Gene Regulation in Memory Formation and Circadian Rhythms

1994 ◽  
Author(s):  
Arnold Eskin
Keyword(s):  
Gene Regulation ◽  
Circadian Rhythms ◽  
Memory Formation

scholarly journals Neuronal CTCF Is Necessary for Basal and Experience-Dependent Gene Regulation, Memory Formation, and Genomic Structure of BDNF and Arc

Cell Reports ◽  
2016 ◽  
Vol 17 (9) ◽  
pp. 2418-2430 ◽  
Author(s):  
Dev Sharan Sams ◽  
Stefano Nardone ◽  
Dmitriy Getselter ◽  
Dana Raz ◽  
Moran Tal ◽  
...  
Keyword(s):  
Gene Regulation ◽  
Genomic Structure ◽  
Memory Formation

scholarly journals Circadian rhythms and memory formation

2010 ◽  
Vol 11 (8) ◽  
pp. 577-588 ◽  
Author(s):  
Jason R. Gerstner ◽  
Jerry C. P. Yin
Keyword(s):  
Circadian Rhythms ◽  
Memory Formation

scholarly journals Dynamical Mechanisms for Gene Regulation Mediated by Two Noncoding RNAs in Long-Term Memory Formation

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Lijie Hao ◽  
Zhuoqin Yang
Keyword(s):  
Gene Expression ◽  
Gene Regulation ◽  
Regulation Of Gene Expression ◽  
Network Motif ◽  
Noncoding Rnas ◽  
Memory Formation ◽  
Long Term Memory ◽  
Term Memory ◽  
Motif Model

Noncoding RNAs such as miRNAs and piRNAs have long-lasting effects on the regulation of gene expression involved in long-term synaptic changes. To characterize gene regulation mediated by small noncoding RNAs associated with long-term memory in Aplysia, we consider two noncoding RNAs stimulated by 5-HT into a gene regulatory network motif model, including miR-124 that binds to and inhibits the mRNA of CREB1 and piR-F that facilitates serotonin-dependent DNA methylation to lead to repression of CREB2. Codimension-1 and -2 bifurcation analyses of 5-HT regulating both miR-124 and piR-F and a negative feedback strength for oscillation reveal rich dynamical properties of bistability and oscillations robust to variations in all other parameters. More importantly, we verify three stimulus protocols of 5-HT in experiments by our model and find that application of five pulses of 5-HT leads to a transient decrease of miR-124 but increase of piR-F concentrations, which matters sustained high level of CREB1 concentration associated with long-term memory. Furthermore, we perform bifurcation analyses for the concentrations of miR-124 and piR-F as two parameters to explore dynamical mechanisms underlying the epigenetic regulation in long-term memory formation. This study provides insights into revealing regulatory roles of epigenetic changes in gene expression involving noncoding RNAs associated with synaptic plasticity.

Anatomy of Gene Regulation

2003 ◽  
Author(s):  
Panagiotis A. Tsonis
Keyword(s):  
Gene Regulation

The Biological Clock and Sleep in the Elderly

2006 ◽  
Vol 19 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Myriam Juda ◽  
Mirjam Münch ◽  
Anna Wirz-Justice ◽  
Martha Merrow ◽  
Till Roenneberg
Keyword(s):  
Circadian Rhythms ◽  
Biological Clock ◽  
The Elderly ◽  
Early Morning ◽  
Behavioral Changes ◽  
Older Age ◽  
Age Related ◽  
Theoretical Considerations ◽  
Sleep Difficulties ◽  
Circadian Biology

Abstract: Among many other changes, older age is characterized by advanced sleep-wake cycles, changes in the amplitude of various circadian rhythms, as well as reduced entrainment to zeitgebers. These features reveal themselves through early morning awakenings, sleep difficulties at night, and a re-emergence of daytime napping. This review summarizes the observations concerning the biological clock and sleep in the elderly and discusses the documented and theoretical considerations behind these age-related behavioral changes, especially with respect to circadian biology.

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