scholarly journals Network analysis of core and associated symptoms in preschool children with autism spectrum disorder

2020 ◽  
Author(s):  
Xiaoyi Wang ◽  
Lijuan Shi ◽  
Jianjun Ou ◽  
Yidong Shen ◽  
Ying Wang ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Network Analysis ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
The Other ◽  
Sleep Habits ◽  
Holistic View ◽  
Network Analyses ◽  
Associated Symptoms ◽  
Core Symptoms

Abstract Background: Complex relationships may exist in the symptoms of autism spectrum disorder (ASD) and may interfere with each other. Previous studies investigate the relationships between core and associated symptoms. However, there is still a lack of holistic view, especially in the relationships between core and associated symptoms.Methods: Data were collected from a sample of 474 children with ASD. The Social Responsiveness Scale (SRS) was used to evaluate the existence and severity of autistic core symptoms of social impairment, Children’s Sleep Habits Questionnaire (CSHQ) to sleep status, and Child Behavior Checklist (CBCL/1.5-5) to behavior performance of subjects. A network analysis approach was performed to assess the partial relationships of these symptoms.Results: The social communication problem was the most central symptom of ASD. There were broad relationships between the core and associated symptoms, such as the relationships between autistic core symptoms and characteristic symptoms of ADHD and within associated symptoms. All these correlations were positive, except for a negative relationship between anxious/depressed problems and social awareness. The associations between some of these symptoms were stronger than the other associations, and the relationship between emotional problems and aggressive behavior was relatively stronger than the other relationships. The strength centrality and network edges were highly stable.Limitations: Two main limitations exist in current study. First, the network analyses was conducted by using cross-sectional data, so it remains unknown that whether the network structure will change with the progress of the course of the disease or the change of the severity of symptoms. Second, some nodes may actually be measuring overlapping constructs, which could artificially inflate edge weights and centrality.Conclusions: An overall perspective of connections of symptoms of ASD using network analysis indicated that controlling these associated symptoms may improve core symptoms, such as ADHD-related symptoms. It may help identify new ways to improve symptoms in ASD.

scholarly journals Correction to: Identifying Subgroups of Toddlers with DSM‑5 Autism Spectrum Disorder Based on Core Symptoms

2021 ◽  
Author(s):  
Holly K. Harris ◽  
Collin Lee ◽  
Georgios D. Sideridis ◽  
William J. Barbaresi ◽  
Elizabeth Harstad
Keyword(s):  
Autism Spectrum Disorder ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Dsm 5 ◽  
Core Symptoms

scholarly journals Response (minimum clinically relevant change) in ASD symptoms after an intervention according to CARS-2: consensus from an expert elicitation procedure

2021 ◽  
Author(s):  
Lucie Jurek ◽  
Matias Balthazar ◽  
Sheffali Gulati ◽  
Neda Novakovic ◽  
María Núñez ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Rating Scale ◽  
Expert Knowledge ◽  
Scientific Evidence ◽  
Autism Spectrum ◽  
Expert Elicitation ◽  
Spectrum Disorder ◽  
Initial Finding ◽  
Elicitation Process ◽  
Core Symptoms

AbstractThe lack of consensual measures to monitor core change in Autism Spectrum Disorder (ASD) or response to interventions leads to difficulty to prove intervention efficacy on ASD core symptoms. There are no universally accepted outcome measures developed for measuring changes in core symptoms. However, the CARS (Childhood Autism Rating Scale) is one of the outcomes recommended in the EMA Guideline on the clinical development of medicinal products for the treatment of ASD. Unfortunately, there is currently no consensus on the response definition for CARS among individuals with ASD. The aim of this elicitation process was to determine an appropriate definition of a response on the CARS2 scale for interventions in patients with Autism Spectrum Disorder (ASD). An elicitation process was conducted following the Sheffield Elicitation Framework (SHELF). Five experts in the field of ASD and two experts in expert knowledge elicitation participated in an 1-day elicitation workshop. Experts in ASD were previously trained in the SHELF elicitation process and received a dossier of scientific evidence concerning the topic. The response definition was set as the mean clinically relevant improvement averaged over all patients, levels of functioning, age groups ***and clinicians. Based on the scientific evidence and expert judgment, a normal probability distribution was agreed to represent the state of knowledge of this response with expected value 4.03 and standard deviation 0.664. Considering the remaining uncertainty of the estimation and the available literature, a CARS-2 improvement of 4.5 points has been defined as a threshold to conclude to a response after an intervention. A CARS-2 improvement of 4.5 points could be used to evaluate interventions' meaningfulness in indivudals. This initial finding represents an important new benchmark and may aid decision makers in evaluating the efficacy of interventions in ASD.

scholarly journals Transcranial Direct Current Stimulation (tDCS) over the Left Dorsal Lateral Prefrontal Cortex in Children with Autism Spectrum Disorder (ASD)

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Jiujun Qiu ◽  
Xuejun Kong ◽  
Jihan Li ◽  
Jie Yang ◽  
Yiting Huang ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Prefrontal Cortex ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Sleep Habits ◽  
Lateral Prefrontal Cortex ◽  
Direct Current Stimulation ◽  
Children With Asd

Recently, transcranial direct current stimulation (tDCS) has been applied to relieve symptoms in individuals with autism spectrum disorder (ASD). In this prospective, parallel, single-blinded, randomized study, we investigate the modulation effect of three-week tDCS treatment at the left dorsal lateral prefrontal cortex (DLPFC) in children with ASD. 47 children with ASD were enrolled, and 40 (20 in each group) completed the study. The primary outcomes are Childhood Autism Rating Scale (CARS), Aberrant Behavior Checklist (ABC), and the Repetitive Behavior Scale-Revised (RBS-R). We found that children with ASD can tolerate three-week tDCS treatment with no serious adverse events detected. A within-group comparison showed that real tDCS, but not sham tDCS, can significantly reduce the scores of CARS, Children’s Sleep Habits Questionnaire (CSHQ), and general impressions in CARS (15th item). Real tDCS produced significant score reduction in the CSHQ and in CARS general impressions when compared to the effects of sham tDCS. The pilot study suggests that three-week left DLPFC tDCS is well-tolerated and may hold potential in relieving some symptoms in children with ASD.

scholarly journals Visual Preference for Biological Motion in Children and Adults with Autism Spectrum Disorder: An Eye-Tracking Study

2020 ◽  
Author(s):  
Dzmitry A. Kaliukhovich ◽  
Nikolay V. Manyakov ◽  
Abigail Bangerter ◽  
Seth Ness ◽  
Andrew Skalkin ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Eye Movements ◽  
Biological Motion ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
The Other ◽  
Typically Developing ◽  
Adults With Autism ◽  
Visual Preference ◽  
Monitor Screen

Abstract Participants with autism spectrum disorder (ASD) (n = 121, mean [SD] age: 14.6 [8.0] years) and typically developing (TD) controls (n = 40, 16.4 [13.3] years) were presented with a series of videos representing biological motion on one side of a computer monitor screen and non-biological motion on the other, while their eye movements were recorded. As predicted, participants with ASD spent less overall time looking at presented stimuli than TD participants (P < 10–3) and showed less preference for biological motion (P < 10–5). Participants with ASD also had greater average latencies than TD participants of the first fixation on both biological (P < 0.01) and non-biological motion (P < 0.02). Findings suggest that individuals with ASD differ from TD individuals on multiple properties of eye movements and biological motion preference.

scholarly journals Assistência de enfermagem à criança autista: revisão integrativa

2020 ◽  
Vol 19 (2) ◽  
pp. 531-559
Author(s):  
Juliana Macêdo Magalhães ◽  
Francisca Susyane Viana Lima ◽  
Francisca Rosa De Oliveira Silva ◽  
Ana Beatriz Mendes Rodrigues ◽  
Adriana Vasconcelos Gomes
Keyword(s):  
Autism Spectrum Disorder ◽  
Nursing Care ◽  
El Niño ◽  
Web Of Science ◽  
El Nino ◽  
Neurodevelopmental Disorder ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Holistic View ◽  
Child Preschool

Introducción: El Trastorno del Espectro Autista (TEA) configura un trastorno del neurodesarrollo que compromete la interacción social, comunicación y comportamiento, identificado generalmente, en el niño preescolar. Los profesionales de enfermería deben realizar el manejo y acompañamiento del niño autista.Objetivo: Analizar las evidencias científicas sobre la asistencia de Enfermería al niño autista.Metodología: Revisión integradora de la literatura realizada en la base de datos: CINAHL, Web of Science e LILACS, se utilizó como descriptores: Nursing Care/Cuidados de Enfermagem”, “Child/Criança”, “Child, Preschool/Pré-escolar”, “Autism Disorder/Transtorno Autístico” y “Autism Spectrum Disorder/Transtorno do Espectro Autista”. Se incluyeron artículos publicados entre el período de 2013 a 2017 en portugués, español e inglés.Resultados: Los artículos incluidos fueron presentados en cuadro sinóptico y el análisis de los resultados fue realizado de forma descriptiva presentando la síntesis de los estudios por medio de comparaciones y destaque de diferencias y / o semejanzas. Se identificó que es fundamental que la enfermería tenga empatía, visión holística y conocimiento para realizar asistencia singular y de calidad para el niño y la familia.Conclusión: La enfermería utiliza la empatía, visión holística y diferentes estrategias para el cuidado del niño autista, sin embargo, los profesionales refieren dificultades en la práctica clínica. Las publicaciones sobre la temática son escasas siendo necesario el desarrollo de investigaciones clínicas. Introduction: The Autistic Spectrum Disorder (ASD) configures a neurodevelopmental disorder that involves social interaction, communication and behavior identified generally in pre-school children. The nursing professionals must perform the management and monitoring of the autistic child.Objective: To examine the scientific evidence about nursing care to the autistic child.Methodology: An integrative review of the literature, held in databases: CINAHL, Web of Science and LILACS databases using the search terms: “Nursing Care”, “Child”, “Child, Preschool”, “Autistic Disorder” and “Autism Spectrum Disorder”. There were included articles published between the period of 2013 to 2017 in Portuguese, Spanish and English.Resulted: The articles included were presented in summary table and the analysis of the results was performed descriptively presenting the synthesis of studies through comparisons and highlight of differences and/or similarities. It was identified that is basic to nursing to have empathy, holistic vision and knowledge to perform singular assistance and of quality for the child and family.Conclusion: Nursing uses the empathy, holistic view and different strategies for the care to the autistic child; however, the professionals refer difficulties in clinical practice. The publications on the subject are scarce being necessary the development of clinical research.  

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