scholarly journals Ultrasonographic Features of Arthritis in Patients With Primary Sjögren's Syndrome and Its Clinical Significance

2020 ◽  
Author(s):  
Shasha Wang ◽  
Bin Wu ◽  
Qin Shao
Keyword(s):  
Disease Activity ◽  
Inflammatory Markers ◽  
Clinical Manifestations ◽  
Primary Sjögren’S Syndrome ◽  
Musculoskeletal Ultrasound ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Activity Assessment ◽  
Musculoskeletal Us ◽  
Disease Activity Assessment

Abstract Background: This study aim to observe the feature of joint involvement in the patients with primary Sjögren’s syndrome (pSS) by musculoskeletal ultrasound (US) and analyze its relationship with clinical manifestations and disease activity.Methods: US examinations were performed in a total of 1200 joints of 40 patients with pSS. A semi-quantitative grading method (0 to 3) for scoring synovial hyperplasia, PD synovitis, bone erosion, tenosynovitis was used. The clinical and laboratory data were collected, disease activity was assessed. The correlation between US lesions and disease activity assessment and clinical manifestations were analyzed.Results: The musculoskeletal ultrasound lesions in patients with pSS mainly involved the small joints of the hands and wrists, and the lesions were mild. The semi-quantitative score of musculoskeletal US was positively correlated with ESSPRI. The occurrence of musculoskeletal US lesions was associated with immunological abnormalities and inflammatory markers, and patients with high IgG, RF, and inflammatory markers were prone to abnormal US findings.Conclusion: The incidence of arthritis in patients with pSS is high, and the musculoskeletal US has its characteristics. The musculoskeletal ultrasound semi-quantitative method can effectively evaluate arthritis in patients with pSS, and the US score of arthritis has a certain correlation with the overall disease activity. US can provide reference for the diagnosis of arthritis and disease activity assessment in patients with pSS.

scholarly journals Clinical features and risk factors of Raynaud’s phenomenon in primary Sjögren’s syndrome

2021 ◽  
Author(s):  
Wei Lin ◽  
Zhifei Xin ◽  
Xiaoran Ning ◽  
Yang Li ◽  
Xiuying Ren ◽  
...  
Keyword(s):  
Risk Factors ◽  
Disease Activity ◽  
Raynaud’S Phenomenon ◽  
Sjogren’S Syndrome ◽  
Raynaud's Phenomenon ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Lung Involvement ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome

Abstract Objective The aim at the current study was to investigate the clinical characteristics and risk factors of Raynaud’s phenomenon (RP) in patients with primary Sjögren’s syndrome (pSS). Methods Retrospective analysis of the medical records of 333 new-onset pSS patients was performed. Demographic, clinical, and serological data were compared between individuals with and without RP. Logistic regression analysis was used to identify risk factors. Results RP was present in 11.41% of the pSS patients. pSS-RP patients were younger (49.74±14.56 years vs. 54.46±13.20 years, p=0.04) and exhibited higher disease activity (11 [5.75–15] vs. 7 [4–12], p=0.03) than those without. The prevalence of lung involvement was significantly higher in pSS patients with RP (60.53% vs. 17.29%; p<0.001). A significantly higher proportion of patients with pSS-RP tested positive about antinuclear (ANA), anti-RNP, and anti-centromere antibodies (ACA) compared to those without (p=0.003, <0.001, and 0.01, respectively). Multivariate analysis identified lung involvement (odds ratio [OR]=8.81, 95% confidence interval [CI] 2.02–38.47; p=0.04), anti-RNP positive status (OR=79.41, 95% CI 12.57–501.78; p<0.0001), as well as ACA (OR=13.17, 95% CI 2.60–66.72; p=0.002) as prognostic factors for pSS-RP. Conclusion The presence of RP defined a subset of pSS with a unique phenotype, manifesting as increased lung involvement and a higher frequency of anti-RNP antibodies and ACA, as well as greater disease activity. These results suggest that RP has clinical and prognostic value of pSS patients. Further prospective studies with a larger number of subjects are warranted to confirm our findings and assess the prognostic and treatment implications of RP in pSS patients. Key Points• Raynaud’s phenomenon (RP) was present in 38 (11.41%) of 333 patients with primary Sjögren’s syndrome (pSS), with patients with RP exhibiting a younger age and higher disease activity.• The presence of RP indicates a subset of pSS with a unique phenotype, with manifestations including increased lung involvement and a higher frequency of anti-RNP antibodies and anti-centromere antibodies.• Patients with pSS and RP need close follow-up and long-term observation (including assessment of microangiopathy), with specific attention paid to the possible development of clinical features of systemic sclerosis.

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