Single Nucleotide Polymorphism of the Enhancer of Zeste Homolog 2 Gene rs2072408 is Associated with Lymph Node Metastasis and Depth of Primary Tumor Invasion in Gastric Cancer

2016 ◽  
Vol 62 (11/2016) ◽  
Author(s):  
Baochang Sun ◽  
Youdong Lin ◽  
Xiaoting Wang ◽  
Fenghua Lan ◽  
Yinghao Yu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Single Nucleotide Polymorphism ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Primary Tumor ◽  
Tumor Invasion ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Node Metastasis ◽  
Enhancer Of Zeste

scholarly journals Genome-Wide Copy Number Analysis in a Family With p.G533C RET Mutation and Medullary Thyroid Carcinoma Identified Regions Potentially Associated With a Higher Predisposition to Lymph Node Metastasis

2014 ◽  
Vol 99 (6) ◽  
pp. E1104-E1112 ◽  
Author(s):  
Aline N. Araujo ◽  
Lais Moraes ◽  
Maria Inez C. França ◽  
Hakon Hakonarson ◽  
Jin Li ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Copy Number ◽  
Single Nucleotide Polymorphism Array ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Medullary Thyroid ◽  
Node Metastasis ◽  
Genome Wide

Context: Our group described a p.G533C RET gene mutation in a large family with multiple endocrine neoplasia type 2 syndrome. Clinical heterogeneity, primarily associated with the presence of lymph node metastases, was observed among the p.G533C carriers. Objective: The aim of this study was to use single-nucleotide polymorphism-array technology to identify copy number variations (CNVs), which are present in the constitutional DNA and associated with the established clinical and pathological features of aggressive medullary thyroid carcinoma (MTC), primarily the presence of lymph node metastasis. Design: Fifteen p.G533C carriers with MTC were chosen for the initial screening. The subjects were divided into two groups according the presence (n = 8) or absence (n = 7) of lymph node metastasis. Peripheral blood DNA was independently hybridized using a genome-wide single-nucleotide polymorphism Array 6.0 platform. The results were analyzed using both Genotyping Console and PennCNV software. To identify the possible candidate regions associated with the presence of lymph node metastasis, cases (metastatic MTC) were compared with controls (nonmetastatic MTC). The identified CNVs were validated by quantitative PCR in an extended cohort (n = 32). Results: Using two different algorithms, we identified nine CNV regions that may contribute to susceptibility to lymph node metastasis. The validation step confirmed that a CNV loss impacting the FMN2 gene was potentially associated with a greater predisposition to lymph node metastasis in this family (P = .0179). Finally, we sought to investigate whether the development of lymph node metastasis might not depend on a single CNV but rather a combination of various CNVs. These analyses defined a CNV pattern related to a more aggressive phenotype in this family, with CNV deletions being enriched in the metastatic group (P = .0057). Conclusion: Although hereditable specific RET mutations are important to determine cancer risk, germline CNVs in disease-affected individuals may predispose them to MTC aggressiveness.

scholarly journals Surgical Outcomes and Clinicopathological Characteristics of Patients Who Underwent Potentially Noncurative Endoscopic Resection for Gastric Cancer: A Report of a Single-Center Experience

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Hiroaki Ito ◽  
Haruhiro Inoue ◽  
Haruo Ikeda ◽  
Noriko Odaka ◽  
Akira Yoshida ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Endoscopic Resection ◽  
Surgical Outcomes ◽  
Primary Tumor ◽  
Tumor Invasion ◽  
Venous Invasion ◽  
Incomplete Resection ◽  
Node Metastasis

Background. Standard treatment of early gastric cancer (EGC) after endoscopic resection with risk factors of nodal metastases and incomplete resection is controversial. We investigated optimal management for the patients with potentially noncurative EGC after endoscopic resection.Methods. We retrospectively examined clinicopathological data and surgical outcomes of all patients with clinically solitary gastric adenocarcinoma who underwent curative surgery after a single peroral endoscopic resection at the Digestive Disease Center of Showa University Northern Yokohama Hospital between April 2001 and December 2012. Fisher's exact test was used for univariate analysis. For multivariate analysis, stepwise multiple linear regression was used to identify independent predictors related to lymph node metastasis and remnant of primary tumor.Results. A total of 41 patients were studied. Four patients (9.8%) had lymph node metastases. Primary tumors remained in 6 patients (14.6%). Only venous invasion was statistically significant to lymph node metastasis (P=0.017). With respect to remnant of the primary tumor, pT1b2 tumor invasion (P=0.015) and horizontal margin (P=0.013) were statistically significant.Conclusions. Surgery with limited lymphadenectomy is recommended for tumors with venous invasion or pT1b2 tumor invasion, and additional endoscopic resection may be allowed for tumors with horizontal involvement.

Kindlin-2: a novel adhesion protein related to tumor invasion, lymph node metastasis, and patient outcome in gastric cancer

2012 ◽  
Vol 203 (2) ◽  
pp. 222-229 ◽  
Author(s):  
Zhanlong Shen ◽  
Yingjiang Ye ◽  
Lingyi Dong ◽  
Sanna Vainionpää ◽  
Harri Mustonen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Patient Outcome ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Tumor Invasion ◽  
Adhesion Protein ◽  
Node Metastasis

Expression of cancer stem cell markers ALDH1, CD44 and CD133 in primary tumor and lymph node metastasis of gastric cancer

2011 ◽  
Vol 62 (2) ◽  
pp. 112-119 ◽  
Author(s):  
Yuta Wakamatsu ◽  
Naoya Sakamoto ◽  
Htoo Zarni Oo ◽  
Yutaka Naito ◽  
Naohiro Uraoka ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Stem Cell ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Stem Cell ◽  
Primary Tumor ◽  
Stem Cell Markers ◽  
Cell Markers ◽  
Cancer Stem Cell Markers ◽  
Node Metastasis

Gender and Age Differences in Risk Factors of Lymph Node Metastasis in Patients With Early Gastric Cancer and Analysis Prognosis of Early Gastric Cancer

2020 ◽  
Author(s):  
Jingjing Wang ◽  
Jingjing Wang ◽  
Tao Meng ◽  
Tao Meng ◽  
Ke Chen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Tumor Invasion ◽  
Lymphovascular Invasion ◽  
Univariate Analysis ◽  
Node Metastasis ◽  
Gender And Age

Abstract ObjectiveTo explore the effects of gender and age differences in the risk factors for lymph node metastasis in patients and analysis prognosis of patients of early gastric cancer (EGC). MethodsA total of 411 patients with EGC who underwent surgical treatment at the First Affiliated Hospital of Anhui Medical University from 2011 to 2017 were included in this study and grouped according to gender and age. Retrospective analysis of the effects of gender and age on tumor size, histological type, depth of invasion, and ulcer type was performed, and differences in the clinicopathological characteristics of lymphovascular invasion were noted. Follow-up of the postoperative recurrence and metastasis of the patients and analysis of their prognosis were finally conducted. All follow-ups ended in August 2020. ResultThe participants in this study ranged in age from 25 years to 85 years (average, 60.27 ± 10.77 years). A total of 57 (13.9%) of the patients showed lymph node metastasis. Females accounted for 25.5% (105/411) while males accounted for 74.5% (306/411) of the study population. Patients aged ≤60 years accounted for 55.5% (228/411) while patients aged >60 years accounted for 44.5% (183/411) of the study population. Univariate analysis of male patients showed that tumor size, depth of tumor invasion, ulcerative tumors, and lymphovascular invasion are related to lymph node metastasis (P < 0.05). Univariate analysis of female patients showed that tumor size, depth of tumor invasion, tumor histology, and lymphovascular invasion are related to lymph node metastasis (P < 0.05). Univariate analysis of patients aged ≤60 years showed that depth of tumor invasion, ulcerative tumors, and lymphovascular invasion are related to lymph node metastasis (P < 0.05). Univariate analysis of patients aged >60 years showed that depth of tumor invasion, ulcerative tumors, and lymphovascular invasion are related to lymph node metastasis (P < 0.05). Multivariate analysis of male patients, female patients, and patients aged ≤60 years showed that depth of tumor invasion is an independent risk factor for lymph node metastasis. Multivariate analysis of patients aged >60 years showed that depth of tumor invasion, ulcerative tumors, and lymphovascular invasion are independent risk factors for lymph node metastasis. ConclusionThe risk factors for lymph node metastasis in patients with EGC differed according to gender and age. The results provide a reference for choosing suitable treatment options for these patients.

scholarly journals Deep Muscularis Propria Tumor Invasion Without Lymph Node Metastasis as a Unique Subclassification of Stage IB Gastric Cancer: A Retrospective Study

2021 ◽  
Author(s):  
Kang He ◽  
Cheng Chen ◽  
Lei Xia ◽  
Lixiang Si ◽  
Xiaohua Pan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Adjuvant Chemotherapy ◽  
Lymph Node Metastasis ◽  
Tumor Invasion ◽  
Muscularis Propria ◽  
Node Metastasis ◽  
Stage Ib ◽  
Positive Expression ◽  
Potential Factors

Abstract Background The prognosis difference based on the depth of tumor muscularis propria invasion in gastric cancer (GC) was still debated. Methods A total of 380 patients with pT2 GC after radical surgery were retrospectively analyzed, including 185 in superficial muscularis propria (sMP) group and 195 in deep muscularis propria (dMP) group. Results The overall survival (OS) was significantly better for patients in sMP group than for patients in dMP group (P=0.007). In multivariate analysis, depth of tumor invasion, pN stage, age, primary location, positive expression of p53, elevated maximal LDH, elevated initial CA19-9 and AFP level were independent prognostic factors for OS. The sMP group had a significantly better OS than dMP group (P=0.014) in pN0 stage. After further stratification, the survival outcomes were not significantly different between deep muscularis propria tumor invasion without lymph node metastasis (dMPN0) group (stage IB) and superficial muscularis propria tumor invasion with stage 1-2 lymph node metastasis (sMPN1-2) group (stage II) (P=0.100). Patients with adjuvant chemotherapy had a statistically better survival than those without in dMPN0 group (P=0.045) and dMPN0 patients with adjuvant chemotherapy had better OS than sMPN1-2 patients (P=0.015). In addition, greater postoperative survival could be observed in sMPN0 patients than dMPN0 patients in p53-positive group (P=0.002), and similar OS could be seen between dMPN0 patients with p53-positive and T2N1-2 patients (P=0.872). Conclusion As a unique subclassification of stage IB GC, appropriate adjuvant chemotherapy should be considered for patients with dMPN0 stage. In addition, positive expression of p53, elevated LDH could be potential factors in identifying the different prognoses for stage IB GC patients.

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