Identification of Small Molecules against Botulinum Neurotoxin B Binding to Neuronal Cells at Ganglioside GT1b Binding Site with Low to Moderate Affinity

2014 ◽  
Author(s):  
Nagarajan Pattabiraman ◽  
Carolyn Chambers ◽  
Ayesha Adil ◽  
Gregory E. Garcia
Keyword(s):  
Small Molecules ◽  
Binding Site ◽  
Botulinum Neurotoxin ◽  
Neuronal Cells ◽  
Botulinum Neurotoxin B ◽  
Ganglioside Gt1b

In vitro potency determination of botulinum neurotoxin B based on its receptor-binding and proteolytic characteristics

2016 ◽  
Vol 34 ◽  
pp. 97-104 ◽  
Author(s):  
Emina Wild ◽  
Ursula Bonifas ◽  
Jolanta Klimek ◽  
Jan-Hendrik Trösemeier ◽  
Beate Krämer ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Botulinum Neurotoxin ◽  
Botulinum Neurotoxin B

scholarly journals ADP-ribosylation of 24–26-kDa GTP-binding Proteins Localized in Neuronal and Non-neuronal Cells by Botulinum Neurotoxin D

1989 ◽  
Vol 264 (2) ◽  
pp. 706-712
Author(s):  
I Matsuoka ◽  
H Sakuma ◽  
B Syuto ◽  
K Moriishi ◽  
S Kubo ◽  
...  
Keyword(s):  
Botulinum Neurotoxin ◽  
Binding Proteins ◽  
Neuronal Cells ◽  
Adp Ribosylation ◽  
Gtp Binding Proteins ◽  
Gtp Binding

scholarly journals Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor

2009 ◽  
Vol 110 (6) ◽  
pp. 1942-1954 ◽  
Author(s):  
Andreas Rummel ◽  
Kirstin Häfner ◽  
Stefan Mahrhold ◽  
Natallia Darashchonak ◽  
Matthew Holt ◽  
...  
Keyword(s):  
Binding Site ◽  
Botulinum Neurotoxin ◽  
Botulinum Neurotoxins

Structural basis of cell surface receptor recognition by botulinum neurotoxin B

Nature ◽  
2006 ◽  
Vol 444 (7122) ◽  
pp. 1096-1100 ◽  
Author(s):  
Qing Chai ◽  
Joseph W. Arndt ◽  
Min Dong ◽  
William H. Tepp ◽  
Eric A. Johnson ◽  
...  
Keyword(s):  
Cell Surface ◽  
Botulinum Neurotoxin ◽  
Cell Surface Receptor ◽  
Structural Basis ◽  
Receptor Recognition ◽  
Surface Receptor ◽  
Botulinum Neurotoxin B

scholarly journals Substrate Recognition of VAMP-2 by Botulinum Neurotoxin B and Tetanus Neurotoxin

2008 ◽  
Vol 283 (30) ◽  
pp. 21153-21159 ◽  
Author(s):  
Sheng Chen ◽  
Cherisse Hall ◽  
Joseph T. Barbieri
Keyword(s):  
Botulinum Neurotoxin ◽  
Substrate Recognition ◽  
Tetanus Neurotoxin ◽  
Botulinum Neurotoxin B

scholarly journals Synthetic substrate for application in both high and low throughput assays for botulinum neurotoxin B protease inhibitors

2009 ◽  
Vol 19 (20) ◽  
pp. 5848-5850 ◽  
Author(s):  
Nicholas T. Salzameda ◽  
Joseph T. Barbieri ◽  
Kim D. Janda
Keyword(s):  
Protease Inhibitors ◽  
Botulinum Neurotoxin ◽  
Synthetic Substrate ◽  
Botulinum Neurotoxin B

Recombinant C fragment of botulinum neurotoxin B serotype (rBoNTB (HC)) immune response and protection in the rhesus monkey

Toxicon ◽  
2006 ◽  
Vol 47 (8) ◽  
pp. 877-884 ◽  
Author(s):  
James Boles ◽  
Michael West ◽  
Vicki Montgomery ◽  
Ralph Tammariello ◽  
M. Louise M. Pitt ◽  
...  
Keyword(s):  
Immune Response ◽  
Rhesus Monkey ◽  
Botulinum Neurotoxin ◽  
Botulinum Neurotoxin B

Botulinum neurotoxin B–host receptor recognition: it takes two receptors to tango

2007 ◽  
Vol 14 (1) ◽  
pp. 9-10 ◽  
Author(s):  
Michael R Baldwin ◽  
Jung-Ja P Kim ◽  
Joseph T Barbieri
Keyword(s):  
Botulinum Neurotoxin ◽  
Receptor Recognition ◽  
Botulinum Neurotoxin B

scholarly journals Botulinum neurotoxin type B uses a distinct entry pathway mediated by CDC42 into intestinal cells versus neuronal cells

2017 ◽  
Vol 19 (8) ◽  
pp. e12738 ◽  
Author(s):  
Chloé Connan ◽  
Marie Voillequin ◽  
Carolina Varela Chavez ◽  
Christelle Mazuet ◽  
Christian Leveque ◽  
...  
Keyword(s):  
Botulinum Neurotoxin ◽  
Neuronal Cells ◽  
Intestinal Cells ◽  
Type B ◽  
Entry Pathway
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