scholarly journals The Global, Regional, and National Burden and Trends of Infective Endocarditis From 1990 to 2019: Results From the Global Burden of Disease Study 2019

2021 ◽  
Author(s):  
Huilong Chen ◽  
Yuan Zhan ◽  
Kaimin Zhang ◽  
Liyuan Chen ◽  
Juan Zhan ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Burden Of Disease ◽  
Temporal Trend ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Disability Adjusted Life Years ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Incidence And Mortality ◽  
Disease Study

Abstract Introduction: Infective endocarditis (IE) causes in-mounting incidence and mortality, as well as serious socioeconomic burden in different regions and countries. To compare and interpret the IE burden and temporal trends in the globe and different regions, we conducted this study to report the incidence, death, and disability-adjusted life years (DALYs) from 1990 to 2019. Methods: Data of incidences, deaths and DALYs were extracted and analyzed from the Global Burden of Disease Study 2019. Estimated annual percentage changes (EAPC) were adopted to quantify the change trends of age-standardized rates (ASRs). Besides, potential contributors of serious IE burden were also evaluated including age, gender, social-demographic index (SDI), and ASIR in 1990.Results: In the globe, the number of IE cases increased by 128% from 478,000 in 1990 to 1,090,530 in 2019, and the deaths increased sharply from 28,750 in 1990 to 66,320 in 2019, and both presented the upward temporal trend annually. Whereas the EAPC of age-standardized DALYs demonstrated a negative temporal trend despite of increasing DALYs from 1,118,120 in 1990 to 1,723,590 in 2019. Moreover, graver IE burden was prone to males and aged patients. Meanwhile, different SDI regions had different disease burden, correlation analyses indicated that SDI presented a positive association with ASIR (R=0.58, P<0.0001), no association with ASDR (R=-0.06, P=0.10), and negative association with age-standardized DALYs rate (R=-0.40, P<0.0001). Finally, we discovered the positive associations of EAPC of ASRs with SDI in 2019, while little associations with ASIR in 1990.Conclusion: Generally, the overall burden of infective endocarditis is ever-increasing, and the incidence, mortality and disability-adjusted life years present a huge heterogeneity in gender, age and different regions. The results may be useful for policy makers and medical staffs in response to endocarditis and to formulate cost-effective interventional measures.

scholarly journals Global, regional and national burden of gout, 1990–2017: a systematic analysis of the Global Burden of Disease Study

Rheumatology ◽  
2019 ◽  
Vol 59 (7) ◽  
pp. 1529-1538 ◽  
Author(s):  
Yang Xia ◽  
Qijun Wu ◽  
Hanyuan Wang ◽  
Shuang Zhang ◽  
Yuting Jiang ◽  
...  
Keyword(s):  
Burden Of Disease ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Disability Adjusted Life Years ◽  
Annual Percent Change ◽  
Percent Change ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Study Results ◽  
Disease Study

Abstract Objectives The burden of gout has been increasing globally. However, little is known about the global, regional and national distribution and time trend of this disease. We present a comprehensive analysis of the Global Burden of Disease Study 2017 on gout burden estimates for 195 countries or territories between 1990 and 2017. Methods Age-standardized prevalence and disability-adjusted life-years of gout were reported between 1990 and 2017 in 195 countries and territories, and associations between these estimates and sociodemographic index (SDI) were further explored. Total and annual percent change between 1990 and 2017 were calculated to quantify the time trends of gout burden. Results Age-standardized prevalence rates (95% uncertainty interval) per 100 000 persons were 790.90 (706.10–881.90) and 253.49 (225.69–284.02) in 2017 in males and females, respectively. The annual percent change in age-standardized prevalence (males, 0.22%; females, 0.38%) and disability-adjusted life-years (males, 0.21%; females, 0.38%) of gout increased every year from 1990 to 2017, globally. The highest increase was detected in high-SDI countries, especially in high-income North America. A non-linear association was observed between burden of gout and SDI, with the lowest estimates of gout burden when SDI value was about 0.6. High BMI was the leading risk factor for the burden of gout. Conclusion These study results suggest a globally rising trajectory of gout burden between 1990 and 2017. More effective interventions, such as detailed and intensive dietary managements and other prevention strategies for reducing obesity, should be carried out to reverse this trend, especially in females and high-SDI countries.

scholarly journals Burden of Thyroid Cancer From 1990 to 2019 and Projections of Incidence and Mortality Until 2039 in China: Findings From Global Burden of Disease Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Fang Cheng ◽  
Juan Xiao ◽  
Chunchun Shao ◽  
Fengyan Huang ◽  
Lihua Wang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Burden Of Disease ◽  
Cohort Analysis ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Essential Information ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Incidence And Mortality ◽  
Disease Study

Projecting the burden of thyroid cancer (TC) over time provides essential information to effectively plan measures for its management and prevention. This research obtained data from the Global Burden of Disease (GBD) Study from between 1990 and 2019 to model how TC will affect China until 2039 by conducting the Bayesian age-period-cohort analysis. The number of new TC cases in China was 10,030 in 1990, 39,080 in 2019, and is projected to be 47,820 in 2039. This corresponds to 3,320, 7,240, and 4,160 deaths, respectively. Disability-adjusted life years (DALYs) cases increased from 103,490 in 1990 to 187,320 in 2019. The age-standardized rate (ASR) of incidence increased from 1.01 to 2.05 during 1990-2019 and was projected to increase to 3.37 per 100,000 person-years until 2039. The ASR of mortality (ASMR) remained stable during the study period and was projected to have a mild decline from 0.39 to 0.29/100,000 during 2020-2039. Although the ASMR in male patients has maintained increasing at a rate of 2.2% per year over the past 30 years, it is expected to decline at a rate of 1.07% per year in 2019-2039. The most significant increase in crude incidence occurred in people aged 45-65 from 1990 to 2019, however, this will shift into young people aged 10-24 from 2020 to 2039. In addition, the proportion of deaths and DALYs caused by obesity increased from 1990 to 2019 and affected men more than women. In conclusion, a substantial increase in counts of incidence of TC in China is projected over the next two decades, combined with the slightly declining mortality, indicating that rational health policies are needed in the future to cope with the increasing number of TC patients, especially among males and adolescents.

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