Impact of the myosin heavy chain 9 gene single nucleotide polymorphism on inflammatory bowel disease

Background To date, the cause of inflammatory bowel disease (IBD) remains a mystery. A balance between cell proliferation and apoptosis maintains intestinal tissue homeostasis. Dissociation-induced myosin-actin contraction results in stem cell apoptosis. This study aiming to evaluate the influence of the myosin heavy chain 9 (MYH9) gene single nucleotide polymorphism (SNP) on inflammatory bowel disease. Subjects and methods: The study carried on eighty patients with IBD and seventy controls. All participants subjected to history taking, thorough physical examination examination, colonoscopy and laboratory investigations. Genotyping performed for rs3752462 and rs4821480 by SNP assay real-time PCR methods. Results On analyzing rs4821480, The TG and GG genotypes have significant increased distribution among the IBD patients as compared to the controls with 5.3 fold increase in the risk of IBD and higher prevalence of GG genotype in patients with low hemoglobin level and higher BMI. While on analyzing rs3753462 CT and TT genotypes were significantly more frequent in the in the IBD patients as compared to the controls with 4.6 fold increase in the risk of IBD. Conclusion The allele G of rs4821480 and T of rs3753462 of MYH9 gene associated with more susceptibility to IBD.