The Use of Inhibitors of Mechanosensitive Ion Channels as Local Inhibitors of Peripheral Pain

2014 ◽  
Author(s):  
Frederick Sachs
Keyword(s):  
Ion Channels ◽  
Mechanosensitive Ion Channels ◽  
Peripheral Pain

scholarly journals Biophysics and Modeling of Mechanotransduction in Neurons: A Review

Mathematics ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 323
Author(s):  
Martina Nicoletti ◽  
Letizia Chiodo ◽  
Alessandro Loppini
Keyword(s):  
Ion Channels ◽  
Cell Membrane ◽  
Sensory Neurons ◽  
Neuronal Cell ◽  
Molecular Processes ◽  
Biological Mechanisms ◽  
Mechanosensitive Ion Channels ◽  
Complex Interactions ◽  
Different Types ◽  
Intracellular Organelles

Mechanosensing is a key feature through which organisms can receive inputs from the environment and convert them into specific functional and behavioral outputs. Mechanosensation occurs in many cells and tissues, regulating a plethora of molecular processes based on the distribution of forces and stresses both at the cell membrane and at the intracellular organelles levels, through complex interactions between cells’ microstructures, cytoskeleton, and extracellular matrix. Although several primary and secondary mechanisms have been shown to contribute to mechanosensation, a fundamental pathway in simple organisms and mammals involves the presence of specialized sensory neurons and the presence of different types of mechanosensitive ion channels on the neuronal cell membrane. In this contribution, we present a review of the main ion channels which have been proven to be significantly involved in mechanotransduction in neurons. Further, we discuss recent studies focused on the biological mechanisms and modeling of mechanosensitive ion channels’ gating, and on mechanotransduction modeling at different scales and levels of details.

Non-contact long-range magnetic stimulation of mechanosensitive ion channels in freely moving animals

2021 ◽  
Author(s):  
Jung-uk Lee ◽  
Wookjin Shin ◽  
Yongjun Lim ◽  
Jungsil Kim ◽  
Woon Ryoung Kim ◽  
...  
Keyword(s):  
Ion Channels ◽  
Long Range ◽  
Magnetic Stimulation ◽  
Mechanosensitive Ion Channels ◽  
Freely Moving ◽  
Stimulation Of

Channeling Force in the Brain: Mechanosensitive Ion Channels Choreograph Mechanics and Malignancies

2021 ◽  
Author(s):  
Ali Momin ◽  
Shahrzad Bahrampour ◽  
Hyun-Kee Min ◽  
Xin Chen ◽  
Xian Wang ◽  
...  
Keyword(s):  
Ion Channels ◽  
Mechanosensitive Ion Channels ◽  
The Brain

scholarly journals Reprint of: Mechanosensitive ion channels in cell migration

2021 ◽  
pp. 203730
Author(s):  
Brenda Canales Coutiño ◽  
Roberto Mayor
Keyword(s):  
Cell Migration ◽  
Ion Channels ◽  
Mechanosensitive Ion Channels

The functions of mechanosensitive ion channels in tooth and bone tissues

2021 ◽  
Vol 78 ◽  
pp. 109877
Author(s):  
Fang Pei ◽  
Jialing Liu ◽  
Lan Zhang ◽  
Xuefeng Pan ◽  
Wei Huang ◽  
...  
Keyword(s):  
Ion Channels ◽  
Mechanosensitive Ion Channels
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