scholarly journals Striatal Dopamine Transporter Spect Quantification: Head-to-Head Comparison Between Two Three-Dimensional Automatic Tools

2020 ◽  
Author(s):  
Silvia Morbelli ◽  
Dario Arnaldi ◽  
Eugenia Cella ◽  
Stefano Raffa ◽  
Isabella Donegani ◽  
...  
Keyword(s):  
Dopamine Transporter ◽  
Gold Standard ◽  
Rating Scale ◽  
Three Dimensional ◽  
Correlation Coefficients ◽  
Striatal Dopamine ◽  
Dat Spect ◽  
Disease Rating ◽  
Highly Correlated ◽  
Visual Reading

Abstract Purpose. Our aim was the head-to-head comparison between two automatic tools for semi-quantification of striatal dopamine transporter (DAT) specific-to-non displaceable (SBR) ratio brain SPECT values in a naturalistic cohort of patients. Procedures. We analyzed consecutive scans from one-hundred and fifty-one outpatients submitted to brain DAT SPECT for a suspected parkinsonism. Images were post-processed using a commercial (Datquant®) and a free (BasGanV2) software. Reading by expert was the gold-standard. A subset of patients with pathological or borderline scan was evaluated with the clinical Unified Parkinson’s disease rating scale, motor part (MDS-UPDRS-III).Results. SBR, putamen-to-caudate (P/C) ratio, and both P and C asymmetries were highly correlated between the two software with Pearson’s ‘r’ correlation coefficients ranging from .706 to .887. Correlation coefficients with the MDS-UPDRS III score were higher with caudate than with putamen SBR values with both software, and in general higher with BasGanV2 than with Datquant® . Datquant® correspondence with expert reading was 84.1% (94.0% by additionally considering the P/C ratio as a further index). BasGanV2 correspondence with expert reading was 80.8% (86.1% by additionally considering the P/C ratio). Conclusions. Both Datquant® and BasGanV2 work reasonably well and similarly one another in semi-quantification of DAT SPECT. Both tools have their own strength and pitfalls that must be known in detail by users in order to obtain the best help in visual reading and reporting of DAT SPECT.

scholarly journals Striatal Dopamine Transporter Spect Quantification: Head-To-Head Comparison Between Two Three-Dimensional Automatic Tools

2020 ◽  
Author(s):  
Silvia Morbelli ◽  
Dario Arnaldi ◽  
Eugenia Cella ◽  
Stefano Raffa ◽  
Isabella Donegani ◽  
...  
Keyword(s):  
Dopamine Transporter ◽  
Gold Standard ◽  
Rating Scale ◽  
Three Dimensional ◽  
Correlation Coefficients ◽  
Striatal Dopamine ◽  
Dat Spect ◽  
Disease Rating ◽  
Highly Correlated ◽  
Visual Reading

Abstract Purpose. Our aim was the head-to-head comparison between two automatic tools for semi-quantification of striatal dopamine transporter (DAT) specific-to-non displaceable (SBR) ratio brain SPECT values in a naturalistic cohort of patients. Procedures. We analyzed consecutive scans from one-hundred and fifty-one outpatients submitted to brain DAT SPECT for a suspected parkinsonism. Images were post-processed using a commercial (Datquant®) and a free (BasGanV2) software. Reading by expert was the gold-standard. A subset of patients with pathological or borderline scan was evaluated with the clinical Unified Parkinson’s disease rating scale, motor part (MDS-UPDRS-III). Results. SBR, putamen-to-caudate (P/C) ratio, and both P and C asymmetries were highly correlated between the two software with Pearson’s ‘r’ correlation coefficients ranging from .706 to .887. Correlation coefficients with the MDS-UPDRS III score were higher with caudate than with putamen SBR values with both software, and in general higher with BasGanV2 than with Datquant® . Datquant® correspondence with expert reading was 84.1% (94.0% by additionally considering the P/C ratio as a further index). BasGanV2 correspondence with expert reading was 80.8% (86.1% by additionally considering the P/C ratio). Conclusions. Both Datquant® and BasGanV2 work reasonably well and similarly one another in semi-quantification of DAT SPECT. Both tools have their own strength and pitfalls that must be known in detail by users in order to obtain the best help in visual reading and reporting of DAT SPECT.

scholarly journals STRIATAL DOPAMINE TRANSPORTER SPECT QUANTIFICATION: HEAD-TO-HEAD COMPARISON BETWEEN TWO THREE-DIMENSIONAL AUTOMATIC TOOLS

2020 ◽  
Author(s):  
Silvia Morbelli ◽  
Dario Arnaldi ◽  
Eugenia Cella ◽  
Stefano Raffa ◽  
Isabella Donegani ◽  
...  
Keyword(s):  
Dopamine Transporter ◽  
Gold Standard ◽  
Rating Scale ◽  
Three Dimensional ◽  
Correlation Coefficients ◽  
Striatal Dopamine ◽  
Dat Spect ◽  
Disease Rating ◽  
Highly Correlated ◽  
Visual Reading

Abstract Purpose. Our aim was the head-to-head comparison between two automatic tools for semi-quantification of striatal dopamine transporter (DAT) specific-to-non displaceable (SBR) ratio brain SPECT values in a naturalistic cohort of patients. Procedures. We analyzed consecutive scans from one-hundred and fifty-one outpatients submitted to brain DAT SPECT for a suspected parkinsonism. Images were post-processed using a commercial (Datquant®) and a free (BasGanV2) software. Reading by expert was the gold-standard. A subset of patients with pathological or borderline scan was evaluated with the clinical Unified Parkinson’s disease rating scale, motor part (MDS-UPDRS-III). Results. SBR, putamen-to-caudate (P/C) ratio, and both P and C asymmetries were highly correlated between the two software with Pearson’s ‘r’ correlation coefficients ranging from .706 to .887. Correlation coefficients with the MDS-UPDRS III score were higher with caudate than with putamen SBR values with both software, and in general higher with BasGanV2 than with Datquant® . Datquant® correspondence with expert reading was 84.1% (94.0% by additionally considering the P/C ratio as a further index). BasGanV2 correspondence with expert reading was 80.8% (86.1% by additionally considering the P/C ratio). Conclusions. Both Datquant® and BasGanV2 work reasonably well and similarly one another in semi-quantification of DAT SPECT. Both tools have their own strength and pitfalls that must be known in detail by users in order to obtain the best help in visual reading and reporting of DAT SPECT.

scholarly journals Striatal dopamine transporter SPECT quantification: head-to-head comparison between two three-dimensional automatic tools

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Silvia Morbelli ◽  
Dario Arnaldi ◽  
Eugenia Cella ◽  
Stefano Raffa ◽  
Maria Isabella Donegani ◽  
...  
Keyword(s):  
Gold Standard ◽  
Rating Scale ◽  
Three Dimensional ◽  
Correlation Coefficients ◽  
Free Software ◽  
Motor Score ◽  
Dat Spect ◽  
Disease Rating ◽  
Highly Correlated ◽  
Visual Reading

Abstract Purpose Our aim was to compare a widely distributed commercial tool with an older free software (i) one another, (ii) with a clinical motor score, (iii) versus reading by experts. Procedures We analyzed consecutive scans from one-hundred and fifty-one outpatients submitted to brain DAT SPECT for a suspected parkinsonism. Images were post-processed using a commercial (Datquant®) and a free (BasGanV2) software. Reading by expert was the gold standard. A subset of patients with pathological or borderline scan was evaluated with the clinical Unified Parkinson’s Disease Rating Scale, motor part (MDS-UPDRS-III). Results SBR, putamen-to-caudate (P/C) ratio, and both P and C asymmetries were highly correlated between the two software with Pearson’s ‘r’ correlation coefficients ranging from .706 to .887. Correlation coefficients with the MDS-UPDRS III score were higher with caudate than with putamen SBR values with both software, and in general higher with BasGanV2 than with Datquant®. Datquant® correspondence with expert reading was 84.1% (94.0% by additionally considering the P/C ratio as a further index). BasGanV2 correspondence with expert reading was 80.8% (86.1% by additionally considering the P/C ratio). Conclusions Both Datquant® and BasGanV2 work reasonably well and similarly one another in semi-quantification of DAT SPECT. Both tools have their own strength and pitfalls that must be known in detail by users in order to obtain the best help in visual reading and reporting of DAT SPECT.

scholarly journals The Arabic Version of the Mobile App Rating Scale: Development and Validation Study (Preprint)

2019 ◽  
Author(s):  
Marco Bardus ◽  
Nathalie Awada ◽  
Lilian A Ghandour ◽  
Elie-Jacques Fares ◽  
Tarek Gherbal ◽  
...  
Keyword(s):  
Weight Management ◽  
Information Quality ◽  
Rating Scale ◽  
Arab World ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Mobile App ◽  
Health Apps ◽  
Highly Correlated

BACKGROUND With thousands of health apps in app stores globally, it is crucial to systemically and thoroughly evaluate the quality of these apps due to their potential influence on health decisions and outcomes. The Mobile App Rating Scale (MARS) is the only currently available tool that provides a comprehensive, multidimensional evaluation of app quality, which has been used to compare medical apps from American and European app stores in various areas, available in English, Italian, Spanish, and German. However, this tool is not available in Arabic. OBJECTIVE This study aimed to translate and adapt MARS to Arabic and validate the tool with a sample of health apps aimed at managing or preventing obesity and associated disorders. METHODS We followed a well-established and defined “universalist” process of cross-cultural adaptation using a mixed methods approach. Early translations of the tool, accompanied by confirmation of the contents by two rounds of separate discussions, were included and culminated in a final version, which was then back-translated into English. Two trained researchers piloted the MARS in Arabic (MARS-Ar) with a sample of 10 weight management apps obtained from Google Play and the App Store. Interrater reliability was established using intraclass correlation coefficients (ICCs). After reliability was ascertained, the two researchers independently evaluated a set of additional 56 apps. RESULTS MARS-Ar was highly aligned with the original English version. The ICCs for MARS-Ar (0.836, 95% CI 0.817-0.853) and MARS English (0.838, 95% CI 0.819-0.855) were good. The MARS-Ar subscales were highly correlated with the original counterparts (<i>P</i>&lt;.001). The lowest correlation was observed in the area of usability (<i>r</i>=0.685), followed by aesthetics (<i>r</i>=0.827), information quality (<i>r</i>=0.854), engagement (<i>r</i>=0.894), and total app quality (<i>r</i>=0.897). Subjective quality was also highly correlated (<i>r</i>=0.820). CONCLUSIONS MARS-Ar is a valid instrument to assess app quality among trained Arabic-speaking users of health and fitness apps. Researchers and public health professionals in the Arab world can use the overall MARS score and its subscales to reliably evaluate the quality of weight management apps. Further research is necessary to test the MARS-Ar on apps addressing various health issues, such as attention or anxiety prevention, or sexual and reproductive health.

scholarly journals The Arabic Version of the Mobile App Rating Scale: Development and Validation Study

10.2196/16956 ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. e16956
Author(s):  
Marco Bardus ◽  
Nathalie Awada ◽  
Lilian A Ghandour ◽  
Elie-Jacques Fares ◽  
Tarek Gherbal ◽  
...  
Keyword(s):  
Weight Management ◽  
Information Quality ◽  
Rating Scale ◽  
Arab World ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Mobile App ◽  
Health Apps ◽  
Highly Correlated

Background With thousands of health apps in app stores globally, it is crucial to systemically and thoroughly evaluate the quality of these apps due to their potential influence on health decisions and outcomes. The Mobile App Rating Scale (MARS) is the only currently available tool that provides a comprehensive, multidimensional evaluation of app quality, which has been used to compare medical apps from American and European app stores in various areas, available in English, Italian, Spanish, and German. However, this tool is not available in Arabic. Objective This study aimed to translate and adapt MARS to Arabic and validate the tool with a sample of health apps aimed at managing or preventing obesity and associated disorders. Methods We followed a well-established and defined “universalist” process of cross-cultural adaptation using a mixed methods approach. Early translations of the tool, accompanied by confirmation of the contents by two rounds of separate discussions, were included and culminated in a final version, which was then back-translated into English. Two trained researchers piloted the MARS in Arabic (MARS-Ar) with a sample of 10 weight management apps obtained from Google Play and the App Store. Interrater reliability was established using intraclass correlation coefficients (ICCs). After reliability was ascertained, the two researchers independently evaluated a set of additional 56 apps. Results MARS-Ar was highly aligned with the original English version. The ICCs for MARS-Ar (0.836, 95% CI 0.817-0.853) and MARS English (0.838, 95% CI 0.819-0.855) were good. The MARS-Ar subscales were highly correlated with the original counterparts (P<.001). The lowest correlation was observed in the area of usability (r=0.685), followed by aesthetics (r=0.827), information quality (r=0.854), engagement (r=0.894), and total app quality (r=0.897). Subjective quality was also highly correlated (r=0.820). Conclusions MARS-Ar is a valid instrument to assess app quality among trained Arabic-speaking users of health and fitness apps. Researchers and public health professionals in the Arab world can use the overall MARS score and its subscales to reliably evaluate the quality of weight management apps. Further research is necessary to test the MARS-Ar on apps addressing various health issues, such as attention or anxiety prevention, or sexual and reproductive health.

scholarly journals The AUSCAN and PRWHE Demonstrate Comparable Internal Consistency and Validity in Patients With Early Thumb Carpometacarpal Osteoarthritis

Hand ◽  
2017 ◽  
Vol 13 (6) ◽  
pp. 652-658 ◽  
Author(s):  
Thomas J. McQuillan ◽  
Molly M. Vora ◽  
Deborah E. Kenney ◽  
Joseph J. Crisco ◽  
Arnold-Peter C. Weiss ◽  
...  
Keyword(s):  
Internal Consistency ◽  
Large Scale ◽  
Rating Scale ◽  
Correlation Coefficients ◽  
Criterion Validity ◽  
Pain Scales ◽  
Highly Correlated ◽  
Patient Related Outcome ◽  
Thumb Carpometacarpal

Background: The Australian/Canadian Osteoarthritis Hand Index (AUSCAN) and Patient-Rated Wrist-Hand Evaluation (PRWHE) are 2 patient-related outcome measures to assess pain and disability in patients with osteoarthritis (OA). The purpose of this study was to evaluate the AUSCAN and PRWHE in a large-scale, longitudinal cohort of patients with early thumb carpometacarpal (CMC) OA. Methods: We obtained baseline data on 135 individuals (92 with early CMC OA participants and 43 asymptomatic controls) and at follow-up (year 1.5) on 83 individuals. We assessed the internal consistency using Cronbach alpha, and construct and criterion validity using other pain scales and objective measures of strength, respectively. We also examined the correlation between the AUSCAN and PRWHE and correlation coefficients at baseline and follow-up, as well as the correlation between changes in these instruments over the follow-up period. Results: Internal consistency was high for both AUSCAN and PRWHE totals and subscales (Cronbach α > 0.70). Both instruments demonstrated construct validity compared with the Verbal Rating Scale ( r = 0.52-0.60, P < .01), an assessment of pain, and moderate criterion validity compared with key pinch and grip strength ( r = −.24 to −.33, P < .05). These instruments were highly correlated with each other at baseline and follow-up time points ( r = 0.76−.94, P < .01), and changes in a patient’s total scores over time were also correlated ( r = 0.83, P < .01). Conclusions: The AUSCAN and PRWHE are both valid assessments for pain and/or disability in patients with early thumb CMC OA.

scholarly journals The Feasibility of Using CT-Guided ROI for Semiquantifying Striatal Dopamine Transporter Availability in a Hybrid SPECT/CT System

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Chien-Chin Hsu ◽  
Yen-Hsiang Chang ◽  
Wei-Che Lin ◽  
Shu-Wen Tang ◽  
Pei-Wen Wang ◽  
...  
Keyword(s):  
Dopamine Transporter ◽  
Brain Mri ◽  
Correlation Coefficients ◽  
Occipital Cortex ◽  
Striatal Dopamine ◽  
Binding Potential ◽  
Ct Guided ◽  
Mri Guided ◽  
Ct System ◽  
Ct And Mri

A hybrid SPECT/CT system provides accurate coregistration of functional and morphological images. CT-guided region of interest (ROI) for semiquantifying striatal dopamine transporter (DAT) availability may be a feasible method. We therefore assessed the intra- and interobserver reproducibility of manual SPECT and CT-guided ROI methods and compared their semiquantitative data with data from MRI-guided ROIs. We enrolled twenty-eight patients who underwent Tc-99m TRODAT-1 brain SPECT/CT and brain MRI. ROIs of the striatal, caudate, putamen, and occipital cortex were manually delineated on the SPECT, CT, and MRI. ROIs from CT and MRI were transferred to the coregistered SPECT for semiquantification. The striatal, caudate, and putamen nondisplaceable binding potential(BPND)were calculated. Using CT-guided ROIs had higher intra- and interobserver concordance correlation coefficients, closer Bland-Altman biases to zero, and narrower limits of agreement than using manual SPECT ROIs. The correlation coefficients of striatal, caudate, and putamenBPNDwere good between manual SPECT and MRI-guided ROI methods and even better between CT-guided and MRI-guided ROI methods. Conclusively, CT-guided ROI delineation for semiquantifying striatal DAT availability in a hybrid SPECT/CT system is highly reproducible, and the semiquantitative data correlate well with data from MRI-guided ROIs.

Stimulation of the Subthalamic Nucleus in Parkinson's Disease Does Not Produce Striatal Dopamine Release

Neurosurgery ◽  
2003 ◽  
Vol 53 (5) ◽  
pp. 1095-1105 ◽  
Author(s):  
Aviva Abosch ◽  
Shitij Kapur ◽  
Anthony E. Lang ◽  
Doug Hussey ◽  
Elspeth Sime ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopamine Release ◽  
Rating Scale ◽  
Striatal Dopamine ◽  
Striatal Dopamine Release ◽  
Before And After ◽  
Disease Rating ◽  
The Right ◽  
Stimulation Of

Abstract OBJECTIVE The subthalamic nucleus (STN) is a target in the surgical treatment of Parkinson's disease (PD). The mechanism by which electrical stimulation of the STN ameliorates symptoms of PD remains unknown. One consistent aspect of STN stimulation is the ability to reduce the dosage of dopaminergic medications; sometimes they can be eliminated altogether. Furthermore, nigrostriatal projection axons are apposed to the dorsal surface of the STN and are likely affected by the application of current in this region. We sought to determine whether STN stimulation could release endogenous striatal dopamine. METHODS Five patients with PD, who had previously undergone surgical implantation of bilateral STN stimulators, underwent [11C]raclopride positron emission tomographic scanning. l-dopa was withheld for 12 hours, and both stimulators were turned off 9 hours before scanning. We assayed for striatal dopamine release by measuring radioligand displacement as a consequence of turning on the right STN stimulator after 45 minutes of a 90-minute [11C]raclopride infusion. Patients were evaluated with the motor section of the Unified Parkinson's Disease Rating Scale before and after the studies. RESULTS Comparisons between the right and left striata, before and after right STN stimulation, demonstrated no significant differences in [11C]raclopride binding, despite significant improvements in Unified Parkinson's Disease Rating Scale motor scores with unilateral stimulation (mean improvement, 26.0 ± 16.4%; P &lt; 0.05). This finding was also noted when the striatum was partitioned into dorsal and ventral caudate and putamen and the four regions were analyzed separately. CONCLUSION Our results suggest that STN stimulation does not mediate its anti-PD effects via the release of dopamine, as assessed with [11C]raclopride displacement.

Addition of a frequency-weighted score to the Behavioral Pathology in Alzheimer’s Disease Rating Scale: the BEHAVE-AD-FW: methodology and reliability

2001 ◽  
Vol 16 (S1) ◽  
pp. 5s-24S ◽  
Author(s):  
I.M. Monteiro ◽  
I. Boksay ◽  
S.R. Auer ◽  
C. Torossian ◽  
S.H. Ferris ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Rating Scale ◽  
Present Report ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Frequency Component ◽  
Validity Data ◽  
Disease Rating ◽  
Behavioral Pathology

SummaryThe Behavioral Pathology in Alzheimer’s Disease Rating Scale (BEHAVE-AD) is a well-established instrument, designed to assess potentially remediable behavioral symptoms in Alzheimer’s disease (AD) patients as well as to evaluate treatment outcome. It consists of 25 symptoms grouped into seven categories. Each symptom is scored on the basis of severity on a four-point scale. A knowledgeable caregiver is queried and items are scored on the basis of symptoms noted in the preceding two weeks. Reliability, construct validity and criterion validity data for the BEHAVE-AD have previously been published. Because of the significance of psychopathology in dementia, it is necessary to optimally describe and define the nature, magnitude and prevalence of behavioral symptomalogy. Accordingly, a frequency component was added to each of the 25 items of the BEHAVE-AD scale. The objective of the present report is to describe this new Behavioral Pathology in Alzheimer’s Disease Frequency-Weighted Severity Scale (BEHAVE-AD-FW) and to establish its inter-rater reliability. In this investigation the BEHAVE-AD-FW scale was administered to caregivers of 28 patients with either mildly impaired cognitive function or a dementia diagnosis. Two clinicians separately and independently rated the responses. Analyses determined that the intraclass correlation coefficients (ICCs) for the frequency component varied between 0.86 and 0.97 for each of the seven BEHAVE-AD categories (ps < 0.001). ICCs for the frequency-weighted scores (item severity score x item frequency score) ranged from 0.69 to 0.98 for the seven symptom categories (ps < 0.001). For the BEHAVE-AD-FW total scores, the ICC was 0.91 (P < 0.001). These results indicate that the frequency-weighted component is a reliable addition to the BEHAVE-AD scale.

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