Self-Defense Mechanisms of Normal Breast Cells

2005 ◽  
Author(s):  
Carolyn A. Larabell
Keyword(s):  
Defense Mechanisms ◽  
Normal Breast ◽  
Self Defense ◽  
Breast Cells

scholarly journals Targeting of GLUT5 for Transporter-Mediated Drug-Delivery Is Contingent upon Substrate Hydrophilicity

2021 ◽  
Vol 22 (10) ◽  
pp. 5073
Author(s):  
Nazanin Nahrjou ◽  
Avik Ghosh ◽  
Marina Tanasova
Keyword(s):  
Cancer Cells ◽  
Normal Breast ◽  
Proof Of Concept ◽  
Drug Conjugates ◽  
High Fructose ◽  
Specific Cytotoxicity ◽  
Breast Cells ◽  
Substrate Tolerance ◽  
Bioactive Agents ◽  
Positive Breast Cancer

Specific link between high fructose uptake and cancer development and progression highlighted fructose transporters as potential means to achieve GLUT-mediated discrimination between normal and cancer cells. The gained expression of fructose-specific transporter GLUT5 in various cancers offers a possibility for developing cancer-specific imaging and bioactive agents. Herein, we explore the feasibility of delivering a bioactive agent through cancer-relevant fructose-specific transporter GLUT5. We employed specific targeting of GLUT5 by 2,5-anhydro-D-mannitol and investigated several drug conjugates for their ability to induce cancer-specific cytotoxicity. The proof-of-concept analysis was carried out for conjugates of chlorambucil (CLB) in GLUT5-positive breast cancer cells and normal breast cells. The cytotoxicity of conjugates was assessed over 24 h and 48 h, and significant dependence between cancer-selectivity and conjugate size was observed. The differences were found to relate to the loss of GLUT5-mediated uptake upon increased conjugate size and hydrophobicity. The findings provide information on the substrate tolerance of GLUT5 and highlight the importance of maintaining appropriate hydrophilicity for GLUT-mediated delivery.

scholarly journals SCHIZOPHRENIA SYMPTOMS ACUTE IN TEDDY ALIAS ANDREW IN THE “SHUTTER ISLAND” NOVEL BY DENNIS LEHANE

JURNAL BASIS ◽  
2019 ◽  
Vol 6 (2) ◽  
pp. 225
Author(s):  
Elfi Rahmi ◽  
Tomi Arianto
Keyword(s):  
Mental Disorder ◽  
Sigmund Freud ◽  
Defense Mechanisms ◽  
Traumatic Event ◽  
Traumatic Events ◽  
Main Character ◽  
Acute Schizophrenia ◽  
Self Defense ◽  
Recovery Treatment ◽  
Fictional Story

This research discussed about schizophrenia symptoms in Teddy alias Andrew Laedis that was acute and dangerous and also discussed the psychodrama treatment for Andrew. The main character is described to have a dangerous illness which is schizophrenia due to get from his traumatic events in world of war. Some of traumatic event that Andrew is experienced actually like when Andrew killed hundred soldier during the war in Dachau, his guilt because he did not bring his wife, Dolores to psychiatrists then unpredictable his wife killed her three children and drowning her child in a pond and regret for the rest of his life who was forced to kill his beloved wife until die and he finally lost all his family. Andrew cannot escape from the reality and without unconsciously he became experiencing mental disorder. The fictional story written by Dennis Lehane (2003.This novel was using the theory of psychoanalysis approach by Sigmund Freud. By using the concept of Sigmund's theory this research examined the symptoms of acute schizophrenia in Teddy alias Andrew's character which showed that his id is more dominant than his ego and the superego did not almost non-existent. Andrew points out three types of self defense mechanisms, namely, denial projections, regression and displacement. Meanwhile, the process of psychiatric recovery treatment by Dr. Cawley is used a psychodrama.

scholarly journals Effect of SA96 on self-defense mechanisms in mice

1983 ◽  
Vol 33 ◽  
pp. 124
Author(s):  
Masaaki Hayashi ◽  
Hideyasu Yamauchi ◽  
Tadashi Iso ◽  
Chiyuki Abe ◽  
Yuichi Shiokawa
Keyword(s):  
Defense Mechanisms ◽  
Self Defense

Stimulation of TLRs by LMW‐HA induces self‐defense mechanisms in vaginal epithelium

2010 ◽  
Vol 89 (5) ◽  
pp. 630-639 ◽  
Author(s):  
Giuseppina F Dusio ◽  
Diego Cardani ◽  
Laura Zanobbio ◽  
Martina Mantovani ◽  
Patrizia Luchini ◽  
...  
Keyword(s):  
Defense Mechanisms ◽  
Vaginal Epithelium ◽  
Self Defense ◽  
Stimulation Of
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