Leukocyte Telomere Length: A Potential Biomarker for the Prognosis of Coronary Artery Disease

Aim: This study aimed to explore the prognostic value of leukocyte telomere length (LTL) in patients with coronary artery disease (CAD). Materials & methods: We enrolled 366 CAD patients and 76 healthy subjects in this study. LTL was measured. All subjects were followed up for 6 months for further analysis regarding major adverse cardiac events (MACEs). Results: CAD patients had a significantly shortened LTL compared with healthy subjects (p < 0.05). The area under the curve for LTL prediction of MACEs was 0.769 (p < 0.001), with a shorter LTL being an independent predictor of MACEs (Cox proportional hazards regression, hazard ratio: 2.866; p < 0.001). Conclusion: LTL could be considered as an independent predictor of short-term MACEs in CAD.

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Association Between Oxidative Stress and Peripheral Leukocyte Telomere Length in Patients with Premature Coronary Artery Disease

Medical Science Monitor ◽

10.12659/msm.902106 ◽

2017 ◽

Vol 23 ◽

pp. 4382-4390 ◽

Cited By ~ 13

Author(s):

Ran Tian ◽

Lei-Nan Zhang ◽

Ting-Ting Zhang ◽

Hai-Yu Pang ◽

Lian-Feng Chen ◽

...

Keyword(s):

Oxidative Stress ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Telomere Length ◽

Premature Coronary Artery Disease ◽

Leukocyte Telomere Length ◽

Peripheral Leukocyte ◽

Artery Disease

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An investigation of racial/ethnic and sex differences in the association between experiences of everyday discrimination and leukocyte telomere length among patients with coronary artery disease

Psychoneuroendocrinology ◽

10.1016/j.psyneuen.2019.03.021 ◽

2019 ◽

Vol 106 ◽

pp. 122-128 ◽

Cited By ~ 5

Author(s):

Samaah Sullivan ◽

Muhammad Hammadah ◽

Ibhar Al Mheid ◽

Amit Shah ◽

Yan V. Sun ◽

...

Keyword(s):

Coronary Artery Disease ◽

Sex Differences ◽

Coronary Artery ◽

Telomere Length ◽

Leukocyte Telomere Length ◽

Artery Disease ◽

Racial Ethnic ◽

Everyday Discrimination

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Prognostic Value of Leukocyte Telomere Length in Patients With Stable Coronary Artery Disease

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvbaha.108.167049 ◽

2008 ◽

Vol 28 (7) ◽

pp. 1379-1384 ◽

Cited By ~ 127

Author(s):

Ramin Farzaneh-Far ◽

Richard M. Cawthon ◽

Beeya Na ◽

Warren S. Browner ◽

Nelson B. Schiller ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Telomere Length ◽

Prognostic Value ◽

Stable Coronary Artery Disease ◽

Leukocyte Telomere Length ◽

Artery Disease

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Predictive value of leukocyte telomere length for the severity of coronary artery disease

Personalized Medicine ◽

10.2217/pme-2019-0152 ◽

2020 ◽

Vol 17 (3) ◽

pp. 175-183

Author(s):

Ying Sun ◽

Jing-Qian Zhao ◽

Yue-Ru Jiao ◽

Jian Ren ◽

Yan-Hong Zhou ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Telomere Length ◽

Independent Predictor ◽

Area Under The Curve ◽

Rank Correlation ◽

Leukocyte Telomere Length ◽

Spearman’S Rank Correlation ◽

Spearman’S Rank Correlation Coefficient ◽

Artery Disease

Aim: This study aimed to explore leukocyte telomere length (LTL) in the prediction of the severity of coronary artery disease (CAD). Materials & methods: A total of 359 CAD patients who underwent coronary angiography were enrolled in this study. Severity of coronary artery was assessed by Gensini score (GS). Results: LTL is negatively correlated with GS (Spearman's rank correlation coefficient = -0.335; p < 0.001). Multivariate logistic regression results showed that LTL was an independent predictor of high GS (p = 0.001). Area under the curve value of LTL for predicting high GS was 0.659 (p < 0.001). Conclusion: LTL could be considered as a potential predictor of the severity of coronary artery in patients with CAD.

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