scholarly journals Surgery improves the prognosis of colon mucinous adenocarcinoma with liver metastases: A SEER-Based Study

2020 ◽  
Author(s):  
Jia Huang ◽  
Guodong Chen ◽  
Huan Liu ◽  
Yiwei Zhang ◽  
Rong Tang ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Mucinous Adenocarcinoma ◽  
Protective Factor ◽  
Tumour Size ◽  
Primary Tumour ◽  
Clinicopathological Characteristics ◽  
Cancer Specific Survival ◽  
Term Survival ◽  
Partial Colectomy ◽  
Colon Cancer Liver Metastases

Abstract Background: Mucinous adenocarcinoma (MC) is the second most common pathological type of colon carcinoma (CC). Colon cancer liver metastases (CLMs) are common and lethal, and complete resection of the primary tumour and metastases for CLM patients would be beneficial. However, there is still no consensus on the role of surgery for MC with liver metastases (M-CLM). Methods: Patients diagnosed with M-CLM or classical adenocarcinoma with CLM (A-CLM) from 2010 to 2013 in the Surveillance, Epidemiology, and End Results (SEER) database were retrieved. The clinicopathological features and overall survival (OS) and cancer-specific survival (CSS) data were compared and analysed.Results: The results showed that the M-CLM group had a larger tumour size, more right colon localizations, higher pT and pN stages, more female patients, and more retrieved and positive lymph nodes and accounted for a higher proportion of surgeries than the A-CLM group. The OS and CSS of M-CLM patients who underwent any type of surgery were significantly better than those of patients who did not undergo any surgery, but poorer than those of A-CLM patients who underwent surgery. Meanwhile, the OS and CSS of M-CLM and A-CLM patients who did not undergo any surgery were comparable. Compared with hemicolectomy, partial colectomy led to similar or better OS and CSS for M-CLM, and surgery was an independent protective factor for long-term survival in M-CLM.Conclusions: M-CLM had distinct clinicopathological characteristics from A-CLM, and surgery could improve the survival and is an independent favourable prognostic factor for M-CLM. In addition, partial colectomy might be a non-inferiority choice as hemicolectomy for M-CLM according to the results from this study.

scholarly journals Surgery improves the prognosis of colon mucinous adenocarcinoma with liver metastases: a SEER-based study

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jia Huang ◽  
Guodong Chen ◽  
Huan Liu ◽  
Yiwei Zhang ◽  
Rong Tang ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Mucinous Adenocarcinoma ◽  
Protective Factor ◽  
Tumour Size ◽  
Primary Tumour ◽  
Clinicopathological Characteristics ◽  
Cancer Specific Survival ◽  
Term Survival ◽  
Partial Colectomy ◽  
Colon Cancer Liver Metastases

Abstract Background Mucinous adenocarcinoma (MC) is the second most common pathological type of colon carcinoma (CC). Colon cancer liver metastases (CLMs) are common and lethal, and complete resection of the primary tumour and metastases for CLM patients would be beneficial. However, there is still no consensus on the role of surgery for MC with liver metastases (M-CLM). Methods Patients diagnosed with M-CLM or classical adenocarcinoma with CLM (A-CLM) from 2010 to 2013 in the Surveillance, Epidemiology, and End Results (SEER) database were retrieved. The clinicopathological features and overall survival (OS) and cancer-specific survival (CSS) data were compared and analysed. Results The results showed that the M-CLM group had a larger tumour size, more right colon localizations, higher pT and pN stages, more female patients, and more retrieved and positive lymph nodes and accounted for a higher proportion of surgeries than the A-CLM group. The OS and CSS of M-CLM patients who underwent any type of surgery were significantly better than those of patients who did not undergo any surgery, but poorer than those of A-CLM patients who underwent surgery. Meanwhile, the OS and CSS of M-CLM and A-CLM patients who did not undergo any surgery were comparable. Compared with hemicolectomy, partial colectomy led to similar or better OS and CSS for M-CLM, and surgery was an independent protective factor for long-term survival in M-CLM. Conclusions M-CLM had distinct clinicopathological characteristics from A-CLM, and surgery could improve the survival and is an independent favourable prognostic factor for M-CLM. In addition, partial colectomy might be a non-inferiority choice as hemicolectomy for M-CLM according to the results from this study.

scholarly journals Surgery improves the prognosis of colon mucinous adenocarcinoma with liver metastases: A SEER-Based Study

2020 ◽  
Author(s):  
Jia Huang ◽  
Guodong Chen ◽  
Huan Liu ◽  
Yiwei Zhang ◽  
Rong Tang ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Mucinous Adenocarcinoma ◽  
Protective Factor ◽  
Tumour Size ◽  
Primary Tumour ◽  
Cancer Specific Survival ◽  
Term Survival ◽  
Long Term Survival ◽  
Partial Colectomy

Abstract Background: Mucinous adenocarcinoma (MC) is the second most common pathological type of colon carcinoma (CC). Colon cancer liver metastases (CLMs) are common and lethal, and complete resection of the primary tumour and metastases for CLM patients would be beneficial. However, there is still no consensus on the role of surgery for MC with liver metastases (M-CLM). Methods: Patients diagnosed with M-CLM or classical adenocarcinoma with CLM (A-CLM) from 2010 to 2013 in the Surveillance, Epidemiology, and End Results (SEER) database were retrieved. The clinicopathological features and overall survival (OS) and cancer-specific survival (CSS) data were compared and analysed. Results: The results showed that the M-CLM group had a larger tumour size, more right colon localizations, higher pT and pN stages, more female patients, and more retrieved and positive lymph nodes and accounted for a higher proportion of surgeries than the A-CLM group. The OS and CSS of M-CLM patients who underwent any type of surgery were significantly better than those of patients who did not undergo any surgery, but poorer than those of A-CLM patients who underwent surgery. Meanwhile, the OS and CSS of M-CLM and A-CLM patients who did not undergo any surgery were comparable. Compared with hemicolectomy, partial colectomy led to similar or better OS and CSS for M-CLM, and surgery was an independent protective factor for long-term survival in M-CLM. Conclusions: M-CLM had distinct clinicopathological characteristics from A-CLM, and surgery could improve the long-term survival and is an independent favourable prognostic factor for M-CLM. In addition, partial colectomy might be a non-inferiority choice as hemicolectomy for M-CLM according to the results from this study.

scholarly journals Surgery improves the prognosis of colon mucinous adenocarcinoma with liver metastases: A SEER-Based Study

2020 ◽  
Author(s):  
Jia Huang ◽  
Guodong Chen ◽  
Huan Liu ◽  
Yiwei Zhang ◽  
Rong Tang ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Mucinous Adenocarcinoma ◽  
Protective Factor ◽  
Tumour Size ◽  
Primary Tumour ◽  
Cancer Specific Survival ◽  
Term Survival ◽  
Long Term Survival ◽  
Partial Colectomy

Abstract Background: Mucinous adenocarcinoma (MC) is the second most common pathological type of colon carcinoma (CC). Colon cancer liver metastases (CLMs) are common and lethal, and complete resection of the primary tumour and metastases for CLM patients would be beneficial. However, there is still no consensus on the role of surgery for MC with liver metastases (M-CLM). Methods: Patients diagnosed with M-CLM or classical adenocarcinoma with CLM (A-CLM) from 2010 to 2013 in the Surveillance, Epidemiology, and End Results (SEER) database were retrieved. The clinicopathological features and overall survival (OS) and cancer-specific survival (CSS) data were compared and analysed.Results: The results showed that the M-CLM group had a larger tumour size, more right colon localizations, higher pT and pN stages, more female patients, and more retrieved and positive lymph nodes and accounted for a higher proportion of surgeries than the A-CLM group. The OS and CSS of M-CLM patients who underwent any type of surgery were significantly better than those of patients who did not undergo any surgery, but poorer than those of A-CLM patients who underwent surgery. Meanwhile, the OS and CSS of M-CLM and A-CLM patients who did not undergo any surgery were comparable. Compared with hemicolectomy, partial colectomy led to similar or better OS and CSS for M-CLM, and surgery was an independent protective factor for long-term survival in M-CLM.Conclusions: M-CLM had distinct clinicopathological characteristics from A-CLM, and surgery could improve the long-term survival and is an independent favourable prognostic factor for M-CLM. In addition, partial colectomy might be a better choice than hemicolectomy for M-CLM according to the results from this study.

scholarly journals Surgery Improve the Prognosis of Colon Mucinous Adenocarcinoma with Liver Metastases: A SEER-Based Study

2020 ◽  
Author(s):  
Jia Huang ◽  
Guodong Chen ◽  
Huan Liu ◽  
Yiwei Zhang ◽  
Rong Tang ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Mucinous Adenocarcinoma ◽  
Protective Factor ◽  
Clinicopathological Characteristics ◽  
Cancer Specific Survival ◽  
Term Survival ◽  
Long Term Survival ◽  
Study Results ◽  
Partial Colectomy

Abstract Background Mucinous adenocarcinoma (MAC) is the second common pathological type of colon carcinoma (CC). Colon cancer liver metastases (CLM) is common and lethal, complete resection for both of the primary tumor and metastases of CLM would be beneficial. However, there is still no consensus for the role of surgery in MAC of CC with liver metastases (M-CLM).Methods Among 5816 patients who diagnosed with M-CLM or classical adenocarcinoma of CLM (A-CLM) from 2010 to 2013 in the Surveillance, Epidemiology, and End Results (SEER) database were retrieved. The clinicopathological features and overall survival (OS) and cancer-specific survival (CSS) data were compared and analyzed.Results Total of 5816 M-CLM and A-CLM patients were enrolled in this study. Results showed M-CLM group had larger tumor size, more right colon location, high pT and pN stage compared with A-CLM group, as well as more female patients, more examined and positive lymph nodes and a higher proportion of surgery than A-CLM group. The OS and CSS of M-CLM patients accepted any surgery were significantly better than that didn’t accept any surgery, but poorer than that of A-CLM patients. Meanwhile, the OS and CSS of M-CLM and A-CLM were comparable when they didn’t receive any surgery. Moreover, partial colectomy provided the similar OS and CSS compared with hemicolectomy or greater for M-CLM, and surgery was an independent protective factor for long-term survival of M-CLM.Conclusions M-CLM had distinct clinicopathological characteristics, surgery could improve the long-term survival and act as an independent protective prognostic factor for M-CLM, additionally, partial colectomy might be a better selection for M-CLM from this study.

Grading lymph node metastasis: a feasible approach for prognostication of patients with stage III colorectal cancer

2015 ◽  
Vol 68 (9) ◽  
pp. 742-745 ◽  
Author(s):  
Annika Resch ◽  
Lars Harbaum ◽  
Marion J Pollheimer ◽  
Peter Kornprat ◽  
Richard A Lindtner ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Metastatic Lymph Node ◽  
Tumour Size ◽  
Primary Tumour ◽  
Multivariable Analysis ◽  
Progression Free Survival ◽  
Stage Iii ◽  
Uicc Stage ◽  
Cancer Specific Survival

This study aimed to assess the clinicopathological significance of tumour differentiation of metastatic lymph node tissue in patients with American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) stage III colorectal cancer. In a cohort of 145 patients, lymph node grades were G1 in 77 (53.1%), G2 in 41 (28.3%) and G3 in 27 (18.6%) cases, respectively. Despite differences in 77 (53.1%) cases, primary tumour and lymph node grade correlated significantly (Somer's D=0.639; p<0.001). Lymph node grade was significantly associated with N classification (p=0.009), tumour size (p=0.024) and lymphovascular invasion (p=0.004). Patients with lymph node grade G1 had better progression-free survival (p=0.031) and cancer-specific survival (p=0.008). Multivariable analysis identified lymph node grade as independent predictor of cancer-specific survival in this cohort. In conclusion, lymph node grade emerged as a promising novel prognostic variable for patients with AJCC/UICC stage III disease. Additional studies are warranted to validate this new finding.

scholarly journals Nomograms Predicting Long-Term Overall Survival and Cancer-Specific Survival in Metastatic Hepatocellular Carcinoma Patients

2020 ◽  
Author(s):  
Chi Cui ◽  
Yaru Duan ◽  
Rui Li ◽  
Hua Ye ◽  
Peng Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Overall Survival ◽  
Cox Regression ◽  
Training Group ◽  
Clinicopathological Characteristics ◽  
Validation Group ◽  
Cancer Specific Survival ◽  
Term Survival ◽  
Metastatic Hepatocellular Carcinoma

Abstract Background This study aims to evaluate the clinicopathological characteristics of metastatic hepatocellular carcinoma (HCC) patients and develop nomograms to predict their long-term overall survival (OS) and cancer-specific survival (CSS). Methods Information on metastatic HCC from 2010 to 2015 was retrieved from the Surveillance, Epidemiology and End Results (SEER) program of the National Cancer Institute. The metastatic HCC patients were divided into a long-term survival (LTS) group and a short-term survival (STS) group with 1 year selected as the cut-off value. Then, we compared the demographic and clinicopathological features between the two groups. Next, all patients were randomly divided into a training group and validation group at a 7:3 ratio. Univariate and multivariate Cox regression analyses were used to identify potential predictors for OS and CSS in the training group, and nomograms of OS and CSS were established. These predictive models were further validated in the validation group. Results A total of 2163 patients were included in the current study according to the inclusion and exclusion criteria. Patients with characteristics including lower T stage and N stage; treatment with surgery, radiation or chemotherapy; no lung metastasis; and AFP negative status showed better survival. The concordance index (C-index) of the OS nomogram was 0.72 based on 9 variables. The C-index of the CSS nomogram was 0.71 based on 8 variables. Conclusions These nomograms may help clinicians make better treatment recommendations for metastatic HCC patients.

scholarly journals Comparison of Sequential, Delayed and Simultaneous Resection Strategies for Synchronous Colorectal Liver Metastases

2020 ◽  
Author(s):  
Li-Jun Wang ◽  
Hong-Wei Wang ◽  
Ke-Min Jin ◽  
Juan Li ◽  
Bao-Cai Xing
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Primary Tumour ◽  
Term Survival ◽  
Surgical Strategies ◽  
Free Survival ◽  
Simultaneous Resection ◽  
Peking University ◽  
Synchronous Colorectal Liver Metastases

Abstract Background: The present study aimed to compare the perioperative safety and long-term survival of patients with synchronous colorectal liver metastases undergoing sequential resection (SeR), delayed resection (DeR) and simultaneous resection (SiR). Methods: From January 2007 to December 2016, data from patients undergoing surgery at Peking University Cancer Hospital for synchronous colorectal liver metastases were retrospectively collected. The above three different surgical strategies were compared. Results: A total of 233 cases were included, with 49 in the SeR group, 98 in the DeR group and 86 in the SiR group. The incidence of severe complications was 26.7% in the SiR group, higher than that in the DeR group (11.2%, P = 0.007) and the SeR group (16.3%, P =0.166). The overall survival at 1 and 3 years in the SeR group (93.9% and 50.1%) was lower than that in the DeR group (94.9% and 64.8%, P = 0.019), but not significantly different from that in the SiR group (93.0% and 55.2%, P = 0.378). Recurrence-free survival at 1 and 3 years in the SeR group (22.4% and 18.4%) was lower than that in the DeR group (43.9% and 24.2%, P = 0.033) but not significantly different from that in the SiR group (31.4% and 19.6%, P = 0.275). Cox multivariate analysis indicated that T4, lymph node-positive primary tumour, liver metastases >30 mm and SiR (compared with DeR) were correlated with poor prognosis. Conclusion: Simultaneous resection has a relatively higher incidence of severe complications, and with a staged resection strategy, the prognosis of delayed resection was better than that of sequential resection.

scholarly journals Comparison of Sequential, Delayed and Simultaneous Resection Strategies for Synchronous Colorectal Liver Metastases

2020 ◽  
Author(s):  
Li-Jun Wang ◽  
Hong-Wei Wang ◽  
Ke-Min Jin ◽  
Juan Li ◽  
Bao-Cai Xing
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Primary Tumour ◽  
Term Survival ◽  
Surgical Strategies ◽  
Free Survival ◽  
Simultaneous Resection ◽  
Peking University ◽  
Synchronous Colorectal Liver Metastases

Abstract Background: The present study aimed to compare the perioperative safety and long-term survival of patients with synchronous colorectal liver metastases undergoing sequential resection (SeR), delayed resection (DeR) and simultaneous resection (SiR). Methods: From January 2007 to December 2016, data from patients undergoing surgery at Peking University Cancer Hospital for synchronous colorectal liver metastases were retrospectively collected. The above three different surgical strategies were compared. Results: A total of 233 cases were included, with 49 in the SeR group, 98 in the DeR group and 86 in the SiR group. The incidence of severe complications was 26.7% in the SiR group, higher than that in the DeR group (11.2%, P = 0.007) and the SeR group (16.3%, P =0.166). The overall survival at 1 and 3 years in the SeR group (93.9% and 50.1%) was lower than that in the DeR group (94.9% and 64.8%, P = 0.019), but not significantly different from that in the SiR group (93.0% and 55.2%, P = 0.378). Recurrence-free survival at 1 and 3 years in the SeR group (22.4% and 18.4%) was lower than that in the DeR group (43.9% and 24.2%, P = 0.033) but not significantly different from that in the SiR group (31.4% and 19.6%, P = 0.275). Cox multivariate analysis indicated that T4, lymph node-positive primary tumour, liver metastases >30 mm and SiR (compared with DeR) were correlated with poor prognosis. Conclusion: Simultaneous resection has a relatively higher incidence of severe complications, and with a staged resection strategy, the prognosis of delayed resection was better than that of sequential resection.

scholarly journals Prognostic factors in patients with endocrine tumours of the duodenopancreatic area

Gut ◽  
1998 ◽  
Vol 43 (3) ◽  
pp. 422-427 ◽  
Author(s):  
I Madeira ◽  
B Terris ◽  
M Voss ◽  
A Denys ◽  
A Sauvanet ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Cell Differentiation ◽  
Liver Metastases ◽  
Tumour Size ◽  
Primary Tumour ◽  
Complete Resection ◽  
Endocrine Tumours ◽  
Tumoral Cell ◽  
Node Metastases ◽  
Extrahepatic Metastases

Background—The development of endocrine tumours of the duodenopancreatic area (ETDP) is thought to be slow, but their natural history is not well known. The aim of this study was to determine the factors that influence survival of patients with ETDP.Patients/Methods—Eighty two patients with ETDP (44 non-functioning tumours, 23 gastrinomas, seven calcitonin-secreting tumours, four glucagonomas, three insulinomas, one somatostatinoma) followed from October 1991 to June 1997 were included in the study. The following factors were investigated: primary tumour size, hormonal clinical syndrome, liver metastases, lymph node metastases, extranodular/extrahepatic metastases, progression of liver metastases, local invasion, complete resection of the primary tumour, and degree of tumoral differentiation. The prognostic significance of these factors was investigated by uni- and multi-variate analysis.Results—Twenty eight patients (34%) died within a median of 17 months (range 1–110) from diagnosis. Liver metastases (p = 0.001), lymph node metastases (p = 0.001), progression of liver metastases (p<0.00001), lack of complete resection of the primary tumour (p = 0.001), extranodular/extrahepatic metastases (p = 0.001), local invasion (p = 0.001), primary tumour size ⩾3 cm (p = 0.001), non-functioning tumours (p = 0.02), and poor tumoral differentiation (p = 0.006) were associated with an unfavourable outcome by univariate analysis. Multivariate analysis identified only liver metastases (risk ratio (RR) = 8.3; p<0.0001), poor tumoral cell differentiation (RR = 8.1; p = 0.0001), and lack of complete resection of the primary tumour (RR = 4.8; p = 0.0007) as independent risk factors. Five year survival rates were 40 and 100% in patients with and without liver metastases, 85 and 42% in patients with and without complete resection of primary tumour, and 17 and 71% in patients with poor and good tumour cell differentiation respectively.Conclusion—Liver metastases are a major prognostic factor in patients with ETDP. Progression of liver metastases is also an important factor which must be taken into account when deciding on the therapeutic approach. The only other independent prognostic factors are tumoral cell differentiation and complete resection of the primary tumour.

scholarly journals Comparison of Sequential, Delayed and Simultaneous Resection Strategies for Synchronous Colorectal Liver Metastases

2019 ◽  
Author(s):  
Li-Jun Wang ◽  
Hong-Wei Wang ◽  
Ke-Min Jin ◽  
Juan Li ◽  
Bao-Cai Xing
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Primary Tumour ◽  
Term Survival ◽  
Surgical Strategies ◽  
Free Survival ◽  
Simultaneous Resection ◽  
Peking University ◽  
Synchronous Colorectal Liver Metastases

Abstract ABSTRACT Background: The present study aimed to compare the perioperative safety and long-term survival of patients with synchronous colorectal liver metastases undergoing sequential resection (SeR), delayed resection (DeR) and simultaneous resection (SiR). Methods: From January 2007 to December 2016, data from patients undergoing surgery at Peking University Cancer Hospital for synchronous colorectal liver metastases were retrospectively collected. The above three different surgical strategies were compared. Results: A total of 233 cases were included, with 49 in the SeR group, 98 in the DeR group and 86 in the SiR group. The incidence of severe complications was 26.7% in the SiR group, higher than that in the DeR group (11.2%, P = 0.007) and the SeR group (16.3%, P =0.166). The overall survival at 1 and 3 years in the SeR group (93.9% and 50.1%) was lower than that in the DeR group (94.9% and 64.8%, P = 0.019), but not significantly different from that in the SiR group (93.0% and 55.2%, P = 0.378). Recurrence-free survival at 1 and 3 years in the SeR group (22.4% and 18.4%) was lower than that in the DeR group (43.9% and 24.2%, P = 0.033) but not significantly different from that in the SiR group (31.4% and 19.6%, P = 0.275). Cox multivariate analysis indicated that T4, lymph node-positive primary tumour, liver metastases >30 mm and SiR (compared with DeR) were correlated with poor prognosis. Conclusion: Simultaneous resection has a relatively higher incidence of severe complications, and with a staged resection strategy, the prognosis of delayed resection was better than that of sequential resection.

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