scholarly journals Neutrophil/Lymphocyte Ratio Is Associated with Non-Calcified Plaque Burden in Patients with Coronary Artery Disease

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e108183 ◽  
Author(s):  
Lennart Nilsson ◽  
Wouter G. Wieringa ◽  
Gabija Pundziute ◽  
Marcus Gjerde ◽  
Jan Engvall ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Plaque Burden ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Calcified Plaque ◽  
Artery Disease

scholarly journals Relationship of Neutrophil–Lymphocyte Ratio with coronary artery disease and plaque composition of coronary artery

2021 ◽  
Author(s):  
Ruopeng Wang ◽  
Hui Gu ◽  
Congshan Ji ◽  
Yan Gao ◽  
Lin Gao ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Logistic Regression ◽  
Coronary Artery ◽  
Plaque Burden ◽  
Plaque Composition ◽  
Plaque Volume ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Calcified Plaque ◽  
Artery Disease

Abstract Evidence suggests that the neutrophil-lymphocyte ratio (NLR) has been considered as useful marker for identifying individuals under risk of coronary artery disease (CAD) and associated events, a more powerful predictor than any other leukocyte subtypes. In this study, we aimed to evaluate association of NLR with CAD and plaque composition of coronary artery analyzed from coronary CT angiography (CCTA). The study population consisted of 469 patients who underwent CCTA due to stable typical or atypical chest pain. The enrolled patients were divided into two groups and three groups according to coronary artery stenosis and tertiles of NLR, respectively. The plaque burden, volume and ratio of calcified, lipid and fibrous components of plaques were measured based on CCTA images. Chi-square, Student’s test, ANOVA, Mann–Whitney U test, KruskalWallis test and multiple logistic regression were used for statistical analysis. Compared with non-CAD group, NLR was significantly higher in CAD group(P = 0.001). The non-calcified plaque volume, fibrotic plaque volume and lipid plaque volume increased with the NLR (P༜0.05). Multivariate logistic regression analysis showed that NLR was an independent risk factor for CAD(OR: 1.792, 95CI 1.067–3.011, P < 0.05). The present study demonstrated that NLR is associated with both the CAD and non-calcified plaque volume of coronary artery.

scholarly journals Atherosclerosis Is Associated with Neutrophil Lymphocyte Ratio As An Inflammatory Marker in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease

2016 ◽  
Vol 24 (1) ◽  
pp. 24-29
Author(s):  
Mohammad Monzurul Alam Bhuiyan ◽  
Tuhin Sultana ◽  
Md Saiful Islam ◽  
Dhiman Borua ◽  
Mostaque Ahmed ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Coronary Angiography ◽  
Inflammatory Marker ◽  
Clinical Pathology ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Type 2 Dm ◽  
Artery Disease

Background: Increased neutrophil lymphocyte ratio is associated with major adverse outcomes of cardiac events in type 2 diabetes mellitus (DM) patients.Objective: To assess the NLR as an inflammatory marker in atherosclerosis in type 2 DM patients with coronary artery disease (CAD).Methods: This case control study was conducted in the Department of Clinical Pathology in collaboration with Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from March 2014 to February 2015. Total 134 patients were enrolled in this study who were waiting for coronary angiography in the Department of Cardiology, BSMMU; 84 cases were considered as Group I (DM with CAD) and 50 controls were Group II (DM without CAD). A 2 ml of blood was collected in EDTA tube from the patients prior to coronary angiogram for complete blood count (CBC) were measured by haematology autoanalyzer, rechecked manually and NLR was calculated in the Department of Clinical Pathology, BSMMU. Coronary artery disease with 50% coronary artery stenosis and more critical lesion that were diagnosed by coronary angiography were included in this study as cases. Coronary artery disease with less than 50% coronary artery stenosis that was diagnosed by coronary angiography was included in this study as control.Results: NLR was higher in CAD positive group compared to group without CAD negative in type 2 DM patients (2.76 (±0.74) vs. 1.56 (±0.15), p<0.001).Conclusion: With the help of neutrophil lymphocyte ratio we can take preventive measure and precaution to reduce the progression of atherosclerosis in type 2 diabetic patients with coronary artery disease.J Dhaka Medical College, Vol. 24, No.1, April, 2015, Page 24-29

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