scholarly journals Treatment of Persistent Post-traumatic Headache With the anti-CGRP Receptor Antibody Erenumab: a Case Report

2021 ◽  
Author(s):  
Mike Christian Papenhoff ◽  
Marcel Dudda
Keyword(s):  
Head Injury ◽  
Traumatic Event ◽  
Cgrp Receptor ◽  
Effective Treatment Option ◽  
Traumatic Head Injury ◽  
Posttraumatic Headache ◽  
History Of ◽  
Traumatic Head ◽  
Post Traumatic ◽  
Excessive Intake

Abstract Background: Calcitonin gene-related peptide (CGRP) has only recently emerged as a potential target in posttraumatic headache. To our knowledge this is the first description of a patient with persistent posttraumatic headache following severe traumatic head injury who has been treated with the CGRP-receptor-monoclonal antibody erenumab.Case presentation: A 56-year-old man presented with a 30-year history of frequent migraine-like posttraumatic headaches following a high-voltage head injury that he treated with an excessive intake of peripheral analgesics. Although amitriptyline was reasonably effective, it had to be discontinued when the patient developed restless legs syndrome in the second year of treatment. Under therapy with erenumab he achieved a rapid and stable reduction in his symptoms down to only 2–3 headache days per month without adverse events.Conclusions: This case demonstrates that the inhibition of the CGRP-receptor with erenumab could be an effective treatment option in migraine-like post-traumatic headache even decades after the traumatic event.

scholarly journals Treatment of Persistent Post-Traumatic Headache with the Anti-CGRP Receptor Antibody Erenumab: A Case Report

2021 ◽  
Author(s):  
Mike Papenhoff ◽  
Marcel Dudda
Keyword(s):  
Head Injury ◽  
Traumatic Event ◽  
Cgrp Receptor ◽  
Effective Treatment Option ◽  
Traumatic Head Injury ◽  
Posttraumatic Headache ◽  
History Of ◽  
Traumatic Head ◽  
Post Traumatic ◽  
Excessive Intake

Abstract Introduction: Calcitonin gene-related peptide (CGRP) has only recently emerged as a potential target in posttraumatic headache. To our knowledge this is the first description of a patient with persistent posttraumatic headache following severe traumatic head injury who has been treated with the CGRP-receptor-monoclonal antibody erenumab.Case presentation: A 56-year-old man presented with a 30-year history of frequent migraine-like posttraumatic headaches following a high-voltage head injury that he treated with an excessive intake of peripheral analgesics. Although amitriptyline was reasonably effective, it had to be discontinued when the patient developed restless legs syndrome in the second year of treatment. Under therapy with erenumab he achieved a rapid and stable reduction in his symptoms down to only 2–3 headache days per month without adverse events.Conclusions: This case demonstrates that the inhibition of the CGRP-receptor with erenumab could be an effective treatment option in migraine-like post-traumatic headache even decades after the traumatic event.

Diabetes inspidus post traumatic head injury

2014 ◽  
Author(s):  
Gideon Mlawa ◽  
Eswari Chinnasamy ◽  
Darshi Sivakumaran ◽  
Gul Bano
Keyword(s):  
Head Injury ◽  
Traumatic Head Injury ◽  
Traumatic Head ◽  
Post Traumatic

scholarly journals l-11. Statistic Survey on Post-traumatic Head Injury

1968 ◽  
Vol 10 ◽  
pp. 238-239
Author(s):  
Norio KOBAYASHI ◽  
Keizo SAKAMOTO ◽  
Chikara KASHIMOTO ◽  
Takao MITSUNO
Keyword(s):  
Head Injury ◽  
Traumatic Head Injury ◽  
Traumatic Head ◽  
Post Traumatic

scholarly journals The role of vagal insulin signaling and enteric hormones in acute stomach and duodenal erosions and ulcers associated with severe concomitant traumatic head injuries

2015 ◽  
Vol 96 (4) ◽  
pp. 485-488
Author(s):  
F I Alyev
Keyword(s):  
Head Injury ◽  
Insulin Signaling ◽  
Vagal Stimulation ◽  
Head Injuries ◽  
Traumatic Injury ◽  
Serum Levels ◽  
Traumatic Head Injury ◽  
Abdominal Organs ◽  
History Of ◽  
Traumatic Head

Aim. Clinical and experimental study of vagal insulin signaling and enteric hormones in occurrence of acute stomach and duodenal erosions and ulcers complicated by bleeding and associated with severe concomitant traumatic head injuries. Methods. Data of 347 patients with severe concomitant traumatic head injuries for 2011-2012 were used for clinical part of the study. Serum levels of insulin, gastrin, C-peptide, histamine, growth hormone, α-amylase were determined. In the experimental part, the model of acute stomach and duodenal erosions and ulcers associated with traumatic head injury were modeled. The first group consisted of 5 intact rats, the second group included 45 rats with modeled isolated traumatic head injury, the third group included 45 rats with modeled traumatic head injury associated with traumatic lung and chest injury, the fourth group included 45 rats with modeled traumatic head injury associated with abdominal organs traumatic injury, the fifth group included 45 rats with modeled traumatic head injury associated with limb and pelvic fractures. Results. Acute stomach and duodenal erosions and ulcers were found in 21 (6.1%) of 347 patients at endoscopy, mainly in those with the highest parameters of vagal insulin signaling and enteric hormones. At the experiment, all types of combined traumatic head injury increased the incidence of erosions as compared to the second group, with the highest incidence in the group of associated abdominal injury. Vagal stimulation and stimulation of enteric hormones secretion in animals of groups 2-5 was associated with higher incidence of erosions. In contrast, decreased vagal stimulation and enteric hormones secretion leaded to statistically significant reduction of erosions incidence in animals of groups 2-5 as compared both to the natural history of the process (first subgroup), and to animals which were administered 5% dextrose (glucose) and 0.1% histamine solutions (second subgroup). Conclusion. The incidence of erosions and ulcers, as well as the indicators of vagal stimulation and enteric hormones secretion depend on the nature of the accompanying injury that may be taken into account in the prevention and treatment of such complications.

Post-Traumatic Short-Lasting Unilateral Headache With Cranial Autonomic Symptoms (SUNA)

Cephalalgia ◽  
2008 ◽  
Vol 28 (9) ◽  
pp. 991-993 ◽  
Author(s):  
S Jacob ◽  
AR Saha ◽  
YA Rajabally
Keyword(s):  
Head Injury ◽  
International Headache Society ◽  
Trigeminal Autonomic Cephalalgias ◽  
Conjunctival Injection ◽  
Traumatic Head Injury ◽  
Autonomic Symptoms ◽  
Cranial Autonomic Symptoms ◽  
Unilateral Headache ◽  
Traumatic Head ◽  
Post Traumatic

Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) syndrome is a rare headache syndrome classified among the trigeminal autonomic cephalalgias. It is usually idiopathic, although infrequent secondary forms have been described. Recently the term short-lasting unilateral headache with cranial autonomic symptoms (SUNA) has been defined by the International Headache Society (ICHD-2) as similar to SUNCT with less prominent or absent conjunctival injection and lacrimation. We report two patients with paroxysmal orbito-fronto-temporal pains, phenotypically suggesting SUNA, occurring after traumatic head injury.

scholarly journals Post-Traumatic Hydrocephalus - A Retrospective Study

2021 ◽  
Vol 10 (40) ◽  
pp. 3511-3514
Author(s):  
Srinivas R. ◽  
Davuluri Venkata Shashank ◽  
Mohamed Mohamed
Keyword(s):  
Retrospective Study ◽  
Head Injury ◽  
Tertiary Care ◽  
Traumatic Head Injury ◽  
Medical College ◽  
Traumatic Head ◽  
Post Traumatic ◽  
Trauma Ct ◽  
Gcs Score ◽  
Early Diagnose

BACKGROUND Post-traumatic hydrocephalus (PTH) can occur as an outcome of moderate and severe traumatic head injury. It is one of the causes of delayed worsening of the early symptoms of head injury. A total of 18 cases of PTH diagnosed and treated at tertiary care hospitals from 2012 to 2015 were studied. The purpose of the study was to evaluate the clinicoradiological profile of patients diagnosed with posttraumatic hydrocephalus and determine the outcome of ventriculoperitoneal (VP) shunting in cases of post-traumatic hydrocephalus. METHODS A retrospective study was conducted in the Department of Neurosurgery in a teaching medical college. The clinicoradiological profile of patients diagnosed with PTH was studied. These cases were treated conservatively as well as by surgery. The demography, cause of trauma, GCS score and response rates were studied. RESULTS Among the 18 reviewed patients, 61.1 % were males, fall and RTA constituted the major cause of trauma. Craniotomy was done in 50 % of the patients, 88.89 % of the patients recovered and the mortality rate was 11.11 %. CONCLUSIONS Post-traumatic hydrocephalus is a consequence of traumatic head injury and can occur with various neurological symptoms after the initial trauma. CT scan of the brain is considered the choice of investigation to early diagnose PTH and the patient outcome after VP shunting is good. KEY WORDS Hydrocephalus, Head Injury, Trauma

Post-traumatic head injury pituitary dysfunction

2012 ◽  
Vol 35 (6) ◽  
pp. 522-525 ◽  
Author(s):  
Malik Zaben ◽  
Wessam El Ghoul ◽  
Antonio Belli
Keyword(s):  
Head Injury ◽  
Traumatic Head Injury ◽  
Pituitary Dysfunction ◽  
Traumatic Head ◽  
Post Traumatic

scholarly journals An Epidemiological Study of Traumatic Head Injury in a Tertiary Care Center in Kancheepuram, Tamil Nadu, India

2019 ◽  
pp. 1-5
Author(s):  
K. Myl Kumaran ◽  
Pragadeesh Raja ◽  
M. Jasmine
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Head Injury ◽  
Tamil Nadu ◽  
Road Traffic ◽  
Tertiary Care ◽  
Major Public Health Problem ◽  
Traumatic Head Injury ◽  
History Of ◽  
Traumatic Head

Introduction: Traumatic brain injury is a major public health problem in India. The severity of a traumatic brain injury may range from mild to severe. The increase in economic growth in India coupled with rise in population, motorization and industrialization has contributed to a significant increase in TBI with each advancing year. India having the highest rate of head injury in the world. In India more than 100000 lives are lost every year with over 1 million suffering from serious head injury. Objectives: To assess the risk factors among for head injury cases and assess the outcome of the traumatic brain injury patients. Materials and Methods: A cross sectional Study conducted among all patients with traumatic head injury attending tertiary care centre and those admitted in intensive care unit with the history of traumatic head injury for the duration of one year (August 2016 to July 2017). Data was collected through questionnaire, hospital records and collected from patients. Data Collected was entered in MS office excel and analyzed in SPSS version 21. Results: Totally 295 cases were reported with history of traumatic brain injury, out of which 82.7% were males and 17.3% were females. Road traffic accidents was the most common cause for TBI 86.4%. Most of the patient was between the age group of 21-40 (51.5%). Most of the cases were from rural areas 55.3%. Based on GCS 49.5%, 28.5% and 22.0% patients had mild, moderate and severe injury respectively. 44.7% injuries occurred between the time period 04.00PM to 12.00AM. Conclusion: This study revealed that most traumatic head injury occur due to Road traffic accident stressing the urgent need to create awareness and conduct health education about prevention of traumatic head injury.

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