scholarly journals Mutated WWP1 Induces an Aberrant Expression of Myosin Heavy Chain Gene in C2C12 Skeletal Muscle Cells

2010 ◽  
Vol 47 (2) ◽  
pp. 115-119 ◽  
Author(s):  
Hirokazu Matsumoto ◽  
Yumi Inba ◽  
Shinji Sasazaki ◽  
Akira Fujiwara ◽  
Nobutsune Ichihara ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Myosin Heavy Chain Gene ◽  
Aberrant Expression ◽  
C2c12 Skeletal Muscle Cells

Function Of Natural Antisense RNA In Coordinating Myosin Heavy Chain Gene Switching In Skeletal Muscle

2005 ◽  
Vol 37 (Supplement) ◽  
pp. S245???S246 ◽  
Author(s):  
Clay E. Pandorf ◽  
Faddia Haddad ◽  
Roland R. Roy ◽  
Anqi X. Qin ◽  
V. Reggie Edgerton ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Antisense Rna ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Myosin Heavy Chain Gene ◽  
Natural Antisense Rna ◽  
Gene Switching

scholarly journals Evidence of MyomiR network regulation of β-myosin heavy chain gene expression during skeletal muscle atrophy

2009 ◽  
Vol 39 (3) ◽  
pp. 219-226 ◽  
Author(s):  
John J. McCarthy ◽  
Karyn A. Esser ◽  
Charlotte A. Peterson ◽  
Esther E. Dupont-Versteegden
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Myosin Heavy Chain ◽  
Muscle Atrophy ◽  
Soleus Muscle ◽  
Heavy Chain ◽  
Hindlimb Suspension ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Myosin Heavy Chain Gene

There is a growing recognition that noncoding RNAs (ncRNA) play an important role in the regulation of gene expression. A class of small (19–22 nt) ncRNAs, known as microRNAs (miRs), have received a great deal of attention lately because of their ability to repress gene expression through a unique posttranscriptional 3′-untranslated region (UTR) mechanism. The objectives of the current study were to identify miRs expressed in the rat soleus muscle and determine if their expression was changed in response to hindlimb suspension. Comprehensive profiling revealed 151 miRs were expressed in the soleus muscle and expression of 18 miRs were significantly ( P < 0.01) changed after 2 and/or 7 days of hindlimb suspension. The significant decrease (16%) in expression of muscle-specific miR-499 in response to hindlimb suspension was confirmed by RT-PCR and suggested activation of the recently proposed miR encoded by myosin gene (MyomiR) network during atrophy. Further analysis of soleus muscle subjected to hindlimb suspension for 28 days provided evidence consistent with MyomiR network repression of β-myosin heavy chain gene (β-MHC) expression. The significant downregulation of network components miR-499 and miR-208b by 40 and 60%, respectively, was associated with increased expression of Sox6 (2.2-fold) and Purβ (23%), predicted target genes of miR-499 and known repressors of β-MHC expression. A Sox6 3′-UTR reporter gene confirmed Sox6 is a target gene of miR-499. These results further expand the role of miRs in adult skeletal muscle and are consistent with a model in which the MyomiR network regulates slow myosin expression during muscle atrophy.

scholarly journals Mutations in the Slow Skeletal Muscle Fiber Myosin Heavy Chain Gene (MYH7) Cause Laing Early-Onset Distal Myopathy (MPD1)

2004 ◽  
Vol 75 (4) ◽  
pp. 703-708 ◽  
Author(s):  
Christopher Meredith ◽  
Ralf Herrmann ◽  
Cheryl Parry ◽  
Khema Liyanage ◽  
Danielle E. Dye ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Early Onset ◽  
Skeletal Muscle Fiber ◽  
Chain Gene ◽  
Distal Myopathy ◽  
Heavy Chain Gene ◽  
Myosin Heavy Chain Gene ◽  
Slow Skeletal Muscle

Function Of Natural Antisense RNA In Coordinating Myosin Heavy Chain Gene Switching In Skeletal Muscle

2005 ◽  
Vol 37 (Supplement) ◽  
pp. S245-S246 ◽  
Author(s):  
Clay E. Pandorf ◽  
Faddia Haddad ◽  
Roland R. Roy ◽  
Anqi X. Qin ◽  
V. Reggie Edgerton ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Antisense Rna ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Myosin Heavy Chain Gene ◽  
Natural Antisense Rna ◽  
Gene Switching
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