A Structure Based, Solid Phase Synthesis Approach to the Development of Novel Selective Estrogen Receptor Modulatory Steroids

2000 ◽  
Author(s):  
Robert Hanson
2015 ◽  
Vol 17 (9) ◽  
pp. 2182-2185 ◽  
Author(s):  
Jordan D. Goodreid ◽  
Eduardo da Silveira dos Santos ◽  
Robert A. Batey

Tetrahedron ◽  
2012 ◽  
Vol 68 (36) ◽  
pp. 7472-7478 ◽  
Author(s):  
Joel Boeglin ◽  
Claire Venin ◽  
Gilles Guichard

Synlett ◽  
2018 ◽  
Vol 29 (10) ◽  
pp. 1346-1350 ◽  
Author(s):  
Luísa Carvalho ◽  
André Sequeira ◽  
Ana Lourenço ◽  
Luísa Ferreira ◽  
Paula Branco ◽  
...  

An efficient solid-phase synthesis approach is here reported for the first time to prepare the EGFR inhibitor Gefitinib. The five-step synthetic strategy used FMP resin as the solid support, and FTIR and colorimetric assays were used to track the reaction’s progress. Gefitinib was obtained with an overall yield of 40%.


2007 ◽  
Vol 85 (4) ◽  
pp. 274-282 ◽  
Author(s):  
Robert A Donga ◽  
Tak-Hang Chan ◽  
Masad J Damha

An oligoribonucleotide has been synthesized in solution, using an ionic-liquid-based soluble tag at a scale several hundred times that of a standard solid-phase synthesis approach. Ogilvie's 2′-TBDMS strategy was adopted, and because of the resultant increase in lipophilicity, it allowed an easier purification of the growing oligomer compared with the previously observed for DNA, which does not require 2′ protection. The procedure is illustrated by the synthesis of the pentaribonucleotide sequence AGAUC, corresponding to a segment of the tRNAfMet from E. coli.Key words: solution-phase RNA synthesis, ionic-liquid tag.


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