Bone formation with a biphasic calcium phosphate combined with fibrin sealant in maxillary sinus floor elevation for delayed dental implant

2012 ◽  
Vol 23 (9) ◽  
pp. 1112-1117 ◽  
Author(s):  
Wilfried Wagner ◽  
Jörg Wiltfang ◽  
Hans Pistner ◽  
Murat Yildirim ◽  
Bettina Ploder ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Maxillary Sinus ◽  
Dental Implant ◽  
Fibrin Sealant ◽  
Biphasic Calcium Phosphate ◽  
Sinus Floor Elevation ◽  
Maxillary Sinus Floor ◽  
Sinus Floor ◽  
Maxillary Sinus Floor Elevation

scholarly journals Evaluation of a new biphasic calcium phosphate for maxillary sinus floor elevation: Micro-CT and histomorphometrical analyses

2018 ◽  
Vol 29 (5) ◽  
pp. 488-498 ◽  
Author(s):  
Marco N. Helder ◽  
Fransisca A. S. van Esterik ◽  
Mardi D. Kwehandjaja ◽  
Christiaan M. ten Bruggenkate ◽  
Jenneke Klein-Nulend ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Maxillary Sinus ◽  
Biphasic Calcium Phosphate ◽  
Micro Ct ◽  
Sinus Floor Elevation ◽  
Maxillary Sinus Floor ◽  
Sinus Floor ◽  
Maxillary Sinus Floor Elevation

scholarly journals The Use of Autogenous Bone Mixed with a Biphasic Calcium Phosphate in a Maxillary Sinus Floor Elevation Procedure with a 6-Month Healing Time: A Clinical, Radiological, Histological and Histomorphometric Evaluation

Coatings ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 462
Author(s):  
Wilhelmus F. Bouwman ◽  
Nathalie Bravenboer ◽  
Christiaan M. ten Bruggenkate ◽  
Engelbert A. J. M. Schulten
Keyword(s):  
Calcium Phosphate ◽  
Maxillary Sinus ◽  
Biphasic Calcium Phosphate ◽  
Autogenous Bone ◽  
Sinus Floor Elevation ◽  
Bone Biopsies ◽  
Osteoid Surface ◽  
Maxillary Sinus Floor ◽  
Sinus Floor ◽  
Maxillary Sinus Floor Elevation

Background: In this study it is evaluated whether autogenous bone mixed with biphasic calcium phosphate (BCP) used in a maxillary sinus floor elevation (MSFE) leads to improved bone formation. Materials and methods: In five patients a unilateral MSFE was performed. Histological and histomorphometric analyses were performed on bone biopsies that were obtained 6 months after MSFE during dental implant surgery. Results: The average vital bone volume was 29.9% of the total biopsy (BV/TV, SD ± 10.1) of which 7.1% was osteoid (OV/BV, SD ± 4.8). The osteoid surface (OS/BS) covered 26.0% (SD ± 13.4) of the bone surface. The BS/TV covered 4.7 mm2/mm3 (SD ± 2.3). Compared with previous studies the analyses showed a difference for trabecular thickness (Tb.Th.) and osteoid surface (OS/BS), but not for BV/TV, OV/BV and the number of osteoclasts. Conclusion: MSFE with autogenous bone mixed with BCP shows an amount of newly formed bone that is comparable with the findings from the previously published 6-month study with pure BCP. However, a better distribution of the new bone over the entire biopsy was observed.

scholarly journals Tissue Level Changes after Maxillary Sinus Floor Elevation with Three Types of Calcium Phosphate Ceramics: A Radiological Study with a 5-Year Follow-Up

Materials ◽  
2021 ◽  
Vol 14 (6) ◽  
pp. 1471
Author(s):  
Wilhelmus F. Bouwman ◽  
Nathalie Bravenboer ◽  
Christiaan M. ten Bruggenkate ◽  
Francis A. Eijsackers ◽  
Najada Stringa ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Dental Implant ◽  
Sinus Floor Elevation ◽  
Radiological Study ◽  
Calcium Phosphate Ceramics ◽  
Implant Placement ◽  
Maxillary Sinus Floor ◽  
Sinus Floor ◽  
Maxillary Sinus Floor Elevation ◽  
Over Time

This study evaluates the radiological changes in tissue height after maxillary sinus floor elevation (MSFE) using three types of calcium phosphate ceramics over a period of up to 5 years after dental implant placement. In 163 patients, MSFE was performed. Three groups of patients were distinguished and treated based on the type of calcium phosphate ceramic used and radiologically evaluated: 40 patients with β-tricalcium phosphate (β-TCP), 76 patients with biphasic calcium phosphate (BCP) 20% hydroxyapatite (HA)-80% β-TCP, and 47 patients with BCP 60% HA-40% β-TCP. Radiological measurements were performed on panoramic radiographs at several time points up to 5 years after dental implant placement. After MSFE, a slow decrease in tissue height measured over time was seen in all three study groups. Resorption of the grafted bone substitutes was more prominent in β-TCP than in BCP ceramics with an HA component (60/40 and 20/80). Loss of tissue height after 5 years was lowest in BCP 60/40 and highest in β-TCP. This radiological study shows a predictable and comparable behavior of the slow decrease in tissue height over time for all three types of calcium phosphate ceramics used in MSFE. The fraction of HA in calcium phosphate ceramics and dental implant loading seems to be beneficial for tissue height maintenance after MSFE.

scholarly journals The Mucosa Change of the Maxillary Sinus after Dental Implant with Maxillary Sinus Floor Elevation

2008 ◽  
Vol 19 (1) ◽  
pp. 57-62
Author(s):  
Dong Jin Yum ◽  
Sang Hyun Park ◽  
Seung Woo Kim ◽  
Jung A Yoo ◽  
Bo Geun Yoon ◽  
...  
Keyword(s):  
Maxillary Sinus ◽  
Dental Implant ◽  
Sinus Floor Elevation ◽  
Maxillary Sinus Floor ◽  
Sinus Floor ◽  
Maxillary Sinus Floor Elevation

scholarly journals Effects of Platelet-rich Fibrin on Osteogenic Differentiation of Schneiderian Membrane Derived Mesenchymal Stem Cells and Bone Formation in Maxillary Sinus

2021 ◽  
Author(s):  
Yanmin Zhou ◽  
Jia Wang ◽  
Yue Sun ◽  
Yiping Liu ◽  
Jize Yu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Formation ◽  
Osteogenic Differentiation ◽  
Maxillary Sinus ◽  
Sinus Floor Elevation ◽  
Schneiderian Membrane ◽  
Maxillary Sinus Floor ◽  
Sinus Floor ◽  
Maxillary Sinus Floor Elevation

Abstract BackgroundThe existence of mesenchymal stem cells (MSCs) in Schneiderian membrane has not been determined. The aim of this study is to investigate whether there are MSCs in Schneiderian membrane, and the effect of platelet-rich fibrin (PRF) on osteogenic differentiation of these cells and on new bone formation in maxillary sinus after maxillary sinus floor elevation.MethodsSchneiderian membrane derived mesenchymal stem cells (SM-MSCs) were isolate from rabbit maxillary sinus. Cells were identified by flow cytometry and multipotential differentiation. Real-time cell analysis assay, fluorescence staining, transwell assay, and wound healing assay were used to determine the effects of PRF stimulation on cell proliferation and migration. The osteogenic differentiation ability of cells stimulated by PRF or osteoinductive medium (OM) was evaluated by alkaline phosphatase (ALP) staining, alizarin red staining, PCR and Western blot. Equivalent volume Bio-oss and the mixture of Bio-oss and PRF were used as bone graft materials for maxillary sinus floor elevation. Micro-CT, bone double-staining, HE staining, Masson staining, and toluidine blue staining were used to evaluate the osteogenic effect in 8 and 12 weeks after surgery.ResultsThe cell surface markers were positive for expression of CD90, CD105, and negative for expression of CD34, CD45. SM-MSCs had the ability of osteogenic, adipogenic and chondrogenic differentiation. PRF can stimulate proliferation, migration and osteogenic differentiation of SM-MSCs, which is achieved by up-regulating ERK 1/2 signaling pathway. PRF can accelerate the formation of new bone in maxillary sinus and increase the amount of new bone formation. ConclusionsMSCs exist in Schneiderian membrane, and PRF stimulation can promote cell proliferation, migration and osteogenic differentiation. The application of PRF in maxillary sinus floor elevation can accelerate bone healing and increase the quantity and quality of new bone.

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