Transcriptional Programming of Human Mechanosensory Neuron Subtypes

2019 ◽  
Author(s):  
Alec Nickolls ◽  
MM Lee ◽  
DF Espinoza ◽  
Marcin Szczot ◽  
R. Lam ◽  
...  
Keyword(s):  
Mechanosensory Neuron

scholarly journals Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn

Neuron ◽  
2014 ◽  
Vol 81 (6) ◽  
pp. 1443 ◽  
Author(s):  
Rita Bardoni ◽  
Vivianne L. Tawfik ◽  
Dong Wang ◽  
Amaury François ◽  
Carlos Solorzano ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Opioid Receptors ◽  
Spinal Cord Dorsal Horn ◽  
Mechanosensory Neuron ◽  
Delta Opioid Receptors ◽  
Spinal Cord Dorsal

Identification of a putative mechanosensory neuron in Lymnaea: characterization of its synaptic and functional connections with the whole-body withdrawal interneuron

1996 ◽  
Vol 76 (5) ◽  
pp. 3230-3238 ◽  
Author(s):  
T. Inoue ◽  
M. Takasaki ◽  
K. Lukowiak ◽  
N. I. Syed
Keyword(s):  
Sensory Neuron ◽  
Action Potentials ◽  
Synaptic Connection ◽  
Lucifer Yellow ◽  
Whole Body ◽  
Pond Snail ◽  
Mechanosensory Neuron ◽  
Functional Connections ◽  
Freshwater Pond ◽  
Withdrawal Behavior

1. In this study, we identified a putative mechanosensory neuron in the freshwater pond snail Lymnaea stagnalis. This sensory neuron, termed right parietal dorsal 3 (RPD3), mediates part of the whole-body withdrawal behavior via the activation of a withdrawal interneuron. 2. RPD3 is located in the central ring ganglia, where its soma is situated on the dorsal surface of the right parietal ganglion. Intracellular injection of the dye Lucifer yellow revealed that RPD3 has both central and peripheral axonal projections. 3. In isolated-CNS preparations, RPD3 was quiescent. In semi-intact preparations, however, a gentle/moderate mechanical touch (by a pair of blunt forceps) to the mantle cavity or columellar musculature elicited action potentials in RPD3 in the absence of prepotential activity. Furthermore, mechanical stimulus-induced action potentials in RPD3 persisted in the presence of zero Ca2+/ high Mg2+ and high Ca2+/high Mg2+ salines. Together, these data suggest that RPD3 is most likely to be a primary sensory neuron. 4. In both isolated-CNS and semi-intact preparations, intracellular depolarization of RPD3 excited the whole-body withdrawal interneuron right pedal dorsal 11 (RPeD11). This synaptic connection persisted in the presence of high Ca2+ and high Mg2+ saline, suggesting that it is likely to be monosynaptic. Moreover, when stimulated electrically, the interneuron RPeD11 induced an hyperpolarizing response in RPD3. The possibility of this connection being monosynaptic was not tested, however, in the present study. Together, these data demonstrate that RPD3 excites RPeD11, which in turn may inhibit RPD3 activity. 5. In the semi-intact preparation, a mechanical touch to the mantle edge excited RPD3, which in turn generated action potentials in RPeD11. Zero Ca2+ saline blocked this synaptic connection between RPD3 and RPeD11, suggesting that it is chemical. 6. To demonstrate that RPD3 was sufficient to induce the withdrawal response and that the withdrawal behavior was mediated indirectly via RPeD11, we made simultaneous intracellular recordings from these two neurons while monitoring muscle contractions via a tension transducer. Intracellular depolarization of RPD3 elicited action potentials in RPeD11, followed by the contraction of the columellar muscle. Similar stimulation of RPD3 failed to excite a simultaneously hyperpolarized RPeD11 and as a result, no contraction of the columellar muscle occurred. Direct intracellular depolarization of RPeD11, however, induced the contraction of the columellar muscle. These data suggest that RPD3-induced withdrawal behavior is mediated in part via RPeD11.

Modulation of the feeding system by a radular mechanosensory neuron in the terrestrial slug, Incilaria fruhstorferi

1995 ◽  
Vol 176 (2) ◽  
Author(s):  
S. Kawahara ◽  
M. Yano ◽  
H. Shimizu
Keyword(s):  
Feeding System ◽  
Mechanosensory Neuron

scholarly journals Peripheral Mechanosensory Neuron Dysfunction Underlies Tactile and Behavioral Deficits in Mouse Models of ASDs

Cell ◽  
2016 ◽  
Vol 166 (2) ◽  
pp. 299-313 ◽  
Author(s):  
Lauren L. Orefice ◽  
Amanda L. Zimmerman ◽  
Anda M. Chirila ◽  
Steven J. Sleboda ◽  
Joshua P. Head ◽  
...  
Keyword(s):  
Mouse Models ◽  
Behavioral Deficits ◽  
Mechanosensory Neuron

scholarly journals ELECTRICAL ACTIVITY IN THE CHEMORECEPTORS OF THE BLOWFLY

1958 ◽  
Vol 42 (2) ◽  
pp. 393-412 ◽  
Author(s):  
M. L. Wolbarsht ◽  
V. G. Dethier
Keyword(s):  
Electrical Activity ◽  
Mechanical Stimulation ◽  
Air Flow ◽  
Chemical Stimulation ◽  
Attack Angle ◽  
Phormia Regina ◽  
Mechanosensory Neuron ◽  
The Third ◽  
Chemical Stimuli ◽  
Electrical Responses

The electrical responses of the neurons associated with the various types of chemosensory hairs of the blowfly, Phormia regina Meigen, following stimulation by chemical and mechanical means have been studied. The singly innervated chemosensory hairs on the ovipositor, maxillary palpi, and antennae respond vigorously to chemical stimulation, but not to mechanical stimulation. The triply innervated chemosensory hairs on the labellum, tarsus, and wing have two neurons which respond only to chemical stimuli. The third neuron responds only to mechanical stimulation. The differential responses of the two chemosensory neurons to various chemical stimuli following the removal of the tip of the hair suggest that the structures responsible for chemoreception are located throughout the distal processes of these neurons. The response of the third neuron to mechanical stimulation is similar to the response recorded from the neuron associated with one type of tactile hair which responds to motion and not to steady deformation. Recordings have been made from the neurons associated with purely tactile hairs using the cut hair as an extension of the micropipette. The mechanosensory neuron of the wing chemosensory hair is capable of responding at the rate of at least 600 impulses per sec. and may serve to indicate changes in air flow over the wing surfaces during flight to enable the fly to correct the wing camber and attack angle.

scholarly journals Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn

Neuron ◽  
2014 ◽  
Vol 81 (6) ◽  
pp. 1312-1327 ◽  
Author(s):  
Rita Bardoni ◽  
Vivianne L. Tawfik ◽  
Dong Wang ◽  
Amaury François ◽  
Carlos Solorzano ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Opioid Receptors ◽  
Spinal Cord Dorsal Horn ◽  
Mechanosensory Neuron ◽  
Delta Opioid Receptors ◽  
Spinal Cord Dorsal

scholarly journals Mechanosensory Neuron Aging: Differential Trajectories with Lifespan-Extending Alaskan Berry and Fungal Treatments in Caenorhabditis elegans

2016 ◽  
Vol 8 ◽  
Author(s):  
Courtney Scerbak ◽  
Elena M. Vayndorf ◽  
Alicia Hernandez ◽  
Colin McGill ◽  
Barbara E. Taylor
Keyword(s):  
Caenorhabditis Elegans ◽  
Mechanosensory Neuron
Sign in / Sign up

Export Citation Format

Share Document