scholarly journals Age Distribution and Associated Factors of Cornea Biochemical Parameter Stress-Strain Index in Chinese Healthy Population

2020 ◽  
Author(s):  
Guihua Liu ◽  
Hua Rong ◽  
Ruxia Pei ◽  
Bei Du ◽  
Nan Jin ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Axial Length ◽  
Regression Models ◽  
Corneal Thickness ◽  
Age Distribution ◽  
Biochemical Parameter ◽  
Healthy Population ◽  
Corneal Curvature ◽  
Stress Strain ◽  
Strain Index

Abstract Background: To investigate the new cornea biochemical parameter stress-strain index (SSI) in Chinese healthy people and the factors associated with SSIMethods: A total of 175 eyes from 175 participants were recruited in this study. Axial length was measured with the Lenstar LS-900. Pentacam was used to measure curvature of the cornea and ACV and cornea biomechanical properties were measured by corneal visualization Scheimpflug technology (Corvis ST). Student’s t-test, one-way ANOVA, univariate and multivariate linear regression were used in the statistical analysis.Results: The mean (±SD) SSI was 1.14 ± 0.22 (range, 0.66–1.78) in all subjects and affected by age significantly after age of 35 (P < 0.05). In univariate regression models, SSI did not vary with biomechanical intraocular pressure (bIOP) (P=0.989), steepest radius of anterior corneal curvature (RsF) (P=0.984) or central corneal thickness (CCT) (P=0.651). In multivariate regression models, SSI was significantly associated with age (β=0.557, P<0.001), axial length (AL) (β=-0.550, P<0.001), intraocular pressure (IOP) (β=0.377, P<0.001) and flattest radius of anterior corneal curvature (RfF) (β=0.222, P<0.001) but not with anterior chamber volume (ACV).Conclusions: SSI was increased by age after the age of 35. In addition to age, SSI and RfF, IOP is positively correlated and negatively correlated with AL.

scholarly journals Age distribution and associated factors of cornea biomechanical parameter stress-strain index in Chinese healthy population

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Guihua Liu ◽  
Hua Rong ◽  
Ruxia Pei ◽  
Bei Du ◽  
Nan Jin ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Axial Length ◽  
Corneal Thickness ◽  
Age Distribution ◽  
Partial Least Square ◽  
Healthy Population ◽  
Corneal Curvature ◽  
Stress Strain ◽  
Strain Index ◽  
Biomechanical Parameter

Abstract Background To investigate the new cornea biomechanical parameter stress-strain index (SSI) in Chinese healthy people and the factors associated with SSI. Methods A total of 175 eyes from 175 participants were included in this study. Axial length was measured with the Lenstar LS-900. Pentacam measured curvature of the cornea and anterior chamber volume (ACV). Cornea biomechanical properties assessments were performed by corneal visualization Scheimpflug technology (Corvis ST). Student’s t-test, one-way ANOVA, partial least square linear regression (PLSLR) and linear mixed effects (LME) model were used in the statistical analysis. Results The mean (±SD) SSI was 1.14 ± 0.22 (range, 0.66–1.78) in all subjects and affected by age significantly after age of 35 (P < 0.05). In LME models, SSI was significantly associated with age (β = 0.526, P < 0.001), axial length (AL) (β = − 0.541, P < 0.001), intraocular pressure (IOP) (β = 0.326, P < 0.001) and steepest radius of anterior corneal curvature (RsF) (β = 0.229, P < 0.001) but not with ACV, biomechanical corrected intraocular pressure (bIOP), flattest radius of anterior corneal curvature (RfF) or central corneal thickness (CCT) (P > 0.05 for each). Conclusions SSI increased with age after the age of 35. In addition to age, SSI was positively correlated with RsF and IOP, while negatively correlated with AL.

scholarly journals Age Distribution and Associated Factors of Cornea Biomechanical Parameter Stress-Strain Index in Chinese Healthy Population

2020 ◽  
Author(s):  
Guihua Liu ◽  
Hua Rong ◽  
Ruxia Pei ◽  
Bei Du ◽  
Nan Jin ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Axial Length ◽  
Corneal Thickness ◽  
Age Distribution ◽  
Partial Least Square ◽  
Healthy Population ◽  
Corneal Curvature ◽  
Stress Strain ◽  
Strain Index ◽  
Biomechanical Parameter

Abstract Background: To investigate the new cornea biomechanical parameter stress-strain index (SSI) in Chinese healthy people and the factors associated with SSI.Methods: A total of 175 eyes from 175 participants were included in this study. Axial length was measured with the Lenstar LS-900. Pentacam measured curvature of the cornea and anterior chamber volume (ACV). Cornea biomechanical properties assessments were performed by corneal visualization Scheimpflug technology (Corvis ST). Student’s t-test, one-way ANOVA, partial least square linear regression (PLSLR) and linear mixed effects (LME) model were used in the statistical analysis.Results: The mean (±SD) SSI was 1.14 ± 0.22 (range, 0.66–1.78) in all subjects and affected by age significantly after age of 35 (P < 0.05). In LME models, SSI was significantly associated with age (β=0.526, P<0.001), axial length (AL) (β=-0.541, P<0.001), intraocular pressure (IOP) (β=0.326, P<0.001) and steepest radius of anterior corneal curvature (RsF) (β=0.229, P<0.001) but not with ACV, biomechanical corrected intraocular pressure (bIOP), flattest radius of anterior corneal curvature (RfF) or central corneal thickness (CCT) (P>0.05 for each).Conclusions: SSI increased with age after the age of 35. In addition to age, SSI was positively correlated with RsF and IOP, while negatively correlated with AL.

scholarly journals Age Distribution and Associated Factors of Cornea Biomechanical Parameter Stress-Strain Index in Chinese Healthy Population

2020 ◽  
Author(s):  
Guihua Liu ◽  
Hua Rong ◽  
Ruxia Pei ◽  
Bei Du ◽  
Nan Jin ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Axial Length ◽  
Corneal Thickness ◽  
Age Distribution ◽  
Partial Least Square ◽  
Healthy Population ◽  
Corneal Curvature ◽  
Stress Strain ◽  
Strain Index ◽  
Biomechanical Parameter

Abstract Background: To investigate the new cornea Biomechanical parameter stress-strain index (SSI) in Chinese healthy people and the factors associated with SSI. Methods: A total of 175 eyes from 175 participants were included in this study. Axial length was measured with the Lenstar LS-900. Pentacam measured curvature of the cornea and anterior chamber volume (ACV). Cornea biomechanical properties assessments were performed by corneal visualization Scheimpflug technology (Corvis ST). Student’s t-test, one-way ANOVA, partial least square linear regression (PLSLR) and linear mixed effects (LME) model were used in the statistical analysis. Results: The mean (±SD) SSI was 1.14 ± 0.22 (range, 0.66–1.78) in all subjects and affected by age significantly after age of 35 (P < 0.05). In LME models, SSI was significantly associated with age (β=0.526, P<0.001), axial length (AL) (β=-0.541, P<0.001), intraocular pressure (IOP) (β=0.326, P<0.001) and steepest radius of anterior corneal curvature (RsF) (β=0.229, P<0.001) but not with ACV, biomechanical corrected intraocular pressure (bIOP), flattest radius of anterior corneal curvature (RfF) or central corneal thickness (CCT) (P>0.05 for each). Conclusions: SSI increased with age after the age of 35. In addition to age, SSI was positively correlated with RsF and IOP, while negatively correlated with AL.

scholarly journals The Guangzhou Twin Eye Study: 2019 Update

2019 ◽  
Vol 22 (6) ◽  
pp. 492-498
Author(s):  
Xiaohu Ding ◽  
Wei Wang ◽  
Jane Scheetz ◽  
Mingguang He
Keyword(s):  
Intraocular Pressure ◽  
Axial Length ◽  
Corneal Thickness ◽  
Environmental Influences ◽  
Eye Diseases ◽  
Future Research ◽  
Research Directions ◽  
Future Research Directions ◽  
The Impact ◽  
Fundus Photo

AbstractThe primary aim of the Guangzhou Twin Eye Study (GTES) is to explore the impact that genes and environmental influences have on common eye diseases. Since 2006, approximately 1300 pairs of twins, aged 7–15 years, were enrolled at baseline. Progressive phenotypes, such as cycloplegic refraction, axial length, height and weight, have been collected annually. Nonprogressive phenotypes such as parental refraction, corneal thickness, fundus photo, intraocular pressure and DNA were collected once at baseline. We are collaborating with fellow international twin researchers and psychologists to further explore links with general medical conditions. In this article, we review the history, major findings and future research directions for the GTES.

scholarly journals Effects of SMILE Surgery on Intraocular Pressure, Central Corneal Thickness, Axial Length, Peripapillary Retinal Nerve Fiber Layer, and Macular Ganglion Cell Complex Thickness

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Zhanlin Zhao ◽  
Sylvain Michée ◽  
Jean-François Faure ◽  
Christophe Baudouin ◽  
Antoine Labbé
Keyword(s):  
Intraocular Pressure ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Axial Length ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Ganglion Cell Complex ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
The Mean

Purpose. To evaluate the change in intraocular pressure (IOP), central corneal thickness (CCT), axial length, peripapillary retinal nerve fiber layer (RNFL) thickness, and macular ganglion cell complex (GCC) thickness after small incision lenticule extraction (SMILE) surgery. Methods. This prospective observational study was conducted in Espace Nouvelle Vision, Ophthalmological Clinic, Paris, France. Fifty eyes of 25 patients were enrolled in this study and underwent SMILE surgeries. IOP, central corneal thickness (CCT), axial length (AL), peripapillary RNFL thickness, and macular GCC thickness were measured before and at 3 months after SMILE. Results. The mean preoperative spherical equivalent was −3.15 ± 1.50 diopters (D), and the mean postoperative value was 0.15 ± 0.28 D. After SMILE surgery, IOP decreased from 15.03 ± 2.79 mmHg to 11.02 ± 2.73 mmHg and 10.02 ± 2.21 mmHg at 1 and 3 months, respectively ( P < 0.01 for both comparisons). The mean decrease in measured IOP as a function of ablation depth was 0.065 ± 0.031 mmHg/μm. CCT decreased from 545.98 ± 26.61 μm to 478.40 ± 30.26 μm after SMILE surgery ( P < 0.01 ). AL decreased from 24.80 ± 0.84 mm to 24.70 ± 0.83 mm ( P < 0.01 ). There was no statistically significant change in mean peripapillary RNFL or mean GCC thickness after SMILE surgery. Conclusions. SMILE surgery modified IOP measurement, CCT, and AL but did not change peripapillary RNFL and macular GCC thicknesses. The postoperative drop in measured IOP might be explained by the decreased CCT. An accurate re-evaluation of AL should be performed before cataract surgery among post-SMILE patients.

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