Deep Muscularis Propria Tumor Invasion Without Lymph Node Metastasis as a Unique Subclassification of pT2 Gastric Cancer: A Retrospective Study

2021 ◽  
Author(s):  
Kang He ◽  
Cheng Chen ◽  
Lei Xia ◽  
Lixiang Si ◽  
Xiaohua Pan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Retrospective Study ◽  
Lymph Node Metastasis ◽  
Tumor Invasion ◽  
Muscularis Propria ◽  
Node Metastasis

scholarly journals Deep Muscularis Propria Tumor Invasion Without Lymph Node Metastasis as a Unique Subclassification of Stage IB Gastric Cancer: A Retrospective Study

2021 ◽  
Author(s):  
Kang He ◽  
Cheng Chen ◽  
Lei Xia ◽  
Lixiang Si ◽  
Xiaohua Pan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Adjuvant Chemotherapy ◽  
Lymph Node Metastasis ◽  
Tumor Invasion ◽  
Muscularis Propria ◽  
Node Metastasis ◽  
Stage Ib ◽  
Positive Expression ◽  
Potential Factors

Abstract Background The prognosis difference based on the depth of tumor muscularis propria invasion in gastric cancer (GC) was still debated. Methods A total of 380 patients with pT2 GC after radical surgery were retrospectively analyzed, including 185 in superficial muscularis propria (sMP) group and 195 in deep muscularis propria (dMP) group. Results The overall survival (OS) was significantly better for patients in sMP group than for patients in dMP group (P=0.007). In multivariate analysis, depth of tumor invasion, pN stage, age, primary location, positive expression of p53, elevated maximal LDH, elevated initial CA19-9 and AFP level were independent prognostic factors for OS. The sMP group had a significantly better OS than dMP group (P=0.014) in pN0 stage. After further stratification, the survival outcomes were not significantly different between deep muscularis propria tumor invasion without lymph node metastasis (dMPN0) group (stage IB) and superficial muscularis propria tumor invasion with stage 1-2 lymph node metastasis (sMPN1-2) group (stage II) (P=0.100). Patients with adjuvant chemotherapy had a statistically better survival than those without in dMPN0 group (P=0.045) and dMPN0 patients with adjuvant chemotherapy had better OS than sMPN1-2 patients (P=0.015). In addition, greater postoperative survival could be observed in sMPN0 patients than dMPN0 patients in p53-positive group (P=0.002), and similar OS could be seen between dMPN0 patients with p53-positive and T2N1-2 patients (P=0.872). Conclusion As a unique subclassification of stage IB GC, appropriate adjuvant chemotherapy should be considered for patients with dMPN0 stage. In addition, positive expression of p53, elevated LDH could be potential factors in identifying the different prognoses for stage IB GC patients.

Kindlin-2: a novel adhesion protein related to tumor invasion, lymph node metastasis, and patient outcome in gastric cancer

2012 ◽  
Vol 203 (2) ◽  
pp. 222-229 ◽  
Author(s):  
Zhanlong Shen ◽  
Yingjiang Ye ◽  
Lingyi Dong ◽  
Sanna Vainionpää ◽  
Harri Mustonen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Patient Outcome ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Tumor Invasion ◽  
Adhesion Protein ◽  
Node Metastasis

scholarly journals Clinically Early Gastric Cancer: Features and Treatment Strategy

2016 ◽  
Vol 101 (11-12) ◽  
pp. 562-569
Author(s):  
Si-Hak Lee ◽  
Cheol Woong Choi ◽  
Su Jin Kim ◽  
Dae-Hwan Kim ◽  
Chang In Choi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Treatment Strategy ◽  
Treatment Strategies ◽  
Muscularis Propria ◽  
Clinicopathologic Features ◽  
Curative Gastrectomy ◽  
Node Metastasis

This study aimed to clarify the clinicopathologic features and explore treatment strategies for patients with pathologically confirmed advanced gastric cancer (AGC) diagnosed as clinically early gastric cancer (cEGC) before surgery. We included 955 patients who were treated by curative gastrectomy between 2008 and 2013; 42 patients had cEGC. The clinicopathologic features of the patients with cEGC were compared with those of patients with early gastric cancer (EGC); AGC; cancer of the muscularis propria (MP cancer, gastric cancer invading the muscularis propria of the stomach); or SM3 cancer (gastric cancer invading all 3 parts of the submucosal layer). Patients with cEGC had more tumor lymph node metastasis; more lymphatic invasion; and more perineural invasion (all P < 0.001) compared with those with EGC. Patients with cEGC had more tumor lymph node metastasis (P = 0.017) than did patients with SM3. Compared with patients with AGC or MP cancer, patients with cEGC were more likely to be operated on using a laparoscopic procedure and less likely to receive lymph node dissection. Multivariate analysis showed that gross type III [odds ratio (OR), 12.92; P < 0.001] and tumor location (middle body, OR, 2.691; P = 0.009) were significant predictors of cEGC before surgery. Although patients with cEGC had clinicopathologic features similar to those of patients with MP cancer, they were treated like patients with SM3 cancer (e.g., limited use of lymphadenectomy). These findings suggest that patients with cEGC should be given a more aggressive treatment strategy.

Gender and Age Differences in Risk Factors of Lymph Node Metastasis in Patients With Early Gastric Cancer and Analysis Prognosis of Early Gastric Cancer

2020 ◽  
Author(s):  
Jingjing Wang ◽  
Jingjing Wang ◽  
Tao Meng ◽  
Tao Meng ◽  
Ke Chen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Tumor Invasion ◽  
Lymphovascular Invasion ◽  
Univariate Analysis ◽  
Node Metastasis ◽  
Gender And Age

Abstract ObjectiveTo explore the effects of gender and age differences in the risk factors for lymph node metastasis in patients and analysis prognosis of patients of early gastric cancer (EGC). MethodsA total of 411 patients with EGC who underwent surgical treatment at the First Affiliated Hospital of Anhui Medical University from 2011 to 2017 were included in this study and grouped according to gender and age. Retrospective analysis of the effects of gender and age on tumor size, histological type, depth of invasion, and ulcer type was performed, and differences in the clinicopathological characteristics of lymphovascular invasion were noted. Follow-up of the postoperative recurrence and metastasis of the patients and analysis of their prognosis were finally conducted. All follow-ups ended in August 2020. ResultThe participants in this study ranged in age from 25 years to 85 years (average, 60.27 ± 10.77 years). A total of 57 (13.9%) of the patients showed lymph node metastasis. Females accounted for 25.5% (105/411) while males accounted for 74.5% (306/411) of the study population. Patients aged ≤60 years accounted for 55.5% (228/411) while patients aged >60 years accounted for 44.5% (183/411) of the study population. Univariate analysis of male patients showed that tumor size, depth of tumor invasion, ulcerative tumors, and lymphovascular invasion are related to lymph node metastasis (P < 0.05). Univariate analysis of female patients showed that tumor size, depth of tumor invasion, tumor histology, and lymphovascular invasion are related to lymph node metastasis (P < 0.05). Univariate analysis of patients aged ≤60 years showed that depth of tumor invasion, ulcerative tumors, and lymphovascular invasion are related to lymph node metastasis (P < 0.05). Univariate analysis of patients aged >60 years showed that depth of tumor invasion, ulcerative tumors, and lymphovascular invasion are related to lymph node metastasis (P < 0.05). Multivariate analysis of male patients, female patients, and patients aged ≤60 years showed that depth of tumor invasion is an independent risk factor for lymph node metastasis. Multivariate analysis of patients aged >60 years showed that depth of tumor invasion, ulcerative tumors, and lymphovascular invasion are independent risk factors for lymph node metastasis. ConclusionThe risk factors for lymph node metastasis in patients with EGC differed according to gender and age. The results provide a reference for choosing suitable treatment options for these patients.

Infiltration of dendritic cells in relation to tumor invasion and lymph node metastasis in human gastric cancer

Cancer ◽  
1990 ◽  
Vol 66 (9) ◽  
pp. 2012-2016 ◽  
Author(s):  
Shunichi Tsujitani ◽  
Yoshihiro Kakeji ◽  
Akihiro Watanabe ◽  
Shunji Kohnoe ◽  
Yoshihiko Maehara ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Dendritic Cells ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Tumor Invasion ◽  
Human Gastric Cancer ◽  
Node Metastasis

scholarly journals Clinicopathologic Significance of TROP2 and Phospho-TROP2 in Gastric Cancer

2020 ◽  
Author(s):  
Shuhei Kushiyama ◽  
Masakazu Yashiro ◽  
Yurie Yamamoto ◽  
Tomohiro Sera ◽  
Atsushi Sugimoto ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Tumor Invasion ◽  
Lymphatic Invasion ◽  
Intestinal Type ◽  
Invasion Depth ◽  
Node Metastasis ◽  
Tumor Invasion Depth

Abstract Background: Trophoblast cell-surface antigen 2 (TROP2) is a transmembrane glycoprotein expressed in epithelial cells. TROP2 overexpression has been reported to be correlated with malignant progression in most carcinomas, but TROP2 showed a tumor-suppressive function in some types of cancers. We currently developed a novel antibody against phospho-TROP2 (pTROP2). Since the function of TROP2 is controversial, we then aimed to clarify the clinicopathologic significance of TROP2 and pTROP2 expression in human gastric cancer (GC) in this study.Methods: We retrospectively analyzed the cases of 704 GC patients who underwent gastrectomy. The expressions of TROP2 and pTROP2 in each tumor were evaluated by immunohistochemistry. We analyzed the correlation between the GC patients' clinicopathologic features and the TROP2 and pTROP2 expression in their tumors.Results: Overexpression of TROP2 and that of pTROP2 were identified in 330 (46.9%) and 306 (43.5%) of the 704 GC patients, respectively. TROP2 overexpression was significantly correlated with the histological intestinal type, high tumor invasion depth (T3/T4), lymph node metastasis, lymphatic invasion, and venous invasion. In contrast, pTROP2 overexpression was significantly correlated with intestinal type, low tumor invasion depth (T1/2), no lymph node metastasis, and no lymphatic invasion. TROP2 overexpression was significantly associated with poorer overall survival (p<0.01, log rank), whereas pTROP2 overexpression was significantly associated with better overall survival (p<0.01, log rank).Conclusion: TROP2, but not pTROP2, might be associated with the metastatic ability of GC, resulting in poor prognoses for GC patients.

scholarly journals Surgical Outcomes and Clinicopathological Characteristics of Patients Who Underwent Potentially Noncurative Endoscopic Resection for Gastric Cancer: A Report of a Single-Center Experience

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Hiroaki Ito ◽  
Haruhiro Inoue ◽  
Haruo Ikeda ◽  
Noriko Odaka ◽  
Akira Yoshida ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Endoscopic Resection ◽  
Surgical Outcomes ◽  
Primary Tumor ◽  
Tumor Invasion ◽  
Venous Invasion ◽  
Incomplete Resection ◽  
Node Metastasis

Background. Standard treatment of early gastric cancer (EGC) after endoscopic resection with risk factors of nodal metastases and incomplete resection is controversial. We investigated optimal management for the patients with potentially noncurative EGC after endoscopic resection.Methods. We retrospectively examined clinicopathological data and surgical outcomes of all patients with clinically solitary gastric adenocarcinoma who underwent curative surgery after a single peroral endoscopic resection at the Digestive Disease Center of Showa University Northern Yokohama Hospital between April 2001 and December 2012. Fisher's exact test was used for univariate analysis. For multivariate analysis, stepwise multiple linear regression was used to identify independent predictors related to lymph node metastasis and remnant of primary tumor.Results. A total of 41 patients were studied. Four patients (9.8%) had lymph node metastases. Primary tumors remained in 6 patients (14.6%). Only venous invasion was statistically significant to lymph node metastasis (P=0.017). With respect to remnant of the primary tumor, pT1b2 tumor invasion (P=0.015) and horizontal margin (P=0.013) were statistically significant.Conclusions. Surgery with limited lymphadenectomy is recommended for tumors with venous invasion or pT1b2 tumor invasion, and additional endoscopic resection may be allowed for tumors with horizontal involvement.

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