Volumetric Assessment and Clinical Predictor of Cirrhotic Livers With Normal Liver Function Undergoing Hepatectomy

Abstract Aim: Indocyanine green retention rate at 15 minutes (ICGR15) is a frequently-used indicator of liver function. However, cirrhotic liver is sometimes observed intraoperatively despite a normal preoperative ICGR15 (<10 %). Herein, we conducted clinical and volumetric assessments of cirrhotic livers with normal ICGR15.Methods: Patients undergoing hepatectomy for hepatocellular carcinoma were divided into 3 groups: non-cirrhotic livers (Group A, n=112): cirrhotic livers with ICGR15 <10% (Group B, n=71): and cirrhotic livers with ICGR15 >10% (Group C, n=296). Background characteristics and surgical outcomes were compared between groups. Functional liver volume (FLV) was computed using total liver volume and signal intensity ratio. Liver parenchymal cell volume ratio was measured in non-cancerous tissue obtained from resected specimens. Univariate and multivariate analyses were performed to detect clinical characteristics correlating with cirrhotic liver pathology with normal ICGR15.Results: There was no significant difference between groups in TLV. FLV was gradually reduced from Group A toward Group C. Liver parenchymal cell volume ratio was also gradually reduced from Group A toward Group C. Multivariate analysis revealed that platelet count (<12 x104/mm3) (P = 0.001) and prothrombin time (<80 %) (P = 0.025) were significantly associated with cirrhotic liver pathology among patients with normal ICGR15.Conclusion: Our results suggested that cirrhotic liver pathology despite normal liver function was characterized by slightly decreasing liver parenchyma as well as slight degree of fibrosis. Platelet count and PT% are useful for predicting liver cirrhosis with normal ICGR15.

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Effects of grade B liver dysfunction on the level of free hexafluoroisopropanol of sevoflurane metabolites in patients with abdominal surgery

10.21203/rs.3.rs-56086/v1 ◽

2020 ◽

Author(s):

Xiao-lin Yang ◽

Ming Li ◽

Yan Feng ◽

Guo-Yuan Zhang

Keyword(s):

Liver Function ◽

Liver Dysfunction ◽

Normal Liver ◽

Time Orientation ◽

Peak Time ◽

Normal Liver Function ◽

Time Points ◽

Extubation Time ◽

Group A ◽

Group B

Abstract Background: Study shows the metabolite, hexafluoroisopropanol (HFIP) from sevoflurane, has a strong inhibition on the central nervous system. This study aims to compare the level of free HFIP in the blood after inhaled a same concentration of sevoflurane in patients with normal liver function versus grade B liver dysfunction and observe its effect on patients’ recovery quality.Methods: Twenty four patients with normal liver function and twenty four patients with grade B liver dysfunction undergoing elective abdominal surgery were selected and assigned to group A and group B, respectively. All patients were inhaled sevoflurane (1.5MAC) for anesthesia about 3 h. The free HFIP concentration was determined at the time points of 0.5 h, 1 h, 2 h, 3 h after inhaled sevoflurane and 0.5 h, 1 h, 2 h, 4 h after discontinuation of sevoflurane, respectively. Patients’ eyes opening time, orientation recovery time, command response time and extubation time were observed after operation. The visual analogue scale (VAS) and Ramsay sedation score (RSS) were also evaluated at different time points after extubation. Results: Although the peak time of free HFIP in group B was 1 h later than that in group A, no significant differences were found in the peak concentration and other corresponding time points’ free HFIP concentrations between the two groups (P<0.05). All the eyes opening time, orientation recovery time, command response time and extubation time in group B were longer than those in group A (P<0.05). Compared to group A, a lower VAS score and a higher RSS score were found in group B at 0 min, 15 min, 30 min,1 h, 2 h and 3 h after extubation, respectively (P<0.05). Conclusion: The status of patients with grade B liver dysfunction does not affect the degree of sevoflurane metabolism. However, it can significantly prolong the peak time of free HFIP when compared with normal liver function.Trial registry number: Identified as ChiCTR 2000028901at http://www.chictr.org.cn/

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Forefront of the viral chronic hepatitis treatment. Treatment of the case for which the treatment plans can not be decided. 5. Treatment for the case of normal liver function.

Kanzo ◽

10.2957/kanzo.45.413 ◽

2004 ◽

Vol 45 (8) ◽

pp. 413-417

Author(s):

YUJIN MINAMI

Keyword(s):

Chronic Hepatitis ◽

Liver Function ◽

Normal Liver ◽

Normal Liver Function ◽

Hepatitis Treatment ◽

Treatment Plans

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An Investigational Study of BMS-986165 in Participants With Normal Liver Function and Participants With Mild, Moderate and Severe Liver Damage

Case Medical Research ◽

10.31525/ct1-nct03890809 ◽

2019 ◽

Author(s):

Keyword(s):

Liver Function ◽

Liver Damage ◽

Normal Liver ◽

Normal Liver Function ◽

Severe Liver ◽

Severe Liver Damage

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Management of Obscurely Dilated Common Bile Duct with Normal Liver Function Tests: A Pragmatic Approach

World Journal of Surgery ◽

10.1007/s00268-021-06175-4 ◽

2021 ◽

Author(s):

Sundeep Singh Saluja ◽

Vaibhav Kumar Varshney ◽

Vidya Sharada Bhat ◽

Phani Kumar Nekarakanti ◽

Asit Arora ◽

...

Keyword(s):

Bile Duct ◽

Common Bile Duct ◽

Liver Function ◽

Normal Liver ◽

Liver Function Tests ◽

Pragmatic Approach ◽

Normal Liver Function ◽

Function Tests

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Persistently raised aspartate aminotransferase (AST) due to macro-AST in a rheumatology clinic

Diagnosis ◽

10.1515/dx-2014-0065 ◽

2015 ◽

Vol 2 (2) ◽

pp. 137-140 ◽

Cited By ~ 2

Author(s):

Wycliffe Mbagaya ◽

Joanne Foo ◽

Ahai Luvai ◽

Claire King ◽

Sarah Mapplebeck ◽

...

Keyword(s):

Liver Function ◽

Aspartate Aminotransferase ◽

Normal Liver ◽

Abdominal Ultrasound ◽

Liver Function Tests ◽

Analytical Investigation ◽

Normal Liver Function ◽

Rheumatology Clinic ◽

History Of ◽

Liver Biopsies

AbstractMacrocomplexes between immunoglobins and aspartate aminotransferase (macro-AST) may result in persistently increased AST concentration. The presence of macro-AST in patients has been implicated in unnecessary investigations of abnormal liver function tests. We report the case of a 44-year-old female who presented to the rheumatology clinic with a 12-months’ history of constant widespread pain affecting her limbs and was found to have an elevated AST concentration. Further information from her GP revealed a 14-years’ history of elevated AST with otherwise normal liver function. Previous abdominal ultrasound and two liver biopsies carried out 2 years apart were normal. This prompted further analytical investigation by the biochemistry department which identified macro-AST as the cause. This case illustrates that persistently raised isolated AST concentration with no other abnormal indices may warrant macroenzyme analysis potentially avoiding unnecessary invasive investigations.

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The relationship between HBV precore region mutation and the variation of T-lymphocyte subpopulations in chronic HBV-infected individuals with normal liver function tests

International Journal of Infectious Diseases ◽

10.1016/j.ijid.2010.02.2016 ◽

2010 ◽

Vol 14 ◽

pp. e237

Author(s):

J. You ◽

Y.-H. Chen ◽

H.-Y. Chen ◽

H.-Q. Yang ◽

R.-D. Yang ◽

...

Keyword(s):

Liver Function ◽

T Lymphocyte ◽

Normal Liver ◽

Liver Function Tests ◽

Lymphocyte Subpopulations ◽

Normal Liver Function ◽

T Lymphocyte Subpopulations ◽

Precore Region ◽

Chronic Hbv ◽

The Relationship

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Mildly elevated succinylacetone and normal liver function in compound heterozygotes with pathogenic and pseudodeficient FAH alleles

Molecular Genetics and Metabolism Reports ◽

10.1016/j.ymgmr.2017.12.002 ◽

2018 ◽

Vol 14 ◽

pp. 55-58 ◽

Cited By ~ 1

Author(s):

Hao Yang ◽

Francis Rossignol ◽

Denis Cyr ◽

Rachel Laframboise ◽

Shu Pei Wang ◽

...

Keyword(s):

Liver Function ◽

Normal Liver ◽

Normal Liver Function ◽

Compound Heterozygotes

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Case 1.4

Mayo Clinic Body MRI Case Review ◽

10.1093/med/9780199915705.003.0004 ◽

2014 ◽

pp. 7-8

Author(s):

Christine U. Lee ◽

James F. Glockner

Keyword(s):

Liver Function ◽

Neutrophil Count ◽

Laboratory Tests ◽

Normal Liver ◽

Normal Liver Function ◽

Nonproductive Cough

67-year-old woman status post fundoplication 2 months ago, with development of fever and nonproductive cough shortly afterward; laboratory tests revealed normal liver function and an increased neutrophil count Coronal SSFSE image (Figure 1.4.1) and axial fat-suppressed T2-weighted FSE image (Figure 1.4.2...

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