scholarly journals Therapeutic Monoclonal Antibodies for Ebola Virus Infection Derived from Vaccinated Humans

2018 ◽  
Author(s):  
Pramila Rijal ◽  
Sean C. Elias ◽  
Samara Rosendo Machado ◽  
Julie Xiao ◽  
Lisa Schimanski ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Virus Infection ◽  
Ebola Virus ◽  
Therapeutic Monoclonal Antibodies ◽  
Ebola Virus Infection

scholarly journals Therapeutic Monoclonal Antibodies for Ebola Virus Infection Derived from Vaccinated Humans

Cell Reports ◽  
2019 ◽  
Vol 27 (1) ◽  
pp. 172-186.e7 ◽  
Author(s):  
Pramila Rijal ◽  
Sean C. Elias ◽  
Samara Rosendo Machado ◽  
Julie Xiao ◽  
Lisa Schimanski ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Virus Infection ◽  
Ebola Virus ◽  
Therapeutic Monoclonal Antibodies ◽  
Ebola Virus Infection

scholarly journals Ebola GP-Specific Monoclonal Antibodies Protect Mice and Guinea Pigs from Lethal Ebola Virus Infection

2012 ◽  
Vol 6 (3) ◽  
pp. e1575 ◽  
Author(s):  
Xiangguo Qiu ◽  
Lisa Fernando ◽  
P. Leno Melito ◽  
Jonathan Audet ◽  
Heinz Feldmann ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Virus Infection ◽  
Guinea Pigs ◽  
Ebola Virus ◽  
Ebola Virus Infection

scholarly journals Intramuscular Adeno-Associated Virus–Mediated Expression of Monoclonal Antibodies Provides 100% Protection Against Ebola Virus Infection in Mice

2018 ◽  
Vol 217 (6) ◽  
pp. 916-925 ◽  
Author(s):  
Laura P van Lieshout ◽  
Geoff Soule ◽  
Debra Sorensen ◽  
Kathy L Frost ◽  
Shihua He ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Virus Infection ◽  
Ebola Virus ◽  
Adeno Associated Virus ◽  
Ebola Virus Infection

scholarly journals Potent neutralizing monoclonal antibodies against Ebola virus infection

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Qi Zhang ◽  
Miao Gui ◽  
Xuefeng Niu ◽  
Shihua He ◽  
Ruoke Wang ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Virus Infection ◽  
Ebola Virus ◽  
Ebola Virus Infection

scholarly journals Antibody-Dependent Enhancement of Ebola Virus Infection

2003 ◽  
Vol 77 (13) ◽  
pp. 7539-7544 ◽  
Author(s):  
Ayato Takada ◽  
Heinz Feldmann ◽  
Thomas G. Ksiazek ◽  
Yoshihiro Kawaoka
Keyword(s):  
Virus Infection ◽  
Ebola Virus ◽  
Human Populations ◽  
Hemorrhagic Disease ◽  
Viral Infectivity ◽  
Kidney Cells ◽  
Emerging Pathogens ◽  
Viral Glycoprotein ◽  
Antibody Dependent Enhancement ◽  
Ebola Virus Infection

ABSTRACT Most strains of Ebola virus cause a rapidly fatal hemorrhagic disease in humans, yet there are still no biologic explanations that adequately account for the extreme virulence of these emerging pathogens. Here we show that Ebola Zaire virus infection in humans induces antibodies that enhance viral infectivity. Plasma or serum from convalescing patients enhanced the infection of primate kidney cells by the Zaire virus, and this enhancement was mediated by antibodies to the viral glycoprotein and by complement component C1q. Our results suggest a novel mechanism of antibody-dependent enhancement of Ebola virus infection, one that would account for the dire outcome of Ebola outbreaks in human populations.

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