Weekly Paclitaxel Plus Bevacizumab versus Docetaxel As Second- or Third-Line Treatment in Advanced Non-Squamous Non-Small Cell Lung Cancer (NSCLC): Results of the IFCT-1103 ULTIMATE Study

2019 ◽  
Author(s):  
Alexis Cortot ◽  
Clarisse Audigier-Valette ◽  
Olivier Molinier ◽  
Sylvestre Le Moulec ◽  
Fabrice Barlesi ◽  
...  
2009 ◽  
Vol 71 (2) ◽  
pp. 117-126 ◽  
Author(s):  
Adolfo Favaretto ◽  
Giulia Pasello ◽  
Cristina Magro ◽  
Clorinda Schettino ◽  
Cesare Gridelli

2009 ◽  
Vol 05 (01) ◽  
pp. 38
Author(s):  
Adolfo Favaretto ◽  
Giulia Pasello ◽  
◽  

Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide. About 50% of patients present with locally advanced or metastatic disease. First-line therapy usually consists of a combination of cisplatin or carboplatin with a third-generation agent (paclitaxel, docetaxel, gemcitabine or vinorelbine) that results in less than 5% five-year survival. In recent years advances in second- and third-line treatment have led to a prognostic improvement. Two cytotoxic agents, docetaxel and pemetrexed, are approved in NSCLC second-line treatment, and a new class of drugs against specific molecular targets – tyrosine kinase inhibitors – has emerged as an alternative to conventional treatment. Many trials are ongoing to assess the activity of new drugs, alone or in association, or new combinations of third-generation chemotherapeutic agents.


Author(s):  
Caitlin Smare ◽  
Kiran Dave ◽  
Ariadna Juarez-Garcia ◽  
Pranav Abraham ◽  
John R. Penrod ◽  
...  

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