Predictive value of leukocyte telomere length for the severity of coronary artery disease

2020 ◽  
Vol 17 (3) ◽  
pp. 175-183
Author(s):  
Ying Sun ◽  
Jing-Qian Zhao ◽  
Yue-Ru Jiao ◽  
Jian Ren ◽  
Yan-Hong Zhou ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Telomere Length ◽  
Independent Predictor ◽  
Area Under The Curve ◽  
Rank Correlation ◽  
Leukocyte Telomere Length ◽  
Spearman’S Rank Correlation ◽  
Spearman’S Rank Correlation Coefficient ◽  
Artery Disease

Aim: This study aimed to explore leukocyte telomere length (LTL) in the prediction of the severity of coronary artery disease (CAD). Materials & methods: A total of 359 CAD patients who underwent coronary angiography were enrolled in this study. Severity of coronary artery was assessed by Gensini score (GS). Results: LTL is negatively correlated with GS (Spearman's rank correlation coefficient = -0.335; p < 0.001). Multivariate logistic regression results showed that LTL was an independent predictor of high GS (p = 0.001). Area under the curve value of LTL for predicting high GS was 0.659 (p < 0.001). Conclusion: LTL could be considered as a potential predictor of the severity of coronary artery in patients with CAD.

Leukocyte telomere length: a potential biomarker for the prognosis of coronary artery disease

2020 ◽  
Vol 14 (11) ◽  
pp. 933-941
Author(s):  
Ying Sun ◽  
Wei Wang ◽  
Yue-Ru Jiao ◽  
Jian Ren ◽  
Lei Gao ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Telomere Length ◽  
Healthy Subjects ◽  
Independent Predictor ◽  
Cox Proportional Hazards ◽  
Leukocyte Telomere Length ◽  
Cardiac Events ◽  
Potential Biomarker ◽  
Artery Disease

Aim: This study aimed to explore the prognostic value of leukocyte telomere length (LTL) in patients with coronary artery disease (CAD). Materials & methods: We enrolled 366 CAD patients and 76 healthy subjects in this study. LTL was measured. All subjects were followed up for 6 months for further analysis regarding major adverse cardiac events (MACEs). Results: CAD patients had a significantly shortened LTL compared with healthy subjects (p < 0.05). The area under the curve for LTL prediction of MACEs was 0.769 (p < 0.001), with a shorter LTL being an independent predictor of MACEs (Cox proportional hazards regression, hazard ratio: 2.866; p < 0.001). Conclusion: LTL could be considered as an independent predictor of short-term MACEs in CAD.

scholarly journals Prognostic Value of Leukocyte Telomere Length in Patients With Stable Coronary Artery Disease

2008 ◽  
Vol 28 (7) ◽  
pp. 1379-1384 ◽  
Author(s):  
Ramin Farzaneh-Far ◽  
Richard M. Cawthon ◽  
Beeya Na ◽  
Warren S. Browner ◽  
Nelson B. Schiller ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Telomere Length ◽  
Prognostic Value ◽  
Stable Coronary Artery Disease ◽  
Leukocyte Telomere Length ◽  
Artery Disease

Circulating oxidized low-density lipoprotein is an independent predictor for cardiac event in patients with coronary artery disease

2004 ◽  
Vol 174 (2) ◽  
pp. 343-347 ◽  
Author(s):  
Kazunori Shimada ◽  
Hiroshi Mokuno ◽  
Eriko Matsunaga ◽  
Tetsuro Miyazaki ◽  
Katsuhiko Sumiyoshi ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cardiac Event ◽  
Independent Predictor ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Artery Disease

Abstract 15233: The Lesion Length Gives a Better Effect on the Fractional Flow Reserve Than the Minimal Luminal Area in the Intermediate Coronary Artery Lesion

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Yoon Juneyoung ◽  
Xiongjie Jin ◽  
Kyong-Woo Seo ◽  
Jin-sun Park ◽  
Hyoung-Mo Yang ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Positive Predictive Value ◽  
Negative Predictive Value ◽  
Predictive Value ◽  
Area Under The Curve ◽  
Lesion Length ◽  
Visual Estimation ◽  
Luminal Area ◽  
Artery Disease

Introduction: The pressure gradient of the circulation fluid in a stenosis area depends on minimal luminal area (MLA) of the stenosis, lesion length (LL), and the fluid velocity. However, the correlation of the LL and the MLA; the cutoff values are uncertain. Hypothesis: LL and MLA differently influences the FFR. Methods: We studied 117 patients with intermediate coronary artery disease who underwent FFR and IVUS measurement out of 302 patients in FAVOR study. This study was a prospective, 1:1 randomized, open label multicenter trial to demonstrate the clinical outcomes between FFR and IVUS-guided PCI. Inclusion criteria were as follows: 1)Angina or documented silent ischemia 2) De novo intermediate coronary artery disease (30-70% diameter stenosis) by visual estimation, 3) Reference vessel diameter ≥ 3.0mm by visual estimation. We excluded left main disease, MI, EF< 40%, and graft vessel. There were no significant differences in baseline clinical characteristics. The mean values are the QCA (54.3±14.0 %), MLA (3.6±1.4 mm2) and LL (20.6±1.4mm), respectively. We were performed the path analysis using AMOS 18, and estimated the ROC curve in SPSS 18. Results: Standardized estimates were the LL -0.47,QCA -0.28 and MLA -0.21 (R2=0.594, p<0.000) in path analysis. The model is recursive and statistically significant. The FFR was ≤0.80 in 47 lesions (31%). The optimal LL for an FFR of ≤0.80 was 15.8mm (90% sensitivity, 50% specificity, 44% positive predictive value, 87% negative predictive value, area under the curve: 0.75, 95% CI: 0.66 to 0.85; p < 0.001) and MLA 3.9mm (sensitivity 86%, specificity 59%, 35% positive predictive value , 94% negative predictive value, area under the curve: 0.78, 95% CI: 0.67 to 0.85; p < 0.001) Conclusions: The lesion length influenced more the FFR than MLA. The lesion length ≥ 15.8mm and MLA ≤ 3.9mm are risk zones, which need to be confirm the functional status with FFR because of the low positive predictive value

scholarly journals A new peripheral endothelial function measurement improves prediction of symptomatic coronary artery disease

2020 ◽  
Vol 48 (6) ◽  
pp. 030006052093281
Author(s):  
Beibei Du ◽  
Daoyuan Si ◽  
Dong Zhao ◽  
Yanan Zhao ◽  
Kenji Wagatsuma ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Endothelial Function ◽  
Reactive Hyperemia ◽  
Multivariate Logistic Regression Analysis ◽  
Area Under The Curve ◽  
Pairwise Comparison ◽  
Function Measurement ◽  
Framingham Risk ◽  
Artery Disease

Objective This study aimed to determine whether a peripheral artery volume (PAV) test can improve the predictive value of the age-adjusted Framingham risk score (AFRS) for coronary artery disease (CAD) in symptomatic patients. Methods A total of 317 consecutive patients who were referred for coronary angiography were prospectively enrolled. Before cardiac catheterization, a PAV test was performed to measure changes in pulsatile blood flow volume following reactive hyperemia. Results PAV was significantly lower in patients with CAD than in those without CAD (1.21 ± 0.32 vs. 1.50 ± 0.45). Multivariate logistic regression analysis showed that PAV and the AFRS were independent predictors of CAD. Pairwise comparison of receiver operating characteristic curves showed that the predictive power for CAD increased when PAV was incorporated into the AFRS (area under the curve: from 0.76 to 0.80). The net reclassification index was also improved when PAV was added to the AFRS (0.65, 95% confidence interval: 0.44–0.85). Conclusions Digital endothelial function measurement is an independent predictor of CAD. PAV is potentially useful for identifying patients at high risk for CAD.

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