scholarly journals Predicting Retinal Sensitivity Using Optical Coherence Tomography Parameters in Central Serous Chorioretinopathy

2021 ◽  
Author(s):  
Satoru Kanda ◽  
Han Peng Zhou ◽  
Tatsuya Inoue ◽  
Ryosuke Fujino ◽  
Aya Sugiura ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Central Serous Chorioretinopathy ◽  
Ganglion Cell Layer ◽  
Outer Nuclear Layer ◽  
Serous Retinal Detachment ◽  
Retinal Sensitivity ◽  
Optical Coherence ◽  
The Mean ◽  
Retinal Structure ◽  
The Relationship

Abstract Purpose To predict the change of retinal sensitivity using optical coherence tomography (OCT) parameters in eyes with central serous chorioretinopathy (CSC). Methods Twenty-three eyes of 23 patients with CSC were enrolled. Retinal sensitivity was measured twice with a microperimetry in all examined eyes. OCT measurement was simultaneously conducted. The relationship between retinal sensitivities and the thicknesses of i) retinal nerve fiver layer + ganglion cell layer (RNFL+GCL), ii) inner nuclear layer (INL) iii) outer nuclear layer (ONL) and iV) serous retinal detachment height (SRDH) were investigated in a point-wise manner. We also investigated the association between the change of retinal sensitivity and OCT parameters at baseline. Results The mean age of participants was 49.8 ± 10.7 years. The mean SRDH was significantly lower (p<0.001) and the mean retinal sensitivity (p<0.001) was significantly higher in the 2nd examination compared to the 1st measurements, however LogMAR visual acuity (VA) was not significantly different between the two measurements (p=0.063). LogMAR VA was associated with retinal sensitivity both in the 1st and 2nd measurements (p<0.001). The retinal sensitivity in the 2nd examination was significantly correlated with retinal sensitivity, RNFL+GCL, INL, ONL, SRDH in the 1st examination and the improvement of SRDH. Conclusions Retinal sensitivity was associated with retinal structure in eyes with CSC; these parameters were useful to predict the change of visual function before the treatment.

Dark and white lesions observed in central serous chorioretinopathy on optical coherence tomography angiography

2018 ◽  
Vol 28 (4) ◽  
pp. 446-453 ◽  
Author(s):  
Flore De Bats ◽  
Pierre-Loïc Cornut ◽  
Benjamin Wolff ◽  
Laurent Kodjikian ◽  
Martine Mauget-Faÿsse
Keyword(s):  
Optical Coherence Tomography ◽  
Central Serous Chorioretinopathy ◽  
Multimodal Imaging ◽  
Optical Coherence Tomography Angiography ◽  
Pigment Epithelium ◽  
Serous Retinal Detachment ◽  
Descriptive Study ◽  
Dark Spot ◽  
Optical Coherence ◽  
Choroidal Neovascular Membrane

Purpose: To describe abnormal dark (hyposignal) and white (hypersignal) lesions observed on optical coherence tomography angiography in central serous chorioretinopathy. Methods: Prospective, multicenter, and descriptive study including patients with active or quiescent central serous chorioretinopathy. All patients had undergone a complete ophthalmic examination. Results: Abnormal dark lesions were detected as “dark spots” and “dark areas” on optical coherence tomography angiography. A “dark spot” could correspond to six different abnormalities: pigment epithelium detachment, subretinal deposit, “Lucency” within surrounding subretinal fibrin, choroidal cavitation, choroidal excavation, and choroidal fluid. A “dark area” could be related to a serous retinal detachment or choriocapillary compression. Abnormal white lesions were also detected: A “white spot” could correspond with the leaking point on fluorescein angiography or with hyper-reflective dots; A “white filamentous pattern” at the Brüch’s membrane level corresponded to abnormal choroidal neovascular vessels. Conclusion: A semiology is described using optical coherence tomography angiography in central serous chorioretinopathy as abnormal dark and white lesions. Multimodal imaging is mandatory in addition to optical coherence tomography angiography to diagnose non-neovascular retinal and choroidal central serous chorioretinopathy lesions. However, optical coherence tomography angiography alone is helpful in detecting choroidal neovascular membrane in central serous chorioretinopathy.

scholarly journals Magnification Effect of Foveal Avascular Zone Measurement Using Optical Coherence Tomography Angiography

2020 ◽  
Vol 5 (2) ◽  
pp. 1-8
Author(s):  
Mika Suda ◽  
Yuji Yoshikawa ◽  
Gaku Terauchi ◽  
Soiti Matsumoto ◽  
Takuhei Shoji ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Axial Length ◽  
Optical Coherence Tomography Angiography ◽  
Foveal Avascular Zone ◽  
Optical Coherence ◽  
En Face ◽  
Avascular Zone ◽  
The Mean ◽  
The Relationship ◽  
Magnification Effect

Purpose: The aim of this study was to evaluate the foveal avascular zone (FAZ) of healthy subjects and examine the magnification effect. Methods: A total of 33 healthy volunteers were enrolled and all subjects were eligible for analysis. Optical coherence tomography angiography (OCTA) examination scanned 3 × 3 mm of the macular area. The FAZ area was measured on the superficial OCTA en face image with and without correction by axial length. The relationship between changes in the FAZ area after correction with the axial length was examined. Results: The mean age was 21.9 ± 0.6 years. The mean axial length was 24.87 ± 1.17 mm and mean spherical equivalent (SE) value was –3.64 ± 2.83 diopters (D). The FAZ area was 0.26 ± 0.10 mm2 before the axial length correction and 0.27 ± 0.10 mm2 after the correction. In the eyes that had an axial length longer than or equal to 26 mm or SE less than or equal to –6 D, the FAZ area after correction was significantly larger than that before correction (p < 0.01). The change of FAZ area after correction with axial length was significantly correlated with the axial length (R2 = 0.88, p < 0.01) or SE value (R2 = 0.55, p < 0.01). Conclusion: FAZ areas were comparable to previous reports. In high myopic cases, the magnification effect needs to be considered when evaluating the FAZ area.

scholarly journals Optical Coherence Tomography Angiography in Central Serous Chorioretinopathy

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Eliana Costanzo ◽  
Salomon Yves Cohen ◽  
Alexandra Miere ◽  
Giuseppe Querques ◽  
Vittorio Capuano ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Neovascularization ◽  
Central Serous Chorioretinopathy ◽  
Multimodal Imaging ◽  
Optical Coherence Tomography Angiography ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Serous Retinal Detachment ◽  
Optical Coherence ◽  
Outer Retina

Purpose. To analyze optical coherence tomography angiography (OCTA) findings in eyes with central serous chorioretinopathy (CSC) and to compare them with those obtained with multimodal imaging.Methods. A series of consecutive patients diagnosed with CSC, underwent OCTA and multimodal imaging, including spectral domain OCT, fluorescein, and indocyanine green angiography. OCTA images were performed at three main depth intervals: automatically segmented outer retina, manually adjusted outer retina, and automatically segmented choriocapillaris.Results. Thirty-three eyes of 32 consecutive patients were analyzed. OCTA showed 3 main anomalies at the choriocapillaris: the presence of dark areas (19/33 eyes) which were frequently associated with serous retinal detachment, presence of dark spots (7/33 eyes) which were frequently associated with retinal pigment epithelium detachment, and presence of abnormal vessels (12/33 eyes) which were frequently, but not systematically, associated with choroidal neovascularization, as confirmed by multimodal imaging.Conclusions. OCTA revealed dark areas and dark spots, which were commonly observed. An abnormal choroidal pattern was also observed in one-third of cases, even when multimodal imaging did not evidence any choroidal neovascularization. Abnormal choroidal vessels should be interpreted with caution, and we could assume that this pathological choroidal vascular pattern observed in many CSC cases could be distinct from CNV.

scholarly journals Morphometric evaluation and measurements of primary pterygium by anterior segment optical coherence tomography and its relation with astigmatism

2021 ◽  
Vol 13 ◽  
pp. 251584142110201
Author(s):  
Anuradha Raj ◽  
Renu Dhasmana ◽  
Harsh Bahadur
Keyword(s):  
Optical Coherence Tomography ◽  
Corneal Thickness ◽  
Anterior Segment ◽  
Cross Sectional Study ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Horizontal Length ◽  
The Mean ◽  
The Relationship ◽  
Primary Pterygium

Purpose: To evaluate the relationship between measurements and various morphometric parameters of primary pterygium on anterior segment optical coherence tomography(AS-OCT) and refractive and keratometric astigmatism. Methods: In this cross-sectional study, patients with primary pterygium were included. The AS-OCT parameters of pterygium consisting of epithelial thickness near apex(µm), apical or head thickness(µm), its thickness at limbus(µm), horizontal length of pterygium(mm), central corneal thickness (µm) and maximum pterygium thickness(mm) were evaluated. Results: Sixty three patients comprising of 63 eyes with a primary pterygium were studied. The mean keratometric and refractive astigmatism were 1.69 ± 3.15 Diopter(D) and0.5 ± 1.4D, respectively. There was a significant association between pterygium grade and stocker’s line with keratometric astigmatism ( p = 0.02, 0.00) respectively. Vertical and horizontal length on slit lamp and horizontal length on AS-OCT showed significant association with keratometric astigmatism ( p = 0.05, 0.00,0.00), respectively. Limbal thickness on AS-OCT showed significant positive correlation with refractive astigmatism ( r = 0.29, p = 0.02). Conclusion: The pterygium grade influences the keratometric astigmatism. Increased limbal thickness of pterygium on AS-OCT leads to more refractive astigmatism.

Evaluation of the choroidal features in pachychoroid spectrum diseases by optical coherence tomography and optical coherence tomography angiography

2019 ◽  
pp. 112067211988709 ◽  
Author(s):  
Sibel Demirel ◽  
Mehmet Fatih Kağan Değirmenci ◽  
Figen Batıoğlu ◽  
Emin Özmert
Keyword(s):  
Optical Coherence Tomography ◽  
Central Serous Chorioretinopathy ◽  
Optical Coherence Tomography Angiography ◽  
Enhanced Depth Imaging ◽  
Optical Coherence ◽  
Flow Area ◽  
Depth Imaging ◽  
Imaging Optical Coherence Tomography ◽  
The Mean ◽  
Pachychoroid Pigment Epitheliopathy

Purpose: To evaluate choroidal area, stroma/lumen ratio, choriocapillaris vessel density, and choriocapillaris flow area in eyes with central serous chorioretinopathy, uncomplicated pachychoroid, and pachychoroid pigment epitheliopathy using enhanced depth imaging-optical coherence tomography and optical coherence tomography angiography. Materials and Methods: This retrospective study analyzed enhanced depth imaging-optical coherence tomography and optical coherence tomography angiography scans of 142 eyes of 92 patients with central serous chorioretinopathy, uncomplicated pachychoroid, and pachychoroid pigment epitheliopathy. The choroidal area and stroma/lumen ratio were measured by binarization of enhanced depth imaging-optical coherence tomography images. Choriocapillaris vessel density and choriocapillaris flow area were measured at the choriocapillaris level by manual segmentation of optical coherence tomography angiography scans. Results: The mean stroma/lumen ratio results were 0.361, 0.345, and 0.354 in central serous chorioretinopathy, uncomplicated pachychoroid, and pachychoroid pigment epitheliopathy groups, respectively ( p > 0.05). The mean whole image choriocapillaris vessel density in uncomplicated pachychoroid group was higher compared with central serous chorioretinopathy and pachychoroid pigment epitheliopathy groups ( p < 0.0001). The mean foveal, parafoveal, and perifoveal choriocapillaris vessel densities were lower in central serous chorioretinopathy group than in uncomplicated pachychoroid group ( p < 0.0001). The mean choriocapillaris flow area was lower in central serous chorioretinopathy group than in uncomplicated pachychoroid and pachychoroid pigment epitheliopathy groups ( p < 0.0001 and p = 0.01, respectively). Conclusion: Our findings suggest that both choroidal vessels and stroma are equally involved in central serous chorioretinopathy, uncomplicated pachychoroid, and pachychoroid pigment epitheliopathy. The choriocapillaris segment seems to be more affected in central serous chorioretinopathy compared to uncomplicated pachychoroid and pachychoroid pigment epitheliopathy. However, the reduced optical coherence tomography angiography signal in central serous chorioretinopathy group could be due to shadowing artifact or choriocapillaris hypoperfusion and further studies with higher quality imaging tools are needed.

scholarly journals Differences in Choroidal Structures Between Idiopathic and Steroid-Induced Central Serous Chorioretinopathy

2018 ◽  
Vol 3 (1) ◽  
pp. 10-15
Author(s):  
Takahiko Izumi ◽  
Hideki Koizumi ◽  
Yohei Takahashi ◽  
Ichiro Maruko ◽  
Shozo Sonoda ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Layer Thickness ◽  
Central Serous Chorioretinopathy ◽  
Choroidal Thickness ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Swept Source ◽  
The Mean ◽  
Binarization Method ◽  
Pathophysiologic Mechanisms

Purpose: The purpose of this article is to investigate the differences in intrachoroidal structures between eyes with idiopathic central serous chorioretinopathy (CSC) and those with steroid-induced CSC. Methods: Thirty eyes of 30 patients with idiopathic CSC and 17 eyes of 15 patients with steroid-induced CSC were studied. Cross-sectional swept-source optical coherence tomography images of eyes with idiopathic and steroid-induced CSC were retrospectively analyzed by the manual layer delineation technique and by the binarization technique. Results: The mean subfoveal choroidal thickness (SCT) was not significantly different between the eyes with idiopathic CSC (408.0 ± 106.6 µm) and those with steroid-induced (389.9 ± 105.4 µm; P = .67) CSC. Manual layer delineation showed that the mean ratio of the large choroidal vessel layer thickness to the SCT was significantly higher in eyes with idiopathic CSC (0.874 ± 0.070) than in eyes with steroid-induced CSC (0.828 ± 0.083; P = .02). The binarization method showed that the mean ratio of the luminal areas to the choroidal areas centered at the fovea was significantly higher in eyes with idiopathic CSC (0.747 ± 0.064) than in eyes with steroid-induced CSC (0.701 ± 0.046; P = .01). Conclusion: The intrachoroidal structures in steroid-induced CSC were different from those in idiopathic CSC. These findings suggest different pathophysiologic mechanisms may be involved in the pathogenesis of these 2 entities.

scholarly journals En Face Optical Coherence Tomography Imaging of the Choroid in a Case with Central Serous Chorioretinopathy during the Course of Vogt-Koyanagi-Harada Disease: A Case Report

2015 ◽  
Vol 6 (3) ◽  
pp. 488-494 ◽  
Author(s):  
Yuki Komuku ◽  
Chiharu Iwahashi ◽  
Shinsaku Yano ◽  
Chika Tanaka ◽  
Tomoya Nakagawa ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Central Serous Chorioretinopathy ◽  
Serous Retinal Detachment ◽  
Steroid Treatment ◽  
Optical Coherence ◽  
En Face Oct ◽  
En Face ◽  
The Right ◽  
Choroidal Vessels ◽  
Vkh Disease

Vogt-Koyanagi-Harada (VKH) disease and central serous chorioretinopathy (CSC) develop serous retinal detachment; however, the treatment of each disease is totally different. Steroids treat VKH but worsen CSC; therefore, it is important to distinguish these diseases. Here, we report a case with CSC which was diagnosed by en face optical coherence tomography (OCT) imaging during the course of VKH disease. A 50-year-old man was referred with blurring of vision in his right eye. Fundus examination showed bilateral optic disc swelling and macular fluid in the right eye. OCT showed thick choroid, and en face OCT images depicted blurry choroid without clear delineation of choroidal vessels. Combined with angiography findings, this patient was diagnosed with VKH disease and treated with steroids. Promptly, fundus abnormalities resolved with the reduction of the choroidal thickness and the choroidal vessels became visible on the en face images. During the tapering of the steroid, serous macular detachment in the right eye recurred several times. Steroid treatment was effective at first; however, at the fourth appearance of submacular fluid, the patient did not respond. At that time, the choroidal vessels on the en face OCT images were clear, which significantly differed from the images at the time of recurrence of VKH. Angiography also suggested CSC-like leakage. The tapering of the steroids was effective in resolving the fluid. Secondary CSC may develop in the eye with VKH after steroid treatment. En face OCT observation of the choroid may be helpful to distinguish each condition.

scholarly journals Personalized analysis of foveal avascular zone with optical coherence tomography angiography

2017 ◽  
Vol 10 (4) ◽  
pp. 32-40
Author(s):  
Maria A Burnasheva ◽  
Alexey N Kulikov ◽  
Dmitrii S Maltsev
Keyword(s):  
Optical Coherence Tomography ◽  
Healthy Subjects ◽  
Optical Coherence Tomography Angiography ◽  
Foveal Avascular Zone ◽  
Optical Coherence ◽  
Free Zone ◽  
Avascular Zone ◽  
The Mean ◽  
The Relationship ◽  
Free Area

Aim. To investigate the relationship between the foveal avascular zone (FAZ) and inner nuclear layer (INL) - free zone in order to provide a personalized approach for evaluation of the FAZ area with optical coherence tomography-angiography (OCTA). Material and methods. Thirty-six healthy individuals (36 eyes) and 9 patients (12 eyes) with nonproliferative diabetic retinopathy (nPDR) were included in this study. The FAZ area as well as INL-free zone were measured in superficial capillary plexus on OCTA images. The FAZ area, INL-free area, and the ratio of the INL-free area to the FAZ area were compared between healthy subjects and nPDR patients. Results. The mean FAZ area in healthy subjects and nPDR patients was 0.33 ± 0.1 and 0.56 ± 0.28 mm2 (p < 0.05), respectively. The mean INL-free zone in healthy subjects and nPDR patients was 0.33 ± 0.07 and 0.28 ± 0.1 mm2 (p > 0.05), respectively. The ratio of the INL-free area to the FAZ area in healthy subjects and nPDR patients was 1.08 ± 0.25 and 0.57 ± 0.2 (p < 0.001), respectively. Receiver operating characteristic analysis showed that the ratio of the INL-free area to the FAZ area had the higher area under curve (0.98; 91.7% sensitivity and 97.2% specificity) compared to the FAZ area (0.8; 66.7% sensitivity and 87.1% specificity) for differentiating nPDR from healthy eyes. Conclusion. This study showed that personalized analysis of the FAZ area based on the relationship between the actual FAZ and INL-free zone has better diagnostic accuracy compared to the conventional FAZ area measurement on OCTA images. (For citation: Burnasheva MA, Kulikov AN, Maltsev DS. Personalized analysis of foveal avascular zone with optical coherence tomography angiography. ­Ophthalmology Journal. 2017;10(4):32-40. doi: 10.17816/OV10432-40).

scholarly journals Fundus Autofluorescence and Optical Coherence Tomography Characteristics in Different Stages of Central Serous Chorioretinopathy

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Mary Ho ◽  
Stephanie H. W. Kwok ◽  
Andrew C. Y. Mak ◽  
Frank H. P. Lai ◽  
Danny S. C. Ng ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Central Serous Chorioretinopathy ◽  
Morphological Changes ◽  
Fundus Autofluorescence ◽  
Serous Retinal Detachment ◽  
Dependent Manner ◽  
Optical Coherence ◽  
Photoreceptor Layer ◽  
Oct Imaging ◽  
Sd Oct

Objective. To describe the morphological changes on fundus autofluorescence (FAF) and spectral-domain optical coherence tomography (SD-OCT) imaging at different chronicity of central serous chorioretinopathy (CSC). Methods. This cross-sectional study included patients with CSC of different chronicity. Changes in FAF scans and morphological changes on SD-OCT were evaluated and compared at different stages of CSC. Results. Sixty-nine patients were enrolled in the study, with a mean age of 52.1 ± 11.8 years. A distinct hypoautofluorescence (AF) pattern was observed at the leakage point in acute CSC (100%). The leakage site was indistinguishable in 48% of the patients with late-chronic CSC. The majority of acute CSC patients showed hyper-AF in the area of serous retinal detachment (SRD), which persisted in the early-chronic stage of CSC. In late-chronic CSC, many cases of hypo-AF (22.2%) and mixed-pattern AF (14.8%) were observed. SD-OCT revealed evolving features of retinal pigment epithelium (RPE) abnormalities in a time-dependent manner: from peaked PEDs in acute CSC to low-lying PEDs in early-chronic CSC and, eventually, flat, irregular PEDs in late-chronic CSC. The average thickness of the photoreceptor layer (inner and outer segment; IS/OS) was 79 μm in the acute group and 55.2 μm in the chronic group. The photoreceptor layer (IS/OS) height was positively associated with visual acuity ( p = 0.002 ). Conclusion. Different stages of CSC present different patterns on FAF and SD-OCT imaging. Chronicity of CSC can be estimated using specific features in these images. Photoreceptor layer (IS/OS) height acts as a good and objective predictor of visual outcomes in CSC patients.

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