Leukocyte telomere length: a potential biomarker for the prognosis of coronary artery disease

2020 ◽  
Vol 14 (11) ◽  
pp. 933-941
Author(s):  
Ying Sun ◽  
Wei Wang ◽  
Yue-Ru Jiao ◽  
Jian Ren ◽  
Lei Gao ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Telomere Length ◽  
Healthy Subjects ◽  
Independent Predictor ◽  
Cox Proportional Hazards ◽  
Leukocyte Telomere Length ◽  
Cardiac Events ◽  
Potential Biomarker ◽  
Artery Disease

Aim: This study aimed to explore the prognostic value of leukocyte telomere length (LTL) in patients with coronary artery disease (CAD). Materials & methods: We enrolled 366 CAD patients and 76 healthy subjects in this study. LTL was measured. All subjects were followed up for 6 months for further analysis regarding major adverse cardiac events (MACEs). Results: CAD patients had a significantly shortened LTL compared with healthy subjects (p < 0.05). The area under the curve for LTL prediction of MACEs was 0.769 (p < 0.001), with a shorter LTL being an independent predictor of MACEs (Cox proportional hazards regression, hazard ratio: 2.866; p < 0.001). Conclusion: LTL could be considered as an independent predictor of short-term MACEs in CAD.

Predictive value of leukocyte telomere length for the severity of coronary artery disease

2020 ◽  
Vol 17 (3) ◽  
pp. 175-183
Author(s):  
Ying Sun ◽  
Jing-Qian Zhao ◽  
Yue-Ru Jiao ◽  
Jian Ren ◽  
Yan-Hong Zhou ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Telomere Length ◽  
Independent Predictor ◽  
Area Under The Curve ◽  
Rank Correlation ◽  
Leukocyte Telomere Length ◽  
Spearman’S Rank Correlation ◽  
Spearman’S Rank Correlation Coefficient ◽  
Artery Disease

Aim: This study aimed to explore leukocyte telomere length (LTL) in the prediction of the severity of coronary artery disease (CAD). Materials & methods: A total of 359 CAD patients who underwent coronary angiography were enrolled in this study. Severity of coronary artery was assessed by Gensini score (GS). Results: LTL is negatively correlated with GS (Spearman's rank correlation coefficient = -0.335; p < 0.001). Multivariate logistic regression results showed that LTL was an independent predictor of high GS (p = 0.001). Area under the curve value of LTL for predicting high GS was 0.659 (p < 0.001). Conclusion: LTL could be considered as a potential predictor of the severity of coronary artery in patients with CAD.

scholarly journals Prognostic Value of Leukocyte Telomere Length in Patients With Stable Coronary Artery Disease

2008 ◽  
Vol 28 (7) ◽  
pp. 1379-1384 ◽  
Author(s):  
Ramin Farzaneh-Far ◽  
Richard M. Cawthon ◽  
Beeya Na ◽  
Warren S. Browner ◽  
Nelson B. Schiller ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Telomere Length ◽  
Prognostic Value ◽  
Stable Coronary Artery Disease ◽  
Leukocyte Telomere Length ◽  
Artery Disease

scholarly journals Exercise responsive micro ribonucleic acids identify patients with coronary artery disease

2018 ◽  
Vol 26 (4) ◽  
pp. 348-355 ◽  
Author(s):  
Barbara Mayr ◽  
Edith E Müller ◽  
Christine Schäfer ◽  
Silke Droese ◽  
Hannelore Breitenbach-Koller ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
At Risk ◽  
Coronary Artery ◽  
Healthy Subjects ◽  
Distinct Pattern ◽  
Cardiac Events ◽  
Ribonucleic Acids ◽  
Before And After ◽  
Coronary Events ◽  
Artery Disease

Aims Exercise is a trigger for acute coronary events especially in the untrained. Identifying subjects at risk remains a challenge. We set out to assess whether a distinct pattern of micro ribonucleic acids (miRNAs) expressed in response to an acute bout of all-out exercise might exist that would allow discrimination between health and disease. Methods Twenty healthy subjects and 20 patients with coronary artery disease (CAD) performed an all-out cycle ergometry. Total RNA was extracted from blood drawn before and after exercise. Each blood sample was analysed for 187 target miRNAs by quantitative reverse transcription polymerase chain reaction. Results At baseline, 18 miRNAs allowed discrimination between healthy subjects and CAD patients. In response to an acute all-out exercise in healthy subjects 51 miRNAs and in CAD patients 60 miRNAs were significantly modulated (all p < 0.05). Using logistic regression analysis, a unique pattern of pre-exercise miR-150-5p, post-exercise miR-101-3p, miR-141-3p and miR-200b-3p together with maximal oxygen uptake and maximal power corrected for bodyweight allowed discrimination between healthy subjects and CAD patients with an accuracy of 92.5%. Conclusion In this most comprehensive analysis of exercise effects on circulating miRNAs to date we demonstrate for the first time that a distinct combination of miRNAs together with variables of exercise capacity allow robust discrimination between healthy subjects and CAD patients. We postulate that miRNAs may eventually serve as biomarkers to identify patients with CAD and possibly even those at risk of exercise-induced cardiac events.

scholarly journals Alkaline Phosphatase-to-Albumin Ratio as a Novel Predictor of Long-Term Adverse Outcomes in Coronary Artery Disease Patients Who underwent PCI

2021 ◽  
Author(s):  
Xin-Ya Dai ◽  
Ying-Ying Zheng ◽  
Jun-Nan Tang ◽  
Wei Wang ◽  
Qian-Qian Guo ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Alkaline Phosphatase ◽  
Coronary Artery ◽  
Cox Regression ◽  
Independent Predictor ◽  
Adverse Outcomes ◽  
Cardiac Events ◽  
Albumin Ratio ◽  
Artery Disease

Background: Alkaline phosphatase (ALP) and albumin (ALB) have been shown to be associated with coronary artery disease (CAD), and it has been reported that alkaline phosphatase-to-albumin ratio (AAR) is associated with the liver damage and poorer prognosis of patients with digestive system malignancy. Moreover, several previous studies showed that there was a higher incidence of malignancy in CAD patients. However, to our knowledge, the relationship between AAR and long-term adverse outcomes in CAD patients after undergoing percutaneous coronary intervention (PCI) has not been investigated. Therefore, we aim to access the relation between AAR and long-term adverse outcomes in post-PCI patients with CAD. Methods: 3378 post-PCI patients with CAD were enrolled in the retrospective CORFCHD-ZZ study from January 2013 to December 2017. The median duration of follow-up was 37.59±22.24 months. The primary endpoint was long-term mortality including all-cause mortality (ACM) and cardiac mortality (CM).The secondary endpoints were major adverse cardiac events (MACEs) and major adverse cardiac and cerebrovascular events (MACCEs). Results: Kaplan-Meier analyses showed that an increased AAR was positively correlated with incidences of long-term ACM (log-rank, P=0.014), CM (log-rank, P=0.011), MACEs (log-rank, P=0.013) and MACCEs (log-rank, P=0.006). Multivariate Cox regression analyses showed that the elevated AAR was an independent predictor of long-term ACM (adjusted HR=1.488 [1.031-2.149], P=0.034), CM (adjusted HR=1.837 [1.141-2.959], P=0.012), MACEs (adjusted HR=1.257 [1.018-1.551], P=0.033) and MACCEs (adjusted HR=1.237 [1.029-1.486], P=0.024). Conclusions: An elevated AAR is a novel independent predictor of long-term adverse outcomes in CAD patients following PCI.

Abstract 15856: Left Ventricular Longitudinal Contractility Measured During Routine Cine-cardiac Magnetic Resonance Imaging is an Independent Predictor of Adverse Cardiac Events

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Vibhav Rangarajan ◽  
Satish J Chacko ◽  
Nikhil Jariwala ◽  
Simone Romano ◽  
Jaehoon Chung ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Independent Predictor ◽  
Suspected Coronary Artery Disease ◽  
Left Ventricular ◽  
Cardiac Events ◽  
Kaplan Meier ◽  
Adverse Cardiac Events ◽  
Longitudinal Fiber ◽  
Artery Disease

Background: Left ventricular systole involves coordinated contraction of longitudinal, circumferential, and radial myocardial fibers. Longitudinal fiber dysfunction appears to be an early marker for a number of pathological states. We hypothesized that reduced mitral annular plane systolic excursion (MAPSE) measured during cine-Cardiac Magnetic Resonance (CMR) imaging reflects changes in longitudinal fiber function and may be an early marker for adverse cardiovascular outcomes. Methods: 400 consecutive patients with known or suspected coronary artery disease undergoing CMR were prospectively enrolled. Lateral MAPSE was measured in the 4-chamber cine view by two independent observers. Patients were prospectively followed for major adverse cardiac events (MACE) - death, non-fatal myocardial infarction, hospitalization for heart failure or chest pain, and late revascularization. Cox proportional hazards regression modeling was used to identify factors independently associated with MACE. Results: The mean age of the study population was 58(±15) years, with a mean ejection fraction of 59(±14%). 31% of the individuals had known coronary artery disease and 33% were diabetic. 72 MACE occurred during a median follow-up of 14.5 months. By Kaplan-Meier analysis, patients with lateral MAPSE ≤1.11cm (median) experienced significantly higher incidence of MACE than patients with a MAPSE >1.11cm (p = 0.0270) (Figure). After adjustment for established predictors (ejection fraction, age, sex, diabetes, hyperlipidemia, smoking, hypertension, late gadolinium enhancement) lateral MAPSE remained a significant independent predictor of MACE (HR=2.43 per cm decrease; p=0.037). Conclusions: Reduced longitudinal fiber function assessed with lateral MAPSE during cine-CMR is an independent predictor of MACE in patients with known or suspected coronary artery disease. Figure: Kaplan-Meier curves for MACE in patients with MAPSE above and below the median.

scholarly journals Telomere length as a potential biomarker of coronary artery disease

2017 ◽  
Vol 145 (6) ◽  
pp. 730 ◽  
Author(s):  
Joyeeta Bhattacharyya ◽  
Keichiro Mihara ◽  
Deborshi Bhattacharjee ◽  
Manjarí Mukherjee
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Telomere Length ◽  
Potential Biomarker ◽  
Artery Disease
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