Clinical and economic aspects of enhanced treatment efficacy of multiple drug resistant tuberculosis

The objective of the study: To evaluate the clinical and economic efficacy of chemotherapy in patients with newly diagnosed multiple drug resistant tuberculosis (MDR).Subjects and methods. The number and structure of MDR tuberculosis patients living on the territory of the Republic of Karelia from 2008 to 2017 were studied. The clinical and economic efficacy of treatment of MDR tuberculosis patients was assessed.Results. In 2011-2017, decrease in the number of MDR patients in the Republic of Karelia was mainly due to enhanced treatment efficacy of new MDR tuberculosis cases. The introduction of social support methods (food parsels) and express drug sensitivity testing to rifampicin using the Gene Xpert MTB/RIF was associated with higher treatment efficacy – from 37.2% (2013) to 58% (2014), the lower rate of treatment defaults, and significant decrease in mortality, as well as reduction of costs for curing of one MDR tuberculosis patient from1.68 million rubles in 2012 up to 0.77 million rubles in 2014.

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The Role of Medical Ozone in Improving Antioxidant Status in Multiple Drug-Resistant Tuberculosis Patients: A Quasi-experimental Study

Middle East Journal of Rehabilitation and Health ◽

10.5812/mejrh.97125 ◽

2019 ◽

Vol 6 (4) ◽

Author(s):

Mili Arpan Shah ◽

Lalit Kumar Anande ◽

Amar Powar ◽

Jignashah Captain ◽

Pradeep Mk Nair

Keyword(s):

Antioxidant Status ◽

Multiple Drug ◽

Drug Resistant ◽

Drug Resistant Tuberculosis ◽

Tuberculosis Patients ◽

Resistant Tuberculosis ◽

Multiple Drug Resistant ◽

Quasi Experimental ◽

Medical Ozone

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Profile of adverse drug reactions in multiple drug resistant tuberculosis patients at drug resistant-tuberculosis center - Miraj, Maharashtra

International Journal of Medical Science and Public Health ◽

10.5455/ijmsph.2017.1164201122016 ◽

2017 ◽

Vol 6 (4) ◽

pp. 1

Author(s):

Shivaji Patil ◽

Rajendra Bhagwat ◽

Rajsinh Mohite ◽

Shailesh Barphe

Keyword(s):

Adverse Drug Reactions ◽

Multiple Drug ◽

Drug Resistant ◽

Drug Reactions ◽

Drug Resistant Tuberculosis ◽

Tuberculosis Patients ◽

Resistant Tuberculosis ◽

Multiple Drug Resistant

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Burden of tuberculosis and TB/HIV co-infection in Dushanbe

Tuberculosis and lung diseases ◽

10.21292/2075-1230-2021-99-2-40-44 ◽

2021 ◽

Vol 99 (2) ◽

pp. 40-44

Author(s):

B. P. Pirmakhmadzoda ◽

Z. Kh. Tilloeva ◽

Kh. S. Sharifzoda ◽

O. Ya. Kabirov ◽

K. A. Imomnazarova ◽

...

Keyword(s):

Retrospective Study ◽

Treatment Efficacy ◽

Hiv Positive ◽

Multiple Drug ◽

Drug Resistant ◽

Hiv Status ◽

Drug Resistant Tuberculosis ◽

Resistant Tuberculosis ◽

Multiple Drug Resistant ◽

Hiv Negative

The objective of the study: to determine the burden of tuberculosis with concurrent HIV infection in Dushanbe and the prevalence of multiple drug resistant tuberculosis, to assess the treatment efficacy of drug susceptible and drug resistant tuberculosis depending on the HIV status of patients.Subjects: A cohort retrospective study was carried out assessing results of examination and treatment of all patients (1,838 people) registered for tuberculosis treatment from 01.06.2016 to 25.12.2019 in Dushanbe.Results. Among new tuberculosis cases, MDR is more often registered in HIV positive patients versus HIV negative patients (OR 2.3, 95% CI 1.1-4.9, p = 0.03). The chances of successful treatment of tuberculosis in HIV negative patients were higher versus HIV positive patients as well as in drug susceptible tuberculosis (OR 4.7, 95% CI 3.1-7.4; p < 0.000) versus drug resistant tuberculosis (OR 2.5, 95% CI 1.1-75.7; p = 0.03). The chances of tuberculosis cure did not differ statistically significantly among patients with different HIV status for both drug resistant and drug susceptible tuberculosis.

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