The effect of SOX17, MACC1 and c-Met expression in ESCC on prognosis

2021 ◽  
Author(s):  
Yan Shi ◽  
Chao Li ◽  
Mengyan Li ◽  
Gulinaer Abulajiang ◽  
Hui Wang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumor Size ◽  
Vascular Invasion ◽  
Clinicopathological Features ◽  
Hematogenous Metastasis ◽  
Clinical Prognosis ◽  
Nerve Invasion

Abstract Aim: We mainly explored the expression of SOX17, MACC1 and c-Met in esophageal squamous cell carcinoma and their influence on the prognosis of patients.Methods：Expressions of SOX17, MACC1 and c-Met protein in a sample of 232 ESCC and adjacent nontumorous tissues were detected by immunohistochemistry. Their relationships and correlations with clinicopathological features and clinical prognosis were analyzed by SPSS 23.0.Results：SOX17 was associated with Vascular invasion (p=0.017) and Nerve invasion (p=0.014). MACC1 was correlated with Tumor size (p=0.039) and TNM stage (p=0.020).c-Met was significantly associated with hematogenous metastasis (p=0.045). The expression of MACC1 was correlated with c-Met (P<0.001). c-Met expression(p=0.021) were associated with OS. Conclusion: SOX17, MACC1 and c-Met may be new diagnostic targets for esophageal squamous cell carcinoma. c-Met may be a new therapeutic and prognostic target.

scholarly journals Correlation Of SOX17, MACC1, c-Met With Clinicopathological Features And Prognosis of Esophageal Squamous Cell Carcinoma

2021 ◽  
Author(s):  
Yan Shi ◽  
Chao Li ◽  
Mengyan Li ◽  
Gulinaer Abulajiang ◽  
Hui Wang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinicopathological Features ◽  
Clinicopathological Parameters ◽  
Hematogenous Metastasis ◽  
Clinical Prognosis ◽  
Nerve Invasion ◽  
The Relationship

Abstract Aim: We mainly investigated the relationship between the expression of SOX17, MACC1 and c-Met in esophageal squamous cell carcinoma and the clinicopathological parameters of the patients and the effect on prognosis.Methods：Expressions of SOX17, MACC1 and c-Met protein in a sample of 232 ESCC and adjacent nontumorous tissues were detected by immunohistochemistry. Their relationships and correlations with clinicopathological features and clinical prognosis were analyzed by SPSS 23.0.Results：SOX17 was associated with Vascular invasion (p=0.017) and Nerve invasion (p=0.014). MACC1 was correlated with Tumor size (p=0.039) and TNM stage (p=0.020).c-Met was significantly associated with hematogenous metastasis (p=0.045). The expression of MACC1 was correlated with c-Met (P<0.001). c-Met expression(p=0.021) were associated with OS. Conclusion: SOX17, MACC1 and c-Met may be new diagnostic targets for esophageal squamous cell carcinoma. c-Met may be a new therapeutic and prognostic target.

scholarly journals HER-2/neu Overxpression in Esophageal Squamous Cell Carcinoma (ESCC) and Its Correlation with Patient’s Clinicopathological Features

2016 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Ali Taghizadeh Kermani ◽  
Rosita Vakili ◽  
Samaneh Dadkhah ◽  
Amir Hossein Jafarian ◽  
Reza Bagheri
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinicopathological Features ◽  
Her 2

Clinicopathological features of esophageal squamous cell carcinoma in never smoker-never drinkers

2017 ◽  
Vol 30 (5) ◽  
pp. 1-7
Author(s):  
H. Shigaki ◽  
Y. Imamura ◽  
S. Mine ◽  
A. Okamura ◽  
T. Kurogochi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinicopathological Features ◽  
Never Smoker

scholarly journals Histological Differentiation Grade and Surgery Affects Short-Term Mortality in Esophageal Squamous Cell Carcinoma Patients

2020 ◽  
Author(s):  
Hsuan-Chih Kuo ◽  
Yi-Ping Pan ◽  
Ting-You Hsu ◽  
Jui-Ying Lin ◽  
Wen-Chi Chou ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Mortality Rates ◽  
Clinicopathological Features ◽  
Histological Differentiation ◽  
Short Term ◽  
Lymphocyte Ratio ◽  
Short Term Mortality

Abstract Background: This study aimed to examine the relationship between the clinicopathological features, nutritional and inflammatory status, type of treatment, and short-term mortality in esophageal squamous cell carcinoma (ESCC) patients. Methods: 205 patients with ESCC were included. The following malnutrition and inflammation criteria at the time of diagnosis were applied: body mass index < 18.5 kg/m2, serum albumin level < 3.5 g/dL, neutrophil-to-lymphocyte ratio (NLR) > 3.5, platelet-to-lymphocyte ratio (PLR) > 17 and C-reactive protein. Clinicopathological features, Malnutrition status, inflammatory condition and the type of treatment were analyzed for 3-month and 6-month mortality rates by univariate and multivariate analysis. Results: The 3-month and 6-month mortality rates were 13.2% and 27.3%, respectively. The multivariate logistic regression model after adjustment for clinicopathological variables and comorbid status found that surgery and histological differentiation grade were prognostic factors for short-term mortality. Conclusions: In addition to surgery, histological differentiation grade independently contributes to high short-term mortality of ESCC patients.

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