scholarly journals Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial

2020 ◽  
Author(s):  
Andrés Díaz-López ◽  
Nerea Becerra-Tomás ◽  
Verónica Ruiz ◽  
Estefanía Toledo ◽  
Nancy Babio ◽  
...  
Keyword(s):  
Weight Loss ◽  
Randomized Controlled Trial ◽  
Renal Function ◽  
Lifestyle Intervention ◽  
Controlled Trial ◽  
Support Intervention ◽  
Randomized Controlled ◽  
Urine Albumin ◽  
And Control ◽  
Registration Date

Abstract BackgroundLarge randomized trials testing the effect of a multifactorial weight-loss lifestyle intervention including Mediterranean diet (MedDiet) on renal function are lacking. Here, we evaluated the 1-year efficacy of an intensive weight-loss intervention with an energy-reduced MedDiet (erMedDiet) plus increased physical activity (PA) on renal function.MethodsRandomized controlled “PREvención con DIeta MEDiterránea-Plus” (PREDIMED-Plus) trial conducted in 23 Spanish centers comprising 208 primary care clinics. Overweight/obese (n=6719) adults aged 55-75 years with metabolic syndrome were randomly assigned (1:1) to an intensive weight-loss lifestyle intervention with an erMedDiet, PA promotion and behavioral support (intervention) or usual-care advice to adhere to an energy-unrestricted MedDiet (control) between Sept-2013 and Dec-2016. The primary outcome was 1-year change in estimated glomerular filtration rate (eGFR). Secondary outcomes were changes in urine albumin-to-creatinine ratio (UACR), incidence of chronic kidney disease (CKD, eGFR<60 ml/min/1.73m2 or stage 3 CKD) and micro-macroalbuminuria (UACR≥30 mg/g), and reversion of stage 3 to 2 CKD (eGFR between 60-<90 ml/min/1.73m2) or micro-macroalbuminuria.ResultsAfter 1-year eGFR declined by 0.66 and 1.25 ml/min/1.73m2 in the intervention and control groups, respectively (mean difference, 0.58 ml/min/1.73m2; 95%CI, 0.15 to 1.02). There were no between-group differences in mean UACR or micro-macroalbuminuria changes. CKD incidence and reversion of stage 3 to 2 CKD were 40% lower (HR 0.60; 0.44 to 0.82) and 92% higher (HR 1.92; 1.35 to 2.73), respectively, in the intervention group.ConclusionsThe PREDIMED-Plus lifestyle intervention is an effective approach for preserving renal function and preventing/delaying CKD progression in overweight/obese adults.Trial RegistrationThis study was registered at the International Standard Randomized Controlled Trial. isrctn.com Identifier: ISRCTN89898870. Registration date: 24 July 2014-Retrospectively registered.

scholarly journals Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial

2021 ◽  
pp. 1-14
Author(s):  
Andrés Díaz-López ◽  
Nerea Becerra-Tomás ◽  
Verónica Ruiz ◽  
Estefania Toledo ◽  
Nancy Babio ◽  
...  
Keyword(s):  
Weight Loss ◽  
Renal Function ◽  
Lifestyle Intervention ◽  
Controlled Trial ◽  
Intervention Group ◽  
Obese Adults ◽  
Support Intervention ◽  
Randomized Controlled ◽  
Urine Albumin ◽  
And Control

<b><i>Introduction:</i></b> Large randomized trials testing the effect of a multifactorial weight-loss lifestyle intervention including Mediterranean diet (MedDiet) on renal function are lacking. Here, we evaluated the 1-year efficacy of an intensive weight-loss intervention with an energy-reduced MedDiet (erMedDiet) plus increased physical activity (PA) on renal function. <b><i>Methods:</i></b> Randomized controlled “PREvención con DIeta MEDiterránea-Plus” (PREDIMED-Plus) trial is conducted in 23 Spanish centers comprising 208 primary care clinics. Overweight/obese (<i>n</i> = 6,719) adults aged 55–75 years with metabolic syndrome were randomly assigned (1:1) to an intensive weight-loss lifestyle intervention with an erMedDiet, PA promotion, and behavioral support (intervention) or usual-care advice to adhere to an energy-unrestricted MedDiet (control) between September 2013 and December 2016. The primary outcome was 1-year change in estimated glomerular filtration rate (eGFR). Secondary outcomes were changes in urine albumin-to-creatinine ratio (UACR), incidence of moderately/severely impaired eGFR (&#x3c;60 mL/min/1.73 m<sup>2</sup>) and micro- to macroalbuminuria (UACR ≥30 mg/g), and reversion of moderately (45 to &#x3c;60 mL/min/1.73 m<sup>2</sup>) to mildly impaired GFR (60 to &#x3c;90 mL/min/1.73 m<sup>2</sup>) or micro- to macroalbuminuria. <b><i>Results:</i></b> After 1 year, eGFR declined by 0.66 and 1.25 mL/min/1.73 m<sup>2</sup> in the intervention and control groups, respectively (mean difference, 0.58 mL/min/1.73 m<sup>2</sup>; 95% CI: 0.15–1.02). There were no between-group differences in mean UACR or micro- to macroalbuminuria changes. Moderately/severely impaired eGFR incidence and reversion of moderately to mildly impaired GFR were 40% lower (HR 0.60; 0.44–0.82) and 92% higher (HR 1.92; 1.35–2.73), respectively, in the intervention group. <b><i>Conclusions:</i></b> The PREDIMED-Plus lifestyle intervention approach may preserve renal function and delay CKD progression in overweight/obese adults.

scholarly journals Intensive practical lifestyle intervention improves endothelial function in metabolic syndrome independent of weight loss: a randomized controlled trial

Metabolism ◽  
2011 ◽  
Vol 60 (12) ◽  
pp. 1736-1740 ◽  
Author(s):  
Beatriz G.S. Seligman ◽  
Carisi A. Polanczyk ◽  
Angela S.B. Santos ◽  
Murilo Foppa ◽  
Mauricio Junges ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Weight Loss ◽  
Randomized Controlled Trial ◽  
Endothelial Function ◽  
Lifestyle Intervention ◽  
Controlled Trial ◽  
Randomized Controlled

scholarly journals A Self-Directed Mobile Intervention (WaznApp) to Promote Weight Control Among Employees at a Lebanese University: Protocol for a Feasibility Pilot Randomized Controlled Trial (Preprint)

2018 ◽  
Author(s):  
Marco Bardus ◽  
Ghassan Hamadeh ◽  
Bouchra Hayek ◽  
Rawan Al Kherfan
Keyword(s):  
Weight Loss ◽  
Randomized Controlled Trial ◽  
Weight Management ◽  
Weight Control ◽  
Mobile Apps ◽  
Controlled Trial ◽  
Overweight And Obesity ◽  
Randomized Controlled ◽  
Obesity And Overweight ◽  
And Control

BACKGROUND Overweight and obesity have become major health problems globally with more than 1.9 billion overweight adults. In Lebanon, the prevalence of obesity and overweight is 65.4% combined. Risk factors of obesity and overweight are preventable and can be addressed by modifications in the environment and in an individual’s lifestyle. Mobile technologies are increasingly used in behavioral, self-directed weight management interventions, providing users with additional opportunities to attain weight control (weight loss, weight gain prevention, etc). Mobile apps may allow for the delivery of Just-in-Time Adaptive Interventions (JITAIs), which provide support through skill building, emotional support, and instrumental support, following the participants’ progress. A few commercially available apps offer JITAI features, but no studies have tested their efficacy. OBJECTIVE The primary objective of this study is to examine the feasibility of a self-directed weight loss intervention, targeting employees of an academic institution, using a virtual coaching app with JITAI features (Lark) and a self-help calorie-counting app (MyFitnessPal). The secondary objective is to estimate the effects of the intervention on main study outcomes. METHODS This study is a single-center, parallel, randomized controlled trial with 2 study arms (intervention and control). Participants will be randomly allocated in equal proportions to the intervention (Lark) and control groups (MyFitnessPal). To be eligible for this study, participants must be employed full- or part-time at the university or its medical center, able to read English, have a smartphone, and be interested in controlling their weight. Recruitment strategies entail email invitations, printed posters, and social media postings. We will assess quantitative rates of recruitment, adherence, and retention, self-reported app quality using the user version of the Mobile App Rating Scale. We will also assess changes in weight-related outcomes (absolute weight and waist circumference), behavioral outcomes (physical activity and diet), and cognitive factors (motivation to participate in the trial and to manage weight). RESULTS WaznApp was funded in June 2017, and recruitment started in March 2018. CONCLUSIONS This study will provide information as to whether the selected mobile apps offer a feasible solution for promoting weight management in an academic workplace. The results will inform a larger trial whose results might be replicated in similar workplaces in Lebanon and the Middle East and North Africa region, and will be used as a benchmark for further investigations in other settings and similar target groups. CLINICALTRIAL ClinicalTrials.gov NCT03321331; https://clinicaltrials.gov/ct2/show/NCT03321331 (Archived by WebCite at http://www.webcitation.org/6ys9NOLo5) REGISTERED REPORT IDENTIFIER RR1-10.2196/9793

scholarly journals Clinic Versus Online Social Network�Delivered Lifestyle Interventions: Protocol for the Get Social Noninferiority Randomized Controlled Trial (Preprint)

2017 ◽  
Author(s):  
Monica L Wang ◽  
Molly E Waring ◽  
Danielle E Jake-Schoffman ◽  
Jessica L Oleski ◽  
Zachary Michaels ◽  
...  
Keyword(s):  
Weight Loss ◽  
Randomized Controlled Trial ◽  
Social Network ◽  
Lifestyle Intervention ◽  
Online Social Networks ◽  
Controlled Trial ◽  
Online Social Network ◽  
Lifestyle Interventions ◽  
Obese Adults ◽  
Randomized Controlled

BACKGROUND Online social networks may be a promising modality to deliver lifestyle interventions by reducing cost and burden. Although online social networks have been integrated as one component of multimodality lifestyle interventions, no randomized trials to date have compared a lifestyle intervention delivered entirely via online social network with a traditional clinic-delivered intervention. OBJECTIVE This paper describes the design and methods of a noninferiority randomized controlled trial, testing (1) whether a lifestyle intervention delivered entirely through an online social network would produce weight loss that would not be appreciably worse than that induced by a traditional clinic-based lifestyle intervention among overweight and obese adults and (2) whether the former would do so at a lower cost. METHODS Adults with body mass index (BMI) between 27 and 45 kg/m2 (N=328) will be recruited from the communities in central Massachusetts. These overweight or obese adults will be randomized to two conditions: a lifestyle intervention delivered entirely via the online social network Twitter (Get Social condition) and an in-person group-based lifestyle intervention (Traditional condition) among overweight and obese adults. Measures will be obtained at baseline, 6 months, and 12 months after randomization. The primary noninferiority outcome is percentage weight loss at 12 months. Secondary noninferiority outcomes include dietary intake and moderate intensity physical activity at 12 months. Our secondary aim is to compare the conditions on cost. Exploratory outcomes include treatment retention, acceptability, and burden. Finally, we will explore predictors of weight loss in the online social network condition. RESULTS The final wave of data collection is expected to conclude in June 2019. Data analysis will take place in the months following and is expected to be complete in September 2019. CONCLUSIONS Findings will extend the literature by revealing whether delivering a lifestyle intervention via an online social network is an effective alternative to the traditional modality of clinic visits, given the former might be more scalable and feasible to implement in settings that cannot support clinic-based models. CLINICALTRIAL ClinicalTrials.gov NCT02646618; https://clinicaltrials.gov/ct2/show/NCT02646618 (Archived by WebCite at http://www.webcitation.org/6v20waTFW)

scholarly journals Renal Function Following Three Distinct Weight Loss Dietary Strategies During 2 Years of a Randomized Controlled Trial

Diabetes Care ◽  
2013 ◽  
Vol 36 (8) ◽  
pp. 2225-2232 ◽  
Author(s):  
A. Tirosh ◽  
R. Golan ◽  
I. Harman-Boehm ◽  
Y. Henkin ◽  
D. Schwarzfuchs ◽  
...  
Keyword(s):  
Weight Loss ◽  
Randomized Controlled Trial ◽  
Renal Function ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Dietary Strategies
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