visualization ◽  
Before And After ◽  
Spinal Schwannoma ◽  
Near Infrared Fluorescence Imaging

The authors report the first cases of fluorescence-guided spinal surgery of schwannomas using near-infrared fluorescence imaging with the delayed window indocyanine (ICG) green (DWIG) technique for accurate real-time intraoperative tumor visualization. Patients with intradural spinal schwannomas received 0.5 mg/kg ICG at the beginning of surgery. After 1 hour, using the DWIG technique, near-infrared spectroscopy (NIRS) detected the spinal schwannomas, showing the exact tumor location and boundaries. DWIG with NIRS microscopy confirmed the exact location of spinal schwannomas before and after opening of the dura mater, thereby facilitating successful tumor dissection from the surrounding tissues, tumor resection, and confirmation of tumor removal. The video can be found here: https://stream.cadmore.media/r10.3171/2021.10.FOCVID21158

Image-guided tumor resection using real-time near-infrared fluorescence in a syngeneic rat model of primary breast cancer

2010 ◽  
Vol 128 (3) ◽  
pp. 679-689 ◽  
Author(s):  
J. Sven D. Mieog ◽  
Merlijn Hutteman ◽  
Joost R. van der Vorst ◽  
Peter J. K. Kuppen ◽  
Ivo Que ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Real Time ◽  
Rat Model ◽  
Primary Breast Cancer ◽  
Near Infrared ◽  
Tumor Resection ◽  
Near Infrared Fluorescence ◽  
Image Guided

scholarly journals Intraoperative near-infrared fluorescence imaging and spectroscopy identifies residual tumor cells in wounds

2015 ◽  
Vol 20 (7) ◽  
pp. 076002 ◽  
Author(s):  
David Holt ◽  
Ashwin B. Parthasarathy ◽  
Olugbenga Okusanya ◽  
Jane Keating ◽  
Ollin Venegas ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Residual Tumor ◽  
Near Infrared Fluorescence ◽  
Imaging And Spectroscopy ◽  
Near Infrared Fluorescence Imaging
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