scholarly journals Morphological and vascular characteristics of the optic nerve head in normal guinea pigs

2021 ◽  
Author(s):  
Lei Guo ◽  
Jun Tao ◽  
Yang Tong ◽  
Shichao Chen ◽  
Xin Zhao ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Refractive Error ◽  
Guinea Pigs ◽  
Linear Regression Analysis ◽  
Vascular Density ◽  
Optical Coherence ◽  
Vessel Length

Abstract The morphological and vascular characteristics of the optic nerve head (ONH) in normal guinea pigs remain unknown. Therefore, we aimed to investigate these parameters using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). We measured the refractive error, axial length, and intraocular pressure (IOP), and performed OCT and OCTA of the ONH in 3- and 4-week-old tricolour guinea pigs. A total of 208 right eyes from 208 normal guinea pigs were examined. The refractive error in the 3-week group was significantly larger than that in the 4-week group (p < 0.001), the IOP in the 3-week group was significantly lower than that in the 4-week group (p = 0.014), and the circumpapillary retinal nerve fibre layer (cpRNFL) thickness in the 3-week group was significantly larger than that in 4-week group (p = 0.048). There were no significant differences in the average vessel area, vascular density, total number of junctions, total vessel length, total number of endpoints, and vascular diameter between the two groups. However, an age-adjusted linear regression analysis revealed that total vessel length was positively associated with the cpRNFL thickness (p = 0.024) and negatively associated with IOP (p = 0.016). This is the first report on morphological and vascular characteristics of the ONH in normal guinea pigs based on in vivo OCT and OCTA imaging and quantification of ONH parameters. These results may contribute to further research on myopia and glaucoma using guinea pig models.

scholarly journals In vivo analysis of glaucoma-related features within the optic nerve head using enhanced depth imaging optical coherence tomography

PLoS ONE ◽  
2017 ◽  
Vol 12 (7) ◽  
pp. e0180128 ◽  
Author(s):  
Tiago S. Prata ◽  
Flavio S. Lopes ◽  
Vitor G. Prado ◽  
Izabela Almeida ◽  
Igor Matsubara ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Enhanced Depth Imaging ◽  
Optical Coherence ◽  
Depth Imaging ◽  
In Vivo Analysis ◽  
Imaging Optical Coherence Tomography

scholarly journals Vascular density of optic nerve head in diabetic retinopathy using optical coherence tomography angiography

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Fariba Ghassemi ◽  
Sahar Berijani ◽  
Ramak Roohipoor ◽  
Masoumeh Mohebbi ◽  
Ameneh Babeli ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Optical Coherence Tomography Angiography ◽  
Blood Perfusion ◽  
Cross Sectional Study ◽  
Vascular Density ◽  
Optical Coherence ◽  
Cross Sectional

Abstract Purpose To measure optic nerve head (ONH) blood perfusion using optical coherence tomography angiography (OCTA) at various stages of diabetic retinopathy (DR). Methods One hundred seventy six eyes of 94 patients included in this retrospective single-centre cross-sectional study. The subjects were studied in normal, no diabetic retinopathy (NDR), non-proliferative diabetic retinopathy (NPDR) and proliferative retinopathy (PDR) groups. The eyes were subjected to AngioDisc ONH imaging using OCTA for papillary (Disc) and peripapillary (RPC) vascular density (VD) evaluation. Results The mean age of the participants was 56.08 ± 8.87 years and 34 (36.2 percent) were male. With increased DR severity, a statistically significant decrease in peripapillary VD was found. The study showed that only VD of the whole RPC (W-RPC) could be a valid biomarker in the staging assessment. VD of RPC, in all subsections, was considerably different from normal cases in the PDR group. Visual acuity was correlated with whole image ONH VD. The duration of DM, FBS, hyperlipidemia and DME had no effect on the ONH perfusion. Conclusions The study showed that only the W-RPC VD could be a reasonable marker in the staging assessment. VDs assessed by OCTA can be useful for assessing and tracking early ONH changes in DR patients.

scholarly journals Reproducibility of Optical Coherence Tomography Angiography Macular and Optic Nerve Head Vascular Density in Glaucoma and Healthy Eyes

2017 ◽  
Vol 26 (10) ◽  
pp. 851-859 ◽  
Author(s):  
Patricia I.C. Manalastas ◽  
Linda M. Zangwill ◽  
Luke J. Saunders ◽  
Kaweh Mansouri ◽  
Akram Belghith ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Optical Coherence Tomography Angiography ◽  
Vascular Density ◽  
Optical Coherence ◽  
Healthy Eyes

scholarly journals Optic Nerve Head Optical Coherence Tomography Angiography Findings in Patients with Coronavirus Disease 2019

2021 ◽  
Author(s):  
Mojtaba Abrishami ◽  
Ramin Daneshvar ◽  
Zahra Emamverdian ◽  
Naser Shoeibi ◽  
Shima Sedighi ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Optical Coherence Tomography Angiography ◽  
Vascular Complications ◽  
Control Group ◽  
Vascular Density ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Normal Controls

Abstract Purpose: To quantify the microvasculature density of the optic nerve head (ONH) using optical coherence tomography angiography (OCTA) analysis.in patients recovered from Coronavirus Disease 2019 (COVID-19) Methods: In a comparative cross-sectional, observational study patients recovered from COVID-19, whom diagnosis of COVID-19 was confirmed by a positive reverse transcription-polymerase chain reaction of a nasopharyngeal sample were included in this study. The. OCTA of ONH was performed at least 2 weeks after recovery from systemic COVID-19. Vascular density (VD) of the all vessels (AV) and small vessels (SV) inside the disc and radial peripapillary capillary (RPC) network density were measured in COVID-19 recovered patients and compared with similar parameters in an age-matched group of normal controls.Results: Twenty-five COVID-19 patients and 22 age-matched normal controls were enrolled in the study and one eye per participant was evaluated. Mean whole image SV VD in the COVID-19 group (49.94 ± 2.22) was not statistically significantly different from that in the control group (49.31 ± 1.93; p-value= 0.308). An increase in RPC VD was found in all AV and SV VD measured, which became statistically significant in whole peripapillary SV VD, peripapillary inferior nasal SV VD, peripapillary inferior temporal SV VD, peripapillary superior nasal SV VD and grid-based AV VD inferior sector (p<0.05 for all comparisons).Conclusion: Unremarkable increase was found in ONH microvasculature in patients who had recovered from COVID-19. These patients may be at risk of ONH vascular complications.

scholarly journals A high-accuracy and high-efficiency digital volume correlation method to characterize in-vivo optic nerve head biomechanics from optical coherence tomography

2021 ◽  
Author(s):  
Fuqiang Zhong ◽  
Junchao Wei ◽  
Yi Hua ◽  
Bo Wang ◽  
Juan Reynaud ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Gaussian Noise ◽  
High Efficiency ◽  
Speckle Noise ◽  
High Accuracy ◽  
Digital Volume Correlation ◽  
Optical Coherence

In-vivo optic nerve head (ONH) biomechanics characterization is emerging as a promising way to study eye physiology and pathology. We propose a high-accuracy and high-efficiency digital volume correlation (DVC) method for the purpose of characterizing the in-vivo ONH deformation from volumes acquired by optical coherence tomography (OCT). Using a combination of synthetic tests and analysis of OCTs from monkey ONHs subjected to acute and chronically elevated intraocular pressure, we demonstrate that our proposed methodology overcomes several challenges for conventional DVC methods. First, it accounts for large ONH rigid body motion in the OCT volumes which could otherwise lead to analysis failure; second, sub-voxel accuracy displacement can be guaranteed despite high noise and low image contrast of some OCT volumes; third, computational efficiency is greatly improved, such that the memory consumption of our method is substantially lower than with conventional methods; fourth, we introduce a parameter measuring displacements confidence. Test of image noise effects showed that the proposed DVC method had displacement errors smaller than 0.028 voxels with speckle noise and smaller than 0.037 voxels with Gaussian noise; The absolute (relative) strain errors in the three directions were lower than 0.0018 (4%) with speckle noise and than 0.0045 (8%) with Gaussian noise. Compared with conventional DVC methods, the proposed DVC method had substantially improved overall displacement and strain errors under large body motions (lower by up to 70%), with 75% lower computation times, while saving about 30% memory. The study thus demonstrates the potential of the proposed technique to investigate ONH biomechanics.

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