scholarly journals Gray Scale Ultrasound Feature Typing of Metastasis in the Ovary, Especially Signet-ring Cell Carcinoma

2020 ◽  
Author(s):  
Junying Liu ◽  
Cai Chang ◽  
Haixian Zhang
Keyword(s):  
Cell Carcinoma ◽  
Cancer Metastasis ◽  
Type A ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Ovarian Tumors ◽  
Tumor Diameter ◽  
Gray Scale ◽  
Signet Ring ◽  
Ring Cell

Abstract Background To describe the gray scale ultrasound features of metastatic ovarian tumors on the basis of the origin of the primary tumor in a large study population. This retrospective study included 112 patients with 188 histopathologically confirmed metastatic ovarian tumors. Among the patients, 102 were detected with 143 masses via ultrasonography. Patient age, mass bilaterality, and maximum tumor diameter were recorded. Results Ultrasound images were classified into three subtypes: (type A) multilocular-solid, (type B) purely solid, and (type C) solid with several round or oval cysts. The metastatic tumors in the ovaries were mostly bilateral but had a lower rate of bilaterality when detected by ultrasound. Breast cancer metastasis had the highest misdetection rate (69.6%) because its focal metastasis could only be recognized by histology or immunohistochemistry. Stomach was the most common origin of metastasis: 45.7% and 51.0% via pathology and ultrasonography, respectively. Metastases that originated from colon mostly belonged to type A (65.9%) and closely mimicked primary epithelial ovarian tumor morphologically. Metastases that originated from stomach predominantly belonged to types B (31.9%) and C (58.3%). Signet-ring cell carcinoma (SRCC) corresponded to types B and C only regardless of its origin. Conclusions The novel typing method developed herein provides more vivid images for classifying ovary metastasis compared with existing typing methods. Given that no specific sonographic parameters have been established to distinguish metastatic ovarian masses from primary invasive ovarian tumors, these images can be helpful in diagnosing these masses.

scholarly journals Gray scale ultrasound feature typing of metastasis in the ovary, especially signet-ring cell carcinoma

2021 ◽  
Author(s):  
Junying Liu ◽  
Cai Chang ◽  
Haixian Zhang
Keyword(s):  
Cell Carcinoma ◽  
Cancer Metastasis ◽  
Type A ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Ovarian Tumors ◽  
Tumor Diameter ◽  
Gray Scale ◽  
Signet Ring ◽  
Ring Cell

Abstract Background To describe the gray scale ultrasound features of metastatic ovarian tumors on the basis of the origin of the primary tumor in a large study population. This retrospective study included 112 patients with 188 histopathologically confirmed metastatic ovarian tumors. Among the patients, 102 were detected with 143 masses via ultrasonography. Patient age, mass bilaterality, maximum tumor diameter and ultrasound image character were recorded. Results Ultrasound images were classified into three subtypes: (type A) multilocular-solid, (type B) purely solid, and (type C) solid with several round or oval cysts. The metastatic tumors in the ovaries were mostly bilateral but had a lower rate of bilaterality when detected by ultrasound. Breast cancer metastasis had the highest misdetection rate (69.6%) because its focal metastasis could only be recognized by histology or immunohistochemistry. Stomach was the most common origin of metastasis: 45.7% and 51.0% via pathology and ultrasonography, respectively. Metastases that originated from colon mostly belonged to type A (65.9%) and closely mimicked primary epithelial ovarian tumor morphologically. Metastases that originated from stomach predominantly belonged to types B (31.9%) and C (58.3%). Signet-ring cell carcinoma (SRCC) corresponded to types B and C only regardless of its origin. Conclusions The novel typing method developed herein provides more vivid images for classifying ovary metastasis compared with existing typing methods.

scholarly journals Signet ring cell carcinoma of rectum metastasizing to synchronous renal cell carcinoma: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Blagica Krsteska ◽  
Rubens Jovanovic ◽  
Aleksandar Eftimov ◽  
Boro Ilievski ◽  
Dragan Hadzi-Mancev ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cancer Metastasis ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Biological Behavior ◽  
Synchronous Tumors ◽  
Signet Ring ◽  
Ring Cell

Abstract Background Rectal signet ring cell carcinoma is a rare type of colorectal adenocarcinoma characterized by an aggressive biological behavior and poor prognosis. The co-occurrence of colorectal carcinoma and renal cell carcinoma (RCC) has found in many hundreds of patients, many of whom also have additional malignancies. Cancer to cancer metastasis is rare and an uncommon phenomenon in malignancy, especially at the time of initial diagnosis, suggesting a genetic susceptibility. Case presentation We present the case of a 66-year-old Macedonian man with synchronous rectal signet ring cell carcinoma and RCC with tumor to tumor metastasis feature. He underwent a left nephrectomy and anterior rectal resection after complaining of constipation for 3–4 months and the appearance of synchronous tumors on the imaging studies. Morphology and immunohistochemical analysis of specimens from the RCC revealed signet ring cells identical to the rectal signet ring cell carcinoma. The next-generation sequencing study revealed mutations in TP53 and ERBB2, and microsatellite stable signet ring cell carcinoma was determined by deoxyribonucleic acid (DNA) sequencing. Conclusions Cancer to cancer metastasis, although rare, needs to be considered in synchronous tumors. RCC, when diagnosed in multiple synchronous tumors, should be examined carefully. The paucity of reported cases indicates the need for advanced research in imaging methods for metastasis and new therapeutic approaches.

Signet ring cell carcinoma of the appendix manifesting as colonic obstruction and ovarian tumors: Report of a case

Surgery Today ◽  
2009 ◽  
Vol 39 (3) ◽  
pp. 235-240 ◽  
Author(s):  
Jun Suzuki ◽  
Shinsuke Kazama ◽  
Joji Kitayama ◽  
Hiroshi Uozaki ◽  
Tetsuro Miyata ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Colonic Obstruction ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Ovarian Tumors ◽  
Signet Ring ◽  
Ring Cell

scholarly journals Primary signet‐ring cell carcinoma of the lung in an HIV‐positive patient

2021 ◽  
Vol 12 (7) ◽  
pp. 1122-1125
Author(s):  
Alberto Testori ◽  
Gianluca Perroni ◽  
Camilla De Carlo ◽  
Alessandro Crepaldi ◽  
Marco Alloisio ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Positive Patient ◽  
Hiv Positive ◽  
Signet Ring ◽  
Ring Cell

scholarly journals Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Somatic Mutations in CDH1 and Other Clinically Actionable Mutations Imply Early Use of Targeted Agents

2021 ◽  
Vol 28 (1) ◽  
pp. 918-927
Author(s):  
Lei-Chi Wang ◽  
Tai-Chi Lin ◽  
Yi-Chen Yeh ◽  
Hsiang-Ling Ho ◽  
Chieh-Chih Tsai ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Cell Carcinoma ◽  
Tumor Tissue ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Next Generation ◽  
Signet Ring ◽  
Ring Cell ◽  
Generation Sequencing ◽  
E Cadherin

Primary signet ring cell/histiocytoid carcinoma of the eyelid is a rare ocular malignancy and its diagnosis is often delayed. This neoplasm presents as an insidious, diffusely infiltrative mass in the periocular area that later infiltrates the orbit. An exenteration is usually indicated; however, nearly one-third of patients develop local recurrence or metastasis. Morphologically, it resembles signet ring cell carcinoma of the stomach and breast, raising the possibility of mutations in CDH1, the gene encoding E-cadherin. To determine whether primary signet ring cell/histiocytoid carcinoma harbors the CDH1 mutation or other actionable mutations, we analyzed the tumor tissue via next-generation sequencing. We identified only one case of primary signet ring cell carcinoma of the eyelid with adequate DNA quality for sequencing from the pathological archive during the period 2000 to 2020. A comprehensive evaluation including histopathology, immunohistochemistry, and next-generation sequencing assay was performed on tumor tissue. Immunohistochemically, the tumor exhibited E-cadherin membranous staining with the aberrant cytoplasmic staining of β-catenin. Using next-generation sequencing, we demonstrated the mutation in the CDH1 gene. In addition, other clinically actionable mutations including ERBB2 and PIK3CA were also detected. The alterations in other actionable genes indicate a need for larger studies to evaluate the pathogenesis and potential therapies for primary signet ring cell/histiocytoid carcinoma of the eyelid.

Fundic Gland Polyp With Parietal Cell Vacuolation Mimicking Signet Ring Cell Carcinoma

2021 ◽  
pp. 106689692199418
Author(s):  
John D. Coyne ◽  
S. Thampy
Keyword(s):  
Proton Pump Inhibitor ◽  
Cell Carcinoma ◽  
Parietal Cell ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Fundic Gland ◽  
Fundic Gland Polyp ◽  
Signet Ring ◽  
Ring Cell

Pseudo-signet ring parietal cell vacuolation has been described as a mimic of invasive signet ring cell carcinoma. Moreover, signet ring cell carcinoma has been described in a fundic gland polyp. This case demonstrates parietal cell vacuolation in a fundic gland polyp in a patient on a long-term proton pump inhibitor.

scholarly journals A Signet Ring Cell Carcinoma Presented as Refractory Acquired Thrombotic Thrombocytopenic Purpura

2020 ◽  
Vol 13 (3) ◽  
pp. 1368-1372
Author(s):  
Umit Yavuz Malkan ◽  
Murat Albayrak ◽  
Hacer Berna Ozturk ◽  
Merih Reis Aras ◽  
Bugra Saglam ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Plasma Exchange ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Unknown Origin ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Thrombocytopenic Purpura ◽  
Signet Ring ◽  
Gastric Endoscopy ◽  
Ring Cell

Microangiopathic hemolytic anemia (MAHA) can be observed as a paraneoplastic syndrome (PS) in certain tumors. MAHA-related signet ring cell carcinoma (SRCC) of an unknown origin is very infrequent. Herein we present a SRCC case presented with refractory acquired thrombotic thrombocytopenic purpura (TTP). A 35-year-old man applied to the emergency service with fatigue and headache. His laboratory tests resulted as white blood cell 9,020/µL, hemoglobin 3.5 g/dL, platelet 18,000/µL. Schistocytes, micro-spherocytes, and thrombocytopenia were observed in his blood smear. MAHA was present and he was considered as having TTP. Plasma exchange treatment was initiated; however, he was refractory to this treatment. Thorax and abdomen computerized tomography revealed thickening of minor curvature in stomach corpus with hepatogastric and paraceliac lymphadenopathy. Bone marrow (BM) investigation by our clinic resulted as the metastasis of adenocarcinoma. Ulceration and necrosis were observed by gastric endoscopy procedure. Biopsy was taken during endoscopic intervention, which resulted as SRCC. MAHA may be seen as a PS in some tumors, especially gastric cancers. Tumor-related MAHA is generally accompanied by BM metastases. As a result, BM investigation may be used as the main diagnostic method to find the underlying cancer. The clinical course of cases with tumor-related MAHA is usually poor, and these cases are usually refractory to plasma exchange treatment. In conclusion, physicians should suspect a malignancy and BM involvement when faced with a case of refractory TTP.

Primary Signet-Ring Cell Carcinoma of the Urinary Bladder (Linitis plastica)

1985 ◽  
Vol 11 (3) ◽  
pp. 212-214 ◽  
Author(s):  
M. Ponz ◽  
J. Luzuriaga ◽  
J.E. Robles ◽  
F. Guillén ◽  
J.M. Urmeneta ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Cell Carcinoma ◽  
Linitis Plastica ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Signet Ring ◽  
Ring Cell
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