Pulsatile MEK Inhibition Improves Anti-Tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer

2018 ◽  
Author(s):  
Hyejin Choi ◽  
Jiehui Deng ◽  
Shuai Li ◽  
Elliott J. Brea ◽  
Tarik Silk ◽  
...  
Keyword(s):  
Lung Cancer ◽  
T Cell ◽  
Tumor Immunity ◽  
Cell Function ◽  
Mek Inhibition ◽  
T Cell Function

scholarly journals Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer

Cell Reports ◽  
2019 ◽  
Vol 27 (3) ◽  
pp. 806-819.e5 ◽  
Author(s):  
Hyejin Choi ◽  
Jiehui Deng ◽  
Shuai Li ◽  
Tarik Silk ◽  
Lauren Dong ◽  
...  
Keyword(s):  
Lung Cancer ◽  
T Cell ◽  
Tumor Immunity ◽  
Cell Function ◽  
Mek Inhibition ◽  
T Cell Function

Abstract 923: Pulsatile MEK inhibition improves anti-tumor immunity and T cell function in Kras mutant lung cancer

2020 ◽  
Author(s):  
Hyejin Choi ◽  
Jiehui Deng ◽  
Shuai Li ◽  
Tarik Silk ◽  
Lauren Dong ◽  
...  
Keyword(s):  
Lung Cancer ◽  
T Cell ◽  
Tumor Immunity ◽  
Cell Function ◽  
Mek Inhibition ◽  
T Cell Function

The reverse signals of costimulatory molecule B7‐H1 negatively regulate memory CD8 T cell function in tumor immunity

2008 ◽  
Vol 22 (S2) ◽  
pp. 523-523
Author(s):  
Haidong Dong ◽  
Vesna Fulko ◽  
Kimberley Harris ◽  
Xavier Frigola ◽  
Xin Liu
Keyword(s):  
T Cell ◽  
Tumor Immunity ◽  
Cell Function ◽  
Costimulatory Molecule ◽  
Cd8 T Cell ◽  
T Cell Function ◽  
Memory Cd8 T Cell

scholarly journals Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Sathana Dushyanthen ◽  
Zhi Ling Teo ◽  
Franco Caramia ◽  
Peter Savas ◽  
Christopher P. Mintoff ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cell ◽  
Cell Function ◽  
Mek Inhibition ◽  
T Cell Function

scholarly journals Engineered IL-21 Cytokine Muteins Fused to Anti-PD-1 Antibodies Can Improve CD8+ T Cell Function and Anti-tumor Immunity

2020 ◽  
Vol 11 ◽  
Author(s):  
Shanling Shen ◽  
Gail Sckisel ◽  
Anupama Sahoo ◽  
Almin Lalani ◽  
Doug Den Otter ◽  
...  
Keyword(s):  
T Cell ◽  
Tumor Immunity ◽  
Cell Function ◽  
Cd8 T Cell ◽  
T Cell Function

BRAF and MEK Inhibition Variably Affect GD2-specific Chimeric Antigen Receptor (CAR) T-Cell Function In Vitro

2015 ◽  
Vol 38 (1) ◽  
pp. 12-23 ◽  
Author(s):  
Tessa Gargett ◽  
Cara K. Fraser ◽  
Gianpietro Dotti ◽  
Eric S. Yvon ◽  
Michael P. Brown
Keyword(s):  
T Cell ◽  
Chimeric Antigen Receptor ◽  
Cell Function ◽  
Antigen Receptor ◽  
Mek Inhibition ◽  
Car T Cell ◽  
T Cell Function ◽  
Car T

Positive effects of glucocorticoids on T cell function and development by upregulation of interleukin-7 receptor α

2001 ◽  
Vol 120 (5) ◽  
pp. A314-A315
Author(s):  
D FRANCHIMONT ◽  
J GALON ◽  
M VACCHIO ◽  
R VISCONTI ◽  
G CHROUSOS ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Function ◽  
Positive Effects ◽  
Interleukin 7 ◽  
T Cell Function
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