scholarly journals Analysis of Left Ventricular Wall Shear Stress during Diastole in Normal Subjects by Vector Flow Mapping

2021 ◽  
Author(s):  
Li-ping Dong ◽  
Zhen-zhen Wang ◽  
Hai-ru Li ◽  
Wei-dong Yu ◽  
jiawei tian
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Diastolic Function ◽  
Linear Regression Analysis ◽  
Normal Subjects ◽  
Left Ventricular ◽  
Flow Mapping ◽  
Vector Flow Mapping ◽  
Increasing Trend ◽  
Wall Shear

Abstract Objective To observe the diastolic wall shear stress (WSS) pattern of the left ventricle (LV) by using vector flow mapping (VFM) in normal subjects. Methods A total of 371 healthy volunteers were recruited into this study and divided into four age groups. The LV WSS was measured at each diastolic phase, and the mapping of WSS was analyzed. Results Among groups I, II and III, The absolute value of WSS of Anterolateral，Inferoseptal and Anterospetal segments in phase D1；WSS values of inferolateral，Inferoseptal and Anterospetal segments in phase D4 all showed an increasing trend with age. In terms of gender differences, In most cases，women had greater diastolic WSS values compared to men. For each age group, the log-transformed WSS value appeared the increasing-decreasing-increasing trend from phase D1 to D4, with a peak value at the rapid filling phase.Multivariate backward stepwise linear regression analysis revealed that the certain segments log-transformed WSS was independently related to conventional parameters in evaluating diastolic function（mitral lateral E/e', septal E/e', mitral lateral e', septal e' and LAVI）.Conclusions In diastolic period, segmental LV WSS shows a regular variation phenomenon and has specific age- and gender-related patterns in different diastolic phases. The mapping of WSS may help identify the diastolic hemodynamic changes or diastolic function phase by phase.

Left ventricular energy loss and wall shear stress assessed by vector flow mapping in patients with hypertrophic cardiomyopathy

2018 ◽  
Vol 34 (9) ◽  
pp. 1383-1391 ◽  
Author(s):  
Ling Ji ◽  
Wenzhi Hu ◽  
Yonghong Yong ◽  
Hongping Wu ◽  
Lei Zhou ◽  
...  
Keyword(s):  
Shear Stress ◽  
Hypertrophic Cardiomyopathy ◽  
Wall Shear Stress ◽  
Energy Loss ◽  
Left Ventricular ◽  
Flow Mapping ◽  
Vector Flow Mapping ◽  
Wall Shear

Blood Flow Visualization and Wall Shear Stress Measurement of Carotid Arteries Using Vascular Vector Flow Mapping

2020 ◽  
Vol 46 (10) ◽  
pp. 2692-2699
Author(s):  
Kozue Saito ◽  
Soichiro Abe ◽  
Masaya Kumamoto ◽  
Yuto Uchihara ◽  
Akito Tanaka ◽  
...  
Keyword(s):  
Blood Flow ◽  
Shear Stress ◽  
Wall Shear Stress ◽  
Flow Visualization ◽  
Carotid Arteries ◽  
Stress Measurement ◽  
Flow Mapping ◽  
Vector Flow Mapping ◽  
Wall Shear ◽  
Wall Shear Stress Measurement

Wall Shear Stress in the Middle Cerebral Artery of HM II Patients - A Prospective, Mechanistic Study Using Vector Flow Mapping

2019 ◽  
Vol 38 (4) ◽  
pp. S424
Author(s):  
K. Akiyama ◽  
R. Ji ◽  
F. Castagna ◽  
A. Pinsino ◽  
J.R. Cockcroft ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Mechanistic Study ◽  
Flow Mapping ◽  
Vector Flow Mapping ◽  
Wall Shear

scholarly journals Effects of a Short-Term Left Ventricular Assist Device on Hemodynamics in a Heart Failure Patient-Specific Aorta Model: A CFD Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Yu Wang ◽  
Junwei Wang ◽  
Jing Peng ◽  
Mingming Huo ◽  
Zhiqiang Yang ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Pressure Difference ◽  
Left Ventricular ◽  
Patient Specific ◽  
Short Term ◽  
Ventricular Assist ◽  
Left Ventricular Assist ◽  
Wall Shear ◽  
Hemodynamic Performance

Patients with heart failure (HF) or undergoing cardiogenic shock and percutaneous coronary intervention require short-term cardiac support. Short-term cardiac support using a left ventricular assist device (LVAD) alters the pressure and flows of the vasculature by enhancing perfusion and improving the hemodynamic performance for the HF patients. However, due to the position of the inflow and outflow of the LVAD, the local hemodynamics within the aorta is altered with the LVAD support. Specifically, blood velocity, wall shear stress, and pressure difference are altered within the aorta. In this study, computational fluid dynamics (CFD) was used to elucidate the effects of a short-term LVAD for hemodynamic performance in a patient-specific aorta model. The three-dimensional (3D) geometric models of a patient-specific aorta and a short-term LVAD, Impella CP, were created. Velocity, wall shear stress, and pressure difference in the patient-specific aorta model with the Impella CP assistance were calculated and compared with the baseline values of the aorta without Impella CP support. Impella CP support augmented cardiac output, blood velocity, wall shear stress, and pressure difference in the aorta. The proposed CFD study could analyze the quantitative changes in the important hemodynamic parameters while considering the effects of Impella CP, and provide a scientific basis for further predicting and assessing the effects of these hemodynamic signals on the aorta.

scholarly journals Evaluation of Aortic Blood Flow and Wall Shear Stress in Aortic Stenosis and Its Association With Left Ventricular Remodeling

2016 ◽  
Vol 9 (3) ◽  
Author(s):  
Florian von Knobelsdorff-Brenkenhoff ◽  
Achudhan Karunaharamoorthy ◽  
Ralf Felix Trauzeddel ◽  
Alex J. Barker ◽  
Edyta Blaszczyk ◽  
...  
Keyword(s):  
Blood Flow ◽  
Shear Stress ◽  
Wall Shear Stress ◽  
Aortic Stenosis ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Aortic Blood Flow ◽  
Aortic Blood ◽  
Wall Shear

scholarly journals Mis-sizing of stent promotes intimal hyperplasia: impact of endothelial shear and intramural stress

2011 ◽  
Vol 301 (6) ◽  
pp. H2254-H2263 ◽  
Author(s):  
Henry Y. Chen ◽  
Anjan K. Sinha ◽  
Jenny S. Choy ◽  
Hai Zheng ◽  
Michael Sturek ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Coronary Arteries ◽  
Vessel Wall ◽  
Solid Mechanics ◽  
Linear Regression Analysis ◽  
Wall Stress ◽  
Linear Relations ◽  
Flow Disturbances ◽  
Wall Shear

Stent can cause flow disturbances on the endothelium and compliance mismatch and increased stress on the vessel wall. These effects can cause low wall shear stress (WSS), high wall shear stress gradient (WSSG), oscillatory shear index (OSI), and circumferential wall stress (CWS), which may promote neointimal hyperplasia (IH). The hypothesis is that stent-induced abnormal fluid and solid mechanics contribute to IH. To vary the range of WSS, WSSG, OSI, and CWS, we intentionally mismatched the size of stents to that of the vessel lumen. Stents were implanted in coronary arteries of 10 swine. Intravascular ultrasound (IVUS) was used to size the coronary arteries and stents. After 4 wk of stent implantation, IVUS was performed again to determine the extent of IH. In conjunction, computational models of actual stents, the artery, and non-Newtonian blood were created in a computer simulation to yield the distribution of WSS, WSSG, OSI, and CWS in the stented vessel wall. An inverse relation ( R2 = 0.59, P < 0.005) between WSS and IH was found based on a linear regression analysis. Linear relations between WSSG, OSI, and IH were observed ( R2 = 0.48 and 0.50, respectively, P < 0.005). A linear relation ( R2 = 0.58, P < 0.005) between CWS and IH was also found. More statistically significant linear relations between the ratio of CWS to WSS (CWS/WSS), the products CWS × WSSG and CWS × OSI, and IH were observed ( R2 = 0.67, 0.54, and 0.56, respectively, P < 0.005), suggesting that both fluid and solid mechanics influence the extent of IH. Stents create endothelial flow disturbances and intramural wall stress concentrations, which correlate with the extent of IH formation, and these effects were exaggerated with mismatch of stent/vessel size. These findings reveal the importance of reliable vessel and stent sizing to improve the mechanics on the vessel wall and minimize IH.

scholarly journals Aortic flow and wall shear stress in aortic stenosis is associated with left ventricular remodeling

2016 ◽  
Vol 18 (S1) ◽  
Author(s):  
Florian von Knobelsdorff-Brenkenhoff ◽  
Achudhan Karunaharamoorthy ◽  
Ralf F Trauzeddel ◽  
Alex J Barker ◽  
Edyta Blaszczyk ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Aortic Stenosis ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Aortic Flow ◽  
Wall Shear
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