scholarly journals Relationship of Neutrophil–Lymphocyte Ratio with coronary artery disease and plaque composition of coronary artery

2021 ◽  
Author(s):  
Ruopeng Wang ◽  
Hui Gu ◽  
Congshan Ji ◽  
Yan Gao ◽  
Lin Gao ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Logistic Regression ◽  
Coronary Artery ◽  
Plaque Burden ◽  
Plaque Composition ◽  
Plaque Volume ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Calcified Plaque ◽  
Artery Disease

Abstract Evidence suggests that the neutrophil-lymphocyte ratio (NLR) has been considered as useful marker for identifying individuals under risk of coronary artery disease (CAD) and associated events, a more powerful predictor than any other leukocyte subtypes. In this study, we aimed to evaluate association of NLR with CAD and plaque composition of coronary artery analyzed from coronary CT angiography (CCTA). The study population consisted of 469 patients who underwent CCTA due to stable typical or atypical chest pain. The enrolled patients were divided into two groups and three groups according to coronary artery stenosis and tertiles of NLR, respectively. The plaque burden, volume and ratio of calcified, lipid and fibrous components of plaques were measured based on CCTA images. Chi-square, Student’s test, ANOVA, Mann–Whitney U test, KruskalWallis test and multiple logistic regression were used for statistical analysis. Compared with non-CAD group, NLR was significantly higher in CAD group(P = 0.001). The non-calcified plaque volume, fibrotic plaque volume and lipid plaque volume increased with the NLR (P༜0.05). Multivariate logistic regression analysis showed that NLR was an independent risk factor for CAD(OR: 1.792, 95CI 1.067–3.011, P < 0.05). The present study demonstrated that NLR is associated with both the CAD and non-calcified plaque volume of coronary artery.

scholarly journals Neutrophil/Lymphocyte Ratio Is Associated with Non-Calcified Plaque Burden in Patients with Coronary Artery Disease

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e108183 ◽  
Author(s):  
Lennart Nilsson ◽  
Wouter G. Wieringa ◽  
Gabija Pundziute ◽  
Marcus Gjerde ◽  
Jan Engvall ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Plaque Burden ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Calcified Plaque ◽  
Artery Disease

scholarly journals Atherosclerosis Is Associated with Neutrophil Lymphocyte Ratio As An Inflammatory Marker in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease

2016 ◽  
Vol 24 (1) ◽  
pp. 24-29
Author(s):  
Mohammad Monzurul Alam Bhuiyan ◽  
Tuhin Sultana ◽  
Md Saiful Islam ◽  
Dhiman Borua ◽  
Mostaque Ahmed ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Coronary Angiography ◽  
Inflammatory Marker ◽  
Clinical Pathology ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Type 2 Dm ◽  
Artery Disease

Background: Increased neutrophil lymphocyte ratio is associated with major adverse outcomes of cardiac events in type 2 diabetes mellitus (DM) patients.Objective: To assess the NLR as an inflammatory marker in atherosclerosis in type 2 DM patients with coronary artery disease (CAD).Methods: This case control study was conducted in the Department of Clinical Pathology in collaboration with Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from March 2014 to February 2015. Total 134 patients were enrolled in this study who were waiting for coronary angiography in the Department of Cardiology, BSMMU; 84 cases were considered as Group I (DM with CAD) and 50 controls were Group II (DM without CAD). A 2 ml of blood was collected in EDTA tube from the patients prior to coronary angiogram for complete blood count (CBC) were measured by haematology autoanalyzer, rechecked manually and NLR was calculated in the Department of Clinical Pathology, BSMMU. Coronary artery disease with 50% coronary artery stenosis and more critical lesion that were diagnosed by coronary angiography were included in this study as cases. Coronary artery disease with less than 50% coronary artery stenosis that was diagnosed by coronary angiography was included in this study as control.Results: NLR was higher in CAD positive group compared to group without CAD negative in type 2 DM patients (2.76 (±0.74) vs. 1.56 (±0.15), p<0.001).Conclusion: With the help of neutrophil lymphocyte ratio we can take preventive measure and precaution to reduce the progression of atherosclerosis in type 2 diabetic patients with coronary artery disease.J Dhaka Medical College, Vol. 24, No.1, April, 2015, Page 24-29

Abstract 1985: Increased Plaque Mass, but not Relative Plaque Composition, Distinguishes Culprit Coronary Artery Lesions in Patients with Acute Coronary Syndrome: A Lesion Analysis by Intravascular Ultrasound Histology

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Andrew Frutkin ◽  
Sameer K Mehta ◽  
Justin R McCrary ◽  
John House ◽  
Steven P Marso
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Intravascular Ultrasound ◽  
Atherosclerotic Plaque ◽  
Obstructive Coronary Artery Disease ◽  
Plaque Burden ◽  
Lumen Area ◽  
Coronary Artery Lesions ◽  
Plaque Composition ◽  
Artery Disease

INTRODUCTION Intravascular ultrasound Virtual Histology (IVUS-VH) uses radiofrequency analysis to measure coronary artery plaque geometry and classify plaque components into one of four categories: fibrous, fibrofatty, necrotic or calcified. We hypothesized that patients with acute coronary artery syndrome (ACS) would have atherosclerotic plaque geometry and composition that differs from patients with stable, obstructive coronary artery disease. METHODS In a crossectional study we used IVUS-VH to image 38 culprit lesions of 28 ACS patients and 104 lesions of 71 non-ACS patients prior to intervention. In both ACS and non-ACS patients, culprit lesions were defined as the site of percutaneous coronary intervention with at least 3 contiguous frames of > 40% percent plaque burden (100 × [external elastic membrane (EEM ) area − lumen area]/EEM area ) and a neointimal thickness > 600 um subtending an arc of > 10% vessel circumference. Plaque geometry and composition were measured with IVUS-VH software (pcVH v.2.2, Volcano Corp). A remodeling index was calculated as the ratio of the EEM area at the frame of the minimal lumen area to the EEM area of a reference frame (within 10 mm of MLA). RESULTS Lesions of ACS patients were longer and had greater plaque volume than non-ACS patients (Table ). The proportions of IVUS-derived plaque components were similar in both ACS and non-ACS culprit lesions (Table ). CONCLUSION Culprit coronary artery lesions in ACS patients have greater plaque mass than in non-ACS patients, but relative plaque composition is similar between these patient populations. Measurements of atherosclerotic plaque mass may discriminate better than plaque composition as to which patients with severe, obstructive coronary artery disease are at greatest risk of coronary artery thrombosis. Longitudinal studies using IVUS-VH will best resolve which IVUS-VH measurements of plaque geometry and composition have greatest predictive value.

Sign in / Sign up

Export Citation Format

Share Document