Microwave Ablation of Small Hepatic Metastases Using MR Guidance and Monitoring: Clinical Safety and Efficacy

Objective: To review safety and efficacy of percutaneous microwave ablation (MWA) for post-procedural haemostasis. Methods: Institutional databases retrospective research identified 10 cases of iatrogenic bleeding who underwent percutaneous MWA for post-procedural haemostasis. Ultrasound examination with Doppler and contrast enhancement identified a source of active bleeding prior to ablation; additionally they were used as guiding modality for antenna insertion whilst, post-ablation, assessed the lack of active extravasation. Target locations included liver intercostal space spleen and thyroid gland. Technical success was defined as positioning of the antenna on the desired location. Treatment end point was considered the disappearance of active extravasation in both Doppler imaging and contrast-enhanced ultrasound. Results: Technical success (i.e. positioning of the antenna on the desired location) was achieved in all cases. No complications were noted. All patients post MWA remained haemodynamically stable with no need for transfusion and were discharged from the hospital the next morning. Imaging and clinical follow-up in all patients before exiting the hospital did not depict any sign of active extravasation or bleeding. Conclusion: Our limited experience reports preliminary data showing that MWA could be added in the armamentarium of percutaneous therapies for iatrogenic bleeding. More prospective studies with larger patient samples are necessary for verification of this technique as well as for drawing broader conclusions in order to evaluate the place of percutaneous ablation in the treatment algorithm of haemorrhage. Advances in knowledge: Percutaneous ablation might have a role in haemostasis in well-selected cases

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Ecallantide Antibodies: Clinical Safety and Efficacy Evaluation in Treatment of Acute HAE Attacks

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2010.12.1058 ◽

2011 ◽

Vol 127 (2) ◽

pp. AB266-AB266

Author(s):

H.H. Li ◽

P.T. Horn ◽

W.T. Pullman

Keyword(s):

Efficacy Evaluation ◽

Clinical Safety ◽

Safety And Efficacy

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Short and Long Term Clinical Safety and Efficacy of Endeavor Stents in Primary Percutaneous Coronary Intervention

Heart Lung and Circulation ◽

10.1016/j.hlc.2010.06.1025 ◽

2010 ◽

Vol 19 ◽

pp. S151

Author(s):

W. Ahmar ◽

Y. Malaiapan ◽

T. Katticaran ◽

P. See ◽

I. Meredith

Keyword(s):

Percutaneous Coronary Intervention ◽

Primary Percutaneous Coronary Intervention ◽

Coronary Intervention ◽

Clinical Safety ◽

Safety And Efficacy ◽

Percutaneous Coronary ◽

Short And Long Term

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Fab Fragments in Treatment of Digoxin Ingestion

PEDIATRICS ◽

10.1542/peds.71.1.137 ◽

1983 ◽

Vol 71 (1) ◽

pp. 137-137

Author(s):

THOMAS W. SMITH

Keyword(s):

Multicenter Trial ◽

Clinical Safety ◽

Digitalis Toxicity ◽

Safety And Efficacy ◽

Fab Fragments ◽

Life Threatening ◽

September Issue

To the Editor.— Accompanying the paper of Zucker et al in the September issue of Pediatrics1 is a listing of sources from which digoxin-specific Fab fragments are stated to be available. Unfortunately, this is no longer the case. All of the individuals and institutions listed have been part of a multicenter trial of clinical safety and efficacy of purified digoxin-specific Fab fragments in the treatment of advanced, life-threatening digitalis toxicity. At the present time, however, supplies of the material are extremely limited, and several of the centers listed have exhausted their supplies of digoxin-specific Fab fragments.

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