Morphometric and Histomorphometric Evaluations of High-Purity Macro/Microporous β-TCP in Maxillary Sinus Floor Elevation
Abstract Background: The present study examined the effectiveness of high-purity macro/microporous beta-tricalcium phosphate (HPMM β-TCP) as a bone grafting material for maxillary sinus floor elevation by morphometric and histopathological, histomorphometric evaluations.Methods: Ten maxillary sinus floor elevation procedures using 100% HPMM β-TCP were performed on 10 patients. Morphometric evaluation was carried out by CT imaging immediately after augmentation and prior to dental implant placement after 7 months.Histopathological and histomorphometric evaluation were carried out by bone biopsy retrieval at the time of dental implant placement 7 months after sinus floor elevation. Results: All 10 sinus floor elevations were successful. Morphometric evaluation by CT images showed that the vertical height and the volume gained by sinus floor elevation decreased 7 months after surgery. Histopathological evaluation by bone biopsy retrieval specimens showed no signs of inflammation at the newly formed bone area and the native alveolar bone area. New bone formation was observed at the cranial side from the native alveolar bone. The newly formed bone had a trabecular structure and was in intimate contact with the HPMM β-TCP material. Histomorphometric evaluation by bone biopsy retrieval specimens revealed an average new bone volume of 33.97%±2.79% and an average residual HPMM β-TCP volume of 15.81%±4.52%.Conclusions: In this study, HPMM β-TCP showed the osteoconductive properties for vertical augmentation of the atrophied maxilla by means of a maxillary sinus floor elevation procedure allowing subsequent dental implant placement after a 7-month healing period.