scholarly journals YiQiFuMai powder injection ameliorates blood–brain barrier dysfunction and brain edema after focal cerebral ischemia–reperfusion injury in mice

2016 ◽  
pp. 315 ◽  
Author(s):  
Junping Kou ◽  
Guosheng Cao ◽  
Xinyi Ye ◽  
Yingqiong Xu ◽  
Mingzhu Yin ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Reperfusion Injury ◽  
Brain Edema ◽  
Focal Cerebral Ischemia ◽  
Brain Barrier ◽  
Powder Injection ◽  
Barrier Dysfunction

Inhibition of chemokine-like factor 1 improves blood-brain barrier dysfunction in rats following focal cerebral ischemia

2016 ◽  
Vol 627 ◽  
pp. 192-198 ◽  
Author(s):  
Ling-Lei Kong ◽  
Zhi-Yuan Wang ◽  
Jin-Feng Hu ◽  
Yu-He Yuan ◽  
Hua Li ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Blood Brain Barrier ◽  
Focal Cerebral Ischemia ◽  
Brain Barrier ◽  
Barrier Dysfunction ◽  
Blood Brain

scholarly journals Alpha-Tocopherol Reduces Brain Edema and Protects Blood-Brain Barrier Integrity following Focal Cerebral Ischemia in Rats

2016 ◽  
Vol 26 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Adel Haghnejad Azar ◽  
Shahrbanoo Oryan ◽  
Shahab Bohlooli ◽  
Hamdollah Panahpour
Keyword(s):  
Cerebral Ischemia ◽  
Brain Edema ◽  
Blood Brain Barrier ◽  
Focal Cerebral Ischemia ◽  
Alpha Tocopherol ◽  
Brain Barrier ◽  
Barrier Integrity ◽  
Blood Brain ◽  
Blood Brain Barrier Integrity

The protective effect of HET0016 on brain edema and blood–brain barrier dysfunction after cerebral ischemia/reperfusion

2014 ◽  
Vol 1544 ◽  
pp. 45-53 ◽  
Author(s):  
Yu Liu ◽  
Di Wang ◽  
Huan Wang ◽  
Youyang Qu ◽  
Xingjun Xiao ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Protective Effect ◽  
Brain Edema ◽  
Blood Brain Barrier ◽  
Ischemia Reperfusion ◽  
Brain Barrier ◽  
Barrier Dysfunction ◽  
Cerebral Ischemia Reperfusion ◽  
Blood Brain

scholarly journals Increased Blood–Brain Barrier Permeability and Brain Edema After Focal Cerebral Ischemia Induced by Hyperlipidemia

Stroke ◽  
2011 ◽  
Vol 42 (11) ◽  
pp. 3238-3244 ◽  
Author(s):  
Ayman ElAli ◽  
Thorsten R. Doeppner ◽  
Anil Zechariah ◽  
Dirk M. Hermann
Keyword(s):  
Cerebral Ischemia ◽  
Brain Edema ◽  
Blood Brain Barrier ◽  
Focal Cerebral Ischemia ◽  
Brain Barrier ◽  
Barrier Permeability ◽  
Blood Brain Barrier Permeability ◽  
Blood Brain ◽  
Brain Barrier Permeability

Effects of ifenprodil, a polyamine site NMDA receptor antagonist, on reperfusion injury after transient focal cerebral ischemia

1997 ◽  
Vol 87 (6) ◽  
pp. 921-926 ◽  
Author(s):  
Aclan Doğgan ◽  
A. Muralikrishna Rao ◽  
Mustafa K. Başkaya ◽  
V. L. Raghavendra Rao ◽  
Jane Rastl ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Nmda Receptor ◽  
Nmda Receptors ◽  
Reperfusion Injury ◽  
Brain Edema ◽  
Focal Cerebral Ischemia ◽  
Infarct Volume ◽  
Male Rats ◽  
Temporal Muscle ◽  
Transient Focal Cerebral Ischemia

✓ Polyamines and N-methyl-d-aspartate (NMDA) receptors are both thought to play an important role in secondary neuronal injury after cerebral ischemia. Ifenprodil, known as a noncompetitive inhibitor of polyamine sites at the NMDA receptor, was studied after transient focal cerebral ischemia occurred. Spontaneously hypertensive male rats, each weighing between 250 and 350 g, underwent 3 hours of tandem middle cerebral artery (MCA) and common carotid artery occlusion followed by reperfusion for a period of 3 hours or 21 hours. Intravenous ifenprodil (10 µg/kg/minute) or saline infusion was started immediately after the onset of MCA occlusion and continued throughout the ischemic period. Physiological parameters including blood pressure, blood gas levels, blood glucose, hemoglobin, and rectal and temporal muscle temperatures were monitored. Six rats from each group were evaluated at 6 hours postocclusion for brain water content, an indicator of brain edema, and Evans blue dye extravasation for blood-brain barrier breakdown. Infarct volume was also measured in six rats from each group at 6 and 24 hours postocclusion. Ifenprodil treatment significantly reduced brain edema (82.5 ± 0.4% vs. 83.5 ± 0.4%, p < 0.05) and infarct volume (132 ± 14 mm3 vs. 168 ± 25 mm3, p < 0.05) compared with saline treatment, with no alterations in temporal muscle (brain) or rectal (body) temperature (35.9 ± 0.4°C vs. 36.2 ± 0.2°C; 37.7 ± 0.4°C vs. 37.6 ± 0.6°C; not significant). These results demonstrate that ifenprodil has neuroprotective properties after ischemia/reperfusion injury in the absence of hypothermia. This indicates that antagonists selective for the polyamine site of the NMDA receptors may be a viable treatment option and helps to explain some of the pathophysiological mechanisms involved in secondary injury after transient focal cerebral ischemia has occurred.

Hyperbaric oxygen reduces blood-brain barrier damage and edema after transient focal cerebral ischemia

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S266-S266
Author(s):  
Roland Veltkamp ◽  
Li Sun ◽  
Dirk A Siebing ◽  
Katja Bieber ◽  
Sabine Heiland ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Blood Brain Barrier ◽  
Hyperbaric Oxygen ◽  
Focal Cerebral Ischemia ◽  
Brain Barrier ◽  
Blood Brain ◽  
Transient Focal Cerebral Ischemia ◽  
Blood Brain Barrier Damage
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